# library(devtools)
# install_github("michaelyanwang/dcalasso")
library(survival)
library(dcalasso)
## Loading required package: mgcv
## Loading required package: nlme
## This is mgcv 1.9-1. For overview type 'help("mgcv-package")'.
## Loading required package: glmnet
## Loading required package: Matrix
## Loaded glmnet 4.1-8
## Loading required package: doParallel
## Loading required package: foreach
## Loading required package: iterators
## Loading required package: parallel
## Loading required package: MASS
library(profvis)
library(rms)
## Loading required package: Hmisc
##
## Attaching package: 'Hmisc'
## The following objects are masked from 'package:base':
##
## format.pval, units
library(glmnet)
# Helper functions
dac_BIC <- function(cph_mod) {
return(cph_mod$loglik / cph_mod$n + log(cph_mod$nevent) * length(cph_tv$coefficients))
}
concordance_index <- function(mod, data, time_col="stop", event_col="event", cph=TRUE) {
time <- data[, time_col]
status <- data[, event_col]
# Survival package automatically centers the linear predictors
if (cph) {
x <- predict(mod, newdata=data)
} else {
x <- scale(predict(mod, newdata=data)$fit, scale=F)
}
n <- length(time)
ord <- order(time, -status)
time <- time[ord]
status <- status[ord]
x <- x[ord]
wh <- which(status == 1)
total <- concordant <- 0
# Loop over event rows
for (i in wh) {
# Get indices for all subjects that have later times (time[j] > time[i])
later_times <- which(time > time[i])
# Get the predictions for those subjects
x_later <- x[later_times]
x_i <- x[i]
# Compare predictions for concordance
concordant <- concordant + sum(x_later < x_i) + 0.5 * sum(x_later == x_i)
total <- total + length(later_times)
}
# Calculate concordance
concordance <- concordant / total
return(concordance)
}
scale_data <- function(df_train, df_test, cont_var) {
train_means <- colMeans(df_train[, cont_var])
train_sd <- apply(df_train[, cont_var], 2, sd)
df_train[, cont_var] <- scale(df_train[, cont_var], center=train_means, scale=train_sd)
df_test[, cont_var] <- scale(df_test[, cont_var], center=train_means, scale=train_sd)
return(list(train=df_train, test=df_test))
}
load_data <- function(path_train, path_test, cont_var, tv=T) {
df_train <- read.csv(path_train)
df_test <- read.csv(path_test)
scale_res <- scale_data(df_train, df_test, cont_var)
df_train <- scale_res$train
df_test <- scale_res$test
df_train[df_train == "True"] <- 1
df_train[df_train == "False"] <- 0
df_test[df_test == "True"] <- 1
df_test[df_test == "False"] <- 0
if (tv) {
df_train["event"] <- as.integer(df_train$event)
df_test["event"] <- as.integer(df_test$event)
df_train <- df_train[df_train$stop > df_train$start,]
df_test <- df_test[df_test$stop > df_test$start,]
} else {
df_train[c("death", "ami", "stroke")] <- lapply(df_train[c("death", "ami", "stroke")], as.integer)
df_test[c("death", "ami", "stroke")] <- lapply(df_test[c("death", "ami", "stroke")], as.integer)
}
return(list(train=df_train, test=df_test))
}
# fit_cox <- function(df_train, df_test, form, cont_var){
# x_var <- all.vars(form[[3]])
# cat_var <- setdiff(x_var, cont_var)
# rcs_var <- paste0("rcs_", cont_var)
# new_var <- c()
#
# time_col <- all.vars(form[[2]])[1]
# event_col <- all.vars(form[[2]])[2]
#
# # Build X matrix with manually created rcs columns
# X <- df_train[, cat_var]
# X_test <- df_test[, cat_var]
# for (var in cont_var) {
# rcs_var <- rcspline.eval(df_train[, var], nk=5, inclx=T)
# rcs_var_test <- rcspline.eval(df_test[, var], nk=5, inclx=T)
#
# colnames(rcs_var) <- paste0("rcs_", var, "_", seq_len(ncol(rcs_var)))
# colnames(rcs_var_test) <- paste0("rcs_", var, "_", seq_len(ncol(rcs_var_test)))
#
# new_var <- append(new_var, colnames(rcs_var))
#
# X <- cbind(X, rcs_var)
# X_test <- cbind(X_test, rcs_var_test)
# }
#
# # Add interaction columns where necessary
# term_labels <- attr(terms(form), "term.labels")
# int_terms <- term_labels[grepl(":", term_labels)]
# if (length(int_terms) > 0) {
# for (int_term in int_terms) {
# # Extract which variables are in the interaction
# vars <- unlist(strsplit(int_term, ":"))
#
# if (grepl("rcs\\(", vars[1])) {
# var1 <- gsub("rcs\\(|\\)", "", vars[1])
# }
#
# if (grepl("rcs\\(", vars[2])) {
# var2 <- gsub("rcs\\(|\\)", "", vars[2])
# }
#
# cols1 <- new_var[grepl(var1, new_var)]
# cols2 <- new_var[grepl(var2, new_var)]
#
# for (c1 in cols1) {
# for (c2 in cols2) {
# int_var <- as.data.frame(X[, c1] * X[, c2])
# colnames(int_var) <- paste0(c1, "_X_", c2)
#
# new_var <- append(new_var, paste0(c1, "_X_", c2))
# X <- cbind(X, int_var)
# }
# }
#
# }
# }
# new_var <- append(new_var, cat_var)
#
# y <- Surv(df_train[, time_col], df_train[, event_col])
# cv_fit <- cv.glmnet(as.matrix(X), y, family="cox")
# coef_cv <- coef(cv_fit, s="lambda.min")
#
# # Turn into CPH object
# data <- cbind(X, df_train[, c(time_col, event_col)])
# data_test <- cbind(X_test, df_test[, c(time_col, event_col)])
#
# cph <- coxph(as.formula(paste0("Surv(", time_col, ", ", event_col, ") ~ ", paste(new_var, collapse="+"))), data, x=T, init=as.numeric(coef_cv), iter.max=0)
#
# conc_train <- concordance(cph, newdata=data)$concordance
# conc_test <- concordance(cph, newdata=data_test)$concordance
#
# return(list(cph=cph, conc_train=conc_train, conc_test=conc_test))
# }
fit_cox <- function(df_train, df_test, form, gr_i){
# Define null model and variable scope
null_form <- as.formula(paste0(deparse(form[[2]]), " ~ factor(cpap_treated)"))
scope <- as.formula(paste0("~ ", paste(deparse(form[[3]]), collapse="")))
# scope <- update(scope, . ~ . - factor(cpap_treated))
null_mod <- coxph(null_form, df_train)
# Compute and evaluate
step_mod <- stepAIC(null_mod, scope=list(lower=as.formula("~ factor(cpap_treated)"), upper=scope), direction="both")
# Save model to file
# saveRDS(step_mod, paste0("Models/cph_", gr_i, ".rds"))
conc_train <- concordance(step_mod, newdata=df_train)$concordance
conc_test <- concordance(step_mod, newdata=df_test)$concordance
return(list(cph=step_mod, conc_train=conc_train, conc_test=conc_test))
}
fit_dac <- function(df_train, form, gamma_values=seq(0.5, 2, by=0.5), K=20) {
mods <- list()
bics <- c()
j <- 1
for (i in seq_along(gamma_values)) {
gamma <- gamma_values[i]
penalties <- c(0, rep(gamma, length(attr(terms(form), "term.labels")) - 1))
dac <- dcalasso(form, data=df_train, gamma=penalties, K=K)
mods[[j]] <- dac
bics <- c(bics, dac$BIC.opt)
j <- j + 1
}
dac_opt <- mods[[which(bics == min(bics))]]
return(dac_opt)
}
run_models <- function(vec_forms, df_train, df_test, time_col, event_col, cont_var, prof_out_file, gr_i, K=20, bigd=T) {
assign("df_train", df_train, envir=.GlobalEnv)
i <- 1
for (form in vec_forms) {
print(paste("### FORMULA", i, "###"))
# Train models
prof <- profvis({
if (nrow(df_train) > 1000000) {
cph <- coxph(form, df_train, x=T)
conc_train <- concordance(cph, newdata=df_train)$concordance
conc_test <- concordance(cph, newdata=df_test)$concordance
} else {
cph_list <- fit_cox(df_train, df_test, form, cont_var)
cph <- cph_list$cph
conc_train <- cph_list$conc_train
conc_test <- cph_list$conc_test
}
if (bigd) {
try({
dac <- fit_dac(df_train, form, K=K)
print("--- DAC RESULTS ---")
print(summary(dac))
conc_train_dac <- concordance_index(dac, df_train, time_col, event_col, cph=F)
conc_test_dac <- concordance_index(dac, df_test, time_col, event_col, cph=F)
}, silent=T
)
}
# Evaluations
zph <- cox.zph(cph)
# Print summaries and plot
print("--- SURVIVAL RESULTS ---")
print(summary(cph))
plot(zph, resid=F)
termplot(cph)
# Compute concordance index
print("--- CONCORDANCE RESULTS ---")
cat("C-index train:", conc_train,
"\nC-index test:", conc_test
)
if (bigd) {
try({
cat("\nC-index DAC train:", conc_train_dac,
"\nC-index DAC test:", conc_test_dac)
}, silent=T)
}
})
# Save profiling results
htmlwidgets::saveWidget(prof, paste0("Profiling/dac_form", i, "_", prof_out_file))
i <- i + 1
}
}
cont_var <- c("time_to_cpap_start", "time_to_cpap_end", "alder", "bmi", "hba1c", "GFR", "kolesterol", "systoliskt", "DispInkKEHB04", "Raks_AndelArblosInk", "Raks_AndelSjukInk", "Raks_AndelEkBisInk")
# Load data
# tind_load <- load_data("/vault/marja987_amed/subsets_thesis_marijn/Data/ndr_survival_times_train.csv",
# "/vault/marja987_amed/subsets_thesis_marijn/Data/ndr_survival_times_test.csv",
# cont_var, tv=F)
# df_survival_times_train <- tind_load$train
# df_survival_times_test <- tind_load$test
death_load <- load_data("/vault/marja987_amed/subsets_thesis_marijn/Data/death_tv_train.csv",
"/vault/marja987_amed/subsets_thesis_marijn/Data/death_tv_test.csv",
setdiff(cont_var, c("time_to_cpap_start", "time_to_cpap_end")))
df_death_tv_train <- death_load$train
df_death_tv_test <- death_load$test
ami_load <- load_data("/vault/marja987_amed/subsets_thesis_marijn/Data/ami_tv_train.csv",
"/vault/marja987_amed/subsets_thesis_marijn/Data/ami_tv_train.csv",
setdiff(cont_var, c("time_to_cpap_start", "time_to_cpap_end")))
df_ami_tv_train <- ami_load$train
df_ami_tv_test <- ami_load$test
stroke_load <- load_data("/vault/marja987_amed/subsets_thesis_marijn/Data/stroke_tv_train.csv",
"/vault/marja987_amed/subsets_thesis_marijn/Data/stroke_tv_test.csv",
setdiff(cont_var, c("time_to_cpap_start", "time_to_cpap_end")))
df_stroke_tv_train <- stroke_load$train
df_stroke_tv_test <- stroke_load$test
cont_var <- c("time_to_cpap_start", "time_to_cpap_end", "alder", "bmi", "hba1c", "GFR", "kolesterol", "systoliskt", "DispInkKEHB04", "Raks_AndelArblosInk", "Raks_AndelSjukInk", "Raks_AndelEkBisInk")
cont_var_sleep <- c("time_to_cpap_start", "time_to_cpap_end", "alder", "bmi", "hba1c", "GFR", "kolesterol", "systoliskt", "DispInkKEHB04", "Raks_AndelArblosInk", "Raks_AndelSjukInk", "Raks_AndelEkBisInk", "IV_AHI", "IV_ODI", "IV_AverageSaturation")
# Load data
# tind_sub_load <- load_data("/vault/marja987_amed/subsets_thesis_marijn/Data/ndr_sesar_survival_times_train.csv",
# "/vault/marja987_amed/subsets_thesis_marijn/Data/ndr_sesar_survival_times_test.csv",
# cont_var_sleep, tv=F)
# df_survival_times_sub_train <- tind_sub_load$train
# df_survival_times_sub_test <- tind_sub_load$test
death_sub_load <- load_data("/vault/marja987_amed/subsets_thesis_marijn/Data/death_sub_tv_train.csv",
"/vault/marja987_amed/subsets_thesis_marijn/Data/death_sub_tv_test.csv",
setdiff(cont_var_sleep, c("time_to_cpap_start", "time_to_cpap_end")))
df_death_sub_tv_train <- death_sub_load$train
df_death_sub_tv_test <- death_sub_load$test
ami_sub_load <- load_data("/vault/marja987_amed/subsets_thesis_marijn/Data/ami_sub_tv_train.csv",
"/vault/marja987_amed/subsets_thesis_marijn/Data/ami_sub_tv_train.csv",
setdiff(cont_var_sleep, c("time_to_cpap_start", "time_to_cpap_end")))
df_ami_sub_tv_train <- ami_sub_load$train
df_ami_sub_tv_test <- ami_sub_load$test
stroke_sub_load <- load_data("/vault/marja987_amed/subsets_thesis_marijn/Data/stroke_sub_tv_train.csv",
"/vault/marja987_amed/subsets_thesis_marijn/Data/stroke_sub_tv_test.csv",
setdiff(cont_var_sleep, c("time_to_cpap_start", "time_to_cpap_end")))
df_stroke_sub_tv_train <- stroke_sub_load$train
df_stroke_sub_tv_test <- stroke_sub_load$test
base_form <- . ~ factor(cpap_treated) + rcs(alder) + factor(sex) + rcs(bmi) + factor(rokare) + factor(ami_history) + factor(stroke_history) + factor(Civil) + factor(HushallsTyp_RTB) + factor(Sun2000niva_old) + rcs(DispInkKEHB04) + rcs(Raks_AndelArblosInk) + rcs(Raks_AndelSjukInk) + rcs(Raks_AndelEkBisInk) + factor(FodelseLand_EU27_2020) + factor(antithrombotic_agents) + factor(antihypertensive_comb) + factor(lipid_modifying_agents) + factor(cpap_treated):factor(antithrombotic_agents) + factor(cpap_treated):factor(antihypertensive_comb) + factor(cpap_treated):factor(lipid_modifying_agents) + rcs(alder):rcs(bmi)
list_forms <- list()
for (time_setting in c("tind", "tdep")) {
if (time_setting == "tind") {
# In the time-independent formulas, the time and event columns are named accordingly
for (event in c("death", "ami", "stroke")) {
# Create both a spline and categorized instance for updating later
list_forms[[paste0("form_", event, "_", time_setting, "_spl")]] <- update(base_form, paste0("Surv(time_to_", event, ", ", event, ") ~ . + rcs(time_to_cpap_start) + rcs(time_to_cpap_end)"))
list_forms[[paste0("form_", event, "_", time_setting, "_cat")]] <- update(base_form, paste0("Surv(time_to_", event, ", ", event, ") ~ . + rcs(time_to_cpap_start) + rcs(time_to_cpap_end)"))
}
} else {
# In the time-dependent formulas, the time and event columns are start, stop, event always
list_forms[[paste0("form_", time_setting, "_spl")]] <- update(base_form, "Surv(start, stop, event) ~ .")
}
}
# Add spline or categorized variables, respectively
for (type in c("spline", "categorized")) {
i <- 1
for (form_name in names(list_forms)) {
if (grepl("_spl", form_name)) {
list_forms[[i]] <- update(list_forms[[i]], paste(". ~ . + rcs(hba1c) + rcs(GFR) + rcs(kolesterol) + rcs(systoliskt) + rcs(alder):rcs(GFR) + factor(cpap_treated):rcs(GFR)"))
} else if (grepl("_cat", form_name)) {
list_forms[[i]] <- update(list_forms[[i]], paste(". ~ . + factor(hba1c_high) + factor(GFR_high) + factor(kolesterol_high) + factor(systoliskt_high) + rcs(alder):factor(GFR_high) + factor(cpap_treated):factor(GFR_high)"))
}
i <- i + 1
}
}
# Create a copy that has sleep data for Group 2
list_forms_sleep <- list_forms
i <- 1
for (form in list_forms) {
list_forms_sleep[[i]] <- update(form, ". ~ . + rcs(IV_AHI) + rcs(IV_ODI) + rcs(IV_AverageSaturation)")
i <- i + 1
}
# formula_cat_tdep,
run_models(c(list_forms[["form_tdep_spl"]], list_forms[["form_tdep_cat"]]), df_death_tv_train, df_death_tv_test, "stop", "event", cont_var, "prof_death_dep_g1.html")
## [1] "### FORMULA 1 ###"
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in abs(bini)^gamma: longer object length is not a multiple of shorter
## object length
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in abs(bini)^gamma: longer object length is not a multiple of shorter
## object length
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in abs(bini)^gamma: longer object length is not a multiple of shorter
## object length
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in abs(bini)^gamma: longer object length is not a multiple of shorter
