# library(devtools)
# install_github("michaelyanwang/dcalasso")

library(survival)
library(dcalasso)

## Loading required package: mgcv

## Loading required package: nlme

## This is mgcv 1.9-1. For overview type 'help("mgcv-package")'.

## Loading required package: glmnet

## Loading required package: Matrix

## Loaded glmnet 4.1-8

## Loading required package: doParallel

## Loading required package: foreach

## Loading required package: iterators

## Loading required package: parallel

## Loading required package: MASS

library(profvis)
library(rms)

## Loading required package: Hmisc

## 
## Attaching package: 'Hmisc'

## The following objects are masked from 'package:base':
## 
##     format.pval, units

library(glmnet)

# Helper functions
dac_BIC <- function(cph_mod) {
  return(cph_mod$loglik / cph_mod$n + log(cph_mod$nevent) * length(cph_tv$coefficients))
}

concordance_index <- function(mod, data, time_col="stop", event_col="event", cph=TRUE) {
  time <- data[, time_col]
  status <- data[, event_col]
  
  # Survival package automatically centers the linear predictors
  if (cph) {
    x <- predict(mod, newdata=data)
  } else {
    x <- scale(predict(mod, newdata=data)$fit, scale=F)
  }
  
  n <- length(time)
  ord <- order(time, -status)
  time <- time[ord]
  status <- status[ord]
  x <- x[ord]
  
  wh <- which(status == 1)
  total <- concordant <- 0
  
  # Loop over event rows
  for (i in wh) {
    # Get indices for all subjects that have later times (time[j] > time[i])
    later_times <- which(time > time[i])
    
    # Get the predictions for those subjects
    x_later <- x[later_times]
    x_i <- x[i]
    
    # Compare predictions for concordance
    concordant <- concordant + sum(x_later < x_i) + 0.5 * sum(x_later == x_i)
    total <- total + length(later_times)
  }
  
  # Calculate concordance
  concordance <- concordant / total
  return(concordance)
}


scale_data <- function(df_train, df_test, cont_var) {
  train_means <- colMeans(df_train[, cont_var])
  train_sd <- apply(df_train[, cont_var], 2, sd)
  
  df_train[, cont_var] <- scale(df_train[, cont_var], center=train_means, scale=train_sd)
  df_test[, cont_var] <- scale(df_test[, cont_var], center=train_means, scale=train_sd)
  
  return(list(train=df_train, test=df_test))
}


load_data <- function(path_train, path_test, cont_var, tv=T) {
  df_train <- read.csv(path_train)
  df_test <- read.csv(path_test)
  
  scale_res <- scale_data(df_train, df_test, cont_var)
  df_train <- scale_res$train
  df_test <- scale_res$test
  
  df_train[df_train == "True"] <- 1
  df_train[df_train == "False"] <- 0
  
  df_test[df_test == "True"] <- 1
  df_test[df_test == "False"] <- 0
  
  if (tv) {
    df_train["event"] <- as.integer(df_train$event)
    df_test["event"] <- as.integer(df_test$event)
    
    df_train <- df_train[df_train$stop > df_train$start,]
    df_test <- df_test[df_test$stop > df_test$start,]
  } else {
    df_train[c("death", "ami", "stroke")] <- lapply(df_train[c("death", "ami", "stroke")], as.integer)
    df_test[c("death", "ami", "stroke")] <- lapply(df_test[c("death", "ami", "stroke")], as.integer)
  }
  
  return(list(train=df_train, test=df_test))
}


# fit_cox <- function(df_train, df_test, form, cont_var){
#   x_var <- all.vars(form[[3]])
#   cat_var <- setdiff(x_var, cont_var)
#   rcs_var <- paste0("rcs_", cont_var)
#   new_var <- c()
#   
#   time_col <- all.vars(form[[2]])[1]
#   event_col <- all.vars(form[[2]])[2]
#   
#   # Build X matrix with manually created rcs columns
#   X <- df_train[, cat_var]
#   X_test <- df_test[, cat_var]
#   for (var in cont_var) {
#     rcs_var <- rcspline.eval(df_train[, var], nk=5, inclx=T)
#     rcs_var_test <- rcspline.eval(df_test[, var], nk=5, inclx=T)
#     
#     colnames(rcs_var) <- paste0("rcs_", var, "_", seq_len(ncol(rcs_var)))
#     colnames(rcs_var_test) <- paste0("rcs_", var, "_", seq_len(ncol(rcs_var_test)))
#     
#     new_var <- append(new_var, colnames(rcs_var))
#     
#     X <- cbind(X, rcs_var)
#     X_test <- cbind(X_test, rcs_var_test)
#   }
#   
#   # Add interaction columns where necessary
#   term_labels <- attr(terms(form), "term.labels")
#   int_terms <- term_labels[grepl(":", term_labels)]
#   if (length(int_terms) > 0) {
#     for (int_term in int_terms) {
#       # Extract which variables are in the interaction
#       vars <- unlist(strsplit(int_term, ":"))
#       
#       if (grepl("rcs\\(", vars[1])) {
#         var1 <- gsub("rcs\\(|\\)", "", vars[1])  
#       }
#       
#       if (grepl("rcs\\(", vars[2])) {
#         var2 <- gsub("rcs\\(|\\)", "", vars[2])  
#       }
#       
#       cols1 <- new_var[grepl(var1, new_var)]
#       cols2 <- new_var[grepl(var2, new_var)]
#       
#       for (c1 in cols1) {
#         for (c2 in cols2) {
#           int_var <- as.data.frame(X[, c1] * X[, c2])
#           colnames(int_var) <- paste0(c1, "_X_", c2)
#           
#           new_var <- append(new_var, paste0(c1, "_X_", c2))
#           X <- cbind(X, int_var)
#         }
#       }
#       
#     }
#   }
#   new_var <- append(new_var, cat_var)
#   
#   y <- Surv(df_train[, time_col], df_train[, event_col])
#   cv_fit <- cv.glmnet(as.matrix(X), y, family="cox")
#   coef_cv <- coef(cv_fit, s="lambda.min")
#   
#   # Turn into CPH object
#   data <- cbind(X, df_train[, c(time_col, event_col)])
#   data_test <- cbind(X_test, df_test[, c(time_col, event_col)])
#   
#   cph <- coxph(as.formula(paste0("Surv(", time_col, ", ", event_col, ") ~ ", paste(new_var, collapse="+"))), data, x=T, init=as.numeric(coef_cv), iter.max=0)
#   
#   conc_train <- concordance(cph, newdata=data)$concordance
#   conc_test <- concordance(cph, newdata=data_test)$concordance
#   
#   return(list(cph=cph, conc_train=conc_train, conc_test=conc_test))
# }


fit_cox <- function(df_train, df_test, form, gr_i){
  # Define null model and variable scope
  null_form <- as.formula(paste0(deparse(form[[2]]), " ~ factor(cpap_treated)"))
  scope <- as.formula(paste0("~ ", paste(deparse(form[[3]]), collapse="")))
  # scope <- update(scope, . ~ . - factor(cpap_treated))
  null_mod <- coxph(null_form, df_train)
  
  # Compute and evaluate
  step_mod <- stepAIC(null_mod, scope=list(lower=as.formula("~ factor(cpap_treated)"), upper=scope), direction="both")
  
  # Save model to file
  # saveRDS(step_mod, paste0("Models/cph_", gr_i, ".rds"))
  
  conc_train <- concordance(step_mod, newdata=df_train)$concordance
  conc_test <- concordance(step_mod, newdata=df_test)$concordance
  
  return(list(cph=step_mod, conc_train=conc_train, conc_test=conc_test))
}


fit_dac <- function(df_train, form, gamma_values=seq(0.5, 2, by=0.5), K=20) {
  mods <- list()
  bics <- c()
  
  j <- 1
  for (i in seq_along(gamma_values)) {
    gamma <- gamma_values[i]
    penalties <- c(0, rep(gamma, length(attr(terms(form), "term.labels")) - 1))
    dac <- dcalasso(form, data=df_train, gamma=penalties, K=K)
    
    mods[[j]] <- dac
    bics <- c(bics, dac$BIC.opt)
    
    j <- j + 1
  }
  
  dac_opt <- mods[[which(bics == min(bics))]]
  
  return(dac_opt)
}


run_models <- function(vec_forms, df_train, df_test, time_col, event_col, cont_var, prof_out_file, gr_i, K=20, bigd=T) {
  assign("df_train", df_train, envir=.GlobalEnv)

  i <- 1
  for (form in vec_forms) {
    print(paste("### FORMULA", i, "###"))
    
    # Train models
    prof <- profvis({
      if (nrow(df_train) > 1000000) {
        cph <- coxph(form, df_train, x=T)
        conc_train <- concordance(cph, newdata=df_train)$concordance
        conc_test <- concordance(cph, newdata=df_test)$concordance
      } else {
        cph_list <- fit_cox(df_train, df_test, form, cont_var)
        cph <- cph_list$cph
        conc_train <- cph_list$conc_train
        conc_test <- cph_list$conc_test
      }

      if (bigd) {
        try({
          dac <- fit_dac(df_train, form, K=K)
          
          print("--- DAC RESULTS ---")
          print(summary(dac))
          conc_train_dac <- concordance_index(dac, df_train, time_col, event_col, cph=F)
          conc_test_dac <- concordance_index(dac, df_test, time_col, event_col, cph=F)
        }, silent=T
        )
      }

      # Evaluations
      zph <- cox.zph(cph)

      # Print summaries and plot
      print("--- SURVIVAL RESULTS ---")
      print(summary(cph))

      plot(zph, resid=F)
      termplot(cph)
      
      # Compute concordance index
      print("--- CONCORDANCE RESULTS ---")
      cat("C-index train:", conc_train,
          "\nC-index test:", conc_test
          )

      if (bigd) {
        try({
          cat("\nC-index DAC train:", conc_train_dac,
              "\nC-index DAC test:", conc_test_dac)
      }, silent=T)
      }

    })

    # Save profiling results
    htmlwidgets::saveWidget(prof, paste0("Profiling/dac_form", i, "_", prof_out_file))
    
    i <- i + 1
  }
}

Load data

cont_var <- c("time_to_cpap_start", "time_to_cpap_end", "alder", "bmi", "hba1c", "GFR", "kolesterol", "systoliskt", "DispInkKEHB04", "Raks_AndelArblosInk", "Raks_AndelSjukInk", "Raks_AndelEkBisInk")

# Load data
# tind_load <- load_data("/vault/marja987_amed/subsets_thesis_marijn/Data/ndr_survival_times_train.csv",
#                        "/vault/marja987_amed/subsets_thesis_marijn/Data/ndr_survival_times_test.csv",
#                        cont_var, tv=F)
# df_survival_times_train <- tind_load$train
# df_survival_times_test <- tind_load$test

death_load <- load_data("/vault/marja987_amed/subsets_thesis_marijn/Data/death_tv_train.csv",
                        "/vault/marja987_amed/subsets_thesis_marijn/Data/death_tv_test.csv",
                        setdiff(cont_var, c("time_to_cpap_start", "time_to_cpap_end")))
df_death_tv_train <- death_load$train
df_death_tv_test <- death_load$test

ami_load <- load_data("/vault/marja987_amed/subsets_thesis_marijn/Data/ami_tv_train.csv",
                      "/vault/marja987_amed/subsets_thesis_marijn/Data/ami_tv_train.csv",
                       setdiff(cont_var, c("time_to_cpap_start", "time_to_cpap_end")))
df_ami_tv_train <- ami_load$train
df_ami_tv_test <- ami_load$test

stroke_load <- load_data("/vault/marja987_amed/subsets_thesis_marijn/Data/stroke_tv_train.csv",
                         "/vault/marja987_amed/subsets_thesis_marijn/Data/stroke_tv_test.csv",
                         setdiff(cont_var, c("time_to_cpap_start", "time_to_cpap_end")))
df_stroke_tv_train <- stroke_load$train
df_stroke_tv_test <- stroke_load$test

cont_var <- c("time_to_cpap_start", "time_to_cpap_end", "alder", "bmi", "hba1c", "GFR", "kolesterol", "systoliskt", "DispInkKEHB04", "Raks_AndelArblosInk", "Raks_AndelSjukInk", "Raks_AndelEkBisInk")

cont_var_sleep <- c("time_to_cpap_start", "time_to_cpap_end", "alder", "bmi", "hba1c", "GFR", "kolesterol", "systoliskt", "DispInkKEHB04", "Raks_AndelArblosInk", "Raks_AndelSjukInk", "Raks_AndelEkBisInk", "IV_AHI", "IV_ODI", "IV_AverageSaturation")

# Load data
# tind_sub_load <- load_data("/vault/marja987_amed/subsets_thesis_marijn/Data/ndr_sesar_survival_times_train.csv",
#                            "/vault/marja987_amed/subsets_thesis_marijn/Data/ndr_sesar_survival_times_test.csv",
#                            cont_var_sleep, tv=F)
# df_survival_times_sub_train <- tind_sub_load$train
# df_survival_times_sub_test <- tind_sub_load$test

death_sub_load <- load_data("/vault/marja987_amed/subsets_thesis_marijn/Data/death_sub_tv_train.csv",
                            "/vault/marja987_amed/subsets_thesis_marijn/Data/death_sub_tv_test.csv",
                            setdiff(cont_var_sleep, c("time_to_cpap_start", "time_to_cpap_end")))
df_death_sub_tv_train <- death_sub_load$train
df_death_sub_tv_test <- death_sub_load$test

ami_sub_load <- load_data("/vault/marja987_amed/subsets_thesis_marijn/Data/ami_sub_tv_train.csv",
                          "/vault/marja987_amed/subsets_thesis_marijn/Data/ami_sub_tv_train.csv",
                          setdiff(cont_var_sleep, c("time_to_cpap_start", "time_to_cpap_end")))
df_ami_sub_tv_train <- ami_sub_load$train
df_ami_sub_tv_test <- ami_sub_load$test

stroke_sub_load <- load_data("/vault/marja987_amed/subsets_thesis_marijn/Data/stroke_sub_tv_train.csv",
                             "/vault/marja987_amed/subsets_thesis_marijn/Data/stroke_sub_tv_test.csv",
                             setdiff(cont_var_sleep, c("time_to_cpap_start", "time_to_cpap_end")))
df_stroke_sub_tv_train <- stroke_sub_load$train
df_stroke_sub_tv_test <- stroke_sub_load$test

Generate formulas

base_form <- . ~ factor(cpap_treated) + rcs(alder) + factor(sex) + rcs(bmi) + factor(rokare) + factor(ami_history) + factor(stroke_history) + factor(Civil) + factor(HushallsTyp_RTB) + factor(Sun2000niva_old) + rcs(DispInkKEHB04) + rcs(Raks_AndelArblosInk) + rcs(Raks_AndelSjukInk) + rcs(Raks_AndelEkBisInk) + factor(FodelseLand_EU27_2020) + factor(antithrombotic_agents) + factor(antihypertensive_comb) + factor(lipid_modifying_agents) + factor(cpap_treated):factor(antithrombotic_agents) + factor(cpap_treated):factor(antihypertensive_comb) + factor(cpap_treated):factor(lipid_modifying_agents) + rcs(alder):rcs(bmi) 

list_forms <- list()

for (time_setting in c("tind", "tdep")) {
    if (time_setting == "tind") {
      # In the time-independent formulas, the time and event columns are named accordingly
      for (event in c("death", "ami", "stroke")) {
        # Create both a spline and categorized instance for updating later
        list_forms[[paste0("form_", event, "_", time_setting, "_spl")]] <- update(base_form, paste0("Surv(time_to_", event, ", ", event, ") ~ . + rcs(time_to_cpap_start) + rcs(time_to_cpap_end)"))
        list_forms[[paste0("form_", event, "_", time_setting, "_cat")]] <- update(base_form, paste0("Surv(time_to_", event, ", ", event, ") ~ . + rcs(time_to_cpap_start) + rcs(time_to_cpap_end)"))
      } 
    } else {
      # In the time-dependent formulas, the time and event columns are start, stop, event always
      list_forms[[paste0("form_", time_setting, "_spl")]] <- update(base_form, "Surv(start, stop, event) ~ .")
  }
}