## object length
## [1] "--- DAC RESULTS ---"
##
## Divide-and-conquer adaptive lasso for a Cox PH model, n= 7284917 .
##
## Initial estimator computed for K= 20 and one-step estimation with 2 iterations.
##
## Penalized summary:
## Penalized Est Std. Error
## factor(cpap_treated)1 -0.3702846 0.2118433
## rcs(alder)alder 0.7014610 0.2573131
## rcs(alder)alder' 0.0862635 0.7567930
## rcs(alder)alder'' -0.0533951 3.5724664
## rcs(alder)alder''' 3.8131610 5.7404454
## factor(sex)1 -0.3292682 0.0057118
## rcs(bmi)bmi -0.5954298 0.1999532
## rcs(bmi)bmi' 1.2133429 1.8148657
## rcs(bmi)bmi'' -0.3505252 8.1685663
## rcs(bmi)bmi''' -3.8370442 10.1701057
## factor(rokare)1 0.4231005 0.0073617
## factor(ami_history)1 0.1967525 0.0085838
## factor(stroke_history)1 0.3384400 0.0092799
## factor(Civil)1 -0.1231831 0.0076453
## factor(HushallsTyp_RTB)2 -0.2409332 0.0065973
## factor(HushallsTyp_RTB)3 -0.0701581 0.0101050
## factor(Sun2000niva_old)2 0.0332077 0.0095251
## factor(Sun2000niva_old)3 -0.0336706 0.0064250
## factor(Sun2000niva_old)4 -0.0650482 0.0093037
## factor(Sun2000niva_old)5 -0.1150355 0.0109223
## factor(Sun2000niva_old)6 -0.1599910 0.0108673
## factor(Sun2000niva_old)7 -0.2739015 0.0368690
## rcs(DispInkKEHB04)DispInkKEHB04 0.0179591 0.0487995
## rcs(DispInkKEHB04)DispInkKEHB04' -4.7775790 1.1391093
## rcs(DispInkKEHB04)DispInkKEHB04'' 5.1572988 3.6635849
## rcs(DispInkKEHB04)DispInkKEHB04''' 5.9487527 3.6461371
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk 0.5347487 0.1014848
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk' -6.7562238 48.4929447
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'' 0.0833598 52.6247577
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''' 12.1488546 4.7626437
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk 1.2959907 0.1566974
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk' -51.9994227 239.2448663
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'' 6.9517771 276.6783305
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''' 59.2523570 38.4404456
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk 0.4058300 0.0695553
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk' -8.4086246 13.1106866
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'' 7.9119941 13.7428116
## factor(FodelseLand_EU27_2020)1 0.1256849 0.0074949
## factor(antithrombotic_agents)1 0.2183877 0.0057524
## factor(antihypertensive_comb)1 -0.0240591 0.0057563
## factor(lipid_modifying_agents)1 -0.1420829 0.0056154
## rcs(hba1c)hba1c -0.5860117 0.0185339
## rcs(hba1c)hba1c' 4.6428365 0.2563693
## rcs(hba1c)hba1c'' -9.3773059 0.8941112
## rcs(hba1c)hba1c''' 3.0858645 0.9225841
## rcs(GFR)GFR -1.0289514 0.1274711
## rcs(GFR)GFR' 2.1926888 0.9366031
## rcs(GFR)GFR'' -6.2568750 5.3387520
## rcs(GFR)GFR''' 6.7421385 8.4230323
## rcs(kolesterol)kolesterol -0.3447791 0.0130239
## rcs(kolesterol)kolesterol' 3.1101048 0.0995579
## rcs(kolesterol)kolesterol'' -11.5425546 0.3908515
## rcs(kolesterol)kolesterol''' 14.6700143 0.5692163
## rcs(systoliskt)systoliskt -0.4954975 0.0087708
## rcs(systoliskt)systoliskt' 1.1388124 0.0701941
## rcs(systoliskt)systoliskt'' -3.0954108 0.3632794
## rcs(systoliskt)systoliskt''' 3.2070597 0.6702091
## factor(cpap_treated)1:factor(antithrombotic_agents)1 0.0570500 0.0880402
## factor(cpap_treated)1:factor(antihypertensive_comb)1 0.0054404 0.0952475
## factor(cpap_treated)1:factor(lipid_modifying_agents)1 0.1415617 0.0887676
## rcs(alder)alder:rcs(bmi)bmi -0.0466390 0.1580380
## rcs(alder)alder':rcs(bmi)bmi 0.0445031 0.4916397
## rcs(alder)alder'':rcs(bmi)bmi -1.2033376 2.3968935
## rcs(alder)alder''':rcs(bmi)bmi 5.3885788 3.9430612
## rcs(alder)alder:rcs(bmi)bmi' -0.2805040 1.4548125
## rcs(alder)alder':rcs(bmi)bmi' 1.0474600 4.4599453
## rcs(alder)alder'':rcs(bmi)bmi' 0.6287234 21.6387038
## rcs(alder)alder''':rcs(bmi)bmi' -9.3240012 35.6521830
## rcs(alder)alder:rcs(bmi)bmi'' 1.7636820 6.5340169
## rcs(alder)alder':rcs(bmi)bmi'' -1.9760830 20.1078644
## rcs(alder)alder'':rcs(bmi)bmi'' -10.6057440 97.9437203
## rcs(alder)alder''':rcs(bmi)bmi'' 1.9166859 162.3358432
## rcs(alder)alder:rcs(bmi)bmi''' -2.6591145 8.1013934
## rcs(alder)alder':rcs(bmi)bmi''' -1.0528018 25.0910062
## rcs(alder)alder'':rcs(bmi)bmi''' 24.8782607 122.8946055
## rcs(alder)alder''':rcs(bmi)bmi''' 30.5731525 205.1694907
## rcs(alder)alder:rcs(GFR)GFR 0.0735488 0.1050075
## rcs(alder)alder':rcs(GFR)GFR 0.0165337 0.3115956
## rcs(alder)alder'':rcs(GFR)GFR 0.1608518 1.4810759
## rcs(alder)alder''':rcs(GFR)GFR 0.0097614 2.4032458
## rcs(alder)alder:rcs(GFR)GFR' 0.5071164 0.7813677
## rcs(alder)alder':rcs(GFR)GFR' -0.0137708 2.2778916
## rcs(alder)alder'':rcs(GFR)GFR' 1.0769411 10.7266639
## rcs(alder)alder''':rcs(GFR)GFR' -5.3499131 17.2842977
## rcs(alder)alder:rcs(GFR)GFR'' -2.0998377 4.3992407
## rcs(alder)alder':rcs(GFR)GFR'' 1.7104552 13.0724842
## rcs(alder)alder'':rcs(GFR)GFR'' -7.8073929 62.6672546
## rcs(alder)alder''':rcs(GFR)GFR'' -4.8016665 103.2071258
## rcs(alder)alder:rcs(GFR)GFR''' 1.9219810 6.8396257
## rcs(alder)alder':rcs(GFR)GFR''' -4.2713499 20.7990399
## rcs(alder)alder'':rcs(GFR)GFR''' 2.2003491 101.7871895
## rcs(alder)alder''':rcs(GFR)GFR''' 84.7050416 171.7459954
## factor(cpap_treated)1:rcs(GFR)GFR -0.0227394 0.1198867
## factor(cpap_treated)1:rcs(GFR)GFR' -0.0659945 0.9028629
## factor(cpap_treated)1:rcs(GFR)GFR'' -0.9819877 5.5678850
## factor(cpap_treated)1:rcs(GFR)GFR''' 4.6568372 9.4186419
## z value Pr(>|z|)
## factor(cpap_treated)1 -1.7479 0.0804784 .
## rcs(alder)alder 2.7261 0.0064088 **
## rcs(alder)alder' 0.1140 0.9092492
## rcs(alder)alder'' -0.0149 0.9880750
## rcs(alder)alder''' 0.6643 0.5065225
## factor(sex)1 -57.6469 < 2.2e-16 ***
## rcs(bmi)bmi -2.9778 0.0029028 **
## rcs(bmi)bmi' 0.6686 0.5037775
## rcs(bmi)bmi'' -0.0429 0.9657721
## rcs(bmi)bmi''' -0.3773 0.7059607
## factor(rokare)1 57.4730 < 2.2e-16 ***
## factor(ami_history)1 22.9215 < 2.2e-16 ***
## factor(stroke_history)1 36.4704 < 2.2e-16 ***
## factor(Civil)1 -16.1122 < 2.2e-16 ***
## factor(HushallsTyp_RTB)2 -36.5199 < 2.2e-16 ***
## factor(HushallsTyp_RTB)3 -6.9429 3.842e-12 ***
## factor(Sun2000niva_old)2 3.4863 0.0004897 ***
## factor(Sun2000niva_old)3 -5.2406 1.601e-07 ***
## factor(Sun2000niva_old)4 -6.9916 2.717e-12 ***
## factor(Sun2000niva_old)5 -10.5322 < 2.2e-16 ***
## factor(Sun2000niva_old)6 -14.7223 < 2.2e-16 ***
## factor(Sun2000niva_old)7 -7.4291 1.094e-13 ***
## rcs(DispInkKEHB04)DispInkKEHB04 0.3680 0.7128600
## rcs(DispInkKEHB04)DispInkKEHB04' -4.1941 2.739e-05 ***
## rcs(DispInkKEHB04)DispInkKEHB04'' 1.4077 0.1592142
## rcs(DispInkKEHB04)DispInkKEHB04''' 1.6315 0.1027802
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk 5.2693 1.370e-07 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk' -0.1393 0.8891942
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'' 0.0016 0.9987361
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''' 2.5509 0.0107456 *
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk 8.2707 < 2.2e-16 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk' -0.2173 0.8279371
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'' 0.0251 0.9799546
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''' 1.5414 0.1232179
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk 5.8346 5.391e-09 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk' -0.6414 0.5212911
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'' 0.5757 0.5648053
## factor(FodelseLand_EU27_2020)1 16.7695 < 2.2e-16 ***
## factor(antithrombotic_agents)1 37.9647 < 2.2e-16 ***
## factor(antihypertensive_comb)1 -4.1796 2.920e-05 ***
## factor(lipid_modifying_agents)1 -25.3022 < 2.2e-16 ***
## rcs(hba1c)hba1c -31.6183 < 2.2e-16 ***
## rcs(hba1c)hba1c' 18.1100 < 2.2e-16 ***
## rcs(hba1c)hba1c'' -10.4879 < 2.2e-16 ***
## rcs(hba1c)hba1c''' 3.3448 0.0008234 ***
## rcs(GFR)GFR -8.0720 6.914e-16 ***
## rcs(GFR)GFR' 2.3411 0.0192266 *
## rcs(GFR)GFR'' -1.1720 0.2412078
## rcs(GFR)GFR''' 0.8004 0.4234555
## rcs(kolesterol)kolesterol -26.4728 < 2.2e-16 ***
## rcs(kolesterol)kolesterol' 31.2391 < 2.2e-16 ***
## rcs(kolesterol)kolesterol'' -29.5318 < 2.2e-16 ***
## rcs(kolesterol)kolesterol''' 25.7723 < 2.2e-16 ***
## rcs(systoliskt)systoliskt -56.4939 < 2.2e-16 ***
## rcs(systoliskt)systoliskt' 16.2238 < 2.2e-16 ***
## rcs(systoliskt)systoliskt'' -8.5207 < 2.2e-16 ***
## rcs(systoliskt)systoliskt''' 4.7852 1.708e-06 ***
## factor(cpap_treated)1:factor(antithrombotic_agents)1 0.6480 0.5169852
## factor(cpap_treated)1:factor(antihypertensive_comb)1 0.0571 0.9544505
## factor(cpap_treated)1:factor(lipid_modifying_agents)1 1.5947 0.1107691
## rcs(alder)alder:rcs(bmi)bmi -0.2951 0.7679077
## rcs(alder)alder':rcs(bmi)bmi 0.0905 0.9278742
## rcs(alder)alder'':rcs(bmi)bmi -0.5020 0.6156391
## rcs(alder)alder''':rcs(bmi)bmi 1.3666 0.1717514
## rcs(alder)alder:rcs(bmi)bmi' -0.1928 0.8471069
## rcs(alder)alder':rcs(bmi)bmi' 0.2349 0.8143179
## rcs(alder)alder'':rcs(bmi)bmi' 0.0291 0.9768203
## rcs(alder)alder''':rcs(bmi)bmi' -0.2615 0.7936863
## rcs(alder)alder:rcs(bmi)bmi'' 0.2699 0.7872194
## rcs(alder)alder':rcs(bmi)bmi'' -0.0983 0.9217146
## rcs(alder)alder'':rcs(bmi)bmi'' -0.1083 0.9137704
## rcs(alder)alder''':rcs(bmi)bmi'' 0.0118 0.9905797
## rcs(alder)alder:rcs(bmi)bmi''' -0.3282 0.7427383
## rcs(alder)alder':rcs(bmi)bmi''' -0.0420 0.9665311
## rcs(alder)alder'':rcs(bmi)bmi''' 0.2024 0.8395761
## rcs(alder)alder''':rcs(bmi)bmi''' 0.1490 0.8815425
## rcs(alder)alder:rcs(GFR)GFR 0.7004 0.4836685
## rcs(alder)alder':rcs(GFR)GFR 0.0531 0.9576830
## rcs(alder)alder'':rcs(GFR)GFR 0.1086 0.9135160
## rcs(alder)alder''':rcs(GFR)GFR 0.0041 0.9967592
## rcs(alder)alder:rcs(GFR)GFR' 0.6490 0.5163311
## rcs(alder)alder':rcs(GFR)GFR' -0.0060 0.9951765
## rcs(alder)alder'':rcs(GFR)GFR' 0.1004 0.9200279
## rcs(alder)alder''':rcs(GFR)GFR' -0.3095 0.7569226
## rcs(alder)alder:rcs(GFR)GFR'' -0.4773 0.6331355
## rcs(alder)alder':rcs(GFR)GFR'' 0.1308 0.8958988
## rcs(alder)alder'':rcs(GFR)GFR'' -0.1246 0.9008522
## rcs(alder)alder''':rcs(GFR)GFR'' -0.0465 0.9628922
## rcs(alder)alder:rcs(GFR)GFR''' 0.2810 0.7787052
## rcs(alder)alder':rcs(GFR)GFR''' -0.2054 0.8372887
## rcs(alder)alder'':rcs(GFR)GFR''' 0.0216 0.9827534
## rcs(alder)alder''':rcs(GFR)GFR''' 0.4932 0.6218716
## factor(cpap_treated)1:rcs(GFR)GFR -0.1897 0.8495646
## factor(cpap_treated)1:rcs(GFR)GFR' -0.0731 0.9417308
## factor(cpap_treated)1:rcs(GFR)GFR'' -0.1764 0.8600061
## factor(cpap_treated)1:rcs(GFR)GFR''' 0.4944 0.6210042
## ---
## Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
##
## BIC = 8202.851 with lambda = 1e-10
## [1] "--- SURVIVAL RESULTS ---"
## Call:
## coxph(formula = form, data = df_train, x = T)
##
## n= 7284917, number of events= 159570
##
## coef exp(coef)
## factor(cpap_treated)1 -3.491e-01 7.053e-01
## rcs(alder)alder 8.430e-01 2.323e+00
## rcs(alder)alder' -9.272e-01 3.956e-01
## rcs(alder)alder'' 8.868e+00 7.102e+03
## rcs(alder)alder''' -1.713e+01 3.629e-08
## factor(sex)1 -3.344e-01 7.158e-01
## rcs(bmi)bmi -4.605e-01 6.310e-01
## rcs(bmi)bmi' -2.060e+00 1.274e-01
## rcs(bmi)bmi'' 1.858e+01 1.171e+08
## rcs(bmi)bmi''' -3.097e+01 3.547e-14
## factor(rokare)1 4.104e-01 1.507e+00
## factor(ami_history)1 1.921e-01 1.212e+00
## factor(stroke_history)1 3.347e-01 1.397e+00
## factor(Civil)1 -9.581e-02 9.086e-01
## factor(HushallsTyp_RTB)2 -2.228e-01 8.003e-01
## factor(HushallsTyp_RTB)3 -5.235e-02 9.490e-01
## factor(Sun2000niva_old)2 2.359e-02 1.024e+00
## factor(Sun2000niva_old)3 -4.179e-02 9.591e-01
## factor(Sun2000niva_old)4 -6.685e-02 9.353e-01
## factor(Sun2000niva_old)5 -1.126e-01 8.935e-01
## factor(Sun2000niva_old)6 -1.563e-01 8.553e-01
## factor(Sun2000niva_old)7 -2.503e-01 7.785e-01
## rcs(DispInkKEHB04)DispInkKEHB04 3.049e-02 1.031e+00
## rcs(DispInkKEHB04)DispInkKEHB04' -8.868e+00 1.408e-04
## rcs(DispInkKEHB04)DispInkKEHB04'' 1.663e+01 1.669e+07
## rcs(DispInkKEHB04)DispInkKEHB04''' -3.176e+00 4.175e-02
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk 2.932e+00 1.877e+01
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk' -1.314e+03 0.000e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'' 1.421e+03 Inf
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''' -1.194e+02 1.356e-52
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk 9.405e+00 1.215e+04
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk' -1.286e+04 0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'' 1.482e+04 Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''' -1.990e+03 0.000e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk 2.237e+00 9.368e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk' -3.878e+02 3.668e-169
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'' 4.059e+02 1.902e+176
## factor(FodelseLand_EU27_2020)1 1.618e-01 1.176e+00
## factor(antithrombotic_agents)1 2.227e-01 1.249e+00
## factor(antihypertensive_comb)1 -8.805e-03 9.912e-01
## factor(lipid_modifying_agents)1 -1.297e-01 8.784e-01
## rcs(hba1c)hba1c -7.704e-01 4.628e-01
## rcs(hba1c)hba1c' 7.633e+00 2.066e+03
## rcs(hba1c)hba1c'' -1.984e+01 2.415e-09
## rcs(hba1c)hba1c''' 1.357e+01 7.836e+05
## rcs(GFR)GFR -1.186e+00 3.053e-01
## rcs(GFR)GFR' 2.109e+00 8.237e+00
## rcs(GFR)GFR'' -2.106e+00 1.217e-01
## rcs(GFR)GFR''' -3.522e+00 2.955e-02
## rcs(kolesterol)kolesterol -3.593e-01 6.982e-01
## rcs(kolesterol)kolesterol' 3.209e+00 2.475e+01
## rcs(kolesterol)kolesterol'' -1.187e+01 6.983e-06
## rcs(kolesterol)kolesterol''' 1.504e+01 3.401e+06
## rcs(systoliskt)systoliskt -4.990e-01 6.072e-01
## rcs(systoliskt)systoliskt' 1.222e+00 3.395e+00
## rcs(systoliskt)systoliskt'' -3.565e+00 2.830e-02
## rcs(systoliskt)systoliskt''' 4.062e+00 5.807e+01
## factor(cpap_treated)1:factor(antithrombotic_agents)1 4.827e-02 1.049e+00
## factor(cpap_treated)1:factor(antihypertensive_comb)1 1.350e-02 1.014e+00
## factor(cpap_treated)1:factor(lipid_modifying_agents)1 1.272e-01 1.136e+00
## rcs(alder)alder:rcs(bmi)bmi 4.151e-01 1.514e+00
## rcs(alder)alder':rcs(bmi)bmi -1.433e+00 2.387e-01
## rcs(alder)alder'':rcs(bmi)bmi 8.717e+00 6.108e+03
## rcs(alder)alder''':rcs(bmi)bmi -1.593e+01 1.203e-07
## rcs(alder)alder:rcs(bmi)bmi' -4.821e+00 8.062e-03
## rcs(alder)alder':rcs(bmi)bmi' 1.789e+01 5.864e+07
## rcs(alder)alder'':rcs(bmi)bmi' -9.656e+01 1.161e-42
## rcs(alder)alder''':rcs(bmi)bmi' 1.701e+02 7.177e+73
## rcs(alder)alder:rcs(bmi)bmi'' 2.136e+01 1.892e+09
## rcs(alder)alder':rcs(bmi)bmi'' -8.295e+01 9.415e-37
## rcs(alder)alder'':rcs(bmi)bmi'' 4.341e+02 3.435e+188
## rcs(alder)alder''':rcs(bmi)bmi'' -7.630e+02 0.000e+00
## rcs(alder)alder:rcs(bmi)bmi''' -2.547e+01 8.673e-12
## rcs(alder)alder':rcs(bmi)bmi''' 1.026e+02 3.463e+44
## rcs(alder)alder'':rcs(bmi)bmi''' -5.244e+02 1.829e-228
## rcs(alder)alder''':rcs(bmi)bmi''' 9.216e+02 Inf
## rcs(alder)alder:rcs(GFR)GFR -1.456e-01 8.645e-01
## rcs(alder)alder':rcs(GFR)GFR 3.106e-01 1.364e+00
## rcs(alder)alder'':rcs(GFR)GFR -4.197e-01 6.572e-01
## rcs(alder)alder''':rcs(GFR)GFR 1.789e-01 1.196e+00
## rcs(alder)alder:rcs(GFR)GFR' 1.304e+00 3.683e+00
## rcs(alder)alder':rcs(GFR)GFR' 7.749e-01 2.170e+00
## rcs(alder)alder'':rcs(GFR)GFR' -6.652e+00 1.291e-03
## rcs(alder)alder''':rcs(GFR)GFR' 5.848e+00 3.466e+02
## rcs(alder)alder:rcs(GFR)GFR'' -3.526e+00 2.942e-02
## rcs(alder)alder':rcs(GFR)GFR'' -9.729e+00 5.954e-05
## rcs(alder)alder'':rcs(GFR)GFR'' 4.940e+01 2.855e+21
## rcs(alder)alder''':rcs(GFR)GFR'' -4.815e+01 1.230e-21
## rcs(alder)alder:rcs(GFR)GFR''' 6.054e-01 1.832e+00
## rcs(alder)alder':rcs(GFR)GFR''' 1.954e+01 3.058e+08
## rcs(alder)alder'':rcs(GFR)GFR''' -8.623e+01 3.568e-38
## rcs(alder)alder''':rcs(GFR)GFR''' 9.395e+01 6.336e+40
## factor(cpap_treated)1:rcs(GFR)GFR -2.114e-02 9.791e-01
## factor(cpap_treated)1:rcs(GFR)GFR' -3.587e-01 6.986e-01
## factor(cpap_treated)1:rcs(GFR)GFR'' 2.194e+00 8.968e+00
## factor(cpap_treated)1:rcs(GFR)GFR''' -2.697e+00 6.740e-02
## se(coef) z
## factor(cpap_treated)1 2.214e-01 -1.576
## rcs(alder)alder 2.612e-01 3.227
## rcs(alder)alder' 7.654e-01 -1.211
## rcs(alder)alder'' 3.603e+00 2.461
## rcs(alder)alder''' 5.774e+00 -2.967
## factor(sex)1 5.711e-03 -58.551
## rcs(bmi)bmi 2.040e-01 -2.257
## rcs(bmi)bmi' 1.843e+00 -1.118
## rcs(bmi)bmi'' 8.299e+00 2.239
## rcs(bmi)bmi''' 1.035e+01 -2.991
## factor(rokare)1 7.366e-03 55.716
## factor(ami_history)1 8.580e-03 22.386
## factor(stroke_history)1 9.273e-03 36.091
## factor(Civil)1 7.640e-03 -12.541
## factor(HushallsTyp_RTB)2 6.597e-03 -33.775
## factor(HushallsTyp_RTB)3 1.011e-02 -5.178
## factor(Sun2000niva_old)2 9.530e-03 2.476
## factor(Sun2000niva_old)3 6.421e-03 -6.508
## factor(Sun2000niva_old)4 9.303e-03 -7.185
## factor(Sun2000niva_old)5 1.092e-02 -10.312
## factor(Sun2000niva_old)6 1.087e-02 -14.373
## factor(Sun2000niva_old)7 3.765e-02 -6.650
## rcs(DispInkKEHB04)DispInkKEHB04 5.807e-02 0.525
## rcs(DispInkKEHB04)DispInkKEHB04' 1.218e+00 -7.279
## rcs(DispInkKEHB04)DispInkKEHB04'' 3.832e+00 4.340
## rcs(DispInkKEHB04)DispInkKEHB04''' 3.746e+00 -0.848
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk 1.021e-01 28.708
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk' 4.879e+01 -26.930
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'' 5.294e+01 26.843
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''' 4.791e+00 -24.927
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk 1.571e-01 59.851
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk' 2.403e+02 -53.528
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'' 2.780e+02 53.319
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''' 3.864e+01 -51.492
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk 6.982e-02 32.041
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk' 1.320e+01 -29.378
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'' 1.384e+01 29.330
## factor(FodelseLand_EU27_2020)1 7.500e-03 21.574
## factor(antithrombotic_agents)1 5.750e-03 38.735
## factor(antihypertensive_comb)1 5.755e-03 -1.530
## factor(lipid_modifying_agents)1 5.613e-03 -23.106
## rcs(hba1c)hba1c 1.856e-02 -41.515
## rcs(hba1c)hba1c' 2.565e-01 29.759
## rcs(hba1c)hba1c'' 8.944e-01 -22.184
## rcs(hba1c)hba1c''' 9.227e-01 14.709
## rcs(GFR)GFR 1.289e-01 -9.206
## rcs(GFR)GFR' 9.454e-01 2.230
## rcs(GFR)GFR'' 5.394e+00 -0.390
## rcs(GFR)GFR''' 8.526e+00 -0.413
## rcs(kolesterol)kolesterol 1.303e-02 -27.569
## rcs(kolesterol)kolesterol' 9.959e-02 32.223
## rcs(kolesterol)kolesterol'' 3.909e-01 -30.369
## rcs(kolesterol)kolesterol''' 5.693e-01 26.419
## rcs(systoliskt)systoliskt 8.774e-03 -56.867
## rcs(systoliskt)systoliskt' 7.020e-02 17.412
## rcs(systoliskt)systoliskt'' 3.632e-01 -9.814
## rcs(systoliskt)systoliskt''' 6.701e-01 6.062
## factor(cpap_treated)1:factor(antithrombotic_agents)1 9.261e-02 0.521
## factor(cpap_treated)1:factor(antihypertensive_comb)1 1.019e-01 0.132
## factor(cpap_treated)1:factor(lipid_modifying_agents)1 9.385e-02 1.356
## rcs(alder)alder:rcs(bmi)bmi 1.620e-01 2.562
## rcs(alder)alder':rcs(bmi)bmi 5.007e-01 -2.862
## rcs(alder)alder'':rcs(bmi)bmi 2.430e+00 3.588
## rcs(alder)alder''':rcs(bmi)bmi 3.982e+00 -4.002
## rcs(alder)alder:rcs(bmi)bmi' 1.482e+00 -3.253
## rcs(alder)alder':rcs(bmi)bmi' 4.522e+00 3.956
## rcs(alder)alder'':rcs(bmi)bmi' 2.186e+01 -4.417
## rcs(alder)alder''':rcs(bmi)bmi' 3.591e+01 4.736
## rcs(alder)alder:rcs(bmi)bmi'' 6.661e+00 3.207
## rcs(alder)alder':rcs(bmi)bmi'' 2.040e+01 -4.066
## rcs(alder)alder'':rcs(bmi)bmi'' 9.902e+01 4.384
## rcs(alder)alder''':rcs(bmi)bmi'' 1.636e+02 -4.664
## rcs(alder)alder:rcs(bmi)bmi''' 8.278e+00 -3.077
## rcs(alder)alder':rcs(bmi)bmi''' 2.551e+01 4.021
## rcs(alder)alder'':rcs(bmi)bmi''' 1.244e+02 -4.214
## rcs(alder)alder''':rcs(bmi)bmi''' 2.070e+02 4.451
## rcs(alder)alder:rcs(GFR)GFR 1.063e-01 -1.369
## rcs(alder)alder':rcs(GFR)GFR 3.147e-01 0.987
## rcs(alder)alder'':rcs(GFR)GFR 1.492e+00 -0.281
## rcs(alder)alder''':rcs(GFR)GFR 2.415e+00 0.074
## rcs(alder)alder:rcs(GFR)GFR' 7.901e-01 1.650
## rcs(alder)alder':rcs(GFR)GFR' 2.297e+00 0.337
## rcs(alder)alder'':rcs(GFR)GFR' 1.079e+01 -0.616
## rcs(alder)alder''':rcs(GFR)GFR' 1.735e+01 0.337
## rcs(alder)alder:rcs(GFR)GFR'' 4.453e+00 -0.792
## rcs(alder)alder':rcs(GFR)GFR'' 1.319e+01 -0.737
## rcs(alder)alder'':rcs(GFR)GFR'' 6.311e+01 0.783
## rcs(alder)alder''':rcs(GFR)GFR'' 1.037e+02 -0.464
## rcs(alder)alder:rcs(GFR)GFR''' 6.939e+00 0.087
## rcs(alder)alder':rcs(GFR)GFR''' 2.103e+01 0.929
## rcs(alder)alder'':rcs(GFR)GFR''' 1.027e+02 -0.840
## rcs(alder)alder''':rcs(GFR)GFR''' 1.728e+02 0.544
## factor(cpap_treated)1:rcs(GFR)GFR 1.248e-01 -0.169
## factor(cpap_treated)1:rcs(GFR)GFR' 9.541e-01 -0.376
## factor(cpap_treated)1:rcs(GFR)GFR'' 6.005e+00 0.365
## factor(cpap_treated)1:rcs(GFR)GFR''' 1.039e+01 -0.259
## Pr(>|z|)
## factor(cpap_treated)1 0.114925
## rcs(alder)alder 0.001249 **
## rcs(alder)alder' 0.225728
## rcs(alder)alder'' 0.013845 *
## rcs(alder)alder''' 0.003005 **
## factor(sex)1 < 2e-16 ***
## rcs(bmi)bmi 0.023990 *
## rcs(bmi)bmi' 0.263579
## rcs(bmi)bmi'' 0.025184 *
## rcs(bmi)bmi''' 0.002777 **
## factor(rokare)1 < 2e-16 ***
## factor(ami_history)1 < 2e-16 ***
## factor(stroke_history)1 < 2e-16 ***
## factor(Civil)1 < 2e-16 ***
## factor(HushallsTyp_RTB)2 < 2e-16 ***
## factor(HushallsTyp_RTB)3 2.25e-07 ***
## factor(Sun2000niva_old)2 0.013292 *
## factor(Sun2000niva_old)3 7.62e-11 ***
## factor(Sun2000niva_old)4 6.72e-13 ***
## factor(Sun2000niva_old)5 < 2e-16 ***
## factor(Sun2000niva_old)6 < 2e-16 ***
## factor(Sun2000niva_old)7 2.94e-11 ***
## rcs(DispInkKEHB04)DispInkKEHB04 0.599567
## rcs(DispInkKEHB04)DispInkKEHB04' 3.37e-13 ***
## rcs(DispInkKEHB04)DispInkKEHB04'' 1.42e-05 ***
## rcs(DispInkKEHB04)DispInkKEHB04''' 0.396494
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk < 2e-16 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk' < 2e-16 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'' < 2e-16 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''' < 2e-16 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk < 2e-16 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk' < 2e-16 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'' < 2e-16 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''' < 2e-16 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk < 2e-16 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk' < 2e-16 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'' < 2e-16 ***