# Add spline or categorized variables, respectively
for (type in c("spline", "categorized")) {
  i <- 1
  for (form_name in names(list_forms)) {
    if (grepl("_spl", form_name)) {
      list_forms[[i]] <- update(list_forms[[i]], paste(". ~ . + rcs(hba1c) + rcs(GFR) + rcs(kolesterol) + rcs(systoliskt) + rcs(alder):rcs(GFR) + factor(cpap_treated):rcs(GFR)"))
    } else if (grepl("_cat", form_name)) {
      list_forms[[i]] <- update(list_forms[[i]], paste(". ~ . + factor(hba1c_high) + factor(GFR_high) + factor(kolesterol_high) + factor(systoliskt_high) + rcs(alder):factor(GFR_high) + factor(cpap_treated):factor(GFR_high)"))
    }
    i <- i + 1
  } 
}

# Create a copy that has sleep data for Group 2
list_forms_sleep <- list_forms
i <- 1
for (form in list_forms) {
  list_forms_sleep[[i]] <- update(form, ". ~ . + rcs(IV_AHI) + rcs(IV_ODI) + rcs(IV_AverageSaturation)")
  i <- i + 1
}

Death

Time-dependent

Group 1

# formula_cat_tdep, 
run_models(c(list_forms[["form_tdep_spl"]], list_forms[["form_tdep_cat"]]), df_death_tv_train, df_death_tv_test, "stop", "event", cont_var, "prof_death_dep_g1.html")

## [1] "### FORMULA 1 ###"

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in abs(bini)^gamma: longer object length is not a multiple of shorter
## object length

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in abs(bini)^gamma: longer object length is not a multiple of shorter
## object length

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in abs(bini)^gamma: longer object length is not a multiple of shorter
## object length

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in abs(bini)^gamma: longer object length is not a multiple of shorter
## object length

## [1] "--- DAC RESULTS ---"
## 
## Divide-and-conquer adaptive lasso for a  Cox PH  model, n= 7284917 .
## 
## Initial estimator computed for K= 20 and one-step estimation with 2 iterations.
## 
## Penalized summary:
##                                                       Penalized Est  Std. Error
## factor(cpap_treated)1                                    -0.3702846   0.2118433
## rcs(alder)alder                                           0.7014610   0.2573131
## rcs(alder)alder'                                          0.0862635   0.7567930
## rcs(alder)alder''                                        -0.0533951   3.5724664
## rcs(alder)alder'''                                        3.8131610   5.7404454
## factor(sex)1                                             -0.3292682   0.0057118
## rcs(bmi)bmi                                              -0.5954298   0.1999532
## rcs(bmi)bmi'                                              1.2133429   1.8148657
## rcs(bmi)bmi''                                            -0.3505252   8.1685663
## rcs(bmi)bmi'''                                           -3.8370442  10.1701057
## factor(rokare)1                                           0.4231005   0.0073617
## factor(ami_history)1                                      0.1967525   0.0085838
## factor(stroke_history)1                                   0.3384400   0.0092799
## factor(Civil)1                                           -0.1231831   0.0076453
## factor(HushallsTyp_RTB)2                                 -0.2409332   0.0065973
## factor(HushallsTyp_RTB)3                                 -0.0701581   0.0101050
## factor(Sun2000niva_old)2                                  0.0332077   0.0095251
## factor(Sun2000niva_old)3                                 -0.0336706   0.0064250
## factor(Sun2000niva_old)4                                 -0.0650482   0.0093037
## factor(Sun2000niva_old)5                                 -0.1150355   0.0109223
## factor(Sun2000niva_old)6                                 -0.1599910   0.0108673
## factor(Sun2000niva_old)7                                 -0.2739015   0.0368690
## rcs(DispInkKEHB04)DispInkKEHB04                           0.0179591   0.0487995
## rcs(DispInkKEHB04)DispInkKEHB04'                         -4.7775790   1.1391093
## rcs(DispInkKEHB04)DispInkKEHB04''                         5.1572988   3.6635849
## rcs(DispInkKEHB04)DispInkKEHB04'''                        5.9487527   3.6461371
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk               0.5347487   0.1014848
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'             -6.7562238  48.4929447
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''             0.0833598  52.6247577
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''           12.1488546   4.7626437
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                   1.2959907   0.1566974
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'                -51.9994227 239.2448663
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''                 6.9517771 276.6783305
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''               59.2523570  38.4404456
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk                 0.4058300   0.0695553
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'               -8.4086246  13.1106866
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''               7.9119941  13.7428116
## factor(FodelseLand_EU27_2020)1                            0.1256849   0.0074949
## factor(antithrombotic_agents)1                            0.2183877   0.0057524
## factor(antihypertensive_comb)1                           -0.0240591   0.0057563
## factor(lipid_modifying_agents)1                          -0.1420829   0.0056154
## rcs(hba1c)hba1c                                          -0.5860117   0.0185339
## rcs(hba1c)hba1c'                                          4.6428365   0.2563693
## rcs(hba1c)hba1c''                                        -9.3773059   0.8941112
## rcs(hba1c)hba1c'''                                        3.0858645   0.9225841
## rcs(GFR)GFR                                              -1.0289514   0.1274711
## rcs(GFR)GFR'                                              2.1926888   0.9366031
## rcs(GFR)GFR''                                            -6.2568750   5.3387520
## rcs(GFR)GFR'''                                            6.7421385   8.4230323
## rcs(kolesterol)kolesterol                                -0.3447791   0.0130239
## rcs(kolesterol)kolesterol'                                3.1101048   0.0995579
## rcs(kolesterol)kolesterol''                             -11.5425546   0.3908515
## rcs(kolesterol)kolesterol'''                             14.6700143   0.5692163
## rcs(systoliskt)systoliskt                                -0.4954975   0.0087708
## rcs(systoliskt)systoliskt'                                1.1388124   0.0701941
## rcs(systoliskt)systoliskt''                              -3.0954108   0.3632794
## rcs(systoliskt)systoliskt'''                              3.2070597   0.6702091
## factor(cpap_treated)1:factor(antithrombotic_agents)1      0.0570500   0.0880402
## factor(cpap_treated)1:factor(antihypertensive_comb)1      0.0054404   0.0952475
## factor(cpap_treated)1:factor(lipid_modifying_agents)1     0.1415617   0.0887676
## rcs(alder)alder:rcs(bmi)bmi                              -0.0466390   0.1580380
## rcs(alder)alder':rcs(bmi)bmi                              0.0445031   0.4916397
## rcs(alder)alder'':rcs(bmi)bmi                            -1.2033376   2.3968935
## rcs(alder)alder''':rcs(bmi)bmi                            5.3885788   3.9430612
## rcs(alder)alder:rcs(bmi)bmi'                             -0.2805040   1.4548125
## rcs(alder)alder':rcs(bmi)bmi'                             1.0474600   4.4599453
## rcs(alder)alder'':rcs(bmi)bmi'                            0.6287234  21.6387038
## rcs(alder)alder''':rcs(bmi)bmi'                          -9.3240012  35.6521830
## rcs(alder)alder:rcs(bmi)bmi''                             1.7636820   6.5340169
## rcs(alder)alder':rcs(bmi)bmi''                           -1.9760830  20.1078644
## rcs(alder)alder'':rcs(bmi)bmi''                         -10.6057440  97.9437203
## rcs(alder)alder''':rcs(bmi)bmi''                          1.9166859 162.3358432
## rcs(alder)alder:rcs(bmi)bmi'''                           -2.6591145   8.1013934
## rcs(alder)alder':rcs(bmi)bmi'''                          -1.0528018  25.0910062
## rcs(alder)alder'':rcs(bmi)bmi'''                         24.8782607 122.8946055
## rcs(alder)alder''':rcs(bmi)bmi'''                        30.5731525 205.1694907
## rcs(alder)alder:rcs(GFR)GFR                               0.0735488   0.1050075
## rcs(alder)alder':rcs(GFR)GFR                              0.0165337   0.3115956
## rcs(alder)alder'':rcs(GFR)GFR                             0.1608518   1.4810759
## rcs(alder)alder''':rcs(GFR)GFR                            0.0097614   2.4032458
## rcs(alder)alder:rcs(GFR)GFR'                              0.5071164   0.7813677
## rcs(alder)alder':rcs(GFR)GFR'                            -0.0137708   2.2778916
## rcs(alder)alder'':rcs(GFR)GFR'                            1.0769411  10.7266639
## rcs(alder)alder''':rcs(GFR)GFR'                          -5.3499131  17.2842977
## rcs(alder)alder:rcs(GFR)GFR''                            -2.0998377   4.3992407
## rcs(alder)alder':rcs(GFR)GFR''                            1.7104552  13.0724842
## rcs(alder)alder'':rcs(GFR)GFR''                          -7.8073929  62.6672546
## rcs(alder)alder''':rcs(GFR)GFR''                         -4.8016665 103.2071258
## rcs(alder)alder:rcs(GFR)GFR'''                            1.9219810   6.8396257
## rcs(alder)alder':rcs(GFR)GFR'''                          -4.2713499  20.7990399
## rcs(alder)alder'':rcs(GFR)GFR'''                          2.2003491 101.7871895
## rcs(alder)alder''':rcs(GFR)GFR'''                        84.7050416 171.7459954
## factor(cpap_treated)1:rcs(GFR)GFR                        -0.0227394   0.1198867
## factor(cpap_treated)1:rcs(GFR)GFR'                       -0.0659945   0.9028629
## factor(cpap_treated)1:rcs(GFR)GFR''                      -0.9819877   5.5678850
## factor(cpap_treated)1:rcs(GFR)GFR'''                      4.6568372   9.4186419
##                                                        z value  Pr(>|z|)    
## factor(cpap_treated)1                                  -1.7479 0.0804784 .  
## rcs(alder)alder                                         2.7261 0.0064088 ** 
## rcs(alder)alder'                                        0.1140 0.9092492    
## rcs(alder)alder''                                      -0.0149 0.9880750    
## rcs(alder)alder'''                                      0.6643 0.5065225    
## factor(sex)1                                          -57.6469 < 2.2e-16 ***
## rcs(bmi)bmi                                            -2.9778 0.0029028 ** 
## rcs(bmi)bmi'                                            0.6686 0.5037775    
## rcs(bmi)bmi''                                          -0.0429 0.9657721    
## rcs(bmi)bmi'''                                         -0.3773 0.7059607    
## factor(rokare)1                                        57.4730 < 2.2e-16 ***
## factor(ami_history)1                                   22.9215 < 2.2e-16 ***
## factor(stroke_history)1                                36.4704 < 2.2e-16 ***
## factor(Civil)1                                        -16.1122 < 2.2e-16 ***
## factor(HushallsTyp_RTB)2                              -36.5199 < 2.2e-16 ***
## factor(HushallsTyp_RTB)3                               -6.9429 3.842e-12 ***
## factor(Sun2000niva_old)2                                3.4863 0.0004897 ***
## factor(Sun2000niva_old)3                               -5.2406 1.601e-07 ***
## factor(Sun2000niva_old)4                               -6.9916 2.717e-12 ***
## factor(Sun2000niva_old)5                              -10.5322 < 2.2e-16 ***
## factor(Sun2000niva_old)6                              -14.7223 < 2.2e-16 ***
## factor(Sun2000niva_old)7                               -7.4291 1.094e-13 ***
## rcs(DispInkKEHB04)DispInkKEHB04                         0.3680 0.7128600    
## rcs(DispInkKEHB04)DispInkKEHB04'                       -4.1941 2.739e-05 ***
## rcs(DispInkKEHB04)DispInkKEHB04''                       1.4077 0.1592142    
## rcs(DispInkKEHB04)DispInkKEHB04'''                      1.6315 0.1027802    
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk             5.2693 1.370e-07 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'           -0.1393 0.8891942    
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''           0.0016 0.9987361    
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''          2.5509 0.0107456 *  
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                 8.2707 < 2.2e-16 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'               -0.2173 0.8279371    
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''               0.0251 0.9799546    
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''              1.5414 0.1232179    
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk               5.8346 5.391e-09 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'             -0.6414 0.5212911    
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''             0.5757 0.5648053    
## factor(FodelseLand_EU27_2020)1                         16.7695 < 2.2e-16 ***
## factor(antithrombotic_agents)1                         37.9647 < 2.2e-16 ***
## factor(antihypertensive_comb)1                         -4.1796 2.920e-05 ***
## factor(lipid_modifying_agents)1                       -25.3022 < 2.2e-16 ***
## rcs(hba1c)hba1c                                       -31.6183 < 2.2e-16 ***
## rcs(hba1c)hba1c'                                       18.1100 < 2.2e-16 ***
## rcs(hba1c)hba1c''                                     -10.4879 < 2.2e-16 ***
## rcs(hba1c)hba1c'''                                      3.3448 0.0008234 ***
## rcs(GFR)GFR                                            -8.0720 6.914e-16 ***
## rcs(GFR)GFR'                                            2.3411 0.0192266 *  
## rcs(GFR)GFR''                                          -1.1720 0.2412078    
## rcs(GFR)GFR'''                                          0.8004 0.4234555    
## rcs(kolesterol)kolesterol                             -26.4728 < 2.2e-16 ***
## rcs(kolesterol)kolesterol'                             31.2391 < 2.2e-16 ***
## rcs(kolesterol)kolesterol''                           -29.5318 < 2.2e-16 ***
## rcs(kolesterol)kolesterol'''                           25.7723 < 2.2e-16 ***
## rcs(systoliskt)systoliskt                             -56.4939 < 2.2e-16 ***
## rcs(systoliskt)systoliskt'                             16.2238 < 2.2e-16 ***
## rcs(systoliskt)systoliskt''                            -8.5207 < 2.2e-16 ***
## rcs(systoliskt)systoliskt'''                            4.7852 1.708e-06 ***
## factor(cpap_treated)1:factor(antithrombotic_agents)1    0.6480 0.5169852    
## factor(cpap_treated)1:factor(antihypertensive_comb)1    0.0571 0.9544505    
## factor(cpap_treated)1:factor(lipid_modifying_agents)1   1.5947 0.1107691    
## rcs(alder)alder:rcs(bmi)bmi                            -0.2951 0.7679077    
## rcs(alder)alder':rcs(bmi)bmi                            0.0905 0.9278742    
## rcs(alder)alder'':rcs(bmi)bmi                          -0.5020 0.6156391    
## rcs(alder)alder''':rcs(bmi)bmi                          1.3666 0.1717514    
## rcs(alder)alder:rcs(bmi)bmi'                           -0.1928 0.8471069    
## rcs(alder)alder':rcs(bmi)bmi'                           0.2349 0.8143179    
## rcs(alder)alder'':rcs(bmi)bmi'                          0.0291 0.9768203    
## rcs(alder)alder''':rcs(bmi)bmi'                        -0.2615 0.7936863    
## rcs(alder)alder:rcs(bmi)bmi''                           0.2699 0.7872194    
## rcs(alder)alder':rcs(bmi)bmi''                         -0.0983 0.9217146    
## rcs(alder)alder'':rcs(bmi)bmi''                        -0.1083 0.9137704    
## rcs(alder)alder''':rcs(bmi)bmi''                        0.0118 0.9905797    
## rcs(alder)alder:rcs(bmi)bmi'''                         -0.3282 0.7427383    
## rcs(alder)alder':rcs(bmi)bmi'''                        -0.0420 0.9665311    
## rcs(alder)alder'':rcs(bmi)bmi'''                        0.2024 0.8395761    
## rcs(alder)alder''':rcs(bmi)bmi'''                       0.1490 0.8815425    
## rcs(alder)alder:rcs(GFR)GFR                             0.7004 0.4836685    
## rcs(alder)alder':rcs(GFR)GFR                            0.0531 0.9576830    
## rcs(alder)alder'':rcs(GFR)GFR                           0.1086 0.9135160    
## rcs(alder)alder''':rcs(GFR)GFR                          0.0041 0.9967592    
## rcs(alder)alder:rcs(GFR)GFR'                            0.6490 0.5163311    
## rcs(alder)alder':rcs(GFR)GFR'                          -0.0060 0.9951765    
## rcs(alder)alder'':rcs(GFR)GFR'                          0.1004 0.9200279    
## rcs(alder)alder''':rcs(GFR)GFR'                        -0.3095 0.7569226    
## rcs(alder)alder:rcs(GFR)GFR''                          -0.4773 0.6331355    
## rcs(alder)alder':rcs(GFR)GFR''                          0.1308 0.8958988    
## rcs(alder)alder'':rcs(GFR)GFR''                        -0.1246 0.9008522    
## rcs(alder)alder''':rcs(GFR)GFR''                       -0.0465 0.9628922    
## rcs(alder)alder:rcs(GFR)GFR'''                          0.2810 0.7787052    
## rcs(alder)alder':rcs(GFR)GFR'''                        -0.2054 0.8372887    
## rcs(alder)alder'':rcs(GFR)GFR'''                        0.0216 0.9827534    
## rcs(alder)alder''':rcs(GFR)GFR'''                       0.4932 0.6218716    
## factor(cpap_treated)1:rcs(GFR)GFR                      -0.1897 0.8495646    
## factor(cpap_treated)1:rcs(GFR)GFR'                     -0.0731 0.9417308    
## factor(cpap_treated)1:rcs(GFR)GFR''                    -0.1764 0.8600061    
## factor(cpap_treated)1:rcs(GFR)GFR'''                    0.4944 0.6210042    
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
## BIC =  8202.851  with lambda =  1e-10 
## [1] "--- SURVIVAL RESULTS ---"
## Call:
## coxph(formula = form, data = df_train, x = T)
## 
##   n= 7284917, number of events= 159570 
## 
##                                                              coef   exp(coef)
## factor(cpap_treated)1                                  -3.491e-01   7.053e-01
## rcs(alder)alder                                         8.430e-01   2.323e+00
## rcs(alder)alder'                                       -9.272e-01   3.956e-01
## rcs(alder)alder''                                       8.868e+00   7.102e+03
## rcs(alder)alder'''                                     -1.713e+01   3.629e-08
## factor(sex)1                                           -3.344e-01   7.158e-01
## rcs(bmi)bmi                                            -4.605e-01   6.310e-01
## rcs(bmi)bmi'                                           -2.060e+00   1.274e-01
## rcs(bmi)bmi''                                           1.858e+01   1.171e+08
## rcs(bmi)bmi'''                                         -3.097e+01   3.547e-14
## factor(rokare)1                                         4.104e-01   1.507e+00
## factor(ami_history)1                                    1.921e-01   1.212e+00
## factor(stroke_history)1                                 3.347e-01   1.397e+00
## factor(Civil)1                                         -9.581e-02   9.086e-01
## factor(HushallsTyp_RTB)2                               -2.228e-01   8.003e-01
## factor(HushallsTyp_RTB)3                               -5.235e-02   9.490e-01
## factor(Sun2000niva_old)2                                2.359e-02   1.024e+00
## factor(Sun2000niva_old)3                               -4.179e-02   9.591e-01
## factor(Sun2000niva_old)4                               -6.685e-02   9.353e-01
## factor(Sun2000niva_old)5                               -1.126e-01   8.935e-01
## factor(Sun2000niva_old)6                               -1.563e-01   8.553e-01
## factor(Sun2000niva_old)7                               -2.503e-01   7.785e-01
## rcs(DispInkKEHB04)DispInkKEHB04                         3.049e-02   1.031e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                       -8.868e+00   1.408e-04
## rcs(DispInkKEHB04)DispInkKEHB04''                       1.663e+01   1.669e+07
## rcs(DispInkKEHB04)DispInkKEHB04'''                     -3.176e+00   4.175e-02
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk             2.932e+00   1.877e+01
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'           -1.314e+03   0.000e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''           1.421e+03         Inf
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''         -1.194e+02   1.356e-52
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                 9.405e+00   1.215e+04
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'               -1.286e+04   0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''               1.482e+04         Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''             -1.990e+03   0.000e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk               2.237e+00   9.368e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'             -3.878e+02  3.668e-169
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''             4.059e+02  1.902e+176
## factor(FodelseLand_EU27_2020)1                          1.618e-01   1.176e+00
## factor(antithrombotic_agents)1                          2.227e-01   1.249e+00
## factor(antihypertensive_comb)1                         -8.805e-03   9.912e-01
## factor(lipid_modifying_agents)1                        -1.297e-01   8.784e-01
## rcs(hba1c)hba1c                                        -7.704e-01   4.628e-01
## rcs(hba1c)hba1c'                                        7.633e+00   2.066e+03
## rcs(hba1c)hba1c''                                      -1.984e+01   2.415e-09
## rcs(hba1c)hba1c'''                                      1.357e+01   7.836e+05
## rcs(GFR)GFR                                            -1.186e+00   3.053e-01
## rcs(GFR)GFR'                                            2.109e+00   8.237e+00
## rcs(GFR)GFR''                                          -2.106e+00   1.217e-01
## rcs(GFR)GFR'''                                         -3.522e+00   2.955e-02
## rcs(kolesterol)kolesterol                              -3.593e-01   6.982e-01
## rcs(kolesterol)kolesterol'                              3.209e+00   2.475e+01
## rcs(kolesterol)kolesterol''                            -1.187e+01   6.983e-06
## rcs(kolesterol)kolesterol'''                            1.504e+01   3.401e+06
## rcs(systoliskt)systoliskt                              -4.990e-01   6.072e-01
## rcs(systoliskt)systoliskt'                              1.222e+00   3.395e+00
## rcs(systoliskt)systoliskt''                            -3.565e+00   2.830e-02
## rcs(systoliskt)systoliskt'''                            4.062e+00   5.807e+01
## factor(cpap_treated)1:factor(antithrombotic_agents)1    4.827e-02   1.049e+00
## factor(cpap_treated)1:factor(antihypertensive_comb)1    1.350e-02   1.014e+00
## factor(cpap_treated)1:factor(lipid_modifying_agents)1   1.272e-01   1.136e+00
## rcs(alder)alder:rcs(bmi)bmi                             4.151e-01   1.514e+00
## rcs(alder)alder':rcs(bmi)bmi                           -1.433e+00   2.387e-01
## rcs(alder)alder'':rcs(bmi)bmi                           8.717e+00   6.108e+03
## rcs(alder)alder''':rcs(bmi)bmi                         -1.593e+01   1.203e-07
## rcs(alder)alder:rcs(bmi)bmi'                           -4.821e+00   8.062e-03
## rcs(alder)alder':rcs(bmi)bmi'                           1.789e+01   5.864e+07
## rcs(alder)alder'':rcs(bmi)bmi'                         -9.656e+01   1.161e-42
## rcs(alder)alder''':rcs(bmi)bmi'                         1.701e+02   7.177e+73
## rcs(alder)alder:rcs(bmi)bmi''                           2.136e+01   1.892e+09
## rcs(alder)alder':rcs(bmi)bmi''                         -8.295e+01   9.415e-37
## rcs(alder)alder'':rcs(bmi)bmi''                         4.341e+02  3.435e+188
## rcs(alder)alder''':rcs(bmi)bmi''                       -7.630e+02   0.000e+00
## rcs(alder)alder:rcs(bmi)bmi'''                         -2.547e+01   8.673e-12
## rcs(alder)alder':rcs(bmi)bmi'''                         1.026e+02   3.463e+44
## rcs(alder)alder'':rcs(bmi)bmi'''                       -5.244e+02  1.829e-228
## rcs(alder)alder''':rcs(bmi)bmi'''                       9.216e+02         Inf
## rcs(alder)alder:rcs(GFR)GFR                            -1.456e-01   8.645e-01
## rcs(alder)alder':rcs(GFR)GFR                            3.106e-01   1.364e+00
## rcs(alder)alder'':rcs(GFR)GFR                          -4.197e-01   6.572e-01
## rcs(alder)alder''':rcs(GFR)GFR                          1.789e-01   1.196e+00
## rcs(alder)alder:rcs(GFR)GFR'                            1.304e+00   3.683e+00
## rcs(alder)alder':rcs(GFR)GFR'                           7.749e-01   2.170e+00
## rcs(alder)alder'':rcs(GFR)GFR'                         -6.652e+00   1.291e-03
## rcs(alder)alder''':rcs(GFR)GFR'                         5.848e+00   3.466e+02
## rcs(alder)alder:rcs(GFR)GFR''                          -3.526e+00   2.942e-02
## rcs(alder)alder':rcs(GFR)GFR''                         -9.729e+00   5.954e-05
## rcs(alder)alder'':rcs(GFR)GFR''                         4.940e+01   2.855e+21
## rcs(alder)alder''':rcs(GFR)GFR''                       -4.815e+01   1.230e-21
## rcs(alder)alder:rcs(GFR)GFR'''                          6.054e-01   1.832e+00
## rcs(alder)alder':rcs(GFR)GFR'''                         1.954e+01   3.058e+08
## rcs(alder)alder'':rcs(GFR)GFR'''                       -8.623e+01   3.568e-38
## rcs(alder)alder''':rcs(GFR)GFR'''                       9.395e+01   6.336e+40
## factor(cpap_treated)1:rcs(GFR)GFR                      -2.114e-02   9.791e-01
## factor(cpap_treated)1:rcs(GFR)GFR'                     -3.587e-01   6.986e-01
## factor(cpap_treated)1:rcs(GFR)GFR''                     2.194e+00   8.968e+00
## factor(cpap_treated)1:rcs(GFR)GFR'''                   -2.697e+00   6.740e-02
##                                                          se(coef)       z
## factor(cpap_treated)1                                   2.214e-01  -1.576
## rcs(alder)alder                                         2.612e-01   3.227
## rcs(alder)alder'                                        7.654e-01  -1.211
## rcs(alder)alder''                                       3.603e+00   2.461
## rcs(alder)alder'''                                      5.774e+00  -2.967
## factor(sex)1                                            5.711e-03 -58.551
## rcs(bmi)bmi                                             2.040e-01  -2.257
## rcs(bmi)bmi'                                            1.843e+00  -1.118
## rcs(bmi)bmi''                                           8.299e+00   2.239
## rcs(bmi)bmi'''                                          1.035e+01  -2.991
## factor(rokare)1                                         7.366e-03  55.716
## factor(ami_history)1                                    8.580e-03  22.386
## factor(stroke_history)1                                 9.273e-03  36.091
## factor(Civil)1                                          7.640e-03 -12.541
## factor(HushallsTyp_RTB)2                                6.597e-03 -33.775
## factor(HushallsTyp_RTB)3                                1.011e-02  -5.178
## factor(Sun2000niva_old)2                                9.530e-03   2.476
## factor(Sun2000niva_old)3                                6.421e-03  -6.508
## factor(Sun2000niva_old)4                                9.303e-03  -7.185
## factor(Sun2000niva_old)5                                1.092e-02 -10.312
## factor(Sun2000niva_old)6                                1.087e-02 -14.373
## factor(Sun2000niva_old)7                                3.765e-02  -6.650
## rcs(DispInkKEHB04)DispInkKEHB04                         5.807e-02   0.525
## rcs(DispInkKEHB04)DispInkKEHB04'                        1.218e+00  -7.279
## rcs(DispInkKEHB04)DispInkKEHB04''                       3.832e+00   4.340
## rcs(DispInkKEHB04)DispInkKEHB04'''                      3.746e+00  -0.848
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk             1.021e-01  28.708
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'            4.879e+01 -26.930
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''           5.294e+01  26.843
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''          4.791e+00 -24.927
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                 1.571e-01  59.851
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'                2.403e+02 -53.528
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''               2.780e+02  53.319
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''              3.864e+01 -51.492
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk               6.982e-02  32.041