## factor(FodelseLand_EU27_2020)1 < 2e-16 ***
## factor(antithrombotic_agents)1 < 2e-16 ***
## factor(antihypertensive_comb)1 0.125984
## factor(lipid_modifying_agents)1 < 2e-16 ***
## rcs(hba1c)hba1c < 2e-16 ***
## rcs(hba1c)hba1c' < 2e-16 ***
## rcs(hba1c)hba1c'' < 2e-16 ***
## rcs(hba1c)hba1c''' < 2e-16 ***
## rcs(GFR)GFR < 2e-16 ***
## rcs(GFR)GFR' 0.025716 *
## rcs(GFR)GFR'' 0.696227
## rcs(GFR)GFR''' 0.679586
## rcs(kolesterol)kolesterol < 2e-16 ***
## rcs(kolesterol)kolesterol' < 2e-16 ***
## rcs(kolesterol)kolesterol'' < 2e-16 ***
## rcs(kolesterol)kolesterol''' < 2e-16 ***
## rcs(systoliskt)systoliskt < 2e-16 ***
## rcs(systoliskt)systoliskt' < 2e-16 ***
## rcs(systoliskt)systoliskt'' < 2e-16 ***
## rcs(systoliskt)systoliskt''' 1.35e-09 ***
## factor(cpap_treated)1:factor(antithrombotic_agents)1 0.602234
## factor(cpap_treated)1:factor(antihypertensive_comb)1 0.894612
## factor(cpap_treated)1:factor(lipid_modifying_agents)1 0.175254
## rcs(alder)alder:rcs(bmi)bmi 0.010422 *
## rcs(alder)alder':rcs(bmi)bmi 0.004215 **
## rcs(alder)alder'':rcs(bmi)bmi 0.000334 ***
## rcs(alder)alder''':rcs(bmi)bmi 6.29e-05 ***
## rcs(alder)alder:rcs(bmi)bmi' 0.001143 **
## rcs(alder)alder':rcs(bmi)bmi' 7.63e-05 ***
## rcs(alder)alder'':rcs(bmi)bmi' 1.00e-05 ***
## rcs(alder)alder''':rcs(bmi)bmi' 2.18e-06 ***
## rcs(alder)alder:rcs(bmi)bmi'' 0.001342 **
## rcs(alder)alder':rcs(bmi)bmi'' 4.78e-05 ***
## rcs(alder)alder'':rcs(bmi)bmi'' 1.16e-05 ***
## rcs(alder)alder''':rcs(bmi)bmi'' 3.09e-06 ***
## rcs(alder)alder:rcs(bmi)bmi''' 0.002091 **
## rcs(alder)alder':rcs(bmi)bmi''' 5.80e-05 ***
## rcs(alder)alder'':rcs(bmi)bmi''' 2.51e-05 ***
## rcs(alder)alder''':rcs(bmi)bmi''' 8.53e-06 ***
## rcs(alder)alder:rcs(GFR)GFR 0.170884
## rcs(alder)alder':rcs(GFR)GFR 0.323506
## rcs(alder)alder'':rcs(GFR)GFR 0.778472
## rcs(alder)alder''':rcs(GFR)GFR 0.940951
## rcs(alder)alder:rcs(GFR)GFR' 0.098895 .
## rcs(alder)alder':rcs(GFR)GFR' 0.735856
## rcs(alder)alder'':rcs(GFR)GFR' 0.537682
## rcs(alder)alder''':rcs(GFR)GFR' 0.736106
## rcs(alder)alder:rcs(GFR)GFR'' 0.428451
## rcs(alder)alder':rcs(GFR)GFR'' 0.460921
## rcs(alder)alder'':rcs(GFR)GFR'' 0.433715
## rcs(alder)alder''':rcs(GFR)GFR'' 0.642430
## rcs(alder)alder:rcs(GFR)GFR''' 0.930470
## rcs(alder)alder':rcs(GFR)GFR''' 0.352865
## rcs(alder)alder'':rcs(GFR)GFR''' 0.400921
## rcs(alder)alder''':rcs(GFR)GFR''' 0.586647
## factor(cpap_treated)1:rcs(GFR)GFR 0.865507
## factor(cpap_treated)1:rcs(GFR)GFR' 0.706992
## factor(cpap_treated)1:rcs(GFR)GFR'' 0.714909
## factor(cpap_treated)1:rcs(GFR)GFR''' 0.795265
## ---
## Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
##
## exp(coef) exp(-coef)
## factor(cpap_treated)1 7.053e-01 1.418e+00
## rcs(alder)alder 2.323e+00 4.304e-01
## rcs(alder)alder' 3.956e-01 2.528e+00
## rcs(alder)alder'' 7.102e+03 1.408e-04
## rcs(alder)alder''' 3.629e-08 2.756e+07
## factor(sex)1 7.158e-01 1.397e+00
## rcs(bmi)bmi 6.310e-01 1.585e+00
## rcs(bmi)bmi' 1.274e-01 7.847e+00
## rcs(bmi)bmi'' 1.171e+08 8.539e-09
## rcs(bmi)bmi''' 3.547e-14 2.820e+13
## factor(rokare)1 1.507e+00 6.634e-01
## factor(ami_history)1 1.212e+00 8.252e-01
## factor(stroke_history)1 1.397e+00 7.156e-01
## factor(Civil)1 9.086e-01 1.101e+00
## factor(HushallsTyp_RTB)2 8.003e-01 1.250e+00
## factor(HushallsTyp_RTB)3 9.490e-01 1.054e+00
## factor(Sun2000niva_old)2 1.024e+00 9.767e-01
## factor(Sun2000niva_old)3 9.591e-01 1.043e+00
## factor(Sun2000niva_old)4 9.353e-01 1.069e+00
## factor(Sun2000niva_old)5 8.935e-01 1.119e+00
## factor(Sun2000niva_old)6 8.553e-01 1.169e+00
## factor(Sun2000niva_old)7 7.785e-01 1.284e+00
## rcs(DispInkKEHB04)DispInkKEHB04 1.031e+00 9.700e-01
## rcs(DispInkKEHB04)DispInkKEHB04' 1.408e-04 7.102e+03
## rcs(DispInkKEHB04)DispInkKEHB04'' 1.669e+07 5.990e-08
## rcs(DispInkKEHB04)DispInkKEHB04''' 4.175e-02 2.395e+01
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk 1.877e+01 5.328e-02
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk' 0.000e+00 Inf
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'' Inf 0.000e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''' 1.356e-52 7.375e+51
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk 1.215e+04 8.231e-05
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk' 0.000e+00 Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'' Inf 0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''' 0.000e+00 Inf
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk 9.368e+00 1.068e-01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk' 3.668e-169 2.727e+168
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'' 1.902e+176 5.259e-177
## factor(FodelseLand_EU27_2020)1 1.176e+00 8.506e-01
## factor(antithrombotic_agents)1 1.249e+00 8.003e-01
## factor(antihypertensive_comb)1 9.912e-01 1.009e+00
## factor(lipid_modifying_agents)1 8.784e-01 1.138e+00
## rcs(hba1c)hba1c 4.628e-01 2.161e+00
## rcs(hba1c)hba1c' 2.066e+03 4.840e-04
## rcs(hba1c)hba1c'' 2.415e-09 4.141e+08
## rcs(hba1c)hba1c''' 7.836e+05 1.276e-06
## rcs(GFR)GFR 3.053e-01 3.275e+00
## rcs(GFR)GFR' 8.237e+00 1.214e-01
## rcs(GFR)GFR'' 1.217e-01 8.215e+00
## rcs(GFR)GFR''' 2.955e-02 3.384e+01
## rcs(kolesterol)kolesterol 6.982e-01 1.432e+00
## rcs(kolesterol)kolesterol' 2.475e+01 4.040e-02
## rcs(kolesterol)kolesterol'' 6.983e-06 1.432e+05
## rcs(kolesterol)kolesterol''' 3.401e+06 2.940e-07
## rcs(systoliskt)systoliskt 6.072e-01 1.647e+00
## rcs(systoliskt)systoliskt' 3.395e+00 2.946e-01
## rcs(systoliskt)systoliskt'' 2.830e-02 3.534e+01
## rcs(systoliskt)systoliskt''' 5.807e+01 1.722e-02
## factor(cpap_treated)1:factor(antithrombotic_agents)1 1.049e+00 9.529e-01
## factor(cpap_treated)1:factor(antihypertensive_comb)1 1.014e+00 9.866e-01
## factor(cpap_treated)1:factor(lipid_modifying_agents)1 1.136e+00 8.806e-01
## rcs(alder)alder:rcs(bmi)bmi 1.514e+00 6.603e-01
## rcs(alder)alder':rcs(bmi)bmi 2.387e-01 4.190e+00
## rcs(alder)alder'':rcs(bmi)bmi 6.108e+03 1.637e-04
## rcs(alder)alder''':rcs(bmi)bmi 1.203e-07 8.314e+06
## rcs(alder)alder:rcs(bmi)bmi' 8.062e-03 1.240e+02
## rcs(alder)alder':rcs(bmi)bmi' 5.864e+07 1.705e-08
## rcs(alder)alder'':rcs(bmi)bmi' 1.161e-42 8.611e+41
## rcs(alder)alder''':rcs(bmi)bmi' 7.177e+73 1.393e-74
## rcs(alder)alder:rcs(bmi)bmi'' 1.892e+09 5.286e-10
## rcs(alder)alder':rcs(bmi)bmi'' 9.415e-37 1.062e+36
## rcs(alder)alder'':rcs(bmi)bmi'' 3.435e+188 2.911e-189
## rcs(alder)alder''':rcs(bmi)bmi'' 0.000e+00 Inf
## rcs(alder)alder:rcs(bmi)bmi''' 8.673e-12 1.153e+11
## rcs(alder)alder':rcs(bmi)bmi''' 3.463e+44 2.888e-45
## rcs(alder)alder'':rcs(bmi)bmi''' 1.829e-228 5.468e+227
## rcs(alder)alder''':rcs(bmi)bmi''' Inf 0.000e+00
## rcs(alder)alder:rcs(GFR)GFR 8.645e-01 1.157e+00
## rcs(alder)alder':rcs(GFR)GFR 1.364e+00 7.330e-01
## rcs(alder)alder'':rcs(GFR)GFR 6.572e-01 1.522e+00
## rcs(alder)alder''':rcs(GFR)GFR 1.196e+00 8.362e-01
## rcs(alder)alder:rcs(GFR)GFR' 3.683e+00 2.715e-01
## rcs(alder)alder':rcs(GFR)GFR' 2.170e+00 4.608e-01
## rcs(alder)alder'':rcs(GFR)GFR' 1.291e-03 7.744e+02
## rcs(alder)alder''':rcs(GFR)GFR' 3.466e+02 2.885e-03
## rcs(alder)alder:rcs(GFR)GFR'' 2.942e-02 3.400e+01
## rcs(alder)alder':rcs(GFR)GFR'' 5.954e-05 1.680e+04
## rcs(alder)alder'':rcs(GFR)GFR'' 2.855e+21 3.502e-22
## rcs(alder)alder''':rcs(GFR)GFR'' 1.230e-21 8.130e+20
## rcs(alder)alder:rcs(GFR)GFR''' 1.832e+00 5.458e-01
## rcs(alder)alder':rcs(GFR)GFR''' 3.058e+08 3.270e-09
## rcs(alder)alder'':rcs(GFR)GFR''' 3.568e-38 2.802e+37
## rcs(alder)alder''':rcs(GFR)GFR''' 6.336e+40 1.578e-41
## factor(cpap_treated)1:rcs(GFR)GFR 9.791e-01 1.021e+00
## factor(cpap_treated)1:rcs(GFR)GFR' 6.986e-01 1.431e+00
## factor(cpap_treated)1:rcs(GFR)GFR'' 8.968e+00 1.115e-01
## factor(cpap_treated)1:rcs(GFR)GFR''' 6.740e-02 1.484e+01
## lower .95 upper .95
## factor(cpap_treated)1 4.570e-01 1.089e+00
## rcs(alder)alder 1.392e+00 3.876e+00
## rcs(alder)alder' 8.826e-02 1.773e+00
## rcs(alder)alder'' 6.087e+00 8.287e+06
## rcs(alder)alder''' 4.417e-13 2.981e-03
## factor(sex)1 7.078e-01 7.238e-01
## rcs(bmi)bmi 4.230e-01 9.411e-01
## rcs(bmi)bmi' 3.441e-03 4.719e+00
## rcs(bmi)bmi'' 1.010e+01 1.358e+15
## rcs(bmi)bmi''' 5.462e-23 2.303e-05
## factor(rokare)1 1.486e+00 1.529e+00
## factor(ami_history)1 1.192e+00 1.232e+00
## factor(stroke_history)1 1.372e+00 1.423e+00
## factor(Civil)1 8.951e-01 9.223e-01
## factor(HushallsTyp_RTB)2 7.900e-01 8.107e-01
## factor(HushallsTyp_RTB)3 9.304e-01 9.680e-01
## factor(Sun2000niva_old)2 1.005e+00 1.043e+00
## factor(Sun2000niva_old)3 9.471e-01 9.712e-01
## factor(Sun2000niva_old)4 9.184e-01 9.526e-01
## factor(Sun2000niva_old)5 8.746e-01 9.128e-01
## factor(Sun2000niva_old)6 8.373e-01 8.737e-01
## factor(Sun2000niva_old)7 7.232e-01 8.382e-01
## rcs(DispInkKEHB04)DispInkKEHB04 9.200e-01 1.155e+00
## rcs(DispInkKEHB04)DispInkKEHB04' 1.293e-05 1.533e-03
## rcs(DispInkKEHB04)DispInkKEHB04'' 9.140e+03 3.049e+10
## rcs(DispInkKEHB04)DispInkKEHB04''' 2.705e-05 6.443e+01
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk 1.536e+01 2.293e+01
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk' 0.000e+00 0.000e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'' Inf Inf
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''' 1.132e-56 1.624e-48
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk 8.929e+03 1.653e+04
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk' 0.000e+00 0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'' Inf Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''' 0.000e+00 0.000e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk 8.169e+00 1.074e+01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk' 2.124e-180 6.334e-158
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'' 3.159e+164 1.145e+188
## factor(FodelseLand_EU27_2020)1 1.158e+00 1.193e+00
## factor(antithrombotic_agents)1 1.235e+00 1.264e+00
## factor(antihypertensive_comb)1 9.801e-01 1.002e+00
## factor(lipid_modifying_agents)1 8.688e-01 8.881e-01
## rcs(hba1c)hba1c 4.463e-01 4.800e-01
## rcs(hba1c)hba1c' 1.250e+03 3.416e+03
## rcs(hba1c)hba1c'' 4.184e-10 1.394e-08
## rcs(hba1c)hba1c''' 1.284e+05 4.781e+06
## rcs(GFR)GFR 2.372e-01 3.930e-01
## rcs(GFR)GFR' 1.291e+00 5.253e+01
## rcs(GFR)GFR'' 3.119e-06 4.751e+03
## rcs(GFR)GFR''' 1.633e-09 5.347e+05
## rcs(kolesterol)kolesterol 6.806e-01 7.163e-01
## rcs(kolesterol)kolesterol' 2.036e+01 3.009e+01
## rcs(kolesterol)kolesterol'' 3.246e-06 1.502e-05
## rcs(kolesterol)kolesterol''' 1.115e+06 1.038e+07
## rcs(systoliskt)systoliskt 5.968e-01 6.177e-01
## rcs(systoliskt)systoliskt' 2.958e+00 3.896e+00
## rcs(systoliskt)systoliskt'' 1.389e-02 5.767e-02
## rcs(systoliskt)systoliskt''' 1.562e+01 2.160e+02
## factor(cpap_treated)1:factor(antithrombotic_agents)1 8.753e-01 1.258e+00
## factor(cpap_treated)1:factor(antihypertensive_comb)1 8.301e-01 1.238e+00
## factor(cpap_treated)1:factor(lipid_modifying_agents)1 9.449e-01 1.365e+00
## rcs(alder)alder:rcs(bmi)bmi 1.102e+00 2.081e+00
## rcs(alder)alder':rcs(bmi)bmi 8.946e-02 6.367e-01
## rcs(alder)alder'':rcs(bmi)bmi 5.219e+01 7.150e+05
## rcs(alder)alder''':rcs(bmi)bmi 4.910e-11 2.947e-04
## rcs(alder)alder:rcs(bmi)bmi' 4.415e-04 1.472e-01
## rcs(alder)alder':rcs(bmi)bmi' 8.301e+03 4.143e+11
## rcs(alder)alder'':rcs(bmi)bmi' 2.851e-61 4.731e-24
## rcs(alder)alder''':rcs(bmi)bmi' 1.965e+43 2.621e+104
## rcs(alder)alder:rcs(bmi)bmi'' 4.046e+03 8.845e+14
## rcs(alder)alder':rcs(bmi)bmi'' 4.061e-54 2.183e-19
## rcs(alder)alder'':rcs(bmi)bmi'' 1.790e+104 6.590e+272
## rcs(alder)alder''':rcs(bmi)bmi'' 0.000e+00 7.595e-193
## rcs(alder)alder:rcs(bmi)bmi''' 7.798e-19 9.646e-05
## rcs(alder)alder':rcs(bmi)bmi''' 6.743e+22 1.779e+66
## rcs(alder)alder'':rcs(bmi)bmi''' 0.000e+00 1.549e-122
## rcs(alder)alder''':rcs(bmi)bmi''' 1.040e+224 Inf
## rcs(alder)alder:rcs(GFR)GFR 7.018e-01 1.065e+00
## rcs(alder)alder':rcs(GFR)GFR 7.363e-01 2.528e+00
## rcs(alder)alder'':rcs(GFR)GFR 3.529e-02 1.224e+01
## rcs(alder)alder''':rcs(GFR)GFR 1.052e-02 1.359e+02
## rcs(alder)alder:rcs(GFR)GFR' 7.829e-01 1.733e+01
## rcs(alder)alder':rcs(GFR)GFR' 2.406e-02 1.958e+02
## rcs(alder)alder'':rcs(GFR)GFR' 8.392e-13 1.987e+06
## rcs(alder)alder''':rcs(GFR)GFR' 5.875e-13 2.045e+17
## rcs(alder)alder:rcs(GFR)GFR'' 4.764e-06 1.816e+02
## rcs(alder)alder':rcs(GFR)GFR'' 3.495e-16 1.014e+07
## rcs(alder)alder'':rcs(GFR)GFR'' 5.480e-33 1.488e+75
## rcs(alder)alder''':rcs(GFR)GFR'' 6.643e-110 2.278e+67
## rcs(alder)alder:rcs(GFR)GFR''' 2.273e-06 1.477e+06
## rcs(alder)alder':rcs(GFR)GFR''' 3.838e-10 2.437e+26
## rcs(alder)alder'':rcs(GFR)GFR''' 1.493e-125 8.527e+49
## rcs(alder)alder''':rcs(GFR)GFR''' 5.215e-107 7.698e+187
## factor(cpap_treated)1:rcs(GFR)GFR 7.666e-01 1.250e+00
## factor(cpap_treated)1:rcs(GFR)GFR' 1.077e-01 4.533e+00
## factor(cpap_treated)1:rcs(GFR)GFR'' 6.932e-05 1.160e+06
## factor(cpap_treated)1:rcs(GFR)GFR''' 9.575e-11 4.745e+07
##
## Concordance= 0.812 (se = 0.001 )
## Likelihood ratio test= 224745 on 96 df, p=<2e-16
## Wald test = 206572 on 96 df, p=<2e-16
## Score (logrank) test = 321942 on 96 df, p=<2e-16
## Warning in termplot(cph): 'model' appears to involve interactions: see the help
## page
## [1] "--- CONCORDANCE RESULTS ---"
## C-index train: 0.8115603
## C-index test: 0.8118397
## C-index DAC train: 0.8252279
## C-index DAC test: 0.8250712
run_models(c(list_forms_sleep[["form_tdep_spl"]], list_forms_sleep[["form_tdep_cat"]]), df_death_sub_tv_train, df_death_sub_tv_test, "stop", "event", cont_var, "prof_death_dep_g2.html", bigd=F)
## [1] "### FORMULA 1 ###"
## Start: AIC=13087.75
## Surv(start, stop, event) ~ factor(cpap_treated)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Df AIC
## + rcs(alder) 4 12625
## + rcs(GFR) 4 12752
## + factor(antithrombotic_agents) 1 12937
## + rcs(systoliskt) 4 13018
## + factor(antihypertensive_comb) 1 13025
## + factor(Sun2000niva_old) 6 13026
## + rcs(IV_AverageSaturation) 4 13032
## + rcs(DispInkKEHB04) 4 13047
## + factor(ami_history) 1 13047
## + factor(stroke_history) 1 13051
## + rcs(bmi) 4 13056
## + factor(HushallsTyp_RTB) 2 13057
## + factor(Civil) 1 13058
## + rcs(IV_AHI) 4 13066
## + factor(sex) 1 13070
## + factor(FodelseLand_EU27_2020) 1 13070
## + rcs(kolesterol) 4 13075
## + rcs(IV_ODI) 4 13075
## + factor(lipid_modifying_agents) 1 13078
## + rcs(Raks_AndelSjukInk) 4 13080
## + rcs(Raks_AndelEkBisInk) 3 13081
## + rcs(hba1c) 4 13085
## <none> 13088
## + factor(rokare) 1 13089
## + rcs(Raks_AndelArblosInk) 4 13093
## number of knots in rcs defaulting to 5
##
## Step: AIC=12624.72
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Df AIC
## + rcs(GFR) 4 12448
## + rcs(IV_AverageSaturation) 4 12561
## + rcs(systoliskt) 4 12561
## + rcs(bmi) 4 12584
## + factor(antithrombotic_agents) 1 12586
## + factor(sex) 1 12595
## + factor(HushallsTyp_RTB) 2 12598
## + rcs(IV_ODI) 4 12600
## + rcs(DispInkKEHB04) 4 12601
## + factor(antihypertensive_comb) 1 12602
## + rcs(IV_AHI) 4 12603
## + factor(ami_history) 1 12606
## + rcs(hba1c) 4 12608
## + factor(Sun2000niva_old) 6 12608
## + factor(stroke_history) 1 12609
## + rcs(kolesterol) 4 12616
## + rcs(Raks_AndelSjukInk) 4 12619
## + factor(rokare) 1 12619
## + rcs(Raks_AndelEkBisInk) 3 12624
## + factor(FodelseLand_EU27_2020) 1 12624
## <none> 12625
## + factor(lipid_modifying_agents) 1 12626
## + factor(Civil) 1 12627
## + rcs(Raks_AndelArblosInk) 4 12631
## - rcs(alder) 4 13088
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
##
## Step: AIC=12448.27
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## rcs(GFR)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Df AIC
## + rcs(systoliskt) 4 12391
## + rcs(IV_AverageSaturation) 4 12403
## + factor(sex) 1 12414
## + rcs(bmi) 4 12416
## + factor(HushallsTyp_RTB) 2 12423
## + factor(antithrombotic_agents) 1 12424
## + rcs(alder):rcs(GFR) 16 12427
## + rcs(DispInkKEHB04) 4 12433
## + rcs(IV_ODI) 4 12435
## + factor(ami_history) 1 12435
## + factor(stroke_history) 1 12437
## + factor(antihypertensive_comb) 1 12437
## + rcs(IV_AHI) 4 12438
## + factor(Sun2000niva_old) 6 12439
## + rcs(hba1c) 4 12441
## + factor(cpap_treated):rcs(GFR) 4 12442
## + rcs(Raks_AndelSjukInk) 4 12443
## + factor(rokare) 1 12443
## + rcs(kolesterol) 4 12445
## + rcs(Raks_AndelEkBisInk) 3 12447
## + factor(FodelseLand_EU27_2020) 1 12447
## <none> 12448
## + factor(Civil) 1 12450
## + factor(lipid_modifying_agents) 1 12450
## + rcs(Raks_AndelArblosInk) 4 12454
## - rcs(GFR) 4 12625
## - rcs(alder) 4 12752
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
##
## Step: AIC=12391.36
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## rcs(GFR) + rcs(systoliskt)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Df AIC
## + rcs(IV_AverageSaturation) 4 12350
## + factor(sex) 1 12360
## + rcs(bmi) 4 12360
## + factor(HushallsTyp_RTB) 2 12366
## + rcs(alder):rcs(GFR) 16 12371
## + factor(antithrombotic_agents) 1 12372
## + rcs(IV_ODI) 4 12377
## + rcs(DispInkKEHB04) 4 12377
## + factor(antihypertensive_comb) 1 12378
## + factor(stroke_history) 1 12379
## + factor(ami_history) 1 12380
## + rcs(IV_AHI) 4 12381
## + factor(Sun2000niva_old) 6 12382
## + factor(cpap_treated):rcs(GFR) 4 12385
## + rcs(hba1c) 4 12386
## + rcs(Raks_AndelSjukInk) 4 12386
## + factor(rokare) 1 12387
## + factor(FodelseLand_EU27_2020) 1 12389
## + rcs(Raks_AndelEkBisInk) 3 12390
## + rcs(kolesterol) 4 12390
## <none> 12391
## + factor(Civil) 1 12393
## + factor(lipid_modifying_agents) 1 12393
## + rcs(Raks_AndelArblosInk) 4 12397
## - rcs(systoliskt) 4 12448
## - rcs(GFR) 4 12561
## - rcs(alder) 4 12700
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
##
## Step: AIC=12350.27
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Df AIC
## + factor(sex) 1 12314
## + factor(HushallsTyp_RTB) 2 12328
## + rcs(bmi) 4 12330
## + rcs(alder):rcs(GFR) 16 12332
## + factor(antithrombotic_agents) 1 12333
## + factor(stroke_history) 1 12336
## + factor(antihypertensive_comb) 1 12338
## + rcs(DispInkKEHB04) 4 12338
## + factor(ami_history) 1 12339
## + factor(cpap_treated):rcs(GFR) 4 12344
## + rcs(hba1c) 4 12345
## + factor(Sun2000niva_old) 6 12345
## + rcs(Raks_AndelSjukInk) 4 12345
## + factor(rokare) 1 12347
## + factor(FodelseLand_EU27_2020) 1 12348
## + rcs(kolesterol) 4 12348
## + rcs(Raks_AndelEkBisInk) 3 12349
## <none> 12350
## + rcs(IV_ODI) 4 12352
## + factor(Civil) 1 12352
## + factor(lipid_modifying_agents) 1 12352
## + rcs(IV_AHI) 4 12354
## + rcs(Raks_AndelArblosInk) 4 12356
## - rcs(IV_AverageSaturation) 4 12391
## - rcs(systoliskt) 4 12403
## - rcs(GFR) 4 12502
## - rcs(alder) 4 12668
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
##
## Step: AIC=12313.96
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) +
## factor(sex)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Df AIC
## + factor(HushallsTyp_RTB) 2 12278
## + rcs(bmi) 4 12288
## + rcs(DispInkKEHB04) 4 12293
## + rcs(alder):rcs(GFR) 16 12298
## + factor(stroke_history) 1 12300
## + factor(antithrombotic_agents) 1 12302
## + factor(antihypertensive_comb) 1 12303
## + factor(ami_history) 1 12306
## + factor(Sun2000niva_old) 6 12306
## + factor(cpap_treated):rcs(GFR) 4 12307
## + rcs(Raks_AndelSjukInk) 4 12308
## + rcs(hba1c) 4 12308
## + factor(rokare) 1 12311
## + factor(FodelseLand_EU27_2020) 1 12312
## + rcs(Raks_AndelEkBisInk) 3 12313
## <none> 12314
## + rcs(IV_ODI) 4 12314
## + rcs(kolesterol) 4 12314
## + factor(Civil) 1 12314
## + factor(lipid_modifying_agents) 1 12316
## + rcs(IV_AHI) 4 12318
## + rcs(Raks_AndelArblosInk) 4 12320
## - factor(sex) 1 12350
## - rcs(IV_AverageSaturation) 4 12360
## - rcs(systoliskt) 4 12363
## - rcs(GFR) 4 12469
## - rcs(alder) 4 12644
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
##
## Step: AIC=12278.42
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) +
## factor(sex) + factor(HushallsTyp_RTB)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Df AIC
## + rcs(bmi) 4 12253
## + rcs(alder):rcs(GFR) 16 12262
## + factor(stroke_history) 1 12264
## + factor(antithrombotic_agents) 1 12266
## + factor(antihypertensive_comb) 1 12267
## + factor(Sun2000niva_old) 6 12268
## + factor(ami_history) 1 12270
## + rcs(DispInkKEHB04) 4 12272
## + rcs(Raks_AndelSjukInk) 4 12273
## + factor(cpap_treated):rcs(GFR) 4 12273
## + rcs(hba1c) 4 12274
## + factor(FodelseLand_EU27_2020) 1 12276
## + factor(rokare) 1 12277
## + rcs(Raks_AndelEkBisInk) 3 12277
## + rcs(IV_ODI) 4 12278
## <none> 12278
## + rcs(kolesterol) 4 12279
## + factor(Civil) 1 12280
## + factor(lipid_modifying_agents) 1 12280
## + rcs(IV_AHI) 4 12283
## + rcs(Raks_AndelArblosInk) 4 12285
## - factor(HushallsTyp_RTB) 2 12314
## - rcs(IV_AverageSaturation) 4 12320
## - rcs(systoliskt) 4 12326
## - factor(sex) 1 12328
## - rcs(GFR) 4 12434
## - rcs(alder) 4 12608
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
##
## Step: AIC=12253.33
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) +
## factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Df AIC
## + rcs(alder):rcs(GFR) 16 12238
## + factor(stroke_history) 1 12239
## + factor(antithrombotic_agents) 1 12241
## + factor(antihypertensive_comb) 1 12241
## + factor(Sun2000niva_old) 6 12244
## + factor(ami_history) 1 12245
## + factor(cpap_treated):rcs(GFR) 4 12248
## + rcs(DispInkKEHB04) 4 12249
## + rcs(Raks_AndelSjukInk) 4 12250
## + rcs(hba1c) 4 12250
## + factor(FodelseLand_EU27_2020) 1 12251
## + factor(rokare) 1 12252
## + rcs(Raks_AndelEkBisInk) 3 12252
## <none> 12253
## + rcs(kolesterol) 4 12253
## + rcs(IV_ODI) 4 12254
## + factor(Civil) 1 12255
## + factor(lipid_modifying_agents) 1 12255
## + rcs(IV_AHI) 4 12259
## + rcs(Raks_AndelArblosInk) 4 12260
## + rcs(alder):rcs(bmi) 16 12277
## - rcs(bmi) 4 12278
## - rcs(IV_AverageSaturation) 4 12281
## - factor(HushallsTyp_RTB) 2 12288
## - rcs(systoliskt) 4 12300
## - factor(sex) 1 12309
## - rcs(GFR) 4 12406
## - rcs(alder) 4 12577
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
##
## Step: AIC=12238.14
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) +
## factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + rcs(alder):rcs(GFR)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Df AIC
## + factor(stroke_history) 1 12224
## + factor(antithrombotic_agents) 1 12225
## + factor(antihypertensive_comb) 1 12227
## + factor(Sun2000niva_old) 6 12229
## + factor(ami_history) 1 12229
## + rcs(DispInkKEHB04) 4 12233
## + factor(cpap_treated):rcs(GFR) 4 12233
## + rcs(Raks_AndelSjukInk) 4 12235
## + rcs(hba1c) 4 12236
## + factor(rokare) 1 12236
## + factor(FodelseLand_EU27_2020) 1 12236
## + rcs(Raks_AndelEkBisInk) 3 12237
## <none> 12238
## + rcs(kolesterol) 4 12238
## + factor(Civil) 1 12240
## + rcs(IV_ODI) 4 12240
## + factor(lipid_modifying_agents) 1 12240
## + rcs(Raks_AndelArblosInk) 4 12244
## + rcs(IV_AHI) 4 12244
## - rcs(alder):rcs(GFR) 16 12253
## + rcs(alder):rcs(bmi) 16 12257
## - rcs(bmi) 4 12262
## - rcs(IV_AverageSaturation) 4 12263
## - factor(HushallsTyp_RTB) 2 12274
## - rcs(systoliskt) 4 12284
## - factor(sex) 1 12292
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
##
## Step: AIC=12223.82
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) +
## factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) +
## rcs(alder):rcs(GFR)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Df AIC
## + factor(antihypertensive_comb) 1 12214
## + factor(Sun2000niva_old) 6 12215
## + factor(ami_history) 1 12215
## + factor(antithrombotic_agents) 1 12215
## + factor(cpap_treated):rcs(GFR) 4 12218
## + rcs(DispInkKEHB04) 4 12219
## + rcs(Raks_AndelSjukInk) 4 12221
## + rcs(hba1c) 4 12222
## + factor(rokare) 1 12222
## + factor(FodelseLand_EU27_2020) 1 12222
## + rcs(Raks_AndelEkBisInk) 3 12222
## <none> 12224
## + rcs(kolesterol) 4 12224
## + rcs(IV_ODI) 4 12225
## + factor(Civil) 1 12225
## + factor(lipid_modifying_agents) 1 12226
## + rcs(Raks_AndelArblosInk) 4 12229
## + rcs(IV_AHI) 4 12230
## - factor(stroke_history) 1 12238
## - rcs(alder):rcs(GFR) 16 12239
## + rcs(alder):rcs(bmi) 16 12243
## - rcs(bmi) 4 12248
## - rcs(IV_AverageSaturation) 4 12249
## - factor(HushallsTyp_RTB) 2 12260
## - rcs(systoliskt) 4 12271
## - factor(sex) 1 12278
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
##
## Step: AIC=12213.56
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) +
## factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) +
## factor(antihypertensive_comb) + rcs(alder):rcs(GFR)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Df AIC
## + factor(Sun2000niva_old) 6 12205
## + factor(ami_history) 1 12206
## + rcs(DispInkKEHB04) 4 12207
## + factor(cpap_treated):rcs(GFR) 4 12208
## + factor(antithrombotic_agents) 1 12209
## + factor(cpap_treated):factor(antihypertensive_comb) 1 12210
## + rcs(Raks_AndelSjukInk) 4 12211
## + factor(rokare) 1 12211
## + rcs(hba1c) 4 12212
## + rcs(Raks_AndelEkBisInk) 3 12212
## + factor(FodelseLand_EU27_2020) 1 12213
## <none> 12214
## + rcs(kolesterol) 4 12214
## + rcs(IV_ODI) 4 12214
## + factor(lipid_modifying_agents) 1 12214
## + factor(Civil) 1 12215
## + rcs(IV_AHI) 4 12219
## + rcs(Raks_AndelArblosInk) 4 12219
## - factor(antihypertensive_comb) 1 12224
## - factor(stroke_history) 1 12227
## - rcs(alder):rcs(GFR) 16 12228
## + rcs(alder):rcs(bmi) 16 12233
## - rcs(IV_AverageSaturation) 4 12238
## - rcs(bmi) 4 12238
## - factor(HushallsTyp_RTB) 2 12251
## - rcs(systoliskt) 4 12263
## - factor(sex) 1 12266
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
##
## Step: AIC=12205.08
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) +
## factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) +
## factor(antihypertensive_comb) + factor(Sun2000niva_old) +
## rcs(alder):rcs(GFR)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Df AIC
## + factor(ami_history) 1 12198
## + factor(cpap_treated):rcs(GFR) 4 12199
## + factor(antithrombotic_agents) 1 12200
## + factor(cpap_treated):factor(antihypertensive_comb) 1 12202
## + rcs(Raks_AndelSjukInk) 4 12202
## + rcs(hba1c) 4 12203
## + factor(rokare) 1 12203
## + rcs(Raks_AndelEkBisInk) 3 12204
## + rcs(DispInkKEHB04) 4 12204
## + factor(FodelseLand_EU27_2020) 1 12204
## <none> 12205
## + rcs(kolesterol) 4 12205
## + factor(lipid_modifying_agents) 1 12206
## + rcs(IV_ODI) 4 12206
## + factor(Civil) 1 12206
## + rcs(Raks_AndelArblosInk) 4 12211
## + rcs(IV_AHI) 4 12211
## - factor(Sun2000niva_old) 6 12214
## - factor(antihypertensive_comb) 1 12215
## - factor(stroke_history) 1 12218
## - rcs(alder):rcs(GFR) 16 12220
## + rcs(alder):rcs(bmi) 16 12224
## - rcs(IV_AverageSaturation) 4 12228
## - rcs(bmi) 4 12229
## - factor(HushallsTyp_RTB) 2 12245
## - rcs(systoliskt) 4 12255
## - factor(sex) 1 12261
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
##
## Step: AIC=12198.06
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) +
## factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) +
## factor(antihypertensive_comb) + factor(Sun2000niva_old) +
## factor(ami_history) + rcs(alder):rcs(GFR)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Df AIC
## + factor(cpap_treated):rcs(GFR) 4 12192
## + factor(cpap_treated):factor(antihypertensive_comb) 1 12195
## + rcs(Raks_AndelSjukInk) 4 12195
## + rcs(hba1c) 4 12196
## + factor(antithrombotic_agents) 1 12196
## + rcs(Raks_AndelEkBisInk) 3 12196
## + factor(rokare) 1 12196
## + factor(lipid_modifying_agents) 1 12197
## + factor(FodelseLand_EU27_2020) 1 12197
## + rcs(DispInkKEHB04) 4 12198
## <none> 12198
## + rcs(kolesterol) 4 12198
## + rcs(IV_ODI) 4 12199
## + factor(Civil) 1 12199
## + rcs(IV_AHI) 4 12204
## + rcs(Raks_AndelArblosInk) 4 12204
## - factor(ami_history) 1 12205
## - factor(Sun2000niva_old) 6 12206
## - factor(antihypertensive_comb) 1 12207
## - factor(stroke_history) 1 12210
## - rcs(alder):rcs(GFR) 16 12214
## + rcs(alder):rcs(bmi) 16 12217
## - rcs(IV_AverageSaturation) 4 12220
## - rcs(bmi) 4 12222
## - factor(HushallsTyp_RTB) 2 12239
## - rcs(systoliskt) 4 12246
## - factor(sex) 1 12250
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
##
## Step: AIC=12191.88
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) +
## factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) +
## factor(antihypertensive_comb) + factor(Sun2000niva_old) +
## factor(ami_history) + rcs(alder):rcs(GFR) + factor(cpap_treated):rcs(GFR)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Df AIC
## + rcs(Raks_AndelSjukInk) 4 12189
## + factor(cpap_treated):factor(antihypertensive_comb) 1 12190
## + rcs(Raks_AndelEkBisInk) 3 12190
## + rcs(hba1c) 4 12190
## + factor(rokare) 1 12190
## + factor(lipid_modifying_agents) 1 12191
## + factor(antithrombotic_agents) 1 12191
## + factor(FodelseLand_EU27_2020) 1 12191
## <none> 12192
## + rcs(DispInkKEHB04) 4 12192
## + rcs(kolesterol) 4 12192
## + factor(Civil) 1 12193
## + rcs(IV_ODI) 4 12194
## + rcs(IV_AHI) 4 12197
## + rcs(Raks_AndelArblosInk) 4 12198
## - factor(cpap_treated):rcs(GFR) 4 12198
## - factor(ami_history) 1 12199
## - factor(antihypertensive_comb) 1 12200
## - factor(Sun2000niva_old) 6 12201
## - factor(stroke_history) 1 12204
## - rcs(alder):rcs(GFR) 16 12208
## + rcs(alder):rcs(bmi) 16 12211
## - rcs(IV_AverageSaturation) 4 12214
## - rcs(bmi) 4 12216
## - factor(HushallsTyp_RTB) 2 12231
## - rcs(systoliskt) 4 12239
## - factor(sex) 1 12244
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
##
## Step: AIC=12189.21
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) +
## factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) +
## factor(antihypertensive_comb) + factor(Sun2000niva_old) +
## factor(ami_history) + rcs(Raks_AndelSjukInk) + rcs(alder):rcs(GFR) +
## factor(cpap_treated):rcs(GFR)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Df AIC
## + rcs(hba1c) 4 12187
## + factor(cpap_treated):factor(antihypertensive_comb) 1 12187
## + factor(rokare) 1 12187
## + rcs(Raks_AndelEkBisInk) 3 12188
## + factor(lipid_modifying_agents) 1 12188
## + factor(antithrombotic_agents) 1 12188
## + factor(FodelseLand_EU27_2020) 1 12188
## + rcs(DispInkKEHB04) 4 12189
## <none> 12189
## + rcs(kolesterol) 4 12190
## + rcs(IV_ODI) 4 12191
## + factor(Civil) 1 12191
## - rcs(Raks_AndelSjukInk) 4 12192
## + rcs(IV_AHI) 4 12195
## + rcs(Raks_AndelArblosInk) 4 12195
## - factor(cpap_treated):rcs(GFR) 4 12195
## - factor(ami_history) 1 12196
## - factor(antihypertensive_comb) 1 12197
## - factor(Sun2000niva_old) 6 12198
## - factor(stroke_history) 1 12202
## - rcs(alder):rcs(GFR) 16 12205
## + rcs(alder):rcs(bmi) 16 12209
## - rcs(bmi) 4 12211
## - rcs(IV_AverageSaturation) 4 12212
## - factor(HushallsTyp_RTB) 2 12228
## - rcs(systoliskt) 4 12236
## - factor(sex) 1 12242
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
##
## Step: AIC=12186.83
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) +
## factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) +
## factor(antihypertensive_comb) + factor(Sun2000niva_old) +
## factor(ami_history) + rcs(Raks_AndelSjukInk) + rcs(hba1c) +
## rcs(alder):rcs(GFR) + factor(cpap_treated):rcs(GFR)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Df AIC
## + factor(cpap_treated):factor(antihypertensive_comb) 1 12185
## + factor(rokare) 1 12185
## + rcs(Raks_AndelEkBisInk) 3 12185
## + factor(antithrombotic_agents) 1 12186
## + factor(lipid_modifying_agents) 1 12186
## + factor(FodelseLand_EU27_2020) 1 12186
## <none> 12187
## + rcs(DispInkKEHB04) 4 12187
## + rcs(kolesterol) 4 12187
## + factor(Civil) 1 12188
## + rcs(IV_ODI) 4 12188
## - rcs(hba1c) 4 12189
## - rcs(Raks_AndelSjukInk) 4 12190
## + rcs(IV_AHI) 4 12192
## + rcs(Raks_AndelArblosInk) 4 12193
## - factor(cpap_treated):rcs(GFR) 4 12193
## - factor(ami_history) 1 12194
## - factor(antihypertensive_comb) 1 12195
## - factor(Sun2000niva_old) 6 12196
## - factor(stroke_history) 1 12199
## - rcs(alder):rcs(GFR) 16 12201
## + rcs(alder):rcs(bmi) 16 12206
## - rcs(bmi) 4 12209
## - rcs(IV_AverageSaturation) 4 12210
## - factor(HushallsTyp_RTB) 2 12224
## - rcs(systoliskt) 4 12232
## - factor(sex) 1 12240
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
##
## Step: AIC=12184.7
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) +
## factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) +
## factor(antihypertensive_comb) + factor(Sun2000niva_old) +
## factor(ami_history) + rcs(Raks_AndelSjukInk) + rcs(hba1c) +
## rcs(alder):rcs(GFR) + factor(cpap_treated):rcs(GFR) + factor(cpap_treated):factor(antihypertensive_comb)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Df AIC
## + factor(rokare) 1 12183
## + rcs(Raks_AndelEkBisInk) 3 12183
## + factor(antithrombotic_agents) 1 12184
## + factor(lipid_modifying_agents) 1 12184
## + factor(FodelseLand_EU27_2020) 1 12184
## <none> 12185
## + rcs(DispInkKEHB04) 4 12185
## + rcs(kolesterol) 4 12185
## + factor(Civil) 1 12186
## + rcs(IV_ODI) 4 12186
## - factor(cpap_treated):factor(antihypertensive_comb) 1 12187
## - rcs(hba1c) 4 12187
## - rcs(Raks_AndelSjukInk) 4 12188
## - factor(cpap_treated):rcs(GFR) 4 12190
## + rcs(IV_AHI) 4 12190
## + rcs(Raks_AndelArblosInk) 4 12191
## - factor(ami_history) 1 12192
## - factor(Sun2000niva_old) 6 12194
## - factor(stroke_history) 1 12197
## - rcs(alder):rcs(GFR) 16 12199
## + rcs(alder):rcs(bmi) 16 12204
## - rcs(bmi) 4 12206
## - rcs(IV_AverageSaturation) 4 12208
## - factor(HushallsTyp_RTB) 2 12222
## - rcs(systoliskt) 4 12231
## - factor(sex) 1 12237
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
##
## Step: AIC=12182.93
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) +
## factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) +
## factor(antihypertensive_comb) + factor(Sun2000niva_old) +
## factor(ami_history) + rcs(Raks_AndelSjukInk) + rcs(hba1c) +
## factor(rokare) + rcs(alder):rcs(GFR) + factor(cpap_treated):rcs(GFR) +
## factor(cpap_treated):factor(antihypertensive_comb)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Df AIC
## + rcs(Raks_AndelEkBisInk) 3 12182
## + factor(lipid_modifying_agents) 1 12182
## + factor(antithrombotic_agents) 1 12182
## + factor(FodelseLand_EU27_2020) 1 12182
## <none> 12183
## + rcs(kolesterol) 4 12184
## + rcs(DispInkKEHB04) 4 12184
## + factor(Civil) 1 12184
## + rcs(IV_ODI) 4 12184
## - factor(rokare) 1 12185
## - factor(cpap_treated):factor(antihypertensive_comb) 1 12185
## - rcs(hba1c) 4 12185
## - rcs(Raks_AndelSjukInk) 4 12186
## + rcs(IV_AHI) 4 12188
## - factor(cpap_treated):rcs(GFR) 4 12189
## + rcs(Raks_AndelArblosInk) 4 12189
## - factor(ami_history) 1 12190
## - factor(Sun2000niva_old) 6 12191
## - factor(stroke_history) 1 12195
## - rcs(alder):rcs(GFR) 16 12197
## + rcs(alder):rcs(bmi) 16 12202
## - rcs(bmi) 4 12205
## - rcs(IV_AverageSaturation) 4 12205
## - factor(HushallsTyp_RTB) 2 12218
## - rcs(systoliskt) 4 12229
## - factor(sex) 1 12235
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
##
## Step: AIC=12181.45
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) +
## factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) +
## factor(antihypertensive_comb) + factor(Sun2000niva_old) +
## factor(ami_history) + rcs(Raks_AndelSjukInk) + rcs(hba1c) +
## factor(rokare) + rcs(Raks_AndelEkBisInk) + rcs(alder):rcs(GFR) +
## factor(cpap_treated):rcs(GFR) + factor(cpap_treated):factor(antihypertensive_comb)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Df AIC
## + rcs(DispInkKEHB04) 4 12180
## + factor(antithrombotic_agents) 1 12180
## + factor(lipid_modifying_agents) 1 12181
## <none> 12182
## + factor(FodelseLand_EU27_2020) 1 12182
## + rcs(kolesterol) 4 12182
## + rcs(IV_ODI) 4 12182
## + factor(Civil) 1 12183
## - rcs(Raks_AndelEkBisInk) 3 12183
## - factor(rokare) 1 12183
## - factor(cpap_treated):factor(antihypertensive_comb) 1 12183
## - rcs(Raks_AndelSjukInk) 4 12183
## - rcs(hba1c) 4 12184
## + rcs(IV_AHI) 4 12187
## - factor(cpap_treated):rcs(GFR) 4 12188
## + rcs(Raks_AndelArblosInk) 4 12188
## - factor(ami_history) 1 12188
## - factor(Sun2000niva_old) 6 12190
## - factor(stroke_history) 1 12193
## - rcs(alder):rcs(GFR) 16 12196
## + rcs(alder):rcs(bmi) 16 12201
## - rcs(IV_AverageSaturation) 4 12203
## - rcs(bmi) 4 12204
## - factor(HushallsTyp_RTB) 2 12217
## - rcs(systoliskt) 4 12227
## - factor(sex) 1 12233
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
##
## Step: AIC=12179.83
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) +
## factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) +
## factor(antihypertensive_comb) + factor(Sun2000niva_old) +
## factor(ami_history) + rcs(Raks_AndelSjukInk) + rcs(hba1c) +
## factor(rokare) + rcs(Raks_AndelEkBisInk) + rcs(DispInkKEHB04) +
## rcs(alder):rcs(GFR) + factor(cpap_treated):rcs(GFR) + factor(cpap_treated):factor(antihypertensive_comb)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Df AIC
## + factor(FodelseLand_EU27_2020) 1 12178
## + factor(antithrombotic_agents) 1 12179
## + factor(lipid_modifying_agents) 1 12179
## <none> 12180
## + rcs(kolesterol) 4 12181
## + rcs(IV_ODI) 4 12181
## + factor(Civil) 1 12181
## - rcs(DispInkKEHB04) 4 12182
## - rcs(hba1c) 4 12182
## - factor(cpap_treated):factor(antihypertensive_comb) 1 12182
## - factor(rokare) 1 12182
## - rcs(Raks_AndelSjukInk) 4 12182
## - factor(Sun2000niva_old) 6 12183
## - rcs(Raks_AndelEkBisInk) 3 12184
## - factor(cpap_treated):rcs(GFR) 4 12185
## + rcs(IV_AHI) 4 12185
## - factor(ami_history) 1 12186
## + rcs(Raks_AndelArblosInk) 4 12187
## - factor(stroke_history) 1 12192
## - rcs(alder):rcs(GFR) 16 12195
## + rcs(alder):rcs(bmi) 16 12200
## - rcs(bmi) 4 12201
## - rcs(IV_AverageSaturation) 4 12201
## - factor(HushallsTyp_RTB) 2 12203
## - rcs(systoliskt) 4 12225
## - factor(sex) 1 12234
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
##
## Step: AIC=12177.9
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) +
## factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) +
## factor(antihypertensive_comb) + factor(Sun2000niva_old) +
## factor(ami_history) + rcs(Raks_AndelSjukInk) + rcs(hba1c) +
## factor(rokare) + rcs(Raks_AndelEkBisInk) + rcs(DispInkKEHB04) +
## factor(FodelseLand_EU27_2020) + rcs(alder):rcs(GFR) + factor(cpap_treated):rcs(GFR) +
## factor(cpap_treated):factor(antihypertensive_comb)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Df AIC
## + factor(antithrombotic_agents) 1 12177
## + factor(lipid_modifying_agents) 1 12177
## <none> 12178
## + rcs(kolesterol) 4 12179
## + rcs(IV_ODI) 4 12179
## + factor(Civil) 1 12179
## - rcs(hba1c) 4 12180
## - factor(cpap_treated):factor(antihypertensive_comb) 1 12180
## - factor(Sun2000niva_old) 6 12180
## - factor(rokare) 1 12180
## - factor(FodelseLand_EU27_2020) 1 12180
## - rcs(Raks_AndelSjukInk) 4 12180
## - rcs(Raks_AndelEkBisInk) 3 12180
## - rcs(DispInkKEHB04) 4 12182
## - factor(cpap_treated):rcs(GFR) 4 12183
## + rcs(IV_AHI) 4 12183
## - factor(ami_history) 1 12184
## + rcs(Raks_AndelArblosInk) 4 12185
## - factor(stroke_history) 1 12189
## - rcs(alder):rcs(GFR) 16 12192
## + rcs(alder):rcs(bmi) 16 12197
## - rcs(bmi) 4 12200
## - rcs(IV_AverageSaturation) 4 12200
## - factor(HushallsTyp_RTB) 2 12200
## - rcs(systoliskt) 4 12223
## - factor(sex) 1 12232
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
##
## Step: AIC=12176.97
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) +
## factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) +
## factor(antihypertensive_comb) + factor(Sun2000niva_old) +
## factor(ami_history) + rcs(Raks_AndelSjukInk) + rcs(hba1c) +
## factor(rokare) + rcs(Raks_AndelEkBisInk) + rcs(DispInkKEHB04) +
## factor(FodelseLand_EU27_2020) + factor(antithrombotic_agents) +
## rcs(alder):rcs(GFR) + factor(cpap_treated):rcs(GFR) + factor(cpap_treated):factor(antihypertensive_comb)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Df AIC
## + factor(lipid_modifying_agents) 1 12175
## <none> 12177
## + factor(cpap_treated):factor(antithrombotic_agents) 1 12177
## - factor(antithrombotic_agents) 1 12178
## + rcs(kolesterol) 4 12178
## + rcs(IV_ODI) 4 12178
## + factor(Civil) 1 12178
## - factor(rokare) 1 12179
## - rcs(hba1c) 4 12179
## - rcs(Raks_AndelSjukInk) 4 12179
## - factor(cpap_treated):factor(antihypertensive_comb) 1 12179
## - factor(Sun2000niva_old) 6 12179
## - factor(FodelseLand_EU27_2020) 1 12179
## - rcs(Raks_AndelEkBisInk) 3 12180
## - rcs(DispInkKEHB04) 4 12180
## - factor(ami_history) 1 12181
## - factor(cpap_treated):rcs(GFR) 4 12182
## + rcs(IV_AHI) 4 12182
## + rcs(Raks_AndelArblosInk) 4 12184
## - factor(stroke_history) 1 12186
## - rcs(alder):rcs(GFR) 16 12191
## + rcs(alder):rcs(bmi) 16 12196
## - rcs(IV_AverageSaturation) 4 12198
## - rcs(bmi) 4 12199
## - factor(HushallsTyp_RTB) 2 12199
## - rcs(systoliskt) 4 12220
## - factor(sex) 1 12228
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
##
## Step: AIC=12174.74
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) +
## factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) +
## factor(antihypertensive_comb) + factor(Sun2000niva_old) +
## factor(ami_history) + rcs(Raks_AndelSjukInk) + rcs(hba1c) +
## factor(rokare) + rcs(Raks_AndelEkBisInk) + rcs(DispInkKEHB04) +
## factor(FodelseLand_EU27_2020) + factor(antithrombotic_agents) +
## factor(lipid_modifying_agents) + rcs(alder):rcs(GFR) + factor(cpap_treated):rcs(GFR) +
## factor(cpap_treated):factor(antihypertensive_comb)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Df AIC
## <none> 12175
## + factor(cpap_treated):factor(lipid_modifying_agents) 1 12175
## + factor(cpap_treated):factor(antithrombotic_agents) 1 12175
## - rcs(hba1c) 4 12176
## + factor(Civil) 1 12176
## + rcs(IV_ODI) 4 12176
## - factor(rokare) 1 12176
## - rcs(Raks_AndelSjukInk) 4 12176
## + rcs(kolesterol) 4 12176
## - factor(cpap_treated):factor(antihypertensive_comb) 1 12176
## - factor(Sun2000niva_old) 6 12176
## - rcs(Raks_AndelEkBisInk) 3 12177
## - factor(lipid_modifying_agents) 1 12177
## - factor(FodelseLand_EU27_2020) 1 12177
## - factor(antithrombotic_agents) 1 12177
## - rcs(DispInkKEHB04) 4 12178
## - factor(ami_history) 1 12180
## - factor(cpap_treated):rcs(GFR) 4 12180
## + rcs(IV_AHI) 4 12181
## + rcs(Raks_AndelArblosInk) 4 12182
## - factor(stroke_history) 1 12184
## - rcs(alder):rcs(GFR) 16 12189
## + rcs(alder):rcs(bmi) 16 12194
## - rcs(IV_AverageSaturation) 4 12195
## - rcs(bmi) 4 12196
## - factor(HushallsTyp_RTB) 2 12196
## - rcs(systoliskt) 4 12219
## - factor(sex) 1 12227
## [1] "--- SURVIVAL RESULTS ---"
## Call:
## coxph(formula = Surv(start, stop, event) ~ factor(cpap_treated) +
## rcs(alder) + rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) +
## factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) +
## factor(antihypertensive_comb) + factor(Sun2000niva_old) +
## factor(ami_history) + rcs(Raks_AndelSjukInk) + rcs(hba1c) +
## factor(rokare) + rcs(Raks_AndelEkBisInk) + rcs(DispInkKEHB04) +
## factor(FodelseLand_EU27_2020) + factor(antithrombotic_agents) +
## factor(lipid_modifying_agents) + rcs(alder):rcs(GFR) + factor(cpap_treated):rcs(GFR) +
## factor(cpap_treated):factor(antihypertensive_comb), data = df_train)
##
## n= 155393, number of events= 782
##
## coef exp(coef)
## factor(cpap_treated)1 1.754e+00 5.776e+00
## rcs(alder)alder -2.304e-01 7.942e-01
## rcs(alder)alder' 8.904e-01 2.436e+00
## rcs(alder)alder'' -5.641e-01 5.689e-01
## rcs(alder)alder''' -2.594e+00 7.469e-02
## rcs(GFR)GFR -1.250e+00 2.865e-01
## rcs(GFR)GFR' 6.437e+00 6.246e+02
## rcs(GFR)GFR'' -5.483e+01 1.544e-24
## rcs(GFR)GFR''' 1.102e+02 7.591e+47
## rcs(systoliskt)systoliskt -6.051e-01 5.460e-01
## rcs(systoliskt)systoliskt' 1.426e+00 4.164e+00
## rcs(systoliskt)systoliskt'' -4.127e+00 1.613e-02
## rcs(systoliskt)systoliskt''' 5.020e+00 1.514e+02
## rcs(IV_AverageSaturation)IV_AverageSaturation -1.261e-01 8.815e-01
## rcs(IV_AverageSaturation)IV_AverageSaturation' -3.877e-01 6.786e-01
## rcs(IV_AverageSaturation)IV_AverageSaturation'' 3.358e+00 2.874e+01
## rcs(IV_AverageSaturation)IV_AverageSaturation''' -4.917e+00 7.323e-03
## factor(sex)1 -6.173e-01 5.394e-01
## factor(HushallsTyp_RTB)2 -4.286e-01 6.514e-01
## factor(HushallsTyp_RTB)3 -2.450e-01 7.827e-01
## rcs(bmi)bmi -8.151e-01 4.426e-01
## rcs(bmi)bmi' 5.685e+00 2.945e+02
## rcs(bmi)bmi'' -1.680e+01 5.070e-08
## rcs(bmi)bmi''' 1.327e+01 5.780e+05
## factor(stroke_history)1 5.347e-01 1.707e+00
## factor(antihypertensive_comb)1 4.647e-01 1.592e+00
## factor(Sun2000niva_old)2 -3.435e-02 9.662e-01
## factor(Sun2000niva_old)3 -6.315e-02 9.388e-01
## factor(Sun2000niva_old)4 -2.181e-01 8.040e-01
## factor(Sun2000niva_old)5 -3.552e-01 7.011e-01
## factor(Sun2000niva_old)6 -1.931e-01 8.244e-01
## factor(Sun2000niva_old)7 -1.445e+00 2.358e-01
## factor(ami_history)1 3.273e-01 1.387e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk 1.153e-01 1.122e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk' 8.506e+02 Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'' -1.004e+03 0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''' 1.693e+02 3.430e+73
## rcs(hba1c)hba1c -8.009e-01 4.489e-01
## rcs(hba1c)hba1c' 1.099e+01 5.924e+04
## rcs(hba1c)hba1c'' -3.101e+01 3.399e-14
## rcs(hba1c)hba1c''' 2.586e+01 1.709e+11
## factor(rokare)1 2.115e-01 1.236e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk 1.854e-01 1.204e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk' 1.655e+01 1.544e+07