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'              1.320e+01 -29.378
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''             1.384e+01  29.330
## factor(FodelseLand_EU27_2020)1                          7.500e-03  21.574
## factor(antithrombotic_agents)1                          5.750e-03  38.735
## factor(antihypertensive_comb)1                          5.755e-03  -1.530
## factor(lipid_modifying_agents)1                         5.613e-03 -23.106
## rcs(hba1c)hba1c                                         1.856e-02 -41.515
## rcs(hba1c)hba1c'                                        2.565e-01  29.759
## rcs(hba1c)hba1c''                                       8.944e-01 -22.184
## rcs(hba1c)hba1c'''                                      9.227e-01  14.709
## rcs(GFR)GFR                                             1.289e-01  -9.206
## rcs(GFR)GFR'                                            9.454e-01   2.230
## rcs(GFR)GFR''                                           5.394e+00  -0.390
## rcs(GFR)GFR'''                                          8.526e+00  -0.413
## rcs(kolesterol)kolesterol                               1.303e-02 -27.569
## rcs(kolesterol)kolesterol'                              9.959e-02  32.223
## rcs(kolesterol)kolesterol''                             3.909e-01 -30.369
## rcs(kolesterol)kolesterol'''                            5.693e-01  26.419
## rcs(systoliskt)systoliskt                               8.774e-03 -56.867
## rcs(systoliskt)systoliskt'                              7.020e-02  17.412
## rcs(systoliskt)systoliskt''                             3.632e-01  -9.814
## rcs(systoliskt)systoliskt'''                            6.701e-01   6.062
## factor(cpap_treated)1:factor(antithrombotic_agents)1    9.261e-02   0.521
## factor(cpap_treated)1:factor(antihypertensive_comb)1    1.019e-01   0.132
## factor(cpap_treated)1:factor(lipid_modifying_agents)1   9.385e-02   1.356
## rcs(alder)alder:rcs(bmi)bmi                             1.620e-01   2.562
## rcs(alder)alder':rcs(bmi)bmi                            5.007e-01  -2.862
## rcs(alder)alder'':rcs(bmi)bmi                           2.430e+00   3.588
## rcs(alder)alder''':rcs(bmi)bmi                          3.982e+00  -4.002
## rcs(alder)alder:rcs(bmi)bmi'                            1.482e+00  -3.253
## rcs(alder)alder':rcs(bmi)bmi'                           4.522e+00   3.956
## rcs(alder)alder'':rcs(bmi)bmi'                          2.186e+01  -4.417
## rcs(alder)alder''':rcs(bmi)bmi'                         3.591e+01   4.736
## rcs(alder)alder:rcs(bmi)bmi''                           6.661e+00   3.207
## rcs(alder)alder':rcs(bmi)bmi''                          2.040e+01  -4.066
## rcs(alder)alder'':rcs(bmi)bmi''                         9.902e+01   4.384
## rcs(alder)alder''':rcs(bmi)bmi''                        1.636e+02  -4.664
## rcs(alder)alder:rcs(bmi)bmi'''                          8.278e+00  -3.077
## rcs(alder)alder':rcs(bmi)bmi'''                         2.551e+01   4.021
## rcs(alder)alder'':rcs(bmi)bmi'''                        1.244e+02  -4.214
## rcs(alder)alder''':rcs(bmi)bmi'''                       2.070e+02   4.451
## rcs(alder)alder:rcs(GFR)GFR                             1.063e-01  -1.369
## rcs(alder)alder':rcs(GFR)GFR                            3.147e-01   0.987
## rcs(alder)alder'':rcs(GFR)GFR                           1.492e+00  -0.281
## rcs(alder)alder''':rcs(GFR)GFR                          2.415e+00   0.074
## rcs(alder)alder:rcs(GFR)GFR'                            7.901e-01   1.650
## rcs(alder)alder':rcs(GFR)GFR'                           2.297e+00   0.337
## rcs(alder)alder'':rcs(GFR)GFR'                          1.079e+01  -0.616
## rcs(alder)alder''':rcs(GFR)GFR'                         1.735e+01   0.337
## rcs(alder)alder:rcs(GFR)GFR''                           4.453e+00  -0.792
## rcs(alder)alder':rcs(GFR)GFR''                          1.319e+01  -0.737
## rcs(alder)alder'':rcs(GFR)GFR''                         6.311e+01   0.783
## rcs(alder)alder''':rcs(GFR)GFR''                        1.037e+02  -0.464
## rcs(alder)alder:rcs(GFR)GFR'''                          6.939e+00   0.087
## rcs(alder)alder':rcs(GFR)GFR'''                         2.103e+01   0.929
## rcs(alder)alder'':rcs(GFR)GFR'''                        1.027e+02  -0.840
## rcs(alder)alder''':rcs(GFR)GFR'''                       1.728e+02   0.544
## factor(cpap_treated)1:rcs(GFR)GFR                       1.248e-01  -0.169
## factor(cpap_treated)1:rcs(GFR)GFR'                      9.541e-01  -0.376
## factor(cpap_treated)1:rcs(GFR)GFR''                     6.005e+00   0.365
## factor(cpap_treated)1:rcs(GFR)GFR'''                    1.039e+01  -0.259
##                                                       Pr(>|z|)    
## factor(cpap_treated)1                                 0.114925    
## rcs(alder)alder                                       0.001249 ** 
## rcs(alder)alder'                                      0.225728    
## rcs(alder)alder''                                     0.013845 *  
## rcs(alder)alder'''                                    0.003005 ** 
## factor(sex)1                                           < 2e-16 ***
## rcs(bmi)bmi                                           0.023990 *  
## rcs(bmi)bmi'                                          0.263579    
## rcs(bmi)bmi''                                         0.025184 *  
## rcs(bmi)bmi'''                                        0.002777 ** 
## factor(rokare)1                                        < 2e-16 ***
## factor(ami_history)1                                   < 2e-16 ***
## factor(stroke_history)1                                < 2e-16 ***
## factor(Civil)1                                         < 2e-16 ***
## factor(HushallsTyp_RTB)2                               < 2e-16 ***
## factor(HushallsTyp_RTB)3                              2.25e-07 ***
## factor(Sun2000niva_old)2                              0.013292 *  
## factor(Sun2000niva_old)3                              7.62e-11 ***
## factor(Sun2000niva_old)4                              6.72e-13 ***
## factor(Sun2000niva_old)5                               < 2e-16 ***
## factor(Sun2000niva_old)6                               < 2e-16 ***
## factor(Sun2000niva_old)7                              2.94e-11 ***
## rcs(DispInkKEHB04)DispInkKEHB04                       0.599567    
## rcs(DispInkKEHB04)DispInkKEHB04'                      3.37e-13 ***
## rcs(DispInkKEHB04)DispInkKEHB04''                     1.42e-05 ***
## rcs(DispInkKEHB04)DispInkKEHB04'''                    0.396494    
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk            < 2e-16 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'           < 2e-16 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''          < 2e-16 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''         < 2e-16 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                < 2e-16 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'               < 2e-16 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''              < 2e-16 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''             < 2e-16 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk              < 2e-16 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'             < 2e-16 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''            < 2e-16 ***
## factor(FodelseLand_EU27_2020)1                         < 2e-16 ***
## factor(antithrombotic_agents)1                         < 2e-16 ***
## factor(antihypertensive_comb)1                        0.125984    
## factor(lipid_modifying_agents)1                        < 2e-16 ***
## rcs(hba1c)hba1c                                        < 2e-16 ***
## rcs(hba1c)hba1c'                                       < 2e-16 ***
## rcs(hba1c)hba1c''                                      < 2e-16 ***
## rcs(hba1c)hba1c'''                                     < 2e-16 ***
## rcs(GFR)GFR                                            < 2e-16 ***
## rcs(GFR)GFR'                                          0.025716 *  
## rcs(GFR)GFR''                                         0.696227    
## rcs(GFR)GFR'''                                        0.679586    
## rcs(kolesterol)kolesterol                              < 2e-16 ***
## rcs(kolesterol)kolesterol'                             < 2e-16 ***
## rcs(kolesterol)kolesterol''                            < 2e-16 ***
## rcs(kolesterol)kolesterol'''                           < 2e-16 ***
## rcs(systoliskt)systoliskt                              < 2e-16 ***
## rcs(systoliskt)systoliskt'                             < 2e-16 ***
## rcs(systoliskt)systoliskt''                            < 2e-16 ***
## rcs(systoliskt)systoliskt'''                          1.35e-09 ***
## factor(cpap_treated)1:factor(antithrombotic_agents)1  0.602234    
## factor(cpap_treated)1:factor(antihypertensive_comb)1  0.894612    
## factor(cpap_treated)1:factor(lipid_modifying_agents)1 0.175254    
## rcs(alder)alder:rcs(bmi)bmi                           0.010422 *  
## rcs(alder)alder':rcs(bmi)bmi                          0.004215 ** 
## rcs(alder)alder'':rcs(bmi)bmi                         0.000334 ***
## rcs(alder)alder''':rcs(bmi)bmi                        6.29e-05 ***
## rcs(alder)alder:rcs(bmi)bmi'                          0.001143 ** 
## rcs(alder)alder':rcs(bmi)bmi'                         7.63e-05 ***
## rcs(alder)alder'':rcs(bmi)bmi'                        1.00e-05 ***
## rcs(alder)alder''':rcs(bmi)bmi'                       2.18e-06 ***
## rcs(alder)alder:rcs(bmi)bmi''                         0.001342 ** 
## rcs(alder)alder':rcs(bmi)bmi''                        4.78e-05 ***
## rcs(alder)alder'':rcs(bmi)bmi''                       1.16e-05 ***
## rcs(alder)alder''':rcs(bmi)bmi''                      3.09e-06 ***
## rcs(alder)alder:rcs(bmi)bmi'''                        0.002091 ** 
## rcs(alder)alder':rcs(bmi)bmi'''                       5.80e-05 ***
## rcs(alder)alder'':rcs(bmi)bmi'''                      2.51e-05 ***
## rcs(alder)alder''':rcs(bmi)bmi'''                     8.53e-06 ***
## rcs(alder)alder:rcs(GFR)GFR                           0.170884    
## rcs(alder)alder':rcs(GFR)GFR                          0.323506    
## rcs(alder)alder'':rcs(GFR)GFR                         0.778472    
## rcs(alder)alder''':rcs(GFR)GFR                        0.940951    
## rcs(alder)alder:rcs(GFR)GFR'                          0.098895 .  
## rcs(alder)alder':rcs(GFR)GFR'                         0.735856    
## rcs(alder)alder'':rcs(GFR)GFR'                        0.537682    
## rcs(alder)alder''':rcs(GFR)GFR'                       0.736106    
## rcs(alder)alder:rcs(GFR)GFR''                         0.428451    
## rcs(alder)alder':rcs(GFR)GFR''                        0.460921    
## rcs(alder)alder'':rcs(GFR)GFR''                       0.433715    
## rcs(alder)alder''':rcs(GFR)GFR''                      0.642430    
## rcs(alder)alder:rcs(GFR)GFR'''                        0.930470    
## rcs(alder)alder':rcs(GFR)GFR'''                       0.352865    
## rcs(alder)alder'':rcs(GFR)GFR'''                      0.400921    
## rcs(alder)alder''':rcs(GFR)GFR'''                     0.586647    
## factor(cpap_treated)1:rcs(GFR)GFR                     0.865507    
## factor(cpap_treated)1:rcs(GFR)GFR'                    0.706992    
## factor(cpap_treated)1:rcs(GFR)GFR''                   0.714909    
## factor(cpap_treated)1:rcs(GFR)GFR'''                  0.795265    
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
##                                                        exp(coef) exp(-coef)
## factor(cpap_treated)1                                  7.053e-01  1.418e+00
## rcs(alder)alder                                        2.323e+00  4.304e-01
## rcs(alder)alder'                                       3.956e-01  2.528e+00
## rcs(alder)alder''                                      7.102e+03  1.408e-04
## rcs(alder)alder'''                                     3.629e-08  2.756e+07
## factor(sex)1                                           7.158e-01  1.397e+00
## rcs(bmi)bmi                                            6.310e-01  1.585e+00
## rcs(bmi)bmi'                                           1.274e-01  7.847e+00
## rcs(bmi)bmi''                                          1.171e+08  8.539e-09
## rcs(bmi)bmi'''                                         3.547e-14  2.820e+13
## factor(rokare)1                                        1.507e+00  6.634e-01
## factor(ami_history)1                                   1.212e+00  8.252e-01
## factor(stroke_history)1                                1.397e+00  7.156e-01
## factor(Civil)1                                         9.086e-01  1.101e+00
## factor(HushallsTyp_RTB)2                               8.003e-01  1.250e+00
## factor(HushallsTyp_RTB)3                               9.490e-01  1.054e+00
## factor(Sun2000niva_old)2                               1.024e+00  9.767e-01
## factor(Sun2000niva_old)3                               9.591e-01  1.043e+00
## factor(Sun2000niva_old)4                               9.353e-01  1.069e+00
## factor(Sun2000niva_old)5                               8.935e-01  1.119e+00
## factor(Sun2000niva_old)6                               8.553e-01  1.169e+00
## factor(Sun2000niva_old)7                               7.785e-01  1.284e+00
## rcs(DispInkKEHB04)DispInkKEHB04                        1.031e+00  9.700e-01
## rcs(DispInkKEHB04)DispInkKEHB04'                       1.408e-04  7.102e+03
## rcs(DispInkKEHB04)DispInkKEHB04''                      1.669e+07  5.990e-08
## rcs(DispInkKEHB04)DispInkKEHB04'''                     4.175e-02  2.395e+01
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk            1.877e+01  5.328e-02
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'           0.000e+00        Inf
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''                Inf  0.000e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''         1.356e-52  7.375e+51
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                1.215e+04  8.231e-05
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'               0.000e+00        Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''                    Inf  0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''             0.000e+00        Inf
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk              9.368e+00  1.068e-01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'            3.668e-169 2.727e+168
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''           1.902e+176 5.259e-177
## factor(FodelseLand_EU27_2020)1                         1.176e+00  8.506e-01
## factor(antithrombotic_agents)1                         1.249e+00  8.003e-01
## factor(antihypertensive_comb)1                         9.912e-01  1.009e+00
## factor(lipid_modifying_agents)1                        8.784e-01  1.138e+00
## rcs(hba1c)hba1c                                        4.628e-01  2.161e+00
## rcs(hba1c)hba1c'                                       2.066e+03  4.840e-04
## rcs(hba1c)hba1c''                                      2.415e-09  4.141e+08
## rcs(hba1c)hba1c'''                                     7.836e+05  1.276e-06
## rcs(GFR)GFR                                            3.053e-01  3.275e+00
## rcs(GFR)GFR'                                           8.237e+00  1.214e-01
## rcs(GFR)GFR''                                          1.217e-01  8.215e+00
## rcs(GFR)GFR'''                                         2.955e-02  3.384e+01
## rcs(kolesterol)kolesterol                              6.982e-01  1.432e+00
## rcs(kolesterol)kolesterol'                             2.475e+01  4.040e-02
## rcs(kolesterol)kolesterol''                            6.983e-06  1.432e+05
## rcs(kolesterol)kolesterol'''                           3.401e+06  2.940e-07
## rcs(systoliskt)systoliskt                              6.072e-01  1.647e+00
## rcs(systoliskt)systoliskt'                             3.395e+00  2.946e-01
## rcs(systoliskt)systoliskt''                            2.830e-02  3.534e+01
## rcs(systoliskt)systoliskt'''                           5.807e+01  1.722e-02
## factor(cpap_treated)1:factor(antithrombotic_agents)1   1.049e+00  9.529e-01
## factor(cpap_treated)1:factor(antihypertensive_comb)1   1.014e+00  9.866e-01
## factor(cpap_treated)1:factor(lipid_modifying_agents)1  1.136e+00  8.806e-01
## rcs(alder)alder:rcs(bmi)bmi                            1.514e+00  6.603e-01
## rcs(alder)alder':rcs(bmi)bmi                           2.387e-01  4.190e+00
## rcs(alder)alder'':rcs(bmi)bmi                          6.108e+03  1.637e-04
## rcs(alder)alder''':rcs(bmi)bmi                         1.203e-07  8.314e+06
## rcs(alder)alder:rcs(bmi)bmi'                           8.062e-03  1.240e+02
## rcs(alder)alder':rcs(bmi)bmi'                          5.864e+07  1.705e-08
## rcs(alder)alder'':rcs(bmi)bmi'                         1.161e-42  8.611e+41
## rcs(alder)alder''':rcs(bmi)bmi'                        7.177e+73  1.393e-74
## rcs(alder)alder:rcs(bmi)bmi''                          1.892e+09  5.286e-10
## rcs(alder)alder':rcs(bmi)bmi''                         9.415e-37  1.062e+36
## rcs(alder)alder'':rcs(bmi)bmi''                       3.435e+188 2.911e-189
## rcs(alder)alder''':rcs(bmi)bmi''                       0.000e+00        Inf
## rcs(alder)alder:rcs(bmi)bmi'''                         8.673e-12  1.153e+11
## rcs(alder)alder':rcs(bmi)bmi'''                        3.463e+44  2.888e-45
## rcs(alder)alder'':rcs(bmi)bmi'''                      1.829e-228 5.468e+227
## rcs(alder)alder''':rcs(bmi)bmi'''                            Inf  0.000e+00
## rcs(alder)alder:rcs(GFR)GFR                            8.645e-01  1.157e+00
## rcs(alder)alder':rcs(GFR)GFR                           1.364e+00  7.330e-01
## rcs(alder)alder'':rcs(GFR)GFR                          6.572e-01  1.522e+00
## rcs(alder)alder''':rcs(GFR)GFR                         1.196e+00  8.362e-01
## rcs(alder)alder:rcs(GFR)GFR'                           3.683e+00  2.715e-01
## rcs(alder)alder':rcs(GFR)GFR'                          2.170e+00  4.608e-01
## rcs(alder)alder'':rcs(GFR)GFR'                         1.291e-03  7.744e+02
## rcs(alder)alder''':rcs(GFR)GFR'                        3.466e+02  2.885e-03
## rcs(alder)alder:rcs(GFR)GFR''                          2.942e-02  3.400e+01
## rcs(alder)alder':rcs(GFR)GFR''                         5.954e-05  1.680e+04
## rcs(alder)alder'':rcs(GFR)GFR''                        2.855e+21  3.502e-22
## rcs(alder)alder''':rcs(GFR)GFR''                       1.230e-21  8.130e+20
## rcs(alder)alder:rcs(GFR)GFR'''                         1.832e+00  5.458e-01
## rcs(alder)alder':rcs(GFR)GFR'''                        3.058e+08  3.270e-09
## rcs(alder)alder'':rcs(GFR)GFR'''                       3.568e-38  2.802e+37
## rcs(alder)alder''':rcs(GFR)GFR'''                      6.336e+40  1.578e-41
## factor(cpap_treated)1:rcs(GFR)GFR                      9.791e-01  1.021e+00
## factor(cpap_treated)1:rcs(GFR)GFR'                     6.986e-01  1.431e+00
## factor(cpap_treated)1:rcs(GFR)GFR''                    8.968e+00  1.115e-01
## factor(cpap_treated)1:rcs(GFR)GFR'''                   6.740e-02  1.484e+01
##                                                        lower .95  upper .95
## factor(cpap_treated)1                                  4.570e-01  1.089e+00
## rcs(alder)alder                                        1.392e+00  3.876e+00
## rcs(alder)alder'                                       8.826e-02  1.773e+00
## rcs(alder)alder''                                      6.087e+00  8.287e+06
## rcs(alder)alder'''                                     4.417e-13  2.981e-03
## factor(sex)1                                           7.078e-01  7.238e-01
## rcs(bmi)bmi                                            4.230e-01  9.411e-01
## rcs(bmi)bmi'                                           3.441e-03  4.719e+00
## rcs(bmi)bmi''                                          1.010e+01  1.358e+15
## rcs(bmi)bmi'''                                         5.462e-23  2.303e-05
## factor(rokare)1                                        1.486e+00  1.529e+00
## factor(ami_history)1                                   1.192e+00  1.232e+00
## factor(stroke_history)1                                1.372e+00  1.423e+00
## factor(Civil)1                                         8.951e-01  9.223e-01
## factor(HushallsTyp_RTB)2                               7.900e-01  8.107e-01
## factor(HushallsTyp_RTB)3                               9.304e-01  9.680e-01
## factor(Sun2000niva_old)2                               1.005e+00  1.043e+00
## factor(Sun2000niva_old)3                               9.471e-01  9.712e-01
## factor(Sun2000niva_old)4                               9.184e-01  9.526e-01
## factor(Sun2000niva_old)5                               8.746e-01  9.128e-01
## factor(Sun2000niva_old)6                               8.373e-01  8.737e-01
## factor(Sun2000niva_old)7                               7.232e-01  8.382e-01
## rcs(DispInkKEHB04)DispInkKEHB04                        9.200e-01  1.155e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                       1.293e-05  1.533e-03
## rcs(DispInkKEHB04)DispInkKEHB04''                      9.140e+03  3.049e+10
## rcs(DispInkKEHB04)DispInkKEHB04'''                     2.705e-05  6.443e+01
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk            1.536e+01  2.293e+01
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'           0.000e+00  0.000e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''                Inf        Inf
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''         1.132e-56  1.624e-48
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                8.929e+03  1.653e+04
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'               0.000e+00  0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''                    Inf        Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''             0.000e+00  0.000e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk              8.169e+00  1.074e+01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'            2.124e-180 6.334e-158
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''           3.159e+164 1.145e+188
## factor(FodelseLand_EU27_2020)1                         1.158e+00  1.193e+00
## factor(antithrombotic_agents)1                         1.235e+00  1.264e+00
## factor(antihypertensive_comb)1                         9.801e-01  1.002e+00
## factor(lipid_modifying_agents)1                        8.688e-01  8.881e-01
## rcs(hba1c)hba1c                                        4.463e-01  4.800e-01
## rcs(hba1c)hba1c'                                       1.250e+03  3.416e+03
## rcs(hba1c)hba1c''                                      4.184e-10  1.394e-08
## rcs(hba1c)hba1c'''                                     1.284e+05  4.781e+06
## rcs(GFR)GFR                                            2.372e-01  3.930e-01
## rcs(GFR)GFR'                                           1.291e+00  5.253e+01
## rcs(GFR)GFR''                                          3.119e-06  4.751e+03
## rcs(GFR)GFR'''                                         1.633e-09  5.347e+05
## rcs(kolesterol)kolesterol                              6.806e-01  7.163e-01
## rcs(kolesterol)kolesterol'                             2.036e+01  3.009e+01
## rcs(kolesterol)kolesterol''                            3.246e-06  1.502e-05
## rcs(kolesterol)kolesterol'''                           1.115e+06  1.038e+07
## rcs(systoliskt)systoliskt                              5.968e-01  6.177e-01
## rcs(systoliskt)systoliskt'                             2.958e+00  3.896e+00
## rcs(systoliskt)systoliskt''                            1.389e-02  5.767e-02
## rcs(systoliskt)systoliskt'''                           1.562e+01  2.160e+02
## factor(cpap_treated)1:factor(antithrombotic_agents)1   8.753e-01  1.258e+00
## factor(cpap_treated)1:factor(antihypertensive_comb)1   8.301e-01  1.238e+00
## factor(cpap_treated)1:factor(lipid_modifying_agents)1  9.449e-01  1.365e+00
## rcs(alder)alder:rcs(bmi)bmi                            1.102e+00  2.081e+00
## rcs(alder)alder':rcs(bmi)bmi                           8.946e-02  6.367e-01
## rcs(alder)alder'':rcs(bmi)bmi                          5.219e+01  7.150e+05
## rcs(alder)alder''':rcs(bmi)bmi                         4.910e-11  2.947e-04
## rcs(alder)alder:rcs(bmi)bmi'                           4.415e-04  1.472e-01
## rcs(alder)alder':rcs(bmi)bmi'                          8.301e+03  4.143e+11
## rcs(alder)alder'':rcs(bmi)bmi'                         2.851e-61  4.731e-24
## rcs(alder)alder''':rcs(bmi)bmi'                        1.965e+43 2.621e+104
## rcs(alder)alder:rcs(bmi)bmi''                          4.046e+03  8.845e+14
## rcs(alder)alder':rcs(bmi)bmi''                         4.061e-54  2.183e-19
## rcs(alder)alder'':rcs(bmi)bmi''                       1.790e+104 6.590e+272
## rcs(alder)alder''':rcs(bmi)bmi''                       0.000e+00 7.595e-193
## rcs(alder)alder:rcs(bmi)bmi'''                         7.798e-19  9.646e-05
## rcs(alder)alder':rcs(bmi)bmi'''                        6.743e+22  1.779e+66
## rcs(alder)alder'':rcs(bmi)bmi'''                       0.000e+00 1.549e-122
## rcs(alder)alder''':rcs(bmi)bmi'''                     1.040e+224        Inf
## rcs(alder)alder:rcs(GFR)GFR                            7.018e-01  1.065e+00
## rcs(alder)alder':rcs(GFR)GFR                           7.363e-01  2.528e+00
## rcs(alder)alder'':rcs(GFR)GFR                          3.529e-02  1.224e+01
## rcs(alder)alder''':rcs(GFR)GFR                         1.052e-02  1.359e+02
## rcs(alder)alder:rcs(GFR)GFR'                           7.829e-01  1.733e+01
## rcs(alder)alder':rcs(GFR)GFR'                          2.406e-02  1.958e+02
## rcs(alder)alder'':rcs(GFR)GFR'                         8.392e-13  1.987e+06
## rcs(alder)alder''':rcs(GFR)GFR'                        5.875e-13  2.045e+17
## rcs(alder)alder:rcs(GFR)GFR''                          4.764e-06  1.816e+02
## rcs(alder)alder':rcs(GFR)GFR''                         3.495e-16  1.014e+07
## rcs(alder)alder'':rcs(GFR)GFR''                        5.480e-33  1.488e+75
## rcs(alder)alder''':rcs(GFR)GFR''                      6.643e-110  2.278e+67
## rcs(alder)alder:rcs(GFR)GFR'''                         2.273e-06  1.477e+06
## rcs(alder)alder':rcs(GFR)GFR'''                        3.838e-10  2.437e+26
## rcs(alder)alder'':rcs(GFR)GFR'''                      1.493e-125  8.527e+49
## rcs(alder)alder''':rcs(GFR)GFR'''                     5.215e-107 7.698e+187
## factor(cpap_treated)1:rcs(GFR)GFR                      7.666e-01  1.250e+00
## factor(cpap_treated)1:rcs(GFR)GFR'                     1.077e-01  4.533e+00
## factor(cpap_treated)1:rcs(GFR)GFR''                    6.932e-05  1.160e+06
## factor(cpap_treated)1:rcs(GFR)GFR'''                   9.575e-11  4.745e+07
## 
## Concordance= 0.812  (se = 0.001 )
## Likelihood ratio test= 224745  on 96 df,   p=<2e-16
## Wald test            = 206572  on 96 df,   p=<2e-16
## Score (logrank) test = 321942  on 96 df,   p=<2e-16