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'' -1.806e+01 1.433e-08
## rcs(DispInkKEHB04)DispInkKEHB04 -4.414e-01 6.431e-01
## rcs(DispInkKEHB04)DispInkKEHB04' -3.517e+00 2.969e-02
## rcs(DispInkKEHB04)DispInkKEHB04'' 1.300e+01 4.413e+05
## rcs(DispInkKEHB04)DispInkKEHB04''' -1.352e+01 1.347e-06
## factor(FodelseLand_EU27_2020)1 2.043e-01 1.227e+00
## factor(antithrombotic_agents)1 1.840e-01 1.202e+00
## factor(lipid_modifying_agents)1 -1.663e-01 8.468e-01
## rcs(alder)alder:rcs(GFR)GFR -6.634e-02 9.358e-01
## rcs(alder)alder':rcs(GFR)GFR -3.987e-01 6.712e-01
## rcs(alder)alder'':rcs(GFR)GFR 6.973e+00 1.067e+03
## rcs(alder)alder''':rcs(GFR)GFR -1.641e+01 7.492e-08
## rcs(alder)alder:rcs(GFR)GFR' 3.753e+00 4.263e+01
## rcs(alder)alder':rcs(GFR)GFR' -9.379e+00 8.448e-05
## rcs(alder)alder'':rcs(GFR)GFR' 6.094e+01 2.924e+26
## rcs(alder)alder''':rcs(GFR)GFR' -8.837e+01 4.162e-39
## rcs(alder)alder:rcs(GFR)GFR'' -3.480e+01 7.686e-16
## rcs(alder)alder':rcs(GFR)GFR'' 1.261e+02 5.622e+54
## rcs(alder)alder'':rcs(GFR)GFR'' -9.260e+02 0.000e+00
## rcs(alder)alder''':rcs(GFR)GFR'' 1.508e+03 Inf
## rcs(alder)alder:rcs(GFR)GFR''' 6.822e+01 4.263e+29
## rcs(alder)alder':rcs(GFR)GFR''' -2.796e+02 3.893e-122
## rcs(alder)alder'':rcs(GFR)GFR''' 2.079e+03 Inf
## rcs(alder)alder''':rcs(GFR)GFR''' -3.434e+03 0.000e+00
## factor(cpap_treated)1:rcs(GFR)GFR 6.506e-01 1.917e+00
## factor(cpap_treated)1:rcs(GFR)GFR' -4.177e+00 1.534e-02
## factor(cpap_treated)1:rcs(GFR)GFR'' 2.588e+01 1.744e+11
## factor(cpap_treated)1:rcs(GFR)GFR''' -3.929e+01 8.599e-18
## factor(cpap_treated)1:factor(antihypertensive_comb)1 -3.372e-01 7.138e-01
## se(coef) z
## factor(cpap_treated)1 3.397e-01 5.162
## rcs(alder)alder 1.298e+00 -0.177
## rcs(alder)alder' 4.097e+00 0.217
## rcs(alder)alder'' 2.601e+01 -0.022
## rcs(alder)alder''' 4.193e+01 -0.062
## rcs(GFR)GFR 9.788e-01 -1.277
## rcs(GFR)GFR' 7.739e+00 0.832
## rcs(GFR)GFR'' 5.350e+01 -1.025
## rcs(GFR)GFR''' 8.931e+01 1.234
## rcs(systoliskt)systoliskt 1.133e-01 -5.341
## rcs(systoliskt)systoliskt' 8.858e-01 1.610
## rcs(systoliskt)systoliskt'' 4.902e+00 -0.842
## rcs(systoliskt)systoliskt''' 1.040e+01 0.483
## rcs(IV_AverageSaturation)IV_AverageSaturation 5.725e-02 -2.202
## rcs(IV_AverageSaturation)IV_AverageSaturation' 2.768e-01 -1.400
## rcs(IV_AverageSaturation)IV_AverageSaturation'' 3.018e+00 1.113
## rcs(IV_AverageSaturation)IV_AverageSaturation''' 1.211e+01 -0.406
## factor(sex)1 8.674e-02 -7.117
## factor(HushallsTyp_RTB)2 8.356e-02 -5.129
## factor(HushallsTyp_RTB)3 1.386e-01 -1.767
## rcs(bmi)bmi 1.840e-01 -4.430
## rcs(bmi)bmi' 1.689e+00 3.366
## rcs(bmi)bmi'' 6.863e+00 -2.447
## rcs(bmi)bmi''' 8.514e+00 1.558
## factor(stroke_history)1 1.481e-01 3.610
## factor(antihypertensive_comb)1 1.285e-01 3.616
## factor(Sun2000niva_old)2 1.361e-01 -0.252
## factor(Sun2000niva_old)3 1.034e-01 -0.611
## factor(Sun2000niva_old)4 1.296e-01 -1.683
## factor(Sun2000niva_old)5 1.498e-01 -2.371
## factor(Sun2000niva_old)6 1.436e-01 -1.345
## factor(Sun2000niva_old)7 7.154e-01 -2.020
## factor(ami_history)1 1.223e-01 2.675
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk 2.039e+00 0.057
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk' 1.781e+03 0.478
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'' 2.027e+03 -0.495
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''' 2.535e+02 0.668
## rcs(hba1c)hba1c 3.063e-01 -2.615
## rcs(hba1c)hba1c' 4.620e+00 2.379
## rcs(hba1c)hba1c'' 1.371e+01 -2.262
## rcs(hba1c)hba1c''' 1.230e+01 2.103
## factor(rokare)1 1.079e-01 1.960
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk 1.091e+00 0.170
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk' 2.167e+02 0.076
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'' 2.245e+02 -0.080
## rcs(DispInkKEHB04)DispInkKEHB04 2.837e-01 -1.556
## rcs(DispInkKEHB04)DispInkKEHB04' 4.961e+00 -0.709
## rcs(DispInkKEHB04)DispInkKEHB04'' 1.806e+01 0.720
## rcs(DispInkKEHB04)DispInkKEHB04''' 2.142e+01 -0.631
## factor(FodelseLand_EU27_2020)1 1.005e-01 2.032
## factor(antithrombotic_agents)1 8.542e-02 2.154
## factor(lipid_modifying_agents)1 8.074e-02 -2.060
## rcs(alder)alder:rcs(GFR)GFR 7.327e-01 -0.091
## rcs(alder)alder':rcs(GFR)GFR 2.334e+00 -0.171
## rcs(alder)alder'':rcs(GFR)GFR 1.493e+01 0.467
## rcs(alder)alder''':rcs(GFR)GFR 2.425e+01 -0.677
## rcs(alder)alder:rcs(GFR)GFR' 5.813e+00 0.646
## rcs(alder)alder':rcs(GFR)GFR' 1.848e+01 -0.507
## rcs(alder)alder'':rcs(GFR)GFR' 1.182e+02 0.515
## rcs(alder)alder''':rcs(GFR)GFR' 1.916e+02 -0.461
## rcs(alder)alder:rcs(GFR)GFR'' 4.017e+01 -0.866
## rcs(alder)alder':rcs(GFR)GFR'' 1.286e+02 0.981
## rcs(alder)alder'':rcs(GFR)GFR'' 8.319e+02 -1.113
## rcs(alder)alder''':rcs(GFR)GFR'' 1.365e+03 1.105
## rcs(alder)alder:rcs(GFR)GFR''' 6.712e+01 1.017
## rcs(alder)alder':rcs(GFR)GFR''' 2.158e+02 -1.295
## rcs(alder)alder'':rcs(GFR)GFR''' 1.411e+03 1.473
## rcs(alder)alder''':rcs(GFR)GFR''' 2.342e+03 -1.466
## factor(cpap_treated)1:rcs(GFR)GFR 1.820e-01 3.575
## factor(cpap_treated)1:rcs(GFR)GFR' 1.448e+00 -2.886
## factor(cpap_treated)1:rcs(GFR)GFR'' 1.053e+01 2.457
## factor(cpap_treated)1:rcs(GFR)GFR''' 1.837e+01 -2.139
## factor(cpap_treated)1:factor(antihypertensive_comb)1 1.738e-01 -1.940
## Pr(>|z|)
## factor(cpap_treated)1 2.44e-07 ***
## rcs(alder)alder 0.859146
## rcs(alder)alder' 0.827968
## rcs(alder)alder'' 0.982698
## rcs(alder)alder''' 0.950659
## rcs(GFR)GFR 0.201618
## rcs(GFR)GFR' 0.405515
## rcs(GFR)GFR'' 0.305428
## rcs(GFR)GFR''' 0.217053
## rcs(systoliskt)systoliskt 9.24e-08 ***
## rcs(systoliskt)systoliskt' 0.107334
## rcs(systoliskt)systoliskt'' 0.399879
## rcs(systoliskt)systoliskt''' 0.629196
## rcs(IV_AverageSaturation)IV_AverageSaturation 0.027642 *
## rcs(IV_AverageSaturation)IV_AverageSaturation' 0.161421
## rcs(IV_AverageSaturation)IV_AverageSaturation'' 0.265830
## rcs(IV_AverageSaturation)IV_AverageSaturation''' 0.684835
## factor(sex)1 1.11e-12 ***
## factor(HushallsTyp_RTB)2 2.91e-07 ***
## factor(HushallsTyp_RTB)3 0.077206 .
## rcs(bmi)bmi 9.44e-06 ***
## rcs(bmi)bmi' 0.000763 ***
## rcs(bmi)bmi'' 0.014385 *
## rcs(bmi)bmi''' 0.119184
## factor(stroke_history)1 0.000306 ***
## factor(antihypertensive_comb)1 0.000299 ***
## factor(Sun2000niva_old)2 0.800759
## factor(Sun2000niva_old)3 0.541210
## factor(Sun2000niva_old)4 0.092374 .
## factor(Sun2000niva_old)5 0.017754 *
## factor(Sun2000niva_old)6 0.178590
## factor(Sun2000niva_old)7 0.043435 *
## factor(ami_history)1 0.007474 **
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk 0.954925
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk' 0.632953
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'' 0.620433
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''' 0.504136
## rcs(hba1c)hba1c 0.008925 **
## rcs(hba1c)hba1c' 0.017365 *
## rcs(hba1c)hba1c'' 0.023718 *
## rcs(hba1c)hba1c''' 0.035484 *
## factor(rokare)1 0.050049 .
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk 0.865091
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk' 0.939114
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'' 0.935891
## rcs(DispInkKEHB04)DispInkKEHB04 0.119695
## rcs(DispInkKEHB04)DispInkKEHB04' 0.478340
## rcs(DispInkKEHB04)DispInkKEHB04'' 0.471820
## rcs(DispInkKEHB04)DispInkKEHB04''' 0.527917
## factor(FodelseLand_EU27_2020)1 0.042127 *
## factor(antithrombotic_agents)1 0.031217 *
## factor(lipid_modifying_agents)1 0.039393 *
## rcs(alder)alder:rcs(GFR)GFR 0.927853
## rcs(alder)alder':rcs(GFR)GFR 0.864339
## rcs(alder)alder'':rcs(GFR)GFR 0.640560
## rcs(alder)alder''':rcs(GFR)GFR 0.498721
## rcs(alder)alder:rcs(GFR)GFR' 0.518559
## rcs(alder)alder':rcs(GFR)GFR' 0.611805
## rcs(alder)alder'':rcs(GFR)GFR' 0.606206
## rcs(alder)alder''':rcs(GFR)GFR' 0.644648
## rcs(alder)alder:rcs(GFR)GFR'' 0.386328
## rcs(alder)alder':rcs(GFR)GFR'' 0.326811
## rcs(alder)alder'':rcs(GFR)GFR'' 0.265653
## rcs(alder)alder''':rcs(GFR)GFR'' 0.269103
## rcs(alder)alder:rcs(GFR)GFR''' 0.309382
## rcs(alder)alder':rcs(GFR)GFR''' 0.195222
## rcs(alder)alder'':rcs(GFR)GFR''' 0.140686
## rcs(alder)alder''':rcs(GFR)GFR''' 0.142649
## factor(cpap_treated)1:rcs(GFR)GFR 0.000350 ***
## factor(cpap_treated)1:rcs(GFR)GFR' 0.003905 **
## factor(cpap_treated)1:rcs(GFR)GFR'' 0.013996 *
## factor(cpap_treated)1:rcs(GFR)GFR''' 0.032415 *
## factor(cpap_treated)1:factor(antihypertensive_comb)1 0.052391 .
## ---
## Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
##
## exp(coef) exp(-coef)
## factor(cpap_treated)1 5.776e+00 1.731e-01
## rcs(alder)alder 7.942e-01 1.259e+00
## rcs(alder)alder' 2.436e+00 4.105e-01
## rcs(alder)alder'' 5.689e-01 1.758e+00
## rcs(alder)alder''' 7.469e-02 1.339e+01
## rcs(GFR)GFR 2.865e-01 3.490e+00
## rcs(GFR)GFR' 6.246e+02 1.601e-03
## rcs(GFR)GFR'' 1.544e-24 6.476e+23
## rcs(GFR)GFR''' 7.591e+47 1.317e-48
## rcs(systoliskt)systoliskt 5.460e-01 1.831e+00
## rcs(systoliskt)systoliskt' 4.164e+00 2.402e-01
## rcs(systoliskt)systoliskt'' 1.613e-02 6.199e+01
## rcs(systoliskt)systoliskt''' 1.514e+02 6.606e-03
## rcs(IV_AverageSaturation)IV_AverageSaturation 8.815e-01 1.134e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation' 6.786e-01 1.474e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation'' 2.874e+01 3.480e-02
## rcs(IV_AverageSaturation)IV_AverageSaturation''' 7.323e-03 1.366e+02
## factor(sex)1 5.394e-01 1.854e+00
## factor(HushallsTyp_RTB)2 6.514e-01 1.535e+00
## factor(HushallsTyp_RTB)3 7.827e-01 1.278e+00
## rcs(bmi)bmi 4.426e-01 2.259e+00
## rcs(bmi)bmi' 2.945e+02 3.396e-03
## rcs(bmi)bmi'' 5.070e-08 1.972e+07
## rcs(bmi)bmi''' 5.780e+05 1.730e-06
## factor(stroke_history)1 1.707e+00 5.859e-01
## factor(antihypertensive_comb)1 1.592e+00 6.283e-01
## factor(Sun2000niva_old)2 9.662e-01 1.035e+00
## factor(Sun2000niva_old)3 9.388e-01 1.065e+00
## factor(Sun2000niva_old)4 8.040e-01 1.244e+00
## factor(Sun2000niva_old)5 7.011e-01 1.426e+00
## factor(Sun2000niva_old)6 8.244e-01 1.213e+00
## factor(Sun2000niva_old)7 2.358e-01 4.241e+00
## factor(ami_history)1 1.387e+00 7.209e-01
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk 1.122e+00 8.911e-01
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk' Inf 0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'' 0.000e+00 Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''' 3.430e+73 2.916e-74
## rcs(hba1c)hba1c 4.489e-01 2.228e+00
## rcs(hba1c)hba1c' 5.924e+04 1.688e-05
## rcs(hba1c)hba1c'' 3.399e-14 2.942e+13
## rcs(hba1c)hba1c''' 1.709e+11 5.852e-12
## factor(rokare)1 1.236e+00 8.094e-01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk 1.204e+00 8.308e-01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk' 1.544e+07 6.477e-08
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'' 1.433e-08 6.978e+07
## rcs(DispInkKEHB04)DispInkKEHB04 6.431e-01 1.555e+00
## rcs(DispInkKEHB04)DispInkKEHB04' 2.969e-02 3.368e+01
## rcs(DispInkKEHB04)DispInkKEHB04'' 4.413e+05 2.266e-06
## rcs(DispInkKEHB04)DispInkKEHB04''' 1.347e-06 7.423e+05
## factor(FodelseLand_EU27_2020)1 1.227e+00 8.152e-01
## factor(antithrombotic_agents)1 1.202e+00 8.319e-01
## factor(lipid_modifying_agents)1 8.468e-01 1.181e+00
## rcs(alder)alder:rcs(GFR)GFR 9.358e-01 1.069e+00
## rcs(alder)alder':rcs(GFR)GFR 6.712e-01 1.490e+00
## rcs(alder)alder'':rcs(GFR)GFR 1.067e+03 9.373e-04
## rcs(alder)alder''':rcs(GFR)GFR 7.492e-08 1.335e+07
## rcs(alder)alder:rcs(GFR)GFR' 4.263e+01 2.346e-02
## rcs(alder)alder':rcs(GFR)GFR' 8.448e-05 1.184e+04
## rcs(alder)alder'':rcs(GFR)GFR' 2.924e+26 3.420e-27
## rcs(alder)alder''':rcs(GFR)GFR' 4.162e-39 2.402e+38
## rcs(alder)alder:rcs(GFR)GFR'' 7.686e-16 1.301e+15
## rcs(alder)alder':rcs(GFR)GFR'' 5.622e+54 1.779e-55
## rcs(alder)alder'':rcs(GFR)GFR'' 0.000e+00 Inf
## rcs(alder)alder''':rcs(GFR)GFR'' Inf 0.000e+00
## rcs(alder)alder:rcs(GFR)GFR''' 4.263e+29 2.346e-30
## rcs(alder)alder':rcs(GFR)GFR''' 3.893e-122 2.569e+121
## rcs(alder)alder'':rcs(GFR)GFR''' Inf 0.000e+00
## rcs(alder)alder''':rcs(GFR)GFR''' 0.000e+00 Inf
## factor(cpap_treated)1:rcs(GFR)GFR 1.917e+00 5.218e-01
## factor(cpap_treated)1:rcs(GFR)GFR' 1.534e-02 6.520e+01
## factor(cpap_treated)1:rcs(GFR)GFR'' 1.744e+11 5.734e-12
## factor(cpap_treated)1:rcs(GFR)GFR''' 8.599e-18 1.163e+17
## factor(cpap_treated)1:factor(antihypertensive_comb)1 7.138e-01 1.401e+00
## lower .95 upper .95
## factor(cpap_treated)1 2.968e+00 1.124e+01
## rcs(alder)alder 6.233e-02 1.012e+01
## rcs(alder)alder' 7.927e-04 7.487e+03
## rcs(alder)alder'' 4.108e-23 7.878e+21
## rcs(alder)alder''' 1.531e-37 3.644e+34
## rcs(GFR)GFR 4.207e-02 1.951e+00
## rcs(GFR)GFR' 1.616e-04 2.414e+09
## rcs(GFR)GFR'' 4.483e-70 5.319e+21
## rcs(GFR)GFR''' 7.191e-29 8.012e+123
## rcs(systoliskt)systoliskt 4.373e-01 6.818e-01
## rcs(systoliskt)systoliskt' 7.336e-01 2.363e+01
## rcs(systoliskt)systoliskt'' 1.083e-06 2.402e+02
## rcs(systoliskt)systoliskt''' 2.143e-07 1.069e+11
## rcs(IV_AverageSaturation)IV_AverageSaturation 7.880e-01 9.862e-01
## rcs(IV_AverageSaturation)IV_AverageSaturation' 3.945e-01 1.168e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation'' 7.754e-02 1.065e+04
## rcs(IV_AverageSaturation)IV_AverageSaturation''' 3.575e-13 1.500e+08
## factor(sex)1 4.551e-01 6.394e-01
## factor(HushallsTyp_RTB)2 5.530e-01 7.674e-01
## factor(HushallsTyp_RTB)3 5.965e-01 1.027e+00
## rcs(bmi)bmi 3.086e-01 6.348e-01
## rcs(bmi)bmi' 1.075e+01 8.067e+03
## rcs(bmi)bmi'' 7.298e-14 3.523e-02
## rcs(bmi)bmi''' 3.269e-02 1.022e+13
## factor(stroke_history)1 1.277e+00 2.282e+00
## factor(antihypertensive_comb)1 1.237e+00 2.048e+00
## factor(Sun2000niva_old)2 7.400e-01 1.262e+00
## factor(Sun2000niva_old)3 7.667e-01 1.150e+00
## factor(Sun2000niva_old)4 6.237e-01 1.037e+00
## factor(Sun2000niva_old)5 5.227e-01 9.403e-01
## factor(Sun2000niva_old)6 6.222e-01 1.092e+00
## factor(Sun2000niva_old)7 5.802e-02 9.583e-01
## factor(ami_history)1 1.091e+00 1.763e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk 2.063e-02 6.105e+01
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk' 0.000e+00 Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'' 0.000e+00 Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''' 5.968e-143 1.971e+289
## rcs(hba1c)hba1c 2.463e-01 8.182e-01
## rcs(hba1c)hba1c' 6.926e+00 5.067e+08
## rcs(hba1c)hba1c'' 7.233e-26 1.597e-02
## rcs(hba1c)hba1c''' 5.794e+00 5.040e+21
## factor(rokare)1 1.000e+00 1.527e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk 1.418e-01 1.022e+01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk' 5.375e-178 4.436e+191
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'' 1.065e-199 1.929e+183
## rcs(DispInkKEHB04)DispInkKEHB04 3.688e-01 1.121e+00
## rcs(DispInkKEHB04)DispInkKEHB04' 1.779e-06 4.955e+02
## rcs(DispInkKEHB04)DispInkKEHB04'' 1.856e-10 1.049e+21
## rcs(DispInkKEHB04)DispInkKEHB04''' 7.944e-25 2.284e+12
## factor(FodelseLand_EU27_2020)1 1.007e+00 1.494e+00
## factor(antithrombotic_agents)1 1.017e+00 1.421e+00
## factor(lipid_modifying_agents)1 7.228e-01 9.920e-01
## rcs(alder)alder:rcs(GFR)GFR 2.226e-01 3.934e+00
## rcs(alder)alder':rcs(GFR)GFR 6.923e-03 6.507e+01
## rcs(alder)alder'':rcs(GFR)GFR 2.075e-10 5.485e+15
## rcs(alder)alder''':rcs(GFR)GFR 1.701e-28 3.299e+13
## rcs(alder)alder:rcs(GFR)GFR' 4.807e-04 3.781e+06
## rcs(alder)alder':rcs(GFR)GFR' 1.570e-20 4.547e+11
## rcs(alder)alder'':rcs(GFR)GFR' 6.919e-75 1.235e+127
## rcs(alder)alder''':rcs(GFR)GFR' 3.285e-202 5.274e+124
## rcs(alder)alder:rcs(GFR)GFR'' 4.899e-50 1.206e+19
## rcs(alder)alder':rcs(GFR)GFR'' 2.062e-55 1.533e+164
## rcs(alder)alder'':rcs(GFR)GFR'' 0.000e+00 9.070e+305
## rcs(alder)alder''':rcs(GFR)GFR'' 0.000e+00 Inf
## rcs(alder)alder:rcs(GFR)GFR''' 3.164e-28 5.743e+86
## rcs(alder)alder':rcs(GFR)GFR''' 7.562e-306 2.004e+62
## rcs(alder)alder'':rcs(GFR)GFR''' 4.742e-299 Inf
## rcs(alder)alder''':rcs(GFR)GFR''' 0.000e+00 Inf
## factor(cpap_treated)1:rcs(GFR)GFR 1.342e+00 2.738e+00
## factor(cpap_treated)1:rcs(GFR)GFR' 8.985e-04 2.618e-01
## factor(cpap_treated)1:rcs(GFR)GFR'' 1.886e+02 1.613e+20
## factor(cpap_treated)1:rcs(GFR)GFR''' 1.991e-33 3.713e-02
## factor(cpap_treated)1:factor(antihypertensive_comb)1 5.077e-01 1.003e+00
##
## Concordance= 0.813 (se = 0.009 )
## Likelihood ratio test= 1137 on 73 df, p=<2e-16
## Wald test = 1171 on 73 df, p=<2e-16
## Score (logrank) test = 1613 on 73 df, p=<2e-16
## Warning in termplot(cph): 'model' appears to involve interactions: see the help
## page
## [1] "--- CONCORDANCE RESULTS ---"
## C-index train: 0.8129236
## C-index test: 0.8206258
run_models(c(list_forms_sleep[["form_tdep_spl"]], list_forms_sleep[["form_tdep_cat"]]), df_ami_sub_tv_train, df_ami_sub_tv_test, "stop", "event", cont_var, "prof_ami_dep_g2.html", bigd=F)
## [1] "### FORMULA 1 ###"
## Start: AIC=10600.63
## Surv(start, stop, event) ~ factor(cpap_treated)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Df AIC
## + factor(antithrombotic_agents) 1 10481
## + rcs(alder) 4 10505
## + factor(ami_history) 1 10531
## + rcs(GFR) 4 10552
## + factor(lipid_modifying_agents) 1 10563
## + factor(sex) 1 10565
## + factor(antihypertensive_comb) 1 10566
## + rcs(hba1c) 4 10568
## + rcs(systoliskt) 4 10574
## + factor(Sun2000niva_old) 6 10585
## + rcs(IV_ODI) 4 10594
## + rcs(IV_AHI) 4 10595
## + rcs(bmi) 4 10595
## + factor(stroke_history) 1 10598
## + factor(rokare) 1 10599
## + rcs(kolesterol) 4 10599
## + rcs(Raks_AndelSjukInk) 4 10600
## <none> 10601
## + factor(HushallsTyp_RTB) 2 10601
## + factor(FodelseLand_EU27_2020) 1 10601
## + factor(Civil) 1 10602
## + rcs(DispInkKEHB04) 4 10603
## + rcs(Raks_AndelEkBisInk) 3 10604
## + rcs(Raks_AndelArblosInk) 4 10605
## + rcs(IV_AverageSaturation) 4 10606
##
## Step: AIC=10481.41
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Df AIC
## + factor(ami_history) 1 10359
## + rcs(alder) 4 10437
## + rcs(systoliskt) 4 10453
## + rcs(hba1c) 4 10455
## + rcs(GFR) 4 10456
## + factor(sex) 1 10456
## + factor(antihypertensive_comb) 1 10470
## + factor(Sun2000niva_old) 6 10476
## + factor(lipid_modifying_agents) 1 10476
## + factor(rokare) 1 10478
## + rcs(bmi) 4 10479
## + rcs(IV_ODI) 4 10480
## + rcs(IV_AHI) 4 10480
## + factor(cpap_treated):factor(antithrombotic_agents) 1 10481
## <none> 10481
## + rcs(Raks_AndelSjukInk) 4 10482
## + rcs(kolesterol) 4 10482
## + factor(FodelseLand_EU27_2020) 1 10483
## + factor(Civil) 1 10483
## + factor(HushallsTyp_RTB) 2 10483
## + factor(stroke_history) 1 10483
## + rcs(IV_AverageSaturation) 4 10484
## + rcs(DispInkKEHB04) 4 10485
## + rcs(Raks_AndelEkBisInk) 3 10486
## + rcs(Raks_AndelArblosInk) 4 10486
## - factor(antithrombotic_agents) 1 10601
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
##
## Step: AIC=10359.13
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) +
## factor(ami_history)
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Df AIC
## + rcs(alder) 4 10315
## + factor(sex) 1 10329
## + rcs(GFR) 4 10333
## + rcs(hba1c) 4 10334
## + rcs(systoliskt) 4 10334
## + factor(antihypertensive_comb) 1 10346
## + factor(lipid_modifying_agents) 1 10346
## + factor(Sun2000niva_old) 6 10354
## + factor(rokare) 1 10356
## + rcs(bmi) 4 10356
## + factor(cpap_treated):factor(antithrombotic_agents) 1 10357
## + rcs(IV_ODI) 4 10358
## + rcs(IV_AHI) 4 10358
## + rcs(kolesterol) 4 10358
## <none> 10359
## + rcs(Raks_AndelSjukInk) 4 10360
## + factor(stroke_history) 1 10361
## + factor(FodelseLand_EU27_2020) 1 10361
## + factor(HushallsTyp_RTB) 2 10361
## + factor(Civil) 1 10361
## + rcs(IV_AverageSaturation) 4 10361
## + rcs(DispInkKEHB04) 4 10362
## + rcs(Raks_AndelArblosInk) 4 10363
## + rcs(Raks_AndelEkBisInk) 3 10364
## - factor(ami_history) 1 10481
## - factor(antithrombotic_agents) 1 10531
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
##
## Step: AIC=10315.41
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) +
## factor(ami_history) + rcs(alder)
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Df AIC
## + factor(sex) 1 10282
## + rcs(hba1c) 4 10287
## + rcs(systoliskt) 4 10296
## + rcs(GFR) 4 10300
## + factor(rokare) 1 10307
## + factor(lipid_modifying_agents) 1 10308
## + factor(antihypertensive_comb) 1 10310
## + factor(cpap_treated):factor(antithrombotic_agents) 1 10314
## + rcs(IV_AverageSaturation) 4 10314
## + rcs(DispInkKEHB04) 4 10315
## + rcs(kolesterol) 4 10315
## <none> 10315
## + factor(Sun2000niva_old) 6 10316
## + factor(Civil) 1 10316
## + rcs(Raks_AndelSjukInk) 4 10317
## + factor(stroke_history) 1 10317
## + factor(FodelseLand_EU27_2020) 1 10317
## + rcs(IV_ODI) 4 10318
## + factor(HushallsTyp_RTB) 2 10318
## + rcs(Raks_AndelEkBisInk) 3 10318
## + rcs(IV_AHI) 4 10318
## + rcs(bmi) 4 10319
## + rcs(Raks_AndelArblosInk) 4 10320
## - rcs(alder) 4 10359
## - factor(antithrombotic_agents) 1 10423
## - factor(ami_history) 1 10437
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
##
## Step: AIC=10281.98
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) +
## factor(ami_history) + rcs(alder) + factor(sex)
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Df AIC
## + rcs(hba1c) 4 10255
## + rcs(systoliskt) 4 10263
## + rcs(GFR) 4 10263
## + factor(rokare) 1 10272
## + rcs(DispInkKEHB04) 4 10276
## + factor(lipid_modifying_agents) 1 10276
## + factor(antihypertensive_comb) 1 10278
## + rcs(kolesterol) 4 10280
## + factor(cpap_treated):factor(antithrombotic_agents) 1 10280
## + rcs(IV_AverageSaturation) 4 10281
## + factor(Sun2000niva_old) 6 10281
## <none> 10282
## + rcs(Raks_AndelSjukInk) 4 10283
## + factor(FodelseLand_EU27_2020) 1 10284
## + factor(stroke_history) 1 10284
## + rcs(Raks_AndelEkBisInk) 3 10284
## + factor(Civil) 1 10284
## + factor(HushallsTyp_RTB) 2 10286
## + rcs(IV_ODI) 4 10286
## + rcs(Raks_AndelArblosInk) 4 10286
## + rcs(IV_AHI) 4 10286
## + rcs(bmi) 4 10288
## - factor(sex) 1 10315
## - rcs(alder) 4 10329
## - factor(antithrombotic_agents) 1 10378
## - factor(ami_history) 1 10409
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
##
## Step: AIC=10255
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) +
## factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Df AIC
## + rcs(systoliskt) 4 10239
## + rcs(GFR) 4 10239
## + factor(rokare) 1 10247
## + factor(lipid_modifying_agents) 1 10250
## + factor(antihypertensive_comb) 1 10252
## + rcs(kolesterol) 4 10253
## + rcs(DispInkKEHB04) 4 10253
## + factor(cpap_treated):factor(antithrombotic_agents) 1 10253
## + rcs(IV_AverageSaturation) 4 10253
## <none> 10255
## + rcs(Raks_AndelSjukInk) 4 10256
## + factor(FodelseLand_EU27_2020) 1 10256
## + factor(stroke_history) 1 10257
## + factor(Civil) 1 10257
## + factor(Sun2000niva_old) 6 10257
## + rcs(Raks_AndelEkBisInk) 3 10258
## + factor(HushallsTyp_RTB) 2 10258
## + rcs(Raks_AndelArblosInk) 4 10259
## + rcs(IV_ODI) 4 10260
## + rcs(IV_AHI) 4 10260
## + rcs(bmi) 4 10261
## - rcs(hba1c) 4 10282
## - factor(sex) 1 10287
## - rcs(alder) 4 10305
## - factor(antithrombotic_agents) 1 10344
## - factor(ami_history) 1 10380
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
##
## Step: AIC=10238.63
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) +
## factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c) +
## rcs(systoliskt)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Df AIC
## + rcs(GFR) 4 10224
## + factor(rokare) 1 10230
## + factor(lipid_modifying_agents) 1 10233
## + rcs(DispInkKEHB04) 4 10237
## + rcs(IV_AverageSaturation) 4 10237
## + factor(cpap_treated):factor(antithrombotic_agents) 1 10237
## + rcs(kolesterol) 4 10237
## + factor(antihypertensive_comb) 1 10237
## <none> 10239
## + rcs(Raks_AndelSjukInk) 4 10240
## + factor(FodelseLand_EU27_2020) 1 10240
## + factor(Sun2000niva_old) 6 10240
## + factor(stroke_history) 1 10240
## + factor(Civil) 1 10241
## + rcs(Raks_AndelEkBisInk) 3 10241
## + factor(HushallsTyp_RTB) 2 10242
## + rcs(Raks_AndelArblosInk) 4 10243
## + rcs(IV_ODI) 4 10244
## + rcs(bmi) 4 10244
## + rcs(IV_AHI) 4 10244
## - rcs(systoliskt) 4 10255
## - rcs(hba1c) 4 10263
## - factor(sex) 1 10270
## - rcs(alder) 4 10284
## - factor(antithrombotic_agents) 1 10330
## - factor(ami_history) 1 10361
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
##
## Step: AIC=10223.67
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) +
## factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c) +
## rcs(systoliskt) + rcs(GFR)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Df AIC
## + factor(rokare) 1 10215
## + factor(lipid_modifying_agents) 1 10218
## + rcs(IV_AverageSaturation) 4 10221
## + factor(cpap_treated):factor(antithrombotic_agents) 1 10222
## + rcs(DispInkKEHB04) 4 10222
## + rcs(kolesterol) 4 10223
## + factor(antihypertensive_comb) 1 10223
## <none> 10224
## + rcs(Raks_AndelSjukInk) 4 10225
## + factor(FodelseLand_EU27_2020) 1 10225
## + factor(Sun2000niva_old) 6 10225
## + factor(stroke_history) 1 10226
## + factor(cpap_treated):rcs(GFR) 4 10226
## + factor(Civil) 1 10226
## + rcs(Raks_AndelEkBisInk) 3 10226
## + factor(HushallsTyp_RTB) 2 10227
## + rcs(Raks_AndelArblosInk) 4 10228
## + rcs(IV_ODI) 4 10229
## + rcs(bmi) 4 10229
## + rcs(IV_AHI) 4 10230
## - rcs(GFR) 4 10239
## - rcs(systoliskt) 4 10239
## + rcs(alder):rcs(GFR) 16 10241
## - rcs(hba1c) 4 10246
## - rcs(alder) 4 10255
## - factor(sex) 1 10258
## - factor(antithrombotic_agents) 1 10309
## - factor(ami_history) 1 10347
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
##
## Step: AIC=10215.23
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) +
## factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c) +
## rcs(systoliskt) + rcs(GFR) + factor(rokare)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Df AIC
## + factor(lipid_modifying_agents) 1 10210
## + rcs(IV_AverageSaturation) 4 10212
## + factor(cpap_treated):factor(antithrombotic_agents) 1 10214
## + factor(antihypertensive_comb) 1 10214
## + rcs(kolesterol) 4 10215
## + rcs(DispInkKEHB04) 4 10215
## <none> 10215
## + rcs(Raks_AndelSjukInk) 4 10217
## + factor(FodelseLand_EU27_2020) 1 10217
## + factor(stroke_history) 1 10217
## + factor(cpap_treated):rcs(GFR) 4 10217
## + factor(Civil) 1 10217
## + factor(Sun2000niva_old) 6 10218
## + factor(HushallsTyp_RTB) 2 10218
## + rcs(Raks_AndelEkBisInk) 3 10218
## + rcs(Raks_AndelArblosInk) 4 10220
## + rcs(IV_ODI) 4 10220
## + rcs(bmi) 4 10221
## + rcs(IV_AHI) 4 10221
## - factor(rokare) 1 10224
## - rcs(GFR) 4 10230
## - rcs(systoliskt) 4 10231
## + rcs(alder):rcs(GFR) 16 10232
## - rcs(hba1c) 4 10236
## - rcs(alder) 4 10250
## - factor(sex) 1 10251
## - factor(antithrombotic_agents) 1 10298
## - factor(ami_history) 1 10339
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
##
## Step: AIC=10210.16
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) +
## factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c) +
## rcs(systoliskt) + rcs(GFR) + factor(rokare) + factor(lipid_modifying_agents)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Df AIC
## + rcs(IV_AverageSaturation) 4 10206
## + factor(cpap_treated):factor(antithrombotic_agents) 1 10208
## + rcs(kolesterol) 4 10209
## + factor(cpap_treated):factor(lipid_modifying_agents) 1 10210
## <none> 10210
## + rcs(DispInkKEHB04) 4 10210
## + factor(antihypertensive_comb) 1 10210
## + rcs(Raks_AndelSjukInk) 4 10211
## + factor(stroke_history) 1 10212
## + factor(FodelseLand_EU27_2020) 1 10212
## + factor(cpap_treated):rcs(GFR) 4 10212
## + factor(Civil) 1 10212
## + factor(Sun2000niva_old) 6 10213
## + factor(HushallsTyp_RTB) 2 10213
## + rcs(Raks_AndelEkBisInk) 3 10214
## + rcs(Raks_AndelArblosInk) 4 10215
## - factor(lipid_modifying_agents) 1 10215
## + rcs(IV_ODI) 4 10215
## + rcs(bmi) 4 10216
## + rcs(IV_AHI) 4 10216
## - factor(rokare) 1 10218
## - rcs(GFR) 4 10224
## - rcs(systoliskt) 4 10226
## + rcs(alder):rcs(GFR) 16 10227
## - rcs(hba1c) 4 10231
## - rcs(alder) 4 10242
## - factor(sex) 1 10244
## - factor(antithrombotic_agents) 1 10277
## - factor(ami_history) 1 10338
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
##
## Step: AIC=10205.69
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) +
## factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c) +
## rcs(systoliskt) + rcs(GFR) + factor(rokare) + factor(lipid_modifying_agents) +
## rcs(IV_AverageSaturation)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Df AIC
## + factor(cpap_treated):factor(antithrombotic_agents) 1 10204
## + rcs(kolesterol) 4 10205
## + factor(antihypertensive_comb) 1 10205
## + factor(cpap_treated):factor(lipid_modifying_agents) 1 10205
## + rcs(DispInkKEHB04) 4 10206
## <none> 10206
## + rcs(Raks_AndelSjukInk) 4 10207
## + factor(cpap_treated):rcs(GFR) 4 10207
## + factor(stroke_history) 1 10207
## + factor(FodelseLand_EU27_2020) 1 10208
## + factor(Civil) 1 10208
## + rcs(IV_ODI) 4 10208
## + factor(Sun2000niva_old) 6 10208
## + factor(HushallsTyp_RTB) 2 10209
## + rcs(IV_AHI) 4 10209
## + rcs(Raks_AndelEkBisInk) 3 10210
## - rcs(IV_AverageSaturation) 4 10210
## + rcs(Raks_AndelArblosInk) 4 10210
## + rcs(bmi) 4 10211
## - factor(lipid_modifying_agents) 1 10212
## - factor(rokare) 1 10215
## - rcs(GFR) 4 10220
## - rcs(systoliskt) 4 10222
## + rcs(alder):rcs(GFR) 16 10222
## - rcs(hba1c) 4 10227
## - factor(sex) 1 10240
## - rcs(alder) 4 10240
## - factor(antithrombotic_agents) 1 10274
## - factor(ami_history) 1 10335
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
##
## Step: AIC=10204.01
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) +
## factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c) +
## rcs(systoliskt) + rcs(GFR) + factor(rokare) + factor(lipid_modifying_agents) +
## rcs(IV_AverageSaturation) + factor(cpap_treated):factor(antithrombotic_agents)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Df AIC
## + rcs(kolesterol) 4 10203
## + factor(antihypertensive_comb) 1 10204
## <none> 10204
## + rcs(DispInkKEHB04) 4 10204
## + rcs(Raks_AndelSjukInk) 4 10205
## + factor(cpap_treated):factor(lipid_modifying_agents) 1 10205
## + factor(stroke_history) 1 10206
## + factor(cpap_treated):rcs(GFR) 4 10206
## - factor(cpap_treated):factor(antithrombotic_agents) 1 10206
## + factor(FodelseLand_EU27_2020) 1 10206
## + factor(Civil) 1 10206
## + rcs(IV_ODI) 4 10206
## + factor(Sun2000niva_old) 6 10207
## + rcs(IV_AHI) 4 10207
## + factor(HushallsTyp_RTB) 2 10207
## + rcs(Raks_AndelEkBisInk) 3 10208
## - rcs(IV_AverageSaturation) 4 10208
## + rcs(Raks_AndelArblosInk) 4 10209
## + rcs(bmi) 4 10209
## - factor(lipid_modifying_agents) 1 10210
## - factor(rokare) 1 10213
## - rcs(GFR) 4 10219
## - rcs(systoliskt) 4 10220
## + rcs(alder):rcs(GFR) 16 10221
## - rcs(hba1c) 4 10226
## - rcs(alder) 4 10238
## - factor(sex) 1 10238
## - factor(ami_history) 1 10335
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
##
## Step: AIC=10202.98
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) +
## factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c) +
## rcs(systoliskt) + rcs(GFR) + factor(rokare) + factor(lipid_modifying_agents) +
## rcs(IV_AverageSaturation) + rcs(kolesterol) + factor(cpap_treated):factor(antithrombotic_agents)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Df AIC
## + factor(antihypertensive_comb) 1 10202
## + rcs(DispInkKEHB04) 4 10203
## <none> 10203
## + rcs(Raks_AndelSjukInk) 4 10204
## + factor(cpap_treated):factor(lipid_modifying_agents) 1 10204
## - rcs(kolesterol) 4 10204
## + factor(stroke_history) 1 10204
## + factor(cpap_treated):rcs(GFR) 4 10205
## - factor(cpap_treated):factor(antithrombotic_agents) 1 10205
## + factor(FodelseLand_EU27_2020) 1 10205
## + factor(Civil) 1 10205
## + rcs(IV_ODI) 4 10205
## + factor(Sun2000niva_old) 6 10205
## + rcs(IV_AHI) 4 10206
## + factor(HushallsTyp_RTB) 2 10206
## + rcs(Raks_AndelEkBisInk) 3 10207
## - rcs(IV_AverageSaturation) 4 10207
## + rcs(Raks_AndelArblosInk) 4 10208
## + rcs(bmi) 4 10208
## - factor(lipid_modifying_agents) 1 10210
## - factor(rokare) 1 10212
## - rcs(GFR) 4 10217
## - rcs(systoliskt) 4 10218
## + rcs(alder):rcs(GFR) 16 10220
## - rcs(hba1c) 4 10225
## - rcs(alder) 4 10238
## - factor(sex) 1 10238
## - factor(ami_history) 1 10333
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
##
## Step: AIC=10202.28
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) +
## factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c) +
## rcs(systoliskt) + rcs(GFR) + factor(rokare) + factor(lipid_modifying_agents) +
## rcs(IV_AverageSaturation) + rcs(kolesterol) + factor(antihypertensive_comb) +
## factor(cpap_treated):factor(antithrombotic_agents)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Df AIC
## + rcs(DispInkKEHB04) 4 10202
## + factor(cpap_treated):factor(antihypertensive_comb) 1 10202
## <none> 10202
## - factor(antihypertensive_comb) 1 10203
## + rcs(Raks_AndelSjukInk) 4 10203
## + factor(cpap_treated):factor(lipid_modifying_agents) 1 10203
## - rcs(kolesterol) 4 10204
## + factor(cpap_treated):rcs(GFR) 4 10204
## + factor(stroke_history) 1 10204
## - factor(cpap_treated):factor(antithrombotic_agents) 1 10204
## + factor(FodelseLand_EU27_2020) 1 10204
## + factor(Civil) 1 10204
## + rcs(IV_ODI) 4 10205
## + factor(Sun2000niva_old) 6 10205
## + factor(HushallsTyp_RTB) 2 10206
## + rcs(IV_AHI) 4 10206
## + rcs(Raks_AndelEkBisInk) 3 10206
## + rcs(Raks_AndelArblosInk) 4 10207
## - rcs(IV_AverageSaturation) 4 10208
## - factor(lipid_modifying_agents) 1 10208
## + rcs(bmi) 4 10208
## - factor(rokare) 1 10212
## - rcs(systoliskt) 4 10215
## - rcs(GFR) 4 10216
## + rcs(alder):rcs(GFR) 16 10219
## - rcs(hba1c) 4 10225
## - rcs(alder) 4 10235
## - factor(sex) 1 10237
## - factor(ami_history) 1 10333
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
##
## Step: AIC=10201.76
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) +
## factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c) +
## rcs(systoliskt) + rcs(GFR) + factor(rokare) + factor(lipid_modifying_agents) +
## rcs(IV_AverageSaturation) + rcs(kolesterol) + factor(antihypertensive_comb) +
## rcs(DispInkKEHB04) + factor(cpap_treated):factor(antithrombotic_agents)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Df AIC
## + factor(cpap_treated):factor(antihypertensive_comb) 1 10202
## <none> 10202
## + rcs(Raks_AndelSjukInk) 4 10202
## - rcs(DispInkKEHB04) 4 10202
## + factor(cpap_treated):factor(lipid_modifying_agents) 1 10203
## - factor(antihypertensive_comb) 1 10203
## - rcs(kolesterol) 4 10203
## + factor(stroke_history) 1 10203
## - factor(cpap_treated):factor(antithrombotic_agents) 1 10203
## + factor(cpap_treated):rcs(GFR) 4 10203
## + factor(Civil) 1 10204
## + factor(FodelseLand_EU27_2020) 1 10204
## + rcs(IV_ODI) 4 10204
## + factor(HushallsTyp_RTB) 2 10204
## + rcs(IV_AHI) 4 10205
## + rcs(Raks_AndelArblosInk) 4 10207
## - factor(lipid_modifying_agents) 1 10207
## + rcs(Raks_AndelEkBisInk) 3 10207
## + factor(Sun2000niva_old) 6 10207
## - rcs(IV_AverageSaturation) 4 10207
## + rcs(bmi) 4 10207
## - factor(rokare) 1 10210
## - rcs(systoliskt) 4 10214
## - rcs(GFR) 4 10214
## + rcs(alder):rcs(GFR) 16 10219
## - rcs(hba1c) 4 10221
## - rcs(alder) 4 10236
## - factor(sex) 1 10240
## - factor(ami_history) 1 10333
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
##
## Step: AIC=10201.47
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) +
## factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c) +
## rcs(systoliskt) + rcs(GFR) + factor(rokare) + factor(lipid_modifying_agents) +
## rcs(IV_AverageSaturation) + rcs(kolesterol) + factor(antihypertensive_comb) +
## rcs(DispInkKEHB04) + factor(cpap_treated):factor(antithrombotic_agents) +
## factor(cpap_treated):factor(antihypertensive_comb)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Df AIC
## <none> 10202
## + rcs(Raks_AndelSjukInk) 4 10202
## - factor(cpap_treated):factor(antihypertensive_comb) 1 10202
## - factor(cpap_treated):factor(antithrombotic_agents) 1 10202
## - rcs(DispInkKEHB04) 4 10202
## + factor(cpap_treated):rcs(GFR) 4 10203
## - rcs(kolesterol) 4 10203
## + factor(cpap_treated):factor(lipid_modifying_agents) 1 10203
## + factor(stroke_history) 1 10203
## + factor(FodelseLand_EU27_2020) 1 10203
## + factor(Civil) 1 10203
## + rcs(IV_ODI) 4 10204
## + factor(HushallsTyp_RTB) 2 10204
## + rcs(IV_AHI) 4 10205
## + rcs(Raks_AndelArblosInk) 4 10206
## - factor(lipid_modifying_agents) 1 10206
## + rcs(Raks_AndelEkBisInk) 3 10206
## + factor(Sun2000niva_old) 6 10207
## - rcs(IV_AverageSaturation) 4 10207
## + rcs(bmi) 4 10207
## - factor(rokare) 1 10210
## - rcs(GFR) 4 10214
## - rcs(systoliskt) 4 10214
## + rcs(alder):rcs(GFR) 16 10218
## - rcs(hba1c) 4 10220
## - rcs(alder) 4 10236
## - factor(sex) 1 10240
## - factor(ami_history) 1 10333
## [1] "--- SURVIVAL RESULTS ---"
## Call:
## coxph(formula = Surv(start, stop, event) ~ factor(cpap_treated) +
## factor(antithrombotic_agents) + factor(ami_history) + rcs(alder) +
## factor(sex) + rcs(hba1c) + rcs(systoliskt) + rcs(GFR) + factor(rokare) +
## factor(lipid_modifying_agents) + rcs(IV_AverageSaturation) +
## rcs(kolesterol) + factor(antihypertensive_comb) + rcs(DispInkKEHB04) +
## factor(cpap_treated):factor(antithrombotic_agents) + factor(cpap_treated):factor(antihypertensive_comb),
## data = df_train)
##
## n= 149203, number of events= 608
##
## coef exp(coef)
## factor(cpap_treated)1 -8.580e-01 4.240e-01
## factor(antithrombotic_agents)1 6.684e-01 1.951e+00
## factor(ami_history)1 -1.800e+01 1.527e-08
## rcs(alder)alder 8.898e-01 2.435e+00
## rcs(alder)alder' -1.461e+00 2.320e-01
## rcs(alder)alder'' 6.245e+00 5.152e+02
## rcs(alder)alder''' -1.015e+01 3.919e-05
## factor(sex)1 -6.079e-01 5.445e-01
## rcs(hba1c)hba1c 9.687e-01 2.634e+00
## rcs(hba1c)hba1c' -6.722e+00 1.204e-03
## rcs(hba1c)hba1c'' 1.625e+01 1.138e+07
## rcs(hba1c)hba1c''' -1.136e+01 1.164e-05
## rcs(systoliskt)systoliskt -1.613e-01 8.510e-01
## rcs(systoliskt)systoliskt' 6.285e-01 1.875e+00
## rcs(systoliskt)systoliskt'' 1.070e+00 2.915e+00
## rcs(systoliskt)systoliskt''' -9.046e+00 1.179e-04
## rcs(GFR)GFR -3.496e-01 7.050e-01
## rcs(GFR)GFR' 1.463e+00 4.320e+00
## rcs(GFR)GFR'' -1.169e+01 8.377e-06
## rcs(GFR)GFR''' 2.283e+01 8.220e+09
## factor(rokare)1 3.600e-01 1.433e+00
## factor(lipid_modifying_agents)1 2.345e-01 1.264e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation -1.961e-01 8.219e-01
## rcs(IV_AverageSaturation)IV_AverageSaturation' 7.393e-01 2.094e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation'' -4.249e+00 1.427e-02
## rcs(IV_AverageSaturation)IV_AverageSaturation''' 1.070e+01 4.427e+04
## rcs(kolesterol)kolesterol -1.346e-01 8.741e-01
## rcs(kolesterol)kolesterol' -6.052e-01 5.460e-01
## rcs(kolesterol)kolesterol'' 5.759e+00 3.170e+02
## rcs(kolesterol)kolesterol''' -1.213e+01 5.410e-06
## factor(antihypertensive_comb)1 1.088e-01 1.115e+00
## rcs(DispInkKEHB04)DispInkKEHB04 -2.456e-02 9.757e-01
## rcs(DispInkKEHB04)DispInkKEHB04' -2.872e+00 5.656e-02
## rcs(DispInkKEHB04)DispInkKEHB04'' 4.823e+00 1.243e+02
## rcs(DispInkKEHB04)DispInkKEHB04''' 1.518e+00 4.564e+00
## factor(cpap_treated)1:factor(antithrombotic_agents)1 3.386e-01 1.403e+00
## factor(cpap_treated)1:factor(antihypertensive_comb)1 3.922e-01 1.480e+00
## se(coef) z Pr(>|z|)
## factor(cpap_treated)1 2.512e-01 -3.416 0.000635
## factor(antithrombotic_agents)1 9.959e-02 6.712 1.93e-11
## factor(ami_history)1 9.291e+02 -0.019 0.984546
## rcs(alder)alder 3.119e-01 2.853 0.004330
## rcs(alder)alder' 1.035e+00 -1.411 0.158145
## rcs(alder)alder'' 5.261e+00 1.187 0.235276
## rcs(alder)alder''' 9.036e+00 -1.123 0.261479
## factor(sex)1 9.983e-02 -6.089 1.14e-09
## rcs(hba1c)hba1c 4.462e-01 2.171 0.029922
## rcs(hba1c)hba1c' 6.125e+00 -1.098 0.272378
## rcs(hba1c)hba1c'' 1.797e+01 0.904 0.365800
## rcs(hba1c)hba1c''' 1.638e+01 -0.694 0.487978
## rcs(systoliskt)systoliskt 1.980e-01 -0.815 0.415106
## rcs(systoliskt)systoliskt' 1.212e+00 0.519 0.603965
## rcs(systoliskt)systoliskt'' 6.056e+00 0.177 0.859782
## rcs(systoliskt)systoliskt''' 1.187e+01 -0.762 0.445892
## rcs(GFR)GFR 1.470e-01 -2.378 0.017390
## rcs(GFR)GFR' 8.938e-01 1.637 0.101592
## rcs(GFR)GFR'' 5.853e+00 -1.997 0.045783
## rcs(GFR)GFR''' 9.783e+00 2.334 0.019614
## factor(rokare)1 1.094e-01 3.290 0.001003
## factor(lipid_modifying_agents)1 9.005e-02 2.604 0.009226
## rcs(IV_AverageSaturation)IV_AverageSaturation 7.574e-02 -2.589 0.009625
## rcs(IV_AverageSaturation)IV_AverageSaturation' 3.412e-01 2.167 0.030262
## rcs(IV_AverageSaturation)IV_AverageSaturation'' 3.431e+00 -1.238 0.215542
## rcs(IV_AverageSaturation)IV_AverageSaturation''' 1.289e+01 0.830 0.406579
## rcs(kolesterol)kolesterol 2.291e-01 -0.587 0.557042
## rcs(kolesterol)kolesterol' 1.718e+00 -0.352 0.724626
## rcs(kolesterol)kolesterol'' 6.682e+00 0.862 0.388769
## rcs(kolesterol)kolesterol''' 9.580e+00 -1.266 0.205556
## factor(antihypertensive_comb)1 1.075e-01 1.012 0.311572
## rcs(DispInkKEHB04)DispInkKEHB04 4.707e-01 -0.052 0.958386
## rcs(DispInkKEHB04)DispInkKEHB04' 6.345e+00 -0.453 0.650747
## rcs(DispInkKEHB04)DispInkKEHB04'' 2.135e+01 0.226 0.821277
## rcs(DispInkKEHB04)DispInkKEHB04''' 2.414e+01 0.063 0.949848
## factor(cpap_treated)1:factor(antithrombotic_agents)1 2.146e-01 1.578 0.114539
## factor(cpap_treated)1:factor(antihypertensive_comb)1 2.661e-01 1.474 0.140489
##
## factor(cpap_treated)1 ***
## factor(antithrombotic_agents)1 ***
## factor(ami_history)1
## rcs(alder)alder **
## rcs(alder)alder'
## rcs(alder)alder''
## rcs(alder)alder'''
## factor(sex)1 ***
## rcs(hba1c)hba1c *
## rcs(hba1c)hba1c'
## rcs(hba1c)hba1c''
## rcs(hba1c)hba1c'''
## rcs(systoliskt)systoliskt
## rcs(systoliskt)systoliskt'
## rcs(systoliskt)systoliskt''
## rcs(systoliskt)systoliskt'''
## rcs(GFR)GFR *
## rcs(GFR)GFR'
## rcs(GFR)GFR'' *
## rcs(GFR)GFR''' *
## factor(rokare)1 **
## factor(lipid_modifying_agents)1 **
## rcs(IV_AverageSaturation)IV_AverageSaturation **
## rcs(IV_AverageSaturation)IV_AverageSaturation' *
## rcs(IV_AverageSaturation)IV_AverageSaturation''
## rcs(IV_AverageSaturation)IV_AverageSaturation'''
## rcs(kolesterol)kolesterol
## rcs(kolesterol)kolesterol'
## rcs(kolesterol)kolesterol''
## rcs(kolesterol)kolesterol'''
## factor(antihypertensive_comb)1
## rcs(DispInkKEHB04)DispInkKEHB04
## rcs(DispInkKEHB04)DispInkKEHB04'
## rcs(DispInkKEHB04)DispInkKEHB04''
## rcs(DispInkKEHB04)DispInkKEHB04'''
## factor(cpap_treated)1:factor(antithrombotic_agents)1
## factor(cpap_treated)1:factor(antihypertensive_comb)1
## ---
## Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
##
## exp(coef) exp(-coef)
## factor(cpap_treated)1 4.240e-01 2.359e+00
## factor(antithrombotic_agents)1 1.951e+00 5.125e-01
## factor(ami_history)1 1.527e-08 6.547e+07
## rcs(alder)alder 2.435e+00 4.107e-01
## rcs(alder)alder' 2.320e-01 4.311e+00
## rcs(alder)alder'' 5.152e+02 1.941e-03
## rcs(alder)alder''' 3.919e-05 2.552e+04
## factor(sex)1 5.445e-01 1.837e+00
## rcs(hba1c)hba1c 2.634e+00 3.796e-01
## rcs(hba1c)hba1c' 1.204e-03 8.307e+02
## rcs(hba1c)hba1c'' 1.138e+07 8.784e-08
## rcs(hba1c)hba1c''' 1.164e-05 8.588e+04
## rcs(systoliskt)systoliskt 8.510e-01 1.175e+00
## rcs(systoliskt)systoliskt' 1.875e+00 5.334e-01
## rcs(systoliskt)systoliskt'' 2.915e+00 3.431e-01
## rcs(systoliskt)systoliskt''' 1.179e-04 8.483e+03
## rcs(GFR)GFR 7.050e-01 1.418e+00
## rcs(GFR)GFR' 4.320e+00 2.315e-01
## rcs(GFR)GFR'' 8.377e-06 1.194e+05
## rcs(GFR)GFR''' 8.220e+09 1.217e-10
## factor(rokare)1 1.433e+00 6.977e-01
## factor(lipid_modifying_agents)1 1.264e+00 7.910e-01
## rcs(IV_AverageSaturation)IV_AverageSaturation 8.219e-01 1.217e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation' 2.094e+00 4.774e-01
## rcs(IV_AverageSaturation)IV_AverageSaturation'' 1.427e-02 7.006e+01
## rcs(IV_AverageSaturation)IV_AverageSaturation''' 4.427e+04 2.259e-05
## rcs(kolesterol)kolesterol 8.741e-01 1.144e+00
## rcs(kolesterol)kolesterol' 5.460e-01 1.832e+00
## rcs(kolesterol)kolesterol'' 3.170e+02 3.154e-03
## rcs(kolesterol)kolesterol''' 5.410e-06 1.849e+05
## factor(antihypertensive_comb)1 1.115e+00 8.969e-01
## rcs(DispInkKEHB04)DispInkKEHB04 9.757e-01 1.025e+00
## rcs(DispInkKEHB04)DispInkKEHB04' 5.656e-02 1.768e+01
## rcs(DispInkKEHB04)DispInkKEHB04'' 1.243e+02 8.044e-03
## rcs(DispInkKEHB04)DispInkKEHB04''' 4.564e+00 2.191e-01
## factor(cpap_treated)1:factor(antithrombotic_agents)1 1.403e+00 7.128e-01
## factor(cpap_treated)1:factor(antihypertensive_comb)1 1.480e+00 6.756e-01
## lower .95 upper .95
## factor(cpap_treated)1 2.592e-01 6.937e-01
## factor(antithrombotic_agents)1 1.605e+00 2.372e+00
## factor(ami_history)1 0.000e+00 Inf
## rcs(alder)alder 1.321e+00 4.486e+00
## rcs(alder)alder' 3.050e-02 1.765e+00
## rcs(alder)alder'' 1.712e-02 1.551e+07
## rcs(alder)alder''' 7.968e-13 1.928e+03
## factor(sex)1 4.477e-01 6.622e-01
## rcs(hba1c)hba1c 1.099e+00 6.316e+00
## rcs(hba1c)hba1c' 7.368e-09 1.967e+02
## rcs(hba1c)hba1c'' 5.804e-09 2.233e+22
## rcs(hba1c)hba1c''' 1.326e-19 1.022e+09
## rcs(systoliskt)systoliskt 5.774e-01 1.254e+00
## rcs(systoliskt)systoliskt' 1.744e-01 2.015e+01
## rcs(systoliskt)systoliskt'' 2.041e-05 4.161e+05
## rcs(systoliskt)systoliskt''' 9.340e-15 1.488e+06
## rcs(GFR)GFR 5.285e-01 9.404e-01
## rcs(GFR)GFR' 7.494e-01 2.491e+01
## rcs(GFR)GFR'' 8.736e-11 8.033e-01
## rcs(GFR)GFR''' 3.870e+01 1.746e+18
## factor(rokare)1 1.157e+00 1.776e+00
## factor(lipid_modifying_agents)1 1.060e+00 1.508e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation 7.085e-01 9.535e-01
## rcs(IV_AverageSaturation)IV_AverageSaturation' 1.073e+00 4.088e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation'' 1.714e-05 1.189e+01
## rcs(IV_AverageSaturation)IV_AverageSaturation''' 4.718e-07 4.154e+15
## rcs(kolesterol)kolesterol 5.578e-01 1.370e+00
## rcs(kolesterol)kolesterol' 1.884e-02 1.583e+01
## rcs(kolesterol)kolesterol'' 6.505e-04 1.545e+08
## rcs(kolesterol)kolesterol''' 3.789e-14 7.724e+02
## factor(antihypertensive_comb)1 9.031e-01 1.376e+00
## rcs(DispInkKEHB04)DispInkKEHB04 3.878e-01 2.455e+00
## rcs(DispInkKEHB04)DispInkKEHB04' 2.248e-07 1.423e+04
## rcs(DispInkKEHB04)DispInkKEHB04'' 8.361e-17 1.848e+20
## rcs(DispInkKEHB04)DispInkKEHB04''' 1.302e-20 1.600e+21
## factor(cpap_treated)1:factor(antithrombotic_agents)1 9.213e-01 2.136e+00
## factor(cpap_treated)1:factor(antihypertensive_comb)1 8.787e-01 2.494e+00
##
## Concordance= 0.745 (se = 0.01 )
## Likelihood ratio test= 489.4 on 37 df, p=<2e-16
## Wald test = 376.5 on 37 df, p=<2e-16
## Score (logrank) test = 465.7 on 37 df, p=<2e-16
## Warning in termplot(cph): 'model' appears to involve interactions: see the help
## page
## [1] "--- CONCORDANCE RESULTS ---"
## C-index train: 0.7453331
## C-index test: 0.7453331
run_models(c(list_forms[["form_tdep_spl"]], list_forms[["form_tdep_cat"]]), df_stroke_tv_train, df_stroke_tv_test, "stop", "event", cont_var, "prof_stroke_dep_g1.html")
## [1] "### FORMULA 1 ###"
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 13 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(x = X[idx, ], y = Y[idx, ], strata = strata[idx], offset =