## Warning in termplot(cph): 'model' appears to involve interactions: see the help
## page

## [1] "--- CONCORDANCE RESULTS ---"
## C-index train: 0.8115603 
## C-index test: 0.8118397
## C-index DAC train: 0.8252279 
## C-index DAC test: 0.8250712

Group 2

run_models(c(list_forms_sleep[["form_tdep_spl"]], list_forms_sleep[["form_tdep_cat"]]), df_death_sub_tv_train, df_death_sub_tv_test, "stop", "event", cont_var, "prof_death_dep_g2.html", bigd=F)

## [1] "### FORMULA 1 ###"
## Start:  AIC=13087.75
## Surv(start, stop, event) ~ factor(cpap_treated)

## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df   AIC
## + rcs(alder)                      4 12625
## + rcs(GFR)                        4 12752
## + factor(antithrombotic_agents)   1 12937
## + rcs(systoliskt)                 4 13018
## + factor(antihypertensive_comb)   1 13025
## + factor(Sun2000niva_old)         6 13026
## + rcs(IV_AverageSaturation)       4 13032
## + rcs(DispInkKEHB04)              4 13047
## + factor(ami_history)             1 13047
## + factor(stroke_history)          1 13051
## + rcs(bmi)                        4 13056
## + factor(HushallsTyp_RTB)         2 13057
## + factor(Civil)                   1 13058
## + rcs(IV_AHI)                     4 13066
## + factor(sex)                     1 13070
## + factor(FodelseLand_EU27_2020)   1 13070
## + rcs(kolesterol)                 4 13075
## + rcs(IV_ODI)                     4 13075
## + factor(lipid_modifying_agents)  1 13078
## + rcs(Raks_AndelSjukInk)          4 13080
## + rcs(Raks_AndelEkBisInk)         3 13081
## + rcs(hba1c)                      4 13085
## <none>                              13088
## + factor(rokare)                  1 13089
## + rcs(Raks_AndelArblosInk)        4 13093

## number of knots in rcs defaulting to 5

## 
## Step:  AIC=12624.72
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df   AIC
## + rcs(GFR)                        4 12448
## + rcs(IV_AverageSaturation)       4 12561
## + rcs(systoliskt)                 4 12561
## + rcs(bmi)                        4 12584
## + factor(antithrombotic_agents)   1 12586
## + factor(sex)                     1 12595
## + factor(HushallsTyp_RTB)         2 12598
## + rcs(IV_ODI)                     4 12600
## + rcs(DispInkKEHB04)              4 12601
## + factor(antihypertensive_comb)   1 12602
## + rcs(IV_AHI)                     4 12603
## + factor(ami_history)             1 12606
## + rcs(hba1c)                      4 12608
## + factor(Sun2000niva_old)         6 12608
## + factor(stroke_history)          1 12609
## + rcs(kolesterol)                 4 12616
## + rcs(Raks_AndelSjukInk)          4 12619
## + factor(rokare)                  1 12619
## + rcs(Raks_AndelEkBisInk)         3 12624
## + factor(FodelseLand_EU27_2020)   1 12624
## <none>                              12625
## + factor(lipid_modifying_agents)  1 12626
## + factor(Civil)                   1 12627
## + rcs(Raks_AndelArblosInk)        4 12631
## - rcs(alder)                      4 13088

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=12448.27
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df   AIC
## + rcs(systoliskt)                 4 12391
## + rcs(IV_AverageSaturation)       4 12403
## + factor(sex)                     1 12414
## + rcs(bmi)                        4 12416
## + factor(HushallsTyp_RTB)         2 12423
## + factor(antithrombotic_agents)   1 12424
## + rcs(alder):rcs(GFR)            16 12427
## + rcs(DispInkKEHB04)              4 12433
## + rcs(IV_ODI)                     4 12435
## + factor(ami_history)             1 12435
## + factor(stroke_history)          1 12437
## + factor(antihypertensive_comb)   1 12437
## + rcs(IV_AHI)                     4 12438
## + factor(Sun2000niva_old)         6 12439
## + rcs(hba1c)                      4 12441
## + factor(cpap_treated):rcs(GFR)   4 12442
## + rcs(Raks_AndelSjukInk)          4 12443
## + factor(rokare)                  1 12443
## + rcs(kolesterol)                 4 12445
## + rcs(Raks_AndelEkBisInk)         3 12447
## + factor(FodelseLand_EU27_2020)   1 12447
## <none>                              12448
## + factor(Civil)                   1 12450
## + factor(lipid_modifying_agents)  1 12450
## + rcs(Raks_AndelArblosInk)        4 12454
## - rcs(GFR)                        4 12625
## - rcs(alder)                      4 12752

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=12391.36
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(systoliskt)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df   AIC
## + rcs(IV_AverageSaturation)       4 12350
## + factor(sex)                     1 12360
## + rcs(bmi)                        4 12360
## + factor(HushallsTyp_RTB)         2 12366
## + rcs(alder):rcs(GFR)            16 12371
## + factor(antithrombotic_agents)   1 12372
## + rcs(IV_ODI)                     4 12377
## + rcs(DispInkKEHB04)              4 12377
## + factor(antihypertensive_comb)   1 12378
## + factor(stroke_history)          1 12379
## + factor(ami_history)             1 12380
## + rcs(IV_AHI)                     4 12381
## + factor(Sun2000niva_old)         6 12382
## + factor(cpap_treated):rcs(GFR)   4 12385
## + rcs(hba1c)                      4 12386
## + rcs(Raks_AndelSjukInk)          4 12386
## + factor(rokare)                  1 12387
## + factor(FodelseLand_EU27_2020)   1 12389
## + rcs(Raks_AndelEkBisInk)         3 12390
## + rcs(kolesterol)                 4 12390
## <none>                              12391
## + factor(Civil)                   1 12393
## + factor(lipid_modifying_agents)  1 12393
## + rcs(Raks_AndelArblosInk)        4 12397
## - rcs(systoliskt)                 4 12448
## - rcs(GFR)                        4 12561
## - rcs(alder)                      4 12700

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=12350.27
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df   AIC
## + factor(sex)                     1 12314
## + factor(HushallsTyp_RTB)         2 12328
## + rcs(bmi)                        4 12330
## + rcs(alder):rcs(GFR)            16 12332
## + factor(antithrombotic_agents)   1 12333
## + factor(stroke_history)          1 12336
## + factor(antihypertensive_comb)   1 12338
## + rcs(DispInkKEHB04)              4 12338
## + factor(ami_history)             1 12339
## + factor(cpap_treated):rcs(GFR)   4 12344
## + rcs(hba1c)                      4 12345
## + factor(Sun2000niva_old)         6 12345
## + rcs(Raks_AndelSjukInk)          4 12345
## + factor(rokare)                  1 12347
## + factor(FodelseLand_EU27_2020)   1 12348
## + rcs(kolesterol)                 4 12348
## + rcs(Raks_AndelEkBisInk)         3 12349
## <none>                              12350
## + rcs(IV_ODI)                     4 12352
## + factor(Civil)                   1 12352
## + factor(lipid_modifying_agents)  1 12352
## + rcs(IV_AHI)                     4 12354
## + rcs(Raks_AndelArblosInk)        4 12356
## - rcs(IV_AverageSaturation)       4 12391
## - rcs(systoliskt)                 4 12403
## - rcs(GFR)                        4 12502
## - rcs(alder)                      4 12668

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=12313.96
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) + 
##     factor(sex)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df   AIC
## + factor(HushallsTyp_RTB)         2 12278
## + rcs(bmi)                        4 12288
## + rcs(DispInkKEHB04)              4 12293
## + rcs(alder):rcs(GFR)            16 12298
## + factor(stroke_history)          1 12300
## + factor(antithrombotic_agents)   1 12302
## + factor(antihypertensive_comb)   1 12303
## + factor(ami_history)             1 12306
## + factor(Sun2000niva_old)         6 12306
## + factor(cpap_treated):rcs(GFR)   4 12307
## + rcs(Raks_AndelSjukInk)          4 12308
## + rcs(hba1c)                      4 12308
## + factor(rokare)                  1 12311
## + factor(FodelseLand_EU27_2020)   1 12312
## + rcs(Raks_AndelEkBisInk)         3 12313
## <none>                              12314
## + rcs(IV_ODI)                     4 12314
## + rcs(kolesterol)                 4 12314
## + factor(Civil)                   1 12314
## + factor(lipid_modifying_agents)  1 12316
## + rcs(IV_AHI)                     4 12318
## + rcs(Raks_AndelArblosInk)        4 12320
## - factor(sex)                     1 12350
## - rcs(IV_AverageSaturation)       4 12360
## - rcs(systoliskt)                 4 12363
## - rcs(GFR)                        4 12469
## - rcs(alder)                      4 12644

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=12278.42
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) + 
##     factor(sex) + factor(HushallsTyp_RTB)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df   AIC
## + rcs(bmi)                        4 12253
## + rcs(alder):rcs(GFR)            16 12262
## + factor(stroke_history)          1 12264
## + factor(antithrombotic_agents)   1 12266
## + factor(antihypertensive_comb)   1 12267
## + factor(Sun2000niva_old)         6 12268
## + factor(ami_history)             1 12270
## + rcs(DispInkKEHB04)              4 12272
## + rcs(Raks_AndelSjukInk)          4 12273
## + factor(cpap_treated):rcs(GFR)   4 12273
## + rcs(hba1c)                      4 12274
## + factor(FodelseLand_EU27_2020)   1 12276
## + factor(rokare)                  1 12277
## + rcs(Raks_AndelEkBisInk)         3 12277
## + rcs(IV_ODI)                     4 12278
## <none>                              12278
## + rcs(kolesterol)                 4 12279
## + factor(Civil)                   1 12280
## + factor(lipid_modifying_agents)  1 12280
## + rcs(IV_AHI)                     4 12283
## + rcs(Raks_AndelArblosInk)        4 12285
## - factor(HushallsTyp_RTB)         2 12314
## - rcs(IV_AverageSaturation)       4 12320
## - rcs(systoliskt)                 4 12326
## - factor(sex)                     1 12328
## - rcs(GFR)                        4 12434
## - rcs(alder)                      4 12608

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=12253.33
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) + 
##     factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df   AIC
## + rcs(alder):rcs(GFR)            16 12238
## + factor(stroke_history)          1 12239
## + factor(antithrombotic_agents)   1 12241
## + factor(antihypertensive_comb)   1 12241
## + factor(Sun2000niva_old)         6 12244
## + factor(ami_history)             1 12245
## + factor(cpap_treated):rcs(GFR)   4 12248
## + rcs(DispInkKEHB04)              4 12249
## + rcs(Raks_AndelSjukInk)          4 12250
## + rcs(hba1c)                      4 12250
## + factor(FodelseLand_EU27_2020)   1 12251
## + factor(rokare)                  1 12252
## + rcs(Raks_AndelEkBisInk)         3 12252
## <none>                              12253
## + rcs(kolesterol)                 4 12253
## + rcs(IV_ODI)                     4 12254
## + factor(Civil)                   1 12255
## + factor(lipid_modifying_agents)  1 12255
## + rcs(IV_AHI)                     4 12259
## + rcs(Raks_AndelArblosInk)        4 12260
## + rcs(alder):rcs(bmi)            16 12277
## - rcs(bmi)                        4 12278
## - rcs(IV_AverageSaturation)       4 12281
## - factor(HushallsTyp_RTB)         2 12288
## - rcs(systoliskt)                 4 12300
## - factor(sex)                     1 12309
## - rcs(GFR)                        4 12406
## - rcs(alder)                      4 12577

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=12238.14
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) + 
##     factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df   AIC
## + factor(stroke_history)          1 12224
## + factor(antithrombotic_agents)   1 12225
## + factor(antihypertensive_comb)   1 12227
## + factor(Sun2000niva_old)         6 12229
## + factor(ami_history)             1 12229
## + rcs(DispInkKEHB04)              4 12233
## + factor(cpap_treated):rcs(GFR)   4 12233
## + rcs(Raks_AndelSjukInk)          4 12235
## + rcs(hba1c)                      4 12236
## + factor(rokare)                  1 12236
## + factor(FodelseLand_EU27_2020)   1 12236
## + rcs(Raks_AndelEkBisInk)         3 12237
## <none>                              12238
## + rcs(kolesterol)                 4 12238
## + factor(Civil)                   1 12240
## + rcs(IV_ODI)                     4 12240
## + factor(lipid_modifying_agents)  1 12240
## + rcs(Raks_AndelArblosInk)        4 12244
## + rcs(IV_AHI)                     4 12244
## - rcs(alder):rcs(GFR)            16 12253
## + rcs(alder):rcs(bmi)            16 12257
## - rcs(bmi)                        4 12262
## - rcs(IV_AverageSaturation)       4 12263
## - factor(HushallsTyp_RTB)         2 12274
## - rcs(systoliskt)                 4 12284
## - factor(sex)                     1 12292

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=12223.82
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) + 
##     factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) + 
##     rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df   AIC
## + factor(antihypertensive_comb)   1 12214
## + factor(Sun2000niva_old)         6 12215
## + factor(ami_history)             1 12215
## + factor(antithrombotic_agents)   1 12215
## + factor(cpap_treated):rcs(GFR)   4 12218
## + rcs(DispInkKEHB04)              4 12219
## + rcs(Raks_AndelSjukInk)          4 12221
## + rcs(hba1c)                      4 12222
## + factor(rokare)                  1 12222
## + factor(FodelseLand_EU27_2020)   1 12222
## + rcs(Raks_AndelEkBisInk)         3 12222
## <none>                              12224
## + rcs(kolesterol)                 4 12224
## + rcs(IV_ODI)                     4 12225
## + factor(Civil)                   1 12225
## + factor(lipid_modifying_agents)  1 12226
## + rcs(Raks_AndelArblosInk)        4 12229
## + rcs(IV_AHI)                     4 12230
## - factor(stroke_history)          1 12238
## - rcs(alder):rcs(GFR)            16 12239
## + rcs(alder):rcs(bmi)            16 12243
## - rcs(bmi)                        4 12248
## - rcs(IV_AverageSaturation)       4 12249
## - factor(HushallsTyp_RTB)         2 12260
## - rcs(systoliskt)                 4 12271
## - factor(sex)                     1 12278

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=12213.56
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) + 
##     factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) + 
##     factor(antihypertensive_comb) + rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(Sun2000niva_old)                             6 12205
## + factor(ami_history)                                 1 12206
## + rcs(DispInkKEHB04)                                  4 12207
## + factor(cpap_treated):rcs(GFR)                       4 12208
## + factor(antithrombotic_agents)                       1 12209
## + factor(cpap_treated):factor(antihypertensive_comb)  1 12210
## + rcs(Raks_AndelSjukInk)                              4 12211
## + factor(rokare)                                      1 12211
## + rcs(hba1c)                                          4 12212
## + rcs(Raks_AndelEkBisInk)                             3 12212
## + factor(FodelseLand_EU27_2020)                       1 12213
## <none>                                                  12214
## + rcs(kolesterol)                                     4 12214
## + rcs(IV_ODI)                                         4 12214
## + factor(lipid_modifying_agents)                      1 12214
## + factor(Civil)                                       1 12215
## + rcs(IV_AHI)                                         4 12219
## + rcs(Raks_AndelArblosInk)                            4 12219
## - factor(antihypertensive_comb)                       1 12224
## - factor(stroke_history)                              1 12227
## - rcs(alder):rcs(GFR)                                16 12228
## + rcs(alder):rcs(bmi)                                16 12233
## - rcs(IV_AverageSaturation)                           4 12238
## - rcs(bmi)                                            4 12238
## - factor(HushallsTyp_RTB)                             2 12251
## - rcs(systoliskt)                                     4 12263
## - factor(sex)                                         1 12266

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=12205.08
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) + 
##     factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) + 
##     factor(antihypertensive_comb) + factor(Sun2000niva_old) + 
##     rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(ami_history)                                 1 12198
## + factor(cpap_treated):rcs(GFR)                       4 12199
## + factor(antithrombotic_agents)                       1 12200
## + factor(cpap_treated):factor(antihypertensive_comb)  1 12202
## + rcs(Raks_AndelSjukInk)                              4 12202
## + rcs(hba1c)                                          4 12203
## + factor(rokare)                                      1 12203
## + rcs(Raks_AndelEkBisInk)                             3 12204
## + rcs(DispInkKEHB04)                                  4 12204
## + factor(FodelseLand_EU27_2020)                       1 12204
## <none>                                                  12205
## + rcs(kolesterol)                                     4 12205
## + factor(lipid_modifying_agents)                      1 12206
## + rcs(IV_ODI)                                         4 12206
## + factor(Civil)                                       1 12206
## + rcs(Raks_AndelArblosInk)                            4 12211
## + rcs(IV_AHI)                                         4 12211
## - factor(Sun2000niva_old)                             6 12214
## - factor(antihypertensive_comb)                       1 12215
## - factor(stroke_history)                              1 12218
## - rcs(alder):rcs(GFR)                                16 12220
## + rcs(alder):rcs(bmi)                                16 12224
## - rcs(IV_AverageSaturation)                           4 12228
## - rcs(bmi)                                            4 12229
## - factor(HushallsTyp_RTB)                             2 12245
## - rcs(systoliskt)                                     4 12255
## - factor(sex)                                         1 12261

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=12198.06
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) + 
##     factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) + 
##     factor(antihypertensive_comb) + factor(Sun2000niva_old) + 
##     factor(ami_history) + rcs(alder):rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(cpap_treated):rcs(GFR)                       4 12192
## + factor(cpap_treated):factor(antihypertensive_comb)  1 12195
## + rcs(Raks_AndelSjukInk)                              4 12195
## + rcs(hba1c)                                          4 12196
## + factor(antithrombotic_agents)                       1 12196
## + rcs(Raks_AndelEkBisInk)                             3 12196
## + factor(rokare)                                      1 12196
## + factor(lipid_modifying_agents)                      1 12197
## + factor(FodelseLand_EU27_2020)                       1 12197
## + rcs(DispInkKEHB04)                                  4 12198
## <none>                                                  12198
## + rcs(kolesterol)                                     4 12198
## + rcs(IV_ODI)                                         4 12199
## + factor(Civil)                                       1 12199
## + rcs(IV_AHI)                                         4 12204
## + rcs(Raks_AndelArblosInk)                            4 12204
## - factor(ami_history)                                 1 12205
## - factor(Sun2000niva_old)                             6 12206
## - factor(antihypertensive_comb)                       1 12207
## - factor(stroke_history)                              1 12210
## - rcs(alder):rcs(GFR)                                16 12214
## + rcs(alder):rcs(bmi)                                16 12217
## - rcs(IV_AverageSaturation)                           4 12220
## - rcs(bmi)                                            4 12222
## - factor(HushallsTyp_RTB)                             2 12239
## - rcs(systoliskt)                                     4 12246
## - factor(sex)                                         1 12250

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=12191.88
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) + 
##     factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) + 
##     factor(antihypertensive_comb) + factor(Sun2000niva_old) + 
##     factor(ami_history) + rcs(alder):rcs(GFR) + factor(cpap_treated):rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + rcs(Raks_AndelSjukInk)                              4 12189
## + factor(cpap_treated):factor(antihypertensive_comb)  1 12190
## + rcs(Raks_AndelEkBisInk)                             3 12190
## + rcs(hba1c)                                          4 12190
## + factor(rokare)                                      1 12190
## + factor(lipid_modifying_agents)                      1 12191
## + factor(antithrombotic_agents)                       1 12191
## + factor(FodelseLand_EU27_2020)                       1 12191
## <none>                                                  12192
## + rcs(DispInkKEHB04)                                  4 12192
## + rcs(kolesterol)                                     4 12192
## + factor(Civil)                                       1 12193
## + rcs(IV_ODI)                                         4 12194
## + rcs(IV_AHI)                                         4 12197
## + rcs(Raks_AndelArblosInk)                            4 12198
## - factor(cpap_treated):rcs(GFR)                       4 12198
## - factor(ami_history)                                 1 12199
## - factor(antihypertensive_comb)                       1 12200
## - factor(Sun2000niva_old)                             6 12201
## - factor(stroke_history)                              1 12204
## - rcs(alder):rcs(GFR)                                16 12208
## + rcs(alder):rcs(bmi)                                16 12211
## - rcs(IV_AverageSaturation)                           4 12214
## - rcs(bmi)                                            4 12216
## - factor(HushallsTyp_RTB)                             2 12231
## - rcs(systoliskt)                                     4 12239
## - factor(sex)                                         1 12244