## offset[idx], : Loglik converged before variable 13 ; beta may be infinite.
## [1] "--- SURVIVAL RESULTS ---"
## Call:
## coxph(formula = form, data = df_train, x = T)
##
## n= 7086751, number of events= 36051
##
## coef exp(coef)
## factor(cpap_treated)1 6.724e-02 1.070e+00
## rcs(alder)alder 1.151e+00 3.162e+00
## rcs(alder)alder' -1.701e+00 1.825e-01
## rcs(alder)alder'' 1.057e+01 3.893e+04
## rcs(alder)alder''' -2.084e+01 8.866e-10
## factor(sex)1 -2.809e-01 7.551e-01
## rcs(bmi)bmi 1.075e-01 1.113e+00
## rcs(bmi)bmi' -3.822e+00 2.189e-02
## rcs(bmi)bmi'' 1.620e+01 1.084e+07
## rcs(bmi)bmi''' -1.771e+01 2.033e-08
## factor(rokare)1 3.180e-01 1.374e+00
## factor(ami_history)1 2.997e-03 1.003e+00
## factor(stroke_history)1 -1.675e+01 5.312e-08
## factor(Civil)1 -3.443e-02 9.662e-01
## factor(HushallsTyp_RTB)2 -1.073e-01 8.982e-01
## factor(HushallsTyp_RTB)3 -1.920e-02 9.810e-01
## factor(Sun2000niva_old)2 4.780e-02 1.049e+00
## factor(Sun2000niva_old)3 1.536e-02 1.015e+00
## factor(Sun2000niva_old)4 1.491e-02 1.015e+00
## factor(Sun2000niva_old)5 2.736e-02 1.028e+00
## factor(Sun2000niva_old)6 -1.280e-02 9.873e-01
## factor(Sun2000niva_old)7 4.471e-02 1.046e+00
## rcs(DispInkKEHB04)DispInkKEHB04 8.096e-02 1.084e+00
## rcs(DispInkKEHB04)DispInkKEHB04' -7.254e+00 7.070e-04
## rcs(DispInkKEHB04)DispInkKEHB04'' 1.332e+01 6.115e+05
## rcs(DispInkKEHB04)DispInkKEHB04''' -2.152e+00 1.163e-01
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk 1.042e+00 2.833e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk' -3.985e+02 9.018e-174
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'' 4.288e+02 1.628e+186
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''' -3.223e+01 1.004e-14
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk 2.803e+00 1.650e+01
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk' -3.498e+03 0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'' 4.028e+03 Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''' -5.379e+02 2.590e-234
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk 1.084e+00 2.957e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk' -1.855e+02 2.861e-81
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'' 1.941e+02 2.033e+84
## factor(FodelseLand_EU27_2020)1 5.298e-02 1.054e+00
## factor(antithrombotic_agents)1 5.071e-01 1.661e+00
## factor(antihypertensive_comb)1 4.178e-02 1.043e+00
## factor(lipid_modifying_agents)1 -4.068e-03 9.959e-01
## rcs(hba1c)hba1c 4.347e-03 1.004e+00
## rcs(hba1c)hba1c' 2.181e+00 8.858e+00
## rcs(hba1c)hba1c'' -5.008e+00 6.686e-03
## rcs(hba1c)hba1c''' 2.160e+00 8.672e+00
## rcs(GFR)GFR -3.599e-01 6.977e-01
## rcs(GFR)GFR' -1.146e+00 3.180e-01
## rcs(GFR)GFR'' 1.286e+01 3.830e+05
## rcs(GFR)GFR''' -2.463e+01 2.013e-11
## rcs(kolesterol)kolesterol -9.338e-02 9.109e-01
## rcs(kolesterol)kolesterol' 1.068e+00 2.910e+00
## rcs(kolesterol)kolesterol'' -4.281e+00 1.384e-02
## rcs(kolesterol)kolesterol''' 4.813e+00 1.231e+02
## rcs(systoliskt)systoliskt -1.558e-01 8.557e-01
## rcs(systoliskt)systoliskt' 5.906e-01 1.805e+00
## rcs(systoliskt)systoliskt'' -8.857e-01 4.124e-01
## rcs(systoliskt)systoliskt''' -6.675e-01 5.130e-01
## factor(cpap_treated)1:factor(antithrombotic_agents)1 -1.335e-01 8.751e-01
## factor(cpap_treated)1:factor(antihypertensive_comb)1 -2.426e-02 9.760e-01
## factor(cpap_treated)1:factor(lipid_modifying_agents)1 -1.286e-01 8.793e-01
## rcs(alder)alder:rcs(bmi)bmi 2.464e-01 1.279e+00
## rcs(alder)alder':rcs(bmi)bmi -8.995e-01 4.068e-01
## rcs(alder)alder'':rcs(bmi)bmi 5.449e+00 2.324e+02
## rcs(alder)alder''':rcs(bmi)bmi -1.066e+01 2.342e-05
## rcs(alder)alder:rcs(bmi)bmi' -3.217e+00 4.006e-02
## rcs(alder)alder':rcs(bmi)bmi' 1.463e+01 2.269e+06
## rcs(alder)alder'':rcs(bmi)bmi' -8.473e+01 1.601e-37
## rcs(alder)alder''':rcs(bmi)bmi' 1.553e+02 2.907e+67
## rcs(alder)alder:rcs(bmi)bmi'' 1.252e+01 2.741e+05
## rcs(alder)alder':rcs(bmi)bmi'' -6.239e+01 7.995e-28
## rcs(alder)alder'':rcs(bmi)bmi'' 3.609e+02 5.503e+156
## rcs(alder)alder''':rcs(bmi)bmi'' -6.580e+02 1.717e-286
## rcs(alder)alder:rcs(bmi)bmi''' -1.285e+01 2.629e-06
## rcs(alder)alder':rcs(bmi)bmi''' 7.020e+01 3.069e+30
## rcs(alder)alder'':rcs(bmi)bmi''' -4.061e+02 4.115e-177
## rcs(alder)alder''':rcs(bmi)bmi''' 7.384e+02 Inf
## rcs(alder)alder:rcs(GFR)GFR 1.816e-01 1.199e+00
## rcs(alder)alder':rcs(GFR)GFR -2.897e-01 7.485e-01
## rcs(alder)alder'':rcs(GFR)GFR 2.139e+00 8.495e+00
## rcs(alder)alder''':rcs(GFR)GFR -4.522e+00 1.087e-02
## rcs(alder)alder:rcs(GFR)GFR' -1.128e+00 3.238e-01
## rcs(alder)alder':rcs(GFR)GFR' 4.096e+00 6.011e+01
## rcs(alder)alder'':rcs(GFR)GFR' -1.756e+01 2.364e-08
## rcs(alder)alder''':rcs(GFR)GFR' 2.020e+01 5.917e+08
## rcs(alder)alder:rcs(GFR)GFR'' 9.713e+00 1.653e+04
## rcs(alder)alder':rcs(GFR)GFR'' -3.102e+01 3.382e-14
## rcs(alder)alder'':rcs(GFR)GFR'' 1.204e+02 1.960e+52
## rcs(alder)alder''':rcs(GFR)GFR'' -1.268e+02 8.777e-56
## rcs(alder)alder:rcs(GFR)GFR''' -1.900e+01 5.582e-09
## rcs(alder)alder':rcs(GFR)GFR''' 5.410e+01 3.132e+23
## rcs(alder)alder'':rcs(GFR)GFR''' -1.954e+02 1.433e-85
## rcs(alder)alder''':rcs(GFR)GFR''' 1.899e+02 2.896e+82
## factor(cpap_treated)1:rcs(GFR)GFR 6.030e-02 1.062e+00
## factor(cpap_treated)1:rcs(GFR)GFR' 1.697e+00 5.455e+00
## factor(cpap_treated)1:rcs(GFR)GFR'' -1.760e+01 2.279e-08
## factor(cpap_treated)1:rcs(GFR)GFR''' 3.763e+01 2.206e+16
## se(coef) z
## factor(cpap_treated)1 4.713e-01 0.143
## rcs(alder)alder 5.212e-01 2.209
## rcs(alder)alder' 1.561e+00 -1.090
## rcs(alder)alder'' 7.548e+00 1.400
## rcs(alder)alder''' 1.256e+01 -1.660
## factor(sex)1 1.191e-02 -23.582
## rcs(bmi)bmi 4.706e-01 0.228
## rcs(bmi)bmi' 3.722e+00 -1.027
## rcs(bmi)bmi'' 1.571e+01 1.031
## rcs(bmi)bmi''' 1.904e+01 -0.930
## factor(rokare)1 1.527e-02 20.826
## factor(ami_history)1 1.922e-02 0.156
## factor(stroke_history)1 8.574e+01 -0.195
## factor(Civil)1 1.709e-02 -2.015
## factor(HushallsTyp_RTB)2 1.377e-02 -7.793
## factor(HushallsTyp_RTB)3 2.111e-02 -0.909
## factor(Sun2000niva_old)2 1.983e-02 2.410
## factor(Sun2000niva_old)3 1.385e-02 1.109
## factor(Sun2000niva_old)4 1.921e-02 0.776
## factor(Sun2000niva_old)5 2.164e-02 1.264
## factor(Sun2000niva_old)6 2.177e-02 -0.588
## factor(Sun2000niva_old)7 6.916e-02 0.646
## rcs(DispInkKEHB04)DispInkKEHB04 1.458e-01 0.555
## rcs(DispInkKEHB04)DispInkKEHB04' 2.757e+00 -2.631
## rcs(DispInkKEHB04)DispInkKEHB04'' 8.391e+00 1.588
## rcs(DispInkKEHB04)DispInkKEHB04''' 7.966e+00 -0.270
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk 2.204e-01 4.726
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk' 9.576e+01 -4.161
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'' 1.036e+02 4.137
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''' 8.913e+00 -3.616
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk 3.793e-01 7.391
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk' 5.499e+02 -6.361
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'' 6.351e+02 6.341
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''' 8.715e+01 -6.172
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk 1.560e-01 6.951
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk' 2.791e+01 -6.644
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'' 2.924e+01 6.639
## factor(FodelseLand_EU27_2020)1 1.503e-02 3.524
## factor(antithrombotic_agents)1 1.197e-02 42.362
## factor(antihypertensive_comb)1 1.231e-02 3.393
## factor(lipid_modifying_agents)1 1.176e-02 -0.346
## rcs(hba1c)hba1c 4.730e-02 0.092
## rcs(hba1c)hba1c' 5.965e-01 3.657
## rcs(hba1c)hba1c'' 2.015e+00 -2.485
## rcs(hba1c)hba1c''' 2.018e+00 1.071
## rcs(GFR)GFR 2.760e-01 -1.304
## rcs(GFR)GFR' 1.744e+00 -0.657
## rcs(GFR)GFR'' 9.562e+00 1.344
## rcs(GFR)GFR''' 1.472e+01 -1.673
## rcs(kolesterol)kolesterol 3.012e-02 -3.100
## rcs(kolesterol)kolesterol' 1.954e-01 5.467
## rcs(kolesterol)kolesterol'' 9.492e-01 -4.509
## rcs(kolesterol)kolesterol''' 1.357e+00 3.548
## rcs(systoliskt)systoliskt 2.566e-02 -6.074
## rcs(systoliskt)systoliskt' 1.700e-01 3.475
## rcs(systoliskt)systoliskt'' 8.418e-01 -1.052
## rcs(systoliskt)systoliskt''' 1.616e+00 -0.413
## factor(cpap_treated)1:factor(antithrombotic_agents)1 1.675e-01 -0.797
## factor(cpap_treated)1:factor(antihypertensive_comb)1 1.802e-01 -0.135
## factor(cpap_treated)1:factor(lipid_modifying_agents)1 1.663e-01 -0.773
## rcs(alder)alder:rcs(bmi)bmi 3.779e-01 0.652
## rcs(alder)alder':rcs(bmi)bmi 1.178e+00 -0.764
## rcs(alder)alder'':rcs(bmi)bmi 5.805e+00 0.939
## rcs(alder)alder''':rcs(bmi)bmi 9.737e+00 -1.095
## rcs(alder)alder:rcs(bmi)bmi' 3.012e+00 -1.068
## rcs(alder)alder':rcs(bmi)bmi' 9.350e+00 1.565
## rcs(alder)alder'':rcs(bmi)bmi' 4.628e+01 -1.831
## rcs(alder)alder''':rcs(bmi)bmi' 7.867e+01 1.975
## rcs(alder)alder:rcs(bmi)bmi'' 1.271e+01 0.985
## rcs(alder)alder':rcs(bmi)bmi'' 3.959e+01 -1.576
## rcs(alder)alder'':rcs(bmi)bmi'' 1.971e+02 1.831
## rcs(alder)alder''':rcs(bmi)bmi'' 3.381e+02 -1.946
## rcs(alder)alder:rcs(bmi)bmi''' 1.538e+01 -0.835
## rcs(alder)alder':rcs(bmi)bmi''' 4.816e+01 1.458
## rcs(alder)alder'':rcs(bmi)bmi''' 2.413e+02 -1.683
## rcs(alder)alder''':rcs(bmi)bmi''' 4.180e+02 1.767
## rcs(alder)alder:rcs(GFR)GFR 2.243e-01 0.810
## rcs(alder)alder':rcs(GFR)GFR 6.911e-01 -0.419
## rcs(alder)alder'':rcs(GFR)GFR 3.396e+00 0.630
## rcs(alder)alder''':rcs(GFR)GFR 5.729e+00 -0.789
## rcs(alder)alder:rcs(GFR)GFR' 1.463e+00 -0.771
## rcs(alder)alder':rcs(GFR)GFR' 4.337e+00 0.944
## rcs(alder)alder'':rcs(GFR)GFR' 2.097e+01 -0.837
## rcs(alder)alder''':rcs(GFR)GFR' 3.520e+01 0.574
## rcs(alder)alder:rcs(GFR)GFR'' 7.936e+00 1.224
## rcs(alder)alder':rcs(GFR)GFR'' 2.399e+01 -1.293
## rcs(alder)alder'':rcs(GFR)GFR'' 1.185e+02 1.016
## rcs(alder)alder''':rcs(GFR)GFR'' 2.047e+02 -0.619
## rcs(alder)alder:rcs(GFR)GFR''' 1.201e+01 -1.583
## rcs(alder)alder':rcs(GFR)GFR''' 3.740e+01 1.446
## rcs(alder)alder'':rcs(GFR)GFR''' 1.903e+02 -1.027
## rcs(alder)alder''':rcs(GFR)GFR''' 3.402e+02 0.558
## factor(cpap_treated)1:rcs(GFR)GFR 3.166e-01 0.190
## factor(cpap_treated)1:rcs(GFR)GFR' 1.890e+00 0.898
## factor(cpap_treated)1:rcs(GFR)GFR'' 1.095e+01 -1.607
## factor(cpap_treated)1:rcs(GFR)GFR''' 1.806e+01 2.084
## Pr(>|z|)
## factor(cpap_treated)1 0.886547
## rcs(alder)alder 0.027191 *
## rcs(alder)alder' 0.275854
## rcs(alder)alder'' 0.161418
## rcs(alder)alder''' 0.096931 .
## factor(sex)1 < 2e-16 ***
## rcs(bmi)bmi 0.819342
## rcs(bmi)bmi' 0.304544
## rcs(bmi)bmi'' 0.302588
## rcs(bmi)bmi''' 0.352254
## factor(rokare)1 < 2e-16 ***
## factor(ami_history)1 0.876121
## factor(stroke_history)1 0.845108
## factor(Civil)1 0.043866 *
## factor(HushallsTyp_RTB)2 6.52e-15 ***
## factor(HushallsTyp_RTB)3 0.363113
## factor(Sun2000niva_old)2 0.015936 *
## factor(Sun2000niva_old)3 0.267607
## factor(Sun2000niva_old)4 0.437853
## factor(Sun2000niva_old)5 0.206191
## factor(Sun2000niva_old)6 0.556476
## factor(Sun2000niva_old)7 0.518005
## rcs(DispInkKEHB04)DispInkKEHB04 0.578562
## rcs(DispInkKEHB04)DispInkKEHB04' 0.008514 **
## rcs(DispInkKEHB04)DispInkKEHB04'' 0.112317
## rcs(DispInkKEHB04)DispInkKEHB04''' 0.787100
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk 2.29e-06 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk' 3.17e-05 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'' 3.52e-05 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''' 0.000299 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk 1.46e-13 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk' 2.00e-10 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'' 2.28e-10 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''' 6.75e-10 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk 3.64e-12 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk' 3.06e-11 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'' 3.17e-11 ***
## factor(FodelseLand_EU27_2020)1 0.000425 ***
## factor(antithrombotic_agents)1 < 2e-16 ***
## factor(antihypertensive_comb)1 0.000691 ***
## factor(lipid_modifying_agents)1 0.729352
## rcs(hba1c)hba1c 0.926772
## rcs(hba1c)hba1c' 0.000256 ***
## rcs(hba1c)hba1c'' 0.012949 *
## rcs(hba1c)hba1c''' 0.284338
## rcs(GFR)GFR 0.192277
## rcs(GFR)GFR' 0.511167
## rcs(GFR)GFR'' 0.178818
## rcs(GFR)GFR''' 0.094388 .
## rcs(kolesterol)kolesterol 0.001935 **
## rcs(kolesterol)kolesterol' 4.57e-08 ***
## rcs(kolesterol)kolesterol'' 6.50e-06 ***
## rcs(kolesterol)kolesterol''' 0.000389 ***
## rcs(systoliskt)systoliskt 1.25e-09 ***
## rcs(systoliskt)systoliskt' 0.000511 ***
## rcs(systoliskt)systoliskt'' 0.292761
## rcs(systoliskt)systoliskt''' 0.679580
## factor(cpap_treated)1:factor(antithrombotic_agents)1 0.425640
## factor(cpap_treated)1:factor(antihypertensive_comb)1 0.892873
## factor(cpap_treated)1:factor(lipid_modifying_agents)1 0.439377
## rcs(alder)alder:rcs(bmi)bmi 0.514437
## rcs(alder)alder':rcs(bmi)bmi 0.445117
## rcs(alder)alder'':rcs(bmi)bmi 0.347949
## rcs(alder)alder''':rcs(bmi)bmi 0.273531
## rcs(alder)alder:rcs(bmi)bmi' 0.285401
## rcs(alder)alder':rcs(bmi)bmi' 0.117524
## rcs(alder)alder'':rcs(bmi)bmi' 0.067121 .
## rcs(alder)alder''':rcs(bmi)bmi' 0.048311 *
## rcs(alder)alder:rcs(bmi)bmi'' 0.324537
## rcs(alder)alder':rcs(bmi)bmi'' 0.115049
## rcs(alder)alder'':rcs(bmi)bmi'' 0.067027 .
## rcs(alder)alder''':rcs(bmi)bmi'' 0.051634 .
## rcs(alder)alder:rcs(bmi)bmi''' 0.403522
## rcs(alder)alder':rcs(bmi)bmi''' 0.144944
## rcs(alder)alder'':rcs(bmi)bmi''' 0.092353 .
## rcs(alder)alder''':rcs(bmi)bmi''' 0.077310 .
## rcs(alder)alder:rcs(GFR)GFR 0.418125
## rcs(alder)alder':rcs(GFR)GFR 0.675024
## rcs(alder)alder'':rcs(GFR)GFR 0.528690
## rcs(alder)alder''':rcs(GFR)GFR 0.429904
## rcs(alder)alder:rcs(GFR)GFR' 0.440718
## rcs(alder)alder':rcs(GFR)GFR' 0.344934
## rcs(alder)alder'':rcs(GFR)GFR' 0.402376
## rcs(alder)alder''':rcs(GFR)GFR' 0.566092
## rcs(alder)alder:rcs(GFR)GFR'' 0.220959
## rcs(alder)alder':rcs(GFR)GFR'' 0.196010
## rcs(alder)alder'':rcs(GFR)GFR'' 0.309575
## rcs(alder)alder''':rcs(GFR)GFR'' 0.535626
## rcs(alder)alder:rcs(GFR)GFR''' 0.113493
## rcs(alder)alder':rcs(GFR)GFR''' 0.148042
## rcs(alder)alder'':rcs(GFR)GFR''' 0.304521
## rcs(alder)alder''':rcs(GFR)GFR''' 0.576758
## factor(cpap_treated)1:rcs(GFR)GFR 0.848954
## factor(cpap_treated)1:rcs(GFR)GFR' 0.369319
## factor(cpap_treated)1:rcs(GFR)GFR'' 0.108019
## factor(cpap_treated)1:rcs(GFR)GFR''' 0.037162 *
## ---
## Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
##
## exp(coef) exp(-coef)
## factor(cpap_treated)1 1.070e+00 9.350e-01
## rcs(alder)alder 3.162e+00 3.162e-01
## rcs(alder)alder' 1.825e-01 5.479e+00
## rcs(alder)alder'' 3.893e+04 2.569e-05
## rcs(alder)alder''' 8.866e-10 1.128e+09
## factor(sex)1 7.551e-01 1.324e+00
## rcs(bmi)bmi 1.113e+00 8.981e-01
## rcs(bmi)bmi' 2.189e-02 4.568e+01
## rcs(bmi)bmi'' 1.084e+07 9.225e-08
## rcs(bmi)bmi''' 2.033e-08 4.918e+07
## factor(rokare)1 1.374e+00 7.276e-01
## factor(ami_history)1 1.003e+00 9.970e-01
## factor(stroke_history)1 5.312e-08 1.883e+07
## factor(Civil)1 9.662e-01 1.035e+00
## factor(HushallsTyp_RTB)2 8.982e-01 1.113e+00
## factor(HushallsTyp_RTB)3 9.810e-01 1.019e+00
## factor(Sun2000niva_old)2 1.049e+00 9.533e-01
## factor(Sun2000niva_old)3 1.015e+00 9.848e-01
## factor(Sun2000niva_old)4 1.015e+00 9.852e-01
## factor(Sun2000niva_old)5 1.028e+00 9.730e-01
## factor(Sun2000niva_old)6 9.873e-01 1.013e+00
## factor(Sun2000niva_old)7 1.046e+00 9.563e-01
## rcs(DispInkKEHB04)DispInkKEHB04 1.084e+00 9.222e-01
## rcs(DispInkKEHB04)DispInkKEHB04' 7.070e-04 1.414e+03
## rcs(DispInkKEHB04)DispInkKEHB04'' 6.115e+05 1.635e-06
## rcs(DispInkKEHB04)DispInkKEHB04''' 1.163e-01 8.598e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk 2.833e+00 3.529e-01
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk' 9.018e-174 1.109e+173
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'' 1.628e+186 6.142e-187
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''' 1.004e-14 9.956e+13
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk 1.650e+01 6.061e-02
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk' 0.000e+00 Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'' Inf 0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''' 2.590e-234 3.862e+233
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk 2.957e+00 3.382e-01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk' 2.861e-81 3.496e+80
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'' 2.033e+84 4.920e-85
## factor(FodelseLand_EU27_2020)1 1.054e+00 9.484e-01
## factor(antithrombotic_agents)1 1.661e+00 6.022e-01
## factor(antihypertensive_comb)1 1.043e+00 9.591e-01
## factor(lipid_modifying_agents)1 9.959e-01 1.004e+00
## rcs(hba1c)hba1c 1.004e+00 9.957e-01
## rcs(hba1c)hba1c' 8.858e+00 1.129e-01
## rcs(hba1c)hba1c'' 6.686e-03 1.496e+02
## rcs(hba1c)hba1c''' 8.672e+00 1.153e-01
## rcs(GFR)GFR 6.977e-01 1.433e+00
## rcs(GFR)GFR' 3.180e-01 3.144e+00
## rcs(GFR)GFR'' 3.830e+05 2.611e-06
## rcs(GFR)GFR''' 2.013e-11 4.967e+10
## rcs(kolesterol)kolesterol 9.109e-01 1.098e+00
## rcs(kolesterol)kolesterol' 2.910e+00 3.436e-01
## rcs(kolesterol)kolesterol'' 1.384e-02 7.228e+01
## rcs(kolesterol)kolesterol''' 1.231e+02 8.120e-03
## rcs(systoliskt)systoliskt 8.557e-01 1.169e+00
## rcs(systoliskt)systoliskt' 1.805e+00 5.540e-01
## rcs(systoliskt)systoliskt'' 4.124e-01 2.425e+00
## rcs(systoliskt)systoliskt''' 5.130e-01 1.949e+00
## factor(cpap_treated)1:factor(antithrombotic_agents)1 8.751e-01 1.143e+00
## factor(cpap_treated)1:factor(antihypertensive_comb)1 9.760e-01 1.025e+00
## factor(cpap_treated)1:factor(lipid_modifying_agents)1 8.793e-01 1.137e+00
## rcs(alder)alder:rcs(bmi)bmi 1.279e+00 7.816e-01
## rcs(alder)alder':rcs(bmi)bmi 4.068e-01 2.458e+00
## rcs(alder)alder'':rcs(bmi)bmi 2.324e+02 4.303e-03
## rcs(alder)alder''':rcs(bmi)bmi 2.342e-05 4.270e+04
## rcs(alder)alder:rcs(bmi)bmi' 4.006e-02 2.496e+01
## rcs(alder)alder':rcs(bmi)bmi' 2.269e+06 4.407e-07
## rcs(alder)alder'':rcs(bmi)bmi' 1.601e-37 6.248e+36
## rcs(alder)alder''':rcs(bmi)bmi' 2.907e+67 3.440e-68
## rcs(alder)alder:rcs(bmi)bmi'' 2.741e+05 3.649e-06
## rcs(alder)alder':rcs(bmi)bmi'' 7.995e-28 1.251e+27
## rcs(alder)alder'':rcs(bmi)bmi'' 5.503e+156 1.817e-157
## rcs(alder)alder''':rcs(bmi)bmi'' 1.717e-286 5.824e+285
## rcs(alder)alder:rcs(bmi)bmi''' 2.629e-06 3.804e+05
## rcs(alder)alder':rcs(bmi)bmi''' 3.069e+30 3.258e-31
## rcs(alder)alder'':rcs(bmi)bmi''' 4.115e-177 2.430e+176
## rcs(alder)alder''':rcs(bmi)bmi''' Inf 2.055e-321
## rcs(alder)alder:rcs(GFR)GFR 1.199e+00 8.339e-01
## rcs(alder)alder':rcs(GFR)GFR 7.485e-01 1.336e+00
## rcs(alder)alder'':rcs(GFR)GFR 8.495e+00 1.177e-01
## rcs(alder)alder''':rcs(GFR)GFR 1.087e-02 9.203e+01
## rcs(alder)alder:rcs(GFR)GFR' 3.238e-01 3.089e+00
## rcs(alder)alder':rcs(GFR)GFR' 6.011e+01 1.664e-02
## rcs(alder)alder'':rcs(GFR)GFR' 2.364e-08 4.229e+07
## rcs(alder)alder''':rcs(GFR)GFR' 5.917e+08 1.690e-09
## rcs(alder)alder:rcs(GFR)GFR'' 1.653e+04 6.049e-05
## rcs(alder)alder':rcs(GFR)GFR'' 3.382e-14 2.956e+13
## rcs(alder)alder'':rcs(GFR)GFR'' 1.960e+52 5.101e-53
## rcs(alder)alder''':rcs(GFR)GFR'' 8.777e-56 1.139e+55
## rcs(alder)alder:rcs(GFR)GFR''' 5.582e-09 1.791e+08
## rcs(alder)alder':rcs(GFR)GFR''' 3.132e+23 3.193e-24
## rcs(alder)alder'':rcs(GFR)GFR''' 1.433e-85 6.980e+84
## rcs(alder)alder''':rcs(GFR)GFR''' 2.896e+82 3.453e-83
## factor(cpap_treated)1:rcs(GFR)GFR 1.062e+00 9.415e-01
## factor(cpap_treated)1:rcs(GFR)GFR' 5.455e+00 1.833e-01
## factor(cpap_treated)1:rcs(GFR)GFR'' 2.279e-08 4.388e+07
## factor(cpap_treated)1:rcs(GFR)GFR''' 2.206e+16 4.534e-17
## lower .95 upper .95
## factor(cpap_treated)1 4.247e-01 2.694e+00
## rcs(alder)alder 1.138e+00 8.784e+00
## rcs(alder)alder' 8.561e-03 3.890e+00
## rcs(alder)alder'' 1.464e-02 1.035e+11
## rcs(alder)alder''' 1.816e-20 4.328e+01
## factor(sex)1 7.377e-01 7.730e-01
## rcs(bmi)bmi 4.427e-01 2.801e+00
## rcs(bmi)bmi' 1.485e-05 3.226e+01
## rcs(bmi)bmi'' 4.570e-07 2.571e+20
## rcs(bmi)bmi''' 1.264e-24 3.270e+08
## factor(rokare)1 1.334e+00 1.416e+00
## factor(ami_history)1 9.659e-01 1.042e+00
## factor(stroke_history)1 5.525e-81 5.107e+65
## factor(Civil)1 9.343e-01 9.991e-01
## factor(HushallsTyp_RTB)2 8.743e-01 9.228e-01
## factor(HushallsTyp_RTB)3 9.412e-01 1.022e+00
## factor(Sun2000niva_old)2 1.009e+00 1.091e+00
## factor(Sun2000niva_old)3 9.883e-01 1.043e+00
## factor(Sun2000niva_old)4 9.775e-01 1.054e+00
## factor(Sun2000niva_old)5 9.851e-01 1.072e+00
## factor(Sun2000niva_old)6 9.460e-01 1.030e+00
## factor(Sun2000niva_old)7 9.132e-01 1.198e+00
## rcs(DispInkKEHB04)DispInkKEHB04 8.149e-01 1.443e+00
## rcs(DispInkKEHB04)DispInkKEHB04' 3.180e-06 1.572e-01
## rcs(DispInkKEHB04)DispInkKEHB04'' 4.406e-02 8.487e+12
## rcs(DispInkKEHB04)DispInkKEHB04''' 1.926e-08 7.023e+05
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk 1.840e+00 4.364e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk' 2.805e-255 2.899e-92
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'' 9.813e+97 2.701e+274
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''' 2.601e-22 3.879e-07
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk 7.845e+00 3.470e+01