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=12189.21
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) + 
##     factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) + 
##     factor(antihypertensive_comb) + factor(Sun2000niva_old) + 
##     factor(ami_history) + rcs(Raks_AndelSjukInk) + rcs(alder):rcs(GFR) + 
##     factor(cpap_treated):rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + rcs(hba1c)                                          4 12187
## + factor(cpap_treated):factor(antihypertensive_comb)  1 12187
## + factor(rokare)                                      1 12187
## + rcs(Raks_AndelEkBisInk)                             3 12188
## + factor(lipid_modifying_agents)                      1 12188
## + factor(antithrombotic_agents)                       1 12188
## + factor(FodelseLand_EU27_2020)                       1 12188
## + rcs(DispInkKEHB04)                                  4 12189
## <none>                                                  12189
## + rcs(kolesterol)                                     4 12190
## + rcs(IV_ODI)                                         4 12191
## + factor(Civil)                                       1 12191
## - rcs(Raks_AndelSjukInk)                              4 12192
## + rcs(IV_AHI)                                         4 12195
## + rcs(Raks_AndelArblosInk)                            4 12195
## - factor(cpap_treated):rcs(GFR)                       4 12195
## - factor(ami_history)                                 1 12196
## - factor(antihypertensive_comb)                       1 12197
## - factor(Sun2000niva_old)                             6 12198
## - factor(stroke_history)                              1 12202
## - rcs(alder):rcs(GFR)                                16 12205
## + rcs(alder):rcs(bmi)                                16 12209
## - rcs(bmi)                                            4 12211
## - rcs(IV_AverageSaturation)                           4 12212
## - factor(HushallsTyp_RTB)                             2 12228
## - rcs(systoliskt)                                     4 12236
## - factor(sex)                                         1 12242

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=12186.83
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) + 
##     factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) + 
##     factor(antihypertensive_comb) + factor(Sun2000niva_old) + 
##     factor(ami_history) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + 
##     rcs(alder):rcs(GFR) + factor(cpap_treated):rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(cpap_treated):factor(antihypertensive_comb)  1 12185
## + factor(rokare)                                      1 12185
## + rcs(Raks_AndelEkBisInk)                             3 12185
## + factor(antithrombotic_agents)                       1 12186
## + factor(lipid_modifying_agents)                      1 12186
## + factor(FodelseLand_EU27_2020)                       1 12186
## <none>                                                  12187
## + rcs(DispInkKEHB04)                                  4 12187
## + rcs(kolesterol)                                     4 12187
## + factor(Civil)                                       1 12188
## + rcs(IV_ODI)                                         4 12188
## - rcs(hba1c)                                          4 12189
## - rcs(Raks_AndelSjukInk)                              4 12190
## + rcs(IV_AHI)                                         4 12192
## + rcs(Raks_AndelArblosInk)                            4 12193
## - factor(cpap_treated):rcs(GFR)                       4 12193
## - factor(ami_history)                                 1 12194
## - factor(antihypertensive_comb)                       1 12195
## - factor(Sun2000niva_old)                             6 12196
## - factor(stroke_history)                              1 12199
## - rcs(alder):rcs(GFR)                                16 12201
## + rcs(alder):rcs(bmi)                                16 12206
## - rcs(bmi)                                            4 12209
## - rcs(IV_AverageSaturation)                           4 12210
## - factor(HushallsTyp_RTB)                             2 12224
## - rcs(systoliskt)                                     4 12232
## - factor(sex)                                         1 12240

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=12184.7
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) + 
##     factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) + 
##     factor(antihypertensive_comb) + factor(Sun2000niva_old) + 
##     factor(ami_history) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + 
##     rcs(alder):rcs(GFR) + factor(cpap_treated):rcs(GFR) + factor(cpap_treated):factor(antihypertensive_comb)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(rokare)                                      1 12183
## + rcs(Raks_AndelEkBisInk)                             3 12183
## + factor(antithrombotic_agents)                       1 12184
## + factor(lipid_modifying_agents)                      1 12184
## + factor(FodelseLand_EU27_2020)                       1 12184
## <none>                                                  12185
## + rcs(DispInkKEHB04)                                  4 12185
## + rcs(kolesterol)                                     4 12185
## + factor(Civil)                                       1 12186
## + rcs(IV_ODI)                                         4 12186
## - factor(cpap_treated):factor(antihypertensive_comb)  1 12187
## - rcs(hba1c)                                          4 12187
## - rcs(Raks_AndelSjukInk)                              4 12188
## - factor(cpap_treated):rcs(GFR)                       4 12190
## + rcs(IV_AHI)                                         4 12190
## + rcs(Raks_AndelArblosInk)                            4 12191
## - factor(ami_history)                                 1 12192
## - factor(Sun2000niva_old)                             6 12194
## - factor(stroke_history)                              1 12197
## - rcs(alder):rcs(GFR)                                16 12199
## + rcs(alder):rcs(bmi)                                16 12204
## - rcs(bmi)                                            4 12206
## - rcs(IV_AverageSaturation)                           4 12208
## - factor(HushallsTyp_RTB)                             2 12222
## - rcs(systoliskt)                                     4 12231
## - factor(sex)                                         1 12237

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=12182.93
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) + 
##     factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) + 
##     factor(antihypertensive_comb) + factor(Sun2000niva_old) + 
##     factor(ami_history) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + 
##     factor(rokare) + rcs(alder):rcs(GFR) + factor(cpap_treated):rcs(GFR) + 
##     factor(cpap_treated):factor(antihypertensive_comb)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + rcs(Raks_AndelEkBisInk)                             3 12182
## + factor(lipid_modifying_agents)                      1 12182
## + factor(antithrombotic_agents)                       1 12182
## + factor(FodelseLand_EU27_2020)                       1 12182
## <none>                                                  12183
## + rcs(kolesterol)                                     4 12184
## + rcs(DispInkKEHB04)                                  4 12184
## + factor(Civil)                                       1 12184
## + rcs(IV_ODI)                                         4 12184
## - factor(rokare)                                      1 12185
## - factor(cpap_treated):factor(antihypertensive_comb)  1 12185
## - rcs(hba1c)                                          4 12185
## - rcs(Raks_AndelSjukInk)                              4 12186
## + rcs(IV_AHI)                                         4 12188
## - factor(cpap_treated):rcs(GFR)                       4 12189
## + rcs(Raks_AndelArblosInk)                            4 12189
## - factor(ami_history)                                 1 12190
## - factor(Sun2000niva_old)                             6 12191
## - factor(stroke_history)                              1 12195
## - rcs(alder):rcs(GFR)                                16 12197
## + rcs(alder):rcs(bmi)                                16 12202
## - rcs(bmi)                                            4 12205
## - rcs(IV_AverageSaturation)                           4 12205
## - factor(HushallsTyp_RTB)                             2 12218
## - rcs(systoliskt)                                     4 12229
## - factor(sex)                                         1 12235

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=12181.45
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) + 
##     factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) + 
##     factor(antihypertensive_comb) + factor(Sun2000niva_old) + 
##     factor(ami_history) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + 
##     factor(rokare) + rcs(Raks_AndelEkBisInk) + rcs(alder):rcs(GFR) + 
##     factor(cpap_treated):rcs(GFR) + factor(cpap_treated):factor(antihypertensive_comb)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + rcs(DispInkKEHB04)                                  4 12180
## + factor(antithrombotic_agents)                       1 12180
## + factor(lipid_modifying_agents)                      1 12181
## <none>                                                  12182
## + factor(FodelseLand_EU27_2020)                       1 12182
## + rcs(kolesterol)                                     4 12182
## + rcs(IV_ODI)                                         4 12182
## + factor(Civil)                                       1 12183
## - rcs(Raks_AndelEkBisInk)                             3 12183
## - factor(rokare)                                      1 12183
## - factor(cpap_treated):factor(antihypertensive_comb)  1 12183
## - rcs(Raks_AndelSjukInk)                              4 12183
## - rcs(hba1c)                                          4 12184
## + rcs(IV_AHI)                                         4 12187
## - factor(cpap_treated):rcs(GFR)                       4 12188
## + rcs(Raks_AndelArblosInk)                            4 12188
## - factor(ami_history)                                 1 12188
## - factor(Sun2000niva_old)                             6 12190
## - factor(stroke_history)                              1 12193
## - rcs(alder):rcs(GFR)                                16 12196
## + rcs(alder):rcs(bmi)                                16 12201
## - rcs(IV_AverageSaturation)                           4 12203
## - rcs(bmi)                                            4 12204
## - factor(HushallsTyp_RTB)                             2 12217
## - rcs(systoliskt)                                     4 12227
## - factor(sex)                                         1 12233

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=12179.83
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) + 
##     factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) + 
##     factor(antihypertensive_comb) + factor(Sun2000niva_old) + 
##     factor(ami_history) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + 
##     factor(rokare) + rcs(Raks_AndelEkBisInk) + rcs(DispInkKEHB04) + 
##     rcs(alder):rcs(GFR) + factor(cpap_treated):rcs(GFR) + factor(cpap_treated):factor(antihypertensive_comb)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(FodelseLand_EU27_2020)                       1 12178
## + factor(antithrombotic_agents)                       1 12179
## + factor(lipid_modifying_agents)                      1 12179
## <none>                                                  12180
## + rcs(kolesterol)                                     4 12181
## + rcs(IV_ODI)                                         4 12181
## + factor(Civil)                                       1 12181
## - rcs(DispInkKEHB04)                                  4 12182
## - rcs(hba1c)                                          4 12182
## - factor(cpap_treated):factor(antihypertensive_comb)  1 12182
## - factor(rokare)                                      1 12182
## - rcs(Raks_AndelSjukInk)                              4 12182
## - factor(Sun2000niva_old)                             6 12183
## - rcs(Raks_AndelEkBisInk)                             3 12184
## - factor(cpap_treated):rcs(GFR)                       4 12185
## + rcs(IV_AHI)                                         4 12185
## - factor(ami_history)                                 1 12186
## + rcs(Raks_AndelArblosInk)                            4 12187
## - factor(stroke_history)                              1 12192
## - rcs(alder):rcs(GFR)                                16 12195
## + rcs(alder):rcs(bmi)                                16 12200
## - rcs(bmi)                                            4 12201
## - rcs(IV_AverageSaturation)                           4 12201
## - factor(HushallsTyp_RTB)                             2 12203
## - rcs(systoliskt)                                     4 12225
## - factor(sex)                                         1 12234

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=12177.9
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) + 
##     factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) + 
##     factor(antihypertensive_comb) + factor(Sun2000niva_old) + 
##     factor(ami_history) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + 
##     factor(rokare) + rcs(Raks_AndelEkBisInk) + rcs(DispInkKEHB04) + 
##     factor(FodelseLand_EU27_2020) + rcs(alder):rcs(GFR) + factor(cpap_treated):rcs(GFR) + 
##     factor(cpap_treated):factor(antihypertensive_comb)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(antithrombotic_agents)                       1 12177
## + factor(lipid_modifying_agents)                      1 12177
## <none>                                                  12178
## + rcs(kolesterol)                                     4 12179
## + rcs(IV_ODI)                                         4 12179
## + factor(Civil)                                       1 12179
## - rcs(hba1c)                                          4 12180
## - factor(cpap_treated):factor(antihypertensive_comb)  1 12180
## - factor(Sun2000niva_old)                             6 12180
## - factor(rokare)                                      1 12180
## - factor(FodelseLand_EU27_2020)                       1 12180
## - rcs(Raks_AndelSjukInk)                              4 12180
## - rcs(Raks_AndelEkBisInk)                             3 12180
## - rcs(DispInkKEHB04)                                  4 12182
## - factor(cpap_treated):rcs(GFR)                       4 12183
## + rcs(IV_AHI)                                         4 12183
## - factor(ami_history)                                 1 12184
## + rcs(Raks_AndelArblosInk)                            4 12185
## - factor(stroke_history)                              1 12189
## - rcs(alder):rcs(GFR)                                16 12192
## + rcs(alder):rcs(bmi)                                16 12197
## - rcs(bmi)                                            4 12200
## - rcs(IV_AverageSaturation)                           4 12200
## - factor(HushallsTyp_RTB)                             2 12200
## - rcs(systoliskt)                                     4 12223
## - factor(sex)                                         1 12232

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## 
## Step:  AIC=12176.97
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) + 
##     factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) + 
##     factor(antihypertensive_comb) + factor(Sun2000niva_old) + 
##     factor(ami_history) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + 
##     factor(rokare) + rcs(Raks_AndelEkBisInk) + rcs(DispInkKEHB04) + 
##     factor(FodelseLand_EU27_2020) + factor(antithrombotic_agents) + 
##     rcs(alder):rcs(GFR) + factor(cpap_treated):rcs(GFR) + factor(cpap_treated):factor(antihypertensive_comb)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(lipid_modifying_agents)                      1 12175
## <none>                                                  12177
## + factor(cpap_treated):factor(antithrombotic_agents)  1 12177
## - factor(antithrombotic_agents)                       1 12178
## + rcs(kolesterol)                                     4 12178
## + rcs(IV_ODI)                                         4 12178
## + factor(Civil)                                       1 12178
## - factor(rokare)                                      1 12179
## - rcs(hba1c)                                          4 12179
## - rcs(Raks_AndelSjukInk)                              4 12179
## - factor(cpap_treated):factor(antihypertensive_comb)  1 12179
## - factor(Sun2000niva_old)                             6 12179
## - factor(FodelseLand_EU27_2020)                       1 12179
## - rcs(Raks_AndelEkBisInk)                             3 12180
## - rcs(DispInkKEHB04)                                  4 12180
## - factor(ami_history)                                 1 12181
## - factor(cpap_treated):rcs(GFR)                       4 12182
## + rcs(IV_AHI)                                         4 12182
## + rcs(Raks_AndelArblosInk)                            4 12184
## - factor(stroke_history)                              1 12186
## - rcs(alder):rcs(GFR)                                16 12191
## + rcs(alder):rcs(bmi)                                16 12196
## - rcs(IV_AverageSaturation)                           4 12198
## - rcs(bmi)                                            4 12199
## - factor(HushallsTyp_RTB)                             2 12199
## - rcs(systoliskt)                                     4 12220
## - factor(sex)                                         1 12228

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
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## number of knots in rcs defaulting to 5

## 
## Step:  AIC=12174.74
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) + 
##     factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) + 
##     factor(antihypertensive_comb) + factor(Sun2000niva_old) + 
##     factor(ami_history) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + 
##     factor(rokare) + rcs(Raks_AndelEkBisInk) + rcs(DispInkKEHB04) + 
##     factor(FodelseLand_EU27_2020) + factor(antithrombotic_agents) + 
##     factor(lipid_modifying_agents) + rcs(alder):rcs(GFR) + factor(cpap_treated):rcs(GFR) + 
##     factor(cpap_treated):factor(antihypertensive_comb)