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk' 0.000e+00 0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'' Inf Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''' 1.718e-308 3.904e-160
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk 2.178e+00 4.014e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk' 4.962e-105 1.649e-57
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'' 2.613e+59 1.581e+109
## factor(FodelseLand_EU27_2020)1 1.024e+00 1.086e+00
## factor(antithrombotic_agents)1 1.622e+00 1.700e+00
## factor(antihypertensive_comb)1 1.018e+00 1.068e+00
## factor(lipid_modifying_agents)1 9.733e-01 1.019e+00
## rcs(hba1c)hba1c 9.154e-01 1.102e+00
## rcs(hba1c)hba1c' 2.751e+00 2.852e+01
## rcs(hba1c)hba1c'' 1.288e-04 3.470e-01
## rcs(hba1c)hba1c''' 1.662e-01 4.523e+02
## rcs(GFR)GFR 4.062e-01 1.199e+00
## rcs(GFR)GFR' 1.043e-02 9.696e+00
## rcs(GFR)GFR'' 2.777e-03 5.281e+13
## rcs(GFR)GFR''' 5.899e-24 6.870e+01
## rcs(kolesterol)kolesterol 8.586e-01 9.662e-01
## rcs(kolesterol)kolesterol' 1.984e+00 4.268e+00
## rcs(kolesterol)kolesterol'' 2.153e-03 8.892e-02
## rcs(kolesterol)kolesterol''' 8.620e+00 1.759e+03
## rcs(systoliskt)systoliskt 8.137e-01 8.998e-01
## rcs(systoliskt)systoliskt' 1.294e+00 2.519e+00
## rcs(systoliskt)systoliskt'' 7.921e-02 2.147e+00
## rcs(systoliskt)systoliskt''' 2.161e-02 1.218e+01
## factor(cpap_treated)1:factor(antithrombotic_agents)1 6.301e-01 1.215e+00
## factor(cpap_treated)1:factor(antihypertensive_comb)1 6.857e-01 1.389e+00
## factor(cpap_treated)1:factor(lipid_modifying_agents)1 6.347e-01 1.218e+00
## rcs(alder)alder:rcs(bmi)bmi 6.100e-01 2.683e+00
## rcs(alder)alder':rcs(bmi)bmi 4.042e-02 4.094e+00
## rcs(alder)alder'':rcs(bmi)bmi 2.660e-03 2.030e+07
## rcs(alder)alder''':rcs(bmi)bmi 1.205e-13 4.549e+03
## rcs(alder)alder:rcs(bmi)bmi' 1.094e-04 1.467e+01
## rcs(alder)alder':rcs(bmi)bmi' 2.496e-02 2.063e+14
## rcs(alder)alder'':rcs(bmi)bmi' 6.515e-77 3.932e+02
## rcs(alder)alder''':rcs(bmi)bmi' 3.169e+00 2.666e+134
## rcs(alder)alder:rcs(bmi)bmi'' 4.164e-06 1.804e+16
## rcs(alder)alder':rcs(bmi)bmi'' 1.592e-61 4.016e+06
## rcs(alder)alder'':rcs(bmi)bmi'' 1.013e-11 Inf
## rcs(alder)alder''':rcs(bmi)bmi'' 0.000e+00 1.061e+02
## rcs(alder)alder:rcs(bmi)bmi''' 2.122e-19 3.256e+07
## rcs(alder)alder':rcs(bmi)bmi''' 3.114e-11 3.025e+71
## rcs(alder)alder'':rcs(bmi)bmi''' 0.000e+00 1.030e+29
## rcs(alder)alder''':rcs(bmi)bmi''' 7.615e-36 Inf
## rcs(alder)alder:rcs(GFR)GFR 7.726e-01 1.861e+00
## rcs(alder)alder':rcs(GFR)GFR 1.932e-01 2.900e+00
## rcs(alder)alder'':rcs(GFR)GFR 1.093e-02 6.603e+03
## rcs(alder)alder''':rcs(GFR)GFR 1.444e-07 8.174e+02
## rcs(alder)alder:rcs(GFR)GFR' 1.841e-02 5.693e+00
## rcs(alder)alder':rcs(GFR)GFR' 1.222e-02 2.956e+05
## rcs(alder)alder'':rcs(GFR)GFR' 3.341e-26 1.673e+10
## rcs(alder)alder''':rcs(GFR)GFR' 6.449e-22 5.429e+38
## rcs(alder)alder:rcs(GFR)GFR'' 2.907e-03 9.400e+10
## rcs(alder)alder':rcs(GFR)GFR'' 1.288e-34 8.882e+06
## rcs(alder)alder'':rcs(GFR)GFR'' 2.671e-49 1.439e+153
## rcs(alder)alder''':rcs(GFR)GFR'' 5.485e-230 1.405e+119
## rcs(alder)alder:rcs(GFR)GFR''' 3.359e-19 9.277e+01
## rcs(alder)alder':rcs(GFR)GFR''' 4.563e-09 2.149e+55
## rcs(alder)alder'':rcs(GFR)GFR''' 1.598e-247 1.285e+77
## rcs(alder)alder''':rcs(GFR)GFR''' 7.613e-208 Inf
## factor(cpap_treated)1:rcs(GFR)GFR 5.711e-01 1.975e+00
## factor(cpap_treated)1:rcs(GFR)GFR' 1.343e-01 2.215e+02
## factor(cpap_treated)1:rcs(GFR)GFR'' 1.091e-17 4.760e+01
## factor(cpap_treated)1:rcs(GFR)GFR''' 9.388e+00 5.182e+31
##
## Concordance= 0.758 (se = 0.001 )
## Likelihood ratio test= 29806 on 96 df, p=<2e-16
## Wald test = 23506 on 96 df, p=<2e-16
## Score (logrank) test = 30597 on 96 df, p=<2e-16
## Warning in termplot(cph): 'model' appears to involve interactions: see the help
## page
## [1] "--- CONCORDANCE RESULTS ---"
## C-index train: 0.7582911
## C-index test: 0.7581617
run_models(c(list_forms_sleep[["form_tdep_spl"]], list_forms_sleep[["form_tdep_cat"]]), df_stroke_sub_tv_train, df_stroke_sub_tv_test, "stop", "event", cont_var, "prof_stroke_dep_g2.html", bigd=F)
## [1] "### FORMULA 1 ###"
## Start: AIC=7501.25
## Surv(start, stop, event) ~ factor(cpap_treated)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Df AIC
## + rcs(alder) 4 7401.1
## + factor(antithrombotic_agents) 1 7453.9
## + factor(stroke_history) 1 7479.0
## + rcs(systoliskt) 4 7481.0
## + rcs(GFR) 4 7481.0
## + rcs(DispInkKEHB04) 4 7484.2
## + rcs(hba1c) 4 7491.2
## + rcs(IV_AHI) 4 7492.2
## + rcs(IV_ODI) 4 7492.7
## + factor(antihypertensive_comb) 1 7494.8
## + factor(lipid_modifying_agents) 1 7494.9
## + factor(ami_history) 1 7499.6
## + factor(Civil) 1 7501.2
## <none> 7501.2
## + factor(sex) 1 7501.3
## + factor(FodelseLand_EU27_2020) 1 7501.6
## + rcs(Raks_AndelArblosInk) 4 7501.8
## + factor(HushallsTyp_RTB) 2 7502.6
## + rcs(bmi) 4 7502.6
## + factor(Sun2000niva_old) 6 7502.9
## + factor(rokare) 1 7503.1
## + rcs(Raks_AndelEkBisInk) 3 7505.6
## + rcs(Raks_AndelSjukInk) 4 7505.8
## + rcs(IV_AverageSaturation) 4 7505.8
## + rcs(kolesterol) 4 7506.7
## number of knots in rcs defaulting to 5
##
## Step: AIC=7401.05
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Df AIC
## + factor(stroke_history) 1 7371.9
## + rcs(DispInkKEHB04) 4 7380.0
## + rcs(hba1c) 4 7384.9
## + factor(antithrombotic_agents) 1 7386.5
## + rcs(systoliskt) 4 7387.0
## + rcs(IV_ODI) 4 7397.2
## + factor(rokare) 1 7399.2
## + rcs(IV_AHI) 4 7400.0
## + factor(sex) 1 7400.3
## + rcs(Raks_AndelEkBisInk) 3 7400.9
## <none> 7401.1
## + factor(lipid_modifying_agents) 1 7401.9
## + factor(ami_history) 1 7402.1
## + rcs(Raks_AndelArblosInk) 4 7402.3
## + factor(antihypertensive_comb) 1 7402.5
## + factor(Civil) 1 7402.6
## + factor(FodelseLand_EU27_2020) 1 7402.9
## + rcs(GFR) 4 7403.8
## + factor(HushallsTyp_RTB) 2 7404.6
## + rcs(kolesterol) 4 7405.8
## + rcs(IV_AverageSaturation) 4 7406.9
## + rcs(Raks_AndelSjukInk) 4 7407.5
## + factor(Sun2000niva_old) 6 7408.7
## + rcs(bmi) 4 7408.9
## - rcs(alder) 4 7501.2
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
##
## Step: AIC=7371.86
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## factor(stroke_history)
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## Df AIC
## + factor(antithrombotic_agents) 1 7350.8
## + rcs(DispInkKEHB04) 4 7351.1
## + rcs(hba1c) 4 7355.2
## + rcs(systoliskt) 4 7358.0
## + rcs(IV_ODI) 4 7367.7
## + factor(rokare) 1 7369.7
## + rcs(IV_AHI) 4 7370.1
## + factor(sex) 1 7370.8
## + rcs(Raks_AndelEkBisInk) 3 7371.7
## + factor(lipid_modifying_agents) 1 7371.7
## <none> 7371.9
## + factor(ami_history) 1 7372.8
## + factor(antihypertensive_comb) 1 7373.2
## + rcs(Raks_AndelArblosInk) 4 7373.2
## + factor(Civil) 1 7373.4
## + factor(FodelseLand_EU27_2020) 1 7373.8
## + rcs(GFR) 4 7374.2
## + factor(HushallsTyp_RTB) 2 7375.4
## + rcs(kolesterol) 4 7376.7
## + rcs(IV_AverageSaturation) 4 7377.7
## + rcs(Raks_AndelSjukInk) 4 7378.0
## + factor(Sun2000niva_old) 6 7379.3
## + rcs(bmi) 4 7379.7
## - factor(stroke_history) 1 7401.1
## - rcs(alder) 4 7479.0
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
##
## Step: AIC=7350.85
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## factor(stroke_history) + factor(antithrombotic_agents)
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## Df AIC
## + rcs(DispInkKEHB04) 4 7331.3
## + rcs(systoliskt) 4 7335.5
## + rcs(hba1c) 4 7336.4
## + rcs(IV_ODI) 4 7347.4
## + factor(rokare) 1 7349.2
## + rcs(IV_AHI) 4 7349.4
## + factor(cpap_treated):factor(antithrombotic_agents) 1 7349.5
## + rcs(Raks_AndelEkBisInk) 3 7350.8
## <none> 7350.8
## + factor(sex) 1 7351.4
## + rcs(Raks_AndelArblosInk) 4 7352.3
## + factor(Civil) 1 7352.5
## + factor(ami_history) 1 7352.7
## + factor(FodelseLand_EU27_2020) 1 7352.8
## + factor(lipid_modifying_agents) 1 7352.8
## + factor(antihypertensive_comb) 1 7352.8
## + factor(HushallsTyp_RTB) 2 7354.2
## + rcs(GFR) 4 7354.3
## + rcs(kolesterol) 4 7355.0
## + rcs(IV_AverageSaturation) 4 7356.8
## + rcs(Raks_AndelSjukInk) 4 7357.3
## + rcs(bmi) 4 7358.7
## + factor(Sun2000niva_old) 6 7359.0
## - factor(antithrombotic_agents) 1 7371.9
## - factor(stroke_history) 1 7386.5
## - rcs(alder) 4 7420.3
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
##
## Step: AIC=7331.29
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## factor(stroke_history) + factor(antithrombotic_agents) +
## rcs(DispInkKEHB04)
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## Df AIC
## + rcs(systoliskt) 4 7315.9
## + rcs(hba1c) 4 7319.7
## + rcs(IV_ODI) 4 7328.2
## + factor(cpap_treated):factor(antithrombotic_agents) 1 7329.7
## + rcs(IV_AHI) 4 7329.8
## + factor(rokare) 1 7330.3
## + factor(sex) 1 7330.3
## <none> 7331.3
## + factor(Civil) 1 7332.7
## + factor(FodelseLand_EU27_2020) 1 7332.8
## + factor(ami_history) 1 7333.2
## + rcs(Raks_AndelArblosInk) 4 7333.3
## + factor(antihypertensive_comb) 1 7333.3
## + factor(lipid_modifying_agents) 1 7333.3
## + rcs(Raks_AndelEkBisInk) 3 7333.5
## + factor(HushallsTyp_RTB) 2 7334.6
## + rcs(kolesterol) 4 7335.3
## + rcs(GFR) 4 7335.4
## + rcs(IV_AverageSaturation) 4 7337.6
## + rcs(Raks_AndelSjukInk) 4 7337.9
## + rcs(bmi) 4 7338.9
## + factor(Sun2000niva_old) 6 7341.4
## - rcs(DispInkKEHB04) 4 7350.8
## - factor(antithrombotic_agents) 1 7351.1
## - factor(stroke_history) 1 7366.4
## - rcs(alder) 4 7403.9
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
##
## Step: AIC=7315.9
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## factor(stroke_history) + factor(antithrombotic_agents) +
## rcs(DispInkKEHB04) + rcs(systoliskt)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## Df AIC
## + rcs(hba1c) 4 7305.8
## + rcs(IV_ODI) 4 7313.4
## + factor(cpap_treated):factor(antithrombotic_agents) 1 7314.2
## + factor(rokare) 1 7314.8
## + factor(sex) 1 7315.0
## + rcs(IV_AHI) 4 7315.1
## <none> 7315.9
## + factor(Civil) 1 7317.1
## + factor(FodelseLand_EU27_2020) 1 7317.5
## + factor(antihypertensive_comb) 1 7317.7
## + factor(ami_history) 1 7317.8
## + factor(lipid_modifying_agents) 1 7317.9
## + rcs(Raks_AndelArblosInk) 4 7318.0
## + rcs(Raks_AndelEkBisInk) 3 7318.1
## + factor(HushallsTyp_RTB) 2 7319.2
## + rcs(GFR) 4 7320.1
## + rcs(kolesterol) 4 7320.5
## + rcs(IV_AverageSaturation) 4 7322.3
## + rcs(Raks_AndelSjukInk) 4 7322.4
## + rcs(bmi) 4 7323.4
## + factor(Sun2000niva_old) 6 7326.0
## - rcs(systoliskt) 4 7331.3
## - rcs(DispInkKEHB04) 4 7335.5
## - factor(antithrombotic_agents) 1 7337.1
## - factor(stroke_history) 1 7351.2
## - rcs(alder) 4 7381.7
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
##
## Step: AIC=7305.75
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## factor(stroke_history) + factor(antithrombotic_agents) +
## rcs(DispInkKEHB04) + rcs(systoliskt) + rcs(hba1c)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## Df AIC
## + factor(cpap_treated):factor(antithrombotic_agents) 1 7304.3
## + factor(rokare) 1 7304.7
## + factor(sex) 1 7305.3
## + rcs(IV_ODI) 4 7305.7
## <none> 7305.8
## + factor(Civil) 1 7306.9
## + rcs(IV_AHI) 4 7306.9
## + factor(FodelseLand_EU27_2020) 1 7307.5
## + factor(antihypertensive_comb) 1 7307.5
## + factor(ami_history) 1 7307.7
## + factor(lipid_modifying_agents) 1 7307.7
## + rcs(Raks_AndelArblosInk) 4 7307.8
## + rcs(Raks_AndelEkBisInk) 3 7308.0
## + factor(HushallsTyp_RTB) 2 7309.0
## + rcs(GFR) 4 7310.6
## + rcs(kolesterol) 4 7310.7
## + rcs(Raks_AndelSjukInk) 4 7312.0
## + rcs(IV_AverageSaturation) 4 7312.4
## + rcs(bmi) 4 7312.7
## - rcs(hba1c) 4 7315.9
## + factor(Sun2000niva_old) 6 7315.9
## - rcs(systoliskt) 4 7319.7
## - rcs(DispInkKEHB04) 4 7322.6
## - factor(antithrombotic_agents) 1 7325.2
## - factor(stroke_history) 1 7341.2
## - rcs(alder) 4 7377.6
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
##
## Step: AIC=7304.3
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## factor(stroke_history) + factor(antithrombotic_agents) +
## rcs(DispInkKEHB04) + rcs(systoliskt) + rcs(hba1c) + factor(cpap_treated):factor(antithrombotic_agents)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## Df AIC
## + factor(rokare) 1 7303.1
## + factor(sex) 1 7303.8
## <none> 7304.3
## + rcs(IV_ODI) 4 7304.5
## + factor(Civil) 1 7305.4
## + rcs(IV_AHI) 4 7305.6
## - factor(cpap_treated):factor(antithrombotic_agents) 1 7305.8
## + factor(antihypertensive_comb) 1 7306.0
## + factor(FodelseLand_EU27_2020) 1 7306.1
## + rcs(Raks_AndelArblosInk) 4 7306.3
## + factor(ami_history) 1 7306.3
## + factor(lipid_modifying_agents) 1 7306.3
## + rcs(Raks_AndelEkBisInk) 3 7306.5
## + factor(HushallsTyp_RTB) 2 7307.6
## + rcs(GFR) 4 7309.1
## + rcs(kolesterol) 4 7309.2
## + rcs(Raks_AndelSjukInk) 4 7310.6
## + rcs(IV_AverageSaturation) 4 7311.0
## + rcs(bmi) 4 7311.1
## - rcs(hba1c) 4 7314.2
## + factor(Sun2000niva_old) 6 7314.5
## - rcs(systoliskt) 4 7318.3
## - rcs(DispInkKEHB04) 4 7321.4
## - factor(stroke_history) 1 7339.6
## - rcs(alder) 4 7376.5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
##
## Step: AIC=7303.07
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## factor(stroke_history) + factor(antithrombotic_agents) +
## rcs(DispInkKEHB04) + rcs(systoliskt) + rcs(hba1c) + factor(rokare) +
## factor(cpap_treated):factor(antithrombotic_agents)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## Df AIC
## + factor(sex) 1 7302.6
## <none> 7303.1
## + rcs(IV_ODI) 4 7303.2
## + factor(Civil) 1 7304.2
## - factor(rokare) 1 7304.3
## + rcs(IV_AHI) 4 7304.4
## - factor(cpap_treated):factor(antithrombotic_agents) 1 7304.7
## + factor(FodelseLand_EU27_2020) 1 7304.8
## + factor(antihypertensive_comb) 1 7304.8
## + rcs(Raks_AndelArblosInk) 4 7305.0
## + factor(ami_history) 1 7305.1
## + factor(lipid_modifying_agents) 1 7305.1
## + rcs(Raks_AndelEkBisInk) 3 7305.6
## + factor(HushallsTyp_RTB) 2 7306.2
## + rcs(GFR) 4 7307.9
## + rcs(kolesterol) 4 7308.1
## + rcs(Raks_AndelSjukInk) 4 7309.3
## + rcs(IV_AverageSaturation) 4 7309.9
## + rcs(bmi) 4 7310.1
## - rcs(hba1c) 4 7313.0
## + factor(Sun2000niva_old) 6 7313.3
## - rcs(systoliskt) 4 7317.3
## - rcs(DispInkKEHB04) 4 7319.6
## - factor(stroke_history) 1 7338.6
## - rcs(alder) 4 7378.4
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
##
## Step: AIC=7302.6
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) +
## factor(stroke_history) + factor(antithrombotic_agents) +
## rcs(DispInkKEHB04) + rcs(systoliskt) + rcs(hba1c) + factor(rokare) +
## factor(sex) + factor(cpap_treated):factor(antithrombotic_agents)
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.
## Df AIC
## <none> 7302.6
## - factor(sex) 1 7303.1
## + rcs(IV_ODI) 4 7303.4
## - factor(rokare) 1 7303.8
## + factor(Civil) 1 7304.2
## - factor(cpap_treated):factor(antithrombotic_agents) 1 7304.2
## + factor(FodelseLand_EU27_2020) 1 7304.3
## + factor(antihypertensive_comb) 1 7304.3
## + rcs(Raks_AndelArblosInk) 4 7304.5
## + factor(ami_history) 1 7304.6
## + factor(lipid_modifying_agents) 1 7304.6
## + rcs(IV_AHI) 4 7304.7
## + rcs(Raks_AndelEkBisInk) 3 7305.2
## + factor(HushallsTyp_RTB) 2 7305.8
## + rcs(kolesterol) 4 7307.1
## + rcs(GFR) 4 7307.2
## + rcs(Raks_AndelSjukInk) 4 7308.7
## + rcs(IV_AverageSaturation) 4 7309.3
## + rcs(bmi) 4 7309.9
## - rcs(hba1c) 4 7312.0
## + factor(Sun2000niva_old) 6 7313.0
## - rcs(systoliskt) 4 7316.9
## - rcs(DispInkKEHB04) 4 7320.2
## - factor(stroke_history) 1 7338.0
## - rcs(alder) 4 7379.5
## [1] "--- SURVIVAL RESULTS ---"
## Call:
## coxph(formula = Surv(start, stop, event) ~ factor(cpap_treated) +
## rcs(alder) + factor(stroke_history) + factor(antithrombotic_agents) +
## rcs(DispInkKEHB04) + rcs(systoliskt) + rcs(hba1c) + factor(rokare) +
## factor(sex) + factor(cpap_treated):factor(antithrombotic_agents),
## data = df_train)
##
## n= 151245, number of events= 433
##
## coef exp(coef)
## factor(cpap_treated)1 1.538e-01 1.166e+00
## rcs(alder)alder 4.764e-01 1.610e+00
## rcs(alder)alder' 1.847e-01 1.203e+00
## rcs(alder)alder'' 3.223e-01 1.380e+00
## rcs(alder)alder''' -4.026e+00 1.785e-02
## factor(stroke_history)1 -1.672e+01 5.460e-08
## factor(antithrombotic_agents)1 5.572e-01 1.746e+00
## rcs(DispInkKEHB04)DispInkKEHB04 -1.304e-01 8.777e-01
## rcs(DispInkKEHB04)DispInkKEHB04' 3.884e+00 4.863e+01
## rcs(DispInkKEHB04)DispInkKEHB04'' -2.677e+01 2.359e-12
## rcs(DispInkKEHB04)DispInkKEHB04''' 4.615e+01 1.103e+20
## rcs(systoliskt)systoliskt -2.891e-01 7.490e-01
## rcs(systoliskt)systoliskt' 1.273e+00 3.571e+00
## rcs(systoliskt)systoliskt'' -1.276e+00 2.791e-01
## rcs(systoliskt)systoliskt''' -6.155e+00 2.122e-03
## rcs(hba1c)hba1c -4.468e-01 6.397e-01
## rcs(hba1c)hba1c' 1.116e+01 7.004e+04
## rcs(hba1c)hba1c'' -3.319e+01 3.864e-15
## rcs(hba1c)hba1c''' 2.950e+01 6.478e+12
## factor(rokare)1 2.510e-01 1.285e+00
## factor(sex)1 -1.658e-01 8.472e-01
## factor(cpap_treated)1:factor(antithrombotic_agents)1 -4.143e-01 6.608e-01
## se(coef) z Pr(>|z|)
## factor(cpap_treated)1 1.471e-01 1.046 0.2957
## rcs(alder)alder 3.311e-01 1.439 0.1502
## rcs(alder)alder' 1.182e+00 0.156 0.8759
## rcs(alder)alder'' 6.159e+00 0.052 0.9583
## rcs(alder)alder''' 1.061e+01 -0.379 0.7045
## factor(stroke_history)1 9.692e+02 -0.017 0.9862
## factor(antithrombotic_agents)1 1.168e-01 4.769 1.86e-06
## rcs(DispInkKEHB04)DispInkKEHB04 4.496e-01 -0.290 0.7718
## rcs(DispInkKEHB04)DispInkKEHB04' 6.523e+00 0.596 0.5515
## rcs(DispInkKEHB04)DispInkKEHB04'' 2.298e+01 -1.165 0.2439
## rcs(DispInkKEHB04)DispInkKEHB04''' 2.675e+01 1.725 0.0845
## rcs(systoliskt)systoliskt 2.239e-01 -1.291 0.1966
## rcs(systoliskt)systoliskt' 1.367e+00 0.931 0.3520
## rcs(systoliskt)systoliskt'' 6.931e+00 -0.184 0.8539
## rcs(systoliskt)systoliskt''' 1.378e+01 -0.447 0.6551
## rcs(hba1c)hba1c 4.447e-01 -1.005 0.3151
## rcs(hba1c)hba1c' 6.601e+00 1.690 0.0910
## rcs(hba1c)hba1c'' 1.979e+01 -1.677 0.0935
## rcs(hba1c)hba1c''' 1.844e+01 1.600 0.1096
## factor(rokare)1 1.362e-01 1.842 0.0655
## factor(sex)1 1.065e-01 -1.558 0.1193
## factor(cpap_treated)1:factor(antithrombotic_agents)1 2.201e-01 -1.882 0.0598
##
## factor(cpap_treated)1
## rcs(alder)alder
## rcs(alder)alder'
## rcs(alder)alder''
## rcs(alder)alder'''
## factor(stroke_history)1
## factor(antithrombotic_agents)1 ***
## rcs(DispInkKEHB04)DispInkKEHB04
## rcs(DispInkKEHB04)DispInkKEHB04'
## rcs(DispInkKEHB04)DispInkKEHB04''
## rcs(DispInkKEHB04)DispInkKEHB04''' .
## rcs(systoliskt)systoliskt
## rcs(systoliskt)systoliskt'
## rcs(systoliskt)systoliskt''
## rcs(systoliskt)systoliskt'''
## rcs(hba1c)hba1c
## rcs(hba1c)hba1c' .
## rcs(hba1c)hba1c'' .
## rcs(hba1c)hba1c'''
## factor(rokare)1 .
## factor(sex)1
## factor(cpap_treated)1:factor(antithrombotic_agents)1 .
## ---
## Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
##
## exp(coef) exp(-coef)
## factor(cpap_treated)1 1.166e+00 8.574e-01
## rcs(alder)alder 1.610e+00 6.210e-01
## rcs(alder)alder' 1.203e+00 8.314e-01
## rcs(alder)alder'' 1.380e+00 7.245e-01
## rcs(alder)alder''' 1.785e-02 5.602e+01
## factor(stroke_history)1 5.460e-08 1.832e+07
## factor(antithrombotic_agents)1 1.746e+00 5.728e-01
## rcs(DispInkKEHB04)DispInkKEHB04 8.777e-01 1.139e+00
## rcs(DispInkKEHB04)DispInkKEHB04' 4.863e+01 2.056e-02
## rcs(DispInkKEHB04)DispInkKEHB04'' 2.359e-12 4.239e+11
## rcs(DispInkKEHB04)DispInkKEHB04''' 1.103e+20 9.069e-21
## rcs(systoliskt)systoliskt 7.490e-01 1.335e+00
## rcs(systoliskt)systoliskt' 3.571e+00 2.800e-01
## rcs(systoliskt)systoliskt'' 2.791e-01 3.583e+00
## rcs(systoliskt)systoliskt''' 2.122e-03 4.713e+02
## rcs(hba1c)hba1c 6.397e-01 1.563e+00
## rcs(hba1c)hba1c' 7.004e+04 1.428e-05
## rcs(hba1c)hba1c'' 3.864e-15 2.588e+14
## rcs(hba1c)hba1c''' 6.478e+12 1.544e-13
## factor(rokare)1 1.285e+00 7.780e-01
## factor(sex)1 8.472e-01 1.180e+00
## factor(cpap_treated)1:factor(antithrombotic_agents)1 6.608e-01 1.513e+00
## lower .95 upper .95
## factor(cpap_treated)1 8.742e-01 1.556e+00
## rcs(alder)alder 8.416e-01 3.081e+00
## rcs(alder)alder' 1.185e-01 1.221e+01
## rcs(alder)alder'' 7.889e-06 2.415e+05
## rcs(alder)alder''' 1.646e-11 1.936e+07
## factor(stroke_history)1 0.000e+00 Inf
## factor(antithrombotic_agents)1 1.388e+00 2.195e+00
## rcs(DispInkKEHB04)DispInkKEHB04 3.637e-01 2.119e+00
## rcs(DispInkKEHB04)DispInkKEHB04' 1.364e-04 1.734e+07
## rcs(DispInkKEHB04)DispInkKEHB04'' 6.548e-32 8.500e+07
## rcs(DispInkKEHB04)DispInkKEHB04''' 1.875e-03 6.485e+42
## rcs(systoliskt)systoliskt 4.830e-01 1.161e+00
## rcs(systoliskt)systoliskt' 2.448e-01 5.209e+01
## rcs(systoliskt)systoliskt'' 3.520e-07 2.213e+05
## rcs(systoliskt)systoliskt''' 3.947e-15 1.141e+09
## rcs(hba1c)hba1c 2.676e-01 1.529e+00
## rcs(hba1c)hba1c' 1.684e-01 2.914e+10
## rcs(hba1c)hba1c'' 5.550e-32 2.689e+02
## rcs(hba1c)hba1c''' 1.306e-03 3.214e+28
## factor(rokare)1 9.841e-01 1.679e+00
## factor(sex)1 6.877e-01 1.044e+00
## factor(cpap_treated)1:factor(antithrombotic_agents)1 4.292e-01 1.017e+00
##
## Concordance= 0.721 (se = 0.012 )
## Likelihood ratio test= 240.9 on 22 df, p=<2e-16
## Wald test = 210.5 on 22 df, p=<2e-16
## Score (logrank) test = 248.3 on 22 df, p=<2e-16
## Warning in termplot(cph): 'model' appears to involve interactions: see the help
## page
## [1] "--- CONCORDANCE RESULTS ---"
## C-index train: 0.7213385
## C-index test: 0.7300355