## number of knots in rcs defaulting to 5
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##                                                       Df   AIC
## <none>                                                   12175
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 12175
## + factor(cpap_treated):factor(antithrombotic_agents)   1 12175
## - rcs(hba1c)                                           4 12176
## + factor(Civil)                                        1 12176
## + rcs(IV_ODI)                                          4 12176
## - factor(rokare)                                       1 12176
## - rcs(Raks_AndelSjukInk)                               4 12176
## + rcs(kolesterol)                                      4 12176
## - factor(cpap_treated):factor(antihypertensive_comb)   1 12176
## - factor(Sun2000niva_old)                              6 12176
## - rcs(Raks_AndelEkBisInk)                              3 12177
## - factor(lipid_modifying_agents)                       1 12177
## - factor(FodelseLand_EU27_2020)                        1 12177
## - factor(antithrombotic_agents)                        1 12177
## - rcs(DispInkKEHB04)                                   4 12178
## - factor(ami_history)                                  1 12180
## - factor(cpap_treated):rcs(GFR)                        4 12180
## + rcs(IV_AHI)                                          4 12181
## + rcs(Raks_AndelArblosInk)                             4 12182
## - factor(stroke_history)                               1 12184
## - rcs(alder):rcs(GFR)                                 16 12189
## + rcs(alder):rcs(bmi)                                 16 12194
## - rcs(IV_AverageSaturation)                            4 12195
## - rcs(bmi)                                             4 12196
## - factor(HushallsTyp_RTB)                              2 12196
## - rcs(systoliskt)                                      4 12219
## - factor(sex)                                          1 12227
## [1] "--- SURVIVAL RESULTS ---"
## Call:
## coxph(formula = Surv(start, stop, event) ~ factor(cpap_treated) + 
##     rcs(alder) + rcs(GFR) + rcs(systoliskt) + rcs(IV_AverageSaturation) + 
##     factor(sex) + factor(HushallsTyp_RTB) + rcs(bmi) + factor(stroke_history) + 
##     factor(antihypertensive_comb) + factor(Sun2000niva_old) + 
##     factor(ami_history) + rcs(Raks_AndelSjukInk) + rcs(hba1c) + 
##     factor(rokare) + rcs(Raks_AndelEkBisInk) + rcs(DispInkKEHB04) + 
##     factor(FodelseLand_EU27_2020) + factor(antithrombotic_agents) + 
##     factor(lipid_modifying_agents) + rcs(alder):rcs(GFR) + factor(cpap_treated):rcs(GFR) + 
##     factor(cpap_treated):factor(antihypertensive_comb), data = df_train)
## 
##   n= 155393, number of events= 782 
## 
##                                                             coef   exp(coef)
## factor(cpap_treated)1                                  1.754e+00   5.776e+00
## rcs(alder)alder                                       -2.304e-01   7.942e-01
## rcs(alder)alder'                                       8.904e-01   2.436e+00
## rcs(alder)alder''                                     -5.641e-01   5.689e-01
## rcs(alder)alder'''                                    -2.594e+00   7.469e-02
## rcs(GFR)GFR                                           -1.250e+00   2.865e-01
## rcs(GFR)GFR'                                           6.437e+00   6.246e+02
## rcs(GFR)GFR''                                         -5.483e+01   1.544e-24
## rcs(GFR)GFR'''                                         1.102e+02   7.591e+47
## rcs(systoliskt)systoliskt                             -6.051e-01   5.460e-01
## rcs(systoliskt)systoliskt'                             1.426e+00   4.164e+00
## rcs(systoliskt)systoliskt''                           -4.127e+00   1.613e-02
## rcs(systoliskt)systoliskt'''                           5.020e+00   1.514e+02
## rcs(IV_AverageSaturation)IV_AverageSaturation         -1.261e-01   8.815e-01
## rcs(IV_AverageSaturation)IV_AverageSaturation'        -3.877e-01   6.786e-01
## rcs(IV_AverageSaturation)IV_AverageSaturation''        3.358e+00   2.874e+01
## rcs(IV_AverageSaturation)IV_AverageSaturation'''      -4.917e+00   7.323e-03
## factor(sex)1                                          -6.173e-01   5.394e-01
## factor(HushallsTyp_RTB)2                              -4.286e-01   6.514e-01
## factor(HushallsTyp_RTB)3                              -2.450e-01   7.827e-01
## rcs(bmi)bmi                                           -8.151e-01   4.426e-01
## rcs(bmi)bmi'                                           5.685e+00   2.945e+02
## rcs(bmi)bmi''                                         -1.680e+01   5.070e-08
## rcs(bmi)bmi'''                                         1.327e+01   5.780e+05
## factor(stroke_history)1                                5.347e-01   1.707e+00
## factor(antihypertensive_comb)1                         4.647e-01   1.592e+00
## factor(Sun2000niva_old)2                              -3.435e-02   9.662e-01
## factor(Sun2000niva_old)3                              -6.315e-02   9.388e-01
## factor(Sun2000niva_old)4                              -2.181e-01   8.040e-01
## factor(Sun2000niva_old)5                              -3.552e-01   7.011e-01
## factor(Sun2000niva_old)6                              -1.931e-01   8.244e-01
## factor(Sun2000niva_old)7                              -1.445e+00   2.358e-01
## factor(ami_history)1                                   3.273e-01   1.387e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                1.153e-01   1.122e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'               8.506e+02         Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''             -1.004e+03   0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''             1.693e+02   3.430e+73
## rcs(hba1c)hba1c                                       -8.009e-01   4.489e-01
## rcs(hba1c)hba1c'                                       1.099e+01   5.924e+04
## rcs(hba1c)hba1c''                                     -3.101e+01   3.399e-14
## rcs(hba1c)hba1c'''                                     2.586e+01   1.709e+11
## factor(rokare)1                                        2.115e-01   1.236e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk              1.854e-01   1.204e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'             1.655e+01   1.544e+07
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''           -1.806e+01   1.433e-08
## rcs(DispInkKEHB04)DispInkKEHB04                       -4.414e-01   6.431e-01
## rcs(DispInkKEHB04)DispInkKEHB04'                      -3.517e+00   2.969e-02
## rcs(DispInkKEHB04)DispInkKEHB04''                      1.300e+01   4.413e+05
## rcs(DispInkKEHB04)DispInkKEHB04'''                    -1.352e+01   1.347e-06
## factor(FodelseLand_EU27_2020)1                         2.043e-01   1.227e+00
## factor(antithrombotic_agents)1                         1.840e-01   1.202e+00
## factor(lipid_modifying_agents)1                       -1.663e-01   8.468e-01
## rcs(alder)alder:rcs(GFR)GFR                           -6.634e-02   9.358e-01
## rcs(alder)alder':rcs(GFR)GFR                          -3.987e-01   6.712e-01
## rcs(alder)alder'':rcs(GFR)GFR                          6.973e+00   1.067e+03
## rcs(alder)alder''':rcs(GFR)GFR                        -1.641e+01   7.492e-08
## rcs(alder)alder:rcs(GFR)GFR'                           3.753e+00   4.263e+01
## rcs(alder)alder':rcs(GFR)GFR'                         -9.379e+00   8.448e-05
## rcs(alder)alder'':rcs(GFR)GFR'                         6.094e+01   2.924e+26
## rcs(alder)alder''':rcs(GFR)GFR'                       -8.837e+01   4.162e-39
## rcs(alder)alder:rcs(GFR)GFR''                         -3.480e+01   7.686e-16
## rcs(alder)alder':rcs(GFR)GFR''                         1.261e+02   5.622e+54
## rcs(alder)alder'':rcs(GFR)GFR''                       -9.260e+02   0.000e+00
## rcs(alder)alder''':rcs(GFR)GFR''                       1.508e+03         Inf
## rcs(alder)alder:rcs(GFR)GFR'''                         6.822e+01   4.263e+29
## rcs(alder)alder':rcs(GFR)GFR'''                       -2.796e+02  3.893e-122
## rcs(alder)alder'':rcs(GFR)GFR'''                       2.079e+03         Inf
## rcs(alder)alder''':rcs(GFR)GFR'''                     -3.434e+03   0.000e+00
## factor(cpap_treated)1:rcs(GFR)GFR                      6.506e-01   1.917e+00
## factor(cpap_treated)1:rcs(GFR)GFR'                    -4.177e+00   1.534e-02
## factor(cpap_treated)1:rcs(GFR)GFR''                    2.588e+01   1.744e+11
## factor(cpap_treated)1:rcs(GFR)GFR'''                  -3.929e+01   8.599e-18
## factor(cpap_treated)1:factor(antihypertensive_comb)1  -3.372e-01   7.138e-01
##                                                         se(coef)      z
## factor(cpap_treated)1                                  3.397e-01  5.162
## rcs(alder)alder                                        1.298e+00 -0.177
## rcs(alder)alder'                                       4.097e+00  0.217
## rcs(alder)alder''                                      2.601e+01 -0.022
## rcs(alder)alder'''                                     4.193e+01 -0.062
## rcs(GFR)GFR                                            9.788e-01 -1.277
## rcs(GFR)GFR'                                           7.739e+00  0.832
## rcs(GFR)GFR''                                          5.350e+01 -1.025
## rcs(GFR)GFR'''                                         8.931e+01  1.234
## rcs(systoliskt)systoliskt                              1.133e-01 -5.341
## rcs(systoliskt)systoliskt'                             8.858e-01  1.610
## rcs(systoliskt)systoliskt''                            4.902e+00 -0.842
## rcs(systoliskt)systoliskt'''                           1.040e+01  0.483
## rcs(IV_AverageSaturation)IV_AverageSaturation          5.725e-02 -2.202
## rcs(IV_AverageSaturation)IV_AverageSaturation'         2.768e-01 -1.400
## rcs(IV_AverageSaturation)IV_AverageSaturation''        3.018e+00  1.113
## rcs(IV_AverageSaturation)IV_AverageSaturation'''       1.211e+01 -0.406
## factor(sex)1                                           8.674e-02 -7.117
## factor(HushallsTyp_RTB)2                               8.356e-02 -5.129
## factor(HushallsTyp_RTB)3                               1.386e-01 -1.767
## rcs(bmi)bmi                                            1.840e-01 -4.430
## rcs(bmi)bmi'                                           1.689e+00  3.366
## rcs(bmi)bmi''                                          6.863e+00 -2.447
## rcs(bmi)bmi'''                                         8.514e+00  1.558
## factor(stroke_history)1                                1.481e-01  3.610
## factor(antihypertensive_comb)1                         1.285e-01  3.616
## factor(Sun2000niva_old)2                               1.361e-01 -0.252
## factor(Sun2000niva_old)3                               1.034e-01 -0.611
## factor(Sun2000niva_old)4                               1.296e-01 -1.683
## factor(Sun2000niva_old)5                               1.498e-01 -2.371
## factor(Sun2000niva_old)6                               1.436e-01 -1.345
## factor(Sun2000niva_old)7                               7.154e-01 -2.020
## factor(ami_history)1                                   1.223e-01  2.675
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                2.039e+00  0.057
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'               1.781e+03  0.478
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''              2.027e+03 -0.495
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''             2.535e+02  0.668
## rcs(hba1c)hba1c                                        3.063e-01 -2.615
## rcs(hba1c)hba1c'                                       4.620e+00  2.379
## rcs(hba1c)hba1c''                                      1.371e+01 -2.262
## rcs(hba1c)hba1c'''                                     1.230e+01  2.103
## factor(rokare)1                                        1.079e-01  1.960
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk              1.091e+00  0.170
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'             2.167e+02  0.076
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''            2.245e+02 -0.080
## rcs(DispInkKEHB04)DispInkKEHB04                        2.837e-01 -1.556
## rcs(DispInkKEHB04)DispInkKEHB04'                       4.961e+00 -0.709
## rcs(DispInkKEHB04)DispInkKEHB04''                      1.806e+01  0.720
## rcs(DispInkKEHB04)DispInkKEHB04'''                     2.142e+01 -0.631
## factor(FodelseLand_EU27_2020)1                         1.005e-01  2.032
## factor(antithrombotic_agents)1                         8.542e-02  2.154
## factor(lipid_modifying_agents)1                        8.074e-02 -2.060
## rcs(alder)alder:rcs(GFR)GFR                            7.327e-01 -0.091
## rcs(alder)alder':rcs(GFR)GFR                           2.334e+00 -0.171
## rcs(alder)alder'':rcs(GFR)GFR                          1.493e+01  0.467
## rcs(alder)alder''':rcs(GFR)GFR                         2.425e+01 -0.677
## rcs(alder)alder:rcs(GFR)GFR'                           5.813e+00  0.646
## rcs(alder)alder':rcs(GFR)GFR'                          1.848e+01 -0.507
## rcs(alder)alder'':rcs(GFR)GFR'                         1.182e+02  0.515
## rcs(alder)alder''':rcs(GFR)GFR'                        1.916e+02 -0.461
## rcs(alder)alder:rcs(GFR)GFR''                          4.017e+01 -0.866
## rcs(alder)alder':rcs(GFR)GFR''                         1.286e+02  0.981
## rcs(alder)alder'':rcs(GFR)GFR''                        8.319e+02 -1.113
## rcs(alder)alder''':rcs(GFR)GFR''                       1.365e+03  1.105
## rcs(alder)alder:rcs(GFR)GFR'''                         6.712e+01  1.017
## rcs(alder)alder':rcs(GFR)GFR'''                        2.158e+02 -1.295
## rcs(alder)alder'':rcs(GFR)GFR'''                       1.411e+03  1.473
## rcs(alder)alder''':rcs(GFR)GFR'''                      2.342e+03 -1.466
## factor(cpap_treated)1:rcs(GFR)GFR                      1.820e-01  3.575
## factor(cpap_treated)1:rcs(GFR)GFR'                     1.448e+00 -2.886
## factor(cpap_treated)1:rcs(GFR)GFR''                    1.053e+01  2.457
## factor(cpap_treated)1:rcs(GFR)GFR'''                   1.837e+01 -2.139
## factor(cpap_treated)1:factor(antihypertensive_comb)1   1.738e-01 -1.940
##                                                      Pr(>|z|)    
## factor(cpap_treated)1                                2.44e-07 ***
## rcs(alder)alder                                      0.859146    
## rcs(alder)alder'                                     0.827968    
## rcs(alder)alder''                                    0.982698    
## rcs(alder)alder'''                                   0.950659    
## rcs(GFR)GFR                                          0.201618    
## rcs(GFR)GFR'                                         0.405515    
## rcs(GFR)GFR''                                        0.305428    
## rcs(GFR)GFR'''                                       0.217053    
## rcs(systoliskt)systoliskt                            9.24e-08 ***
## rcs(systoliskt)systoliskt'                           0.107334    
## rcs(systoliskt)systoliskt''                          0.399879    
## rcs(systoliskt)systoliskt'''                         0.629196    
## rcs(IV_AverageSaturation)IV_AverageSaturation        0.027642 *  
## rcs(IV_AverageSaturation)IV_AverageSaturation'       0.161421    
## rcs(IV_AverageSaturation)IV_AverageSaturation''      0.265830    
## rcs(IV_AverageSaturation)IV_AverageSaturation'''     0.684835    
## factor(sex)1                                         1.11e-12 ***
## factor(HushallsTyp_RTB)2                             2.91e-07 ***
## factor(HushallsTyp_RTB)3                             0.077206 .  
## rcs(bmi)bmi                                          9.44e-06 ***
## rcs(bmi)bmi'                                         0.000763 ***
## rcs(bmi)bmi''                                        0.014385 *  
## rcs(bmi)bmi'''                                       0.119184    
## factor(stroke_history)1                              0.000306 ***
## factor(antihypertensive_comb)1                       0.000299 ***
## factor(Sun2000niva_old)2                             0.800759    
## factor(Sun2000niva_old)3                             0.541210    
## factor(Sun2000niva_old)4                             0.092374 .  
## factor(Sun2000niva_old)5                             0.017754 *  
## factor(Sun2000niva_old)6                             0.178590    
## factor(Sun2000niva_old)7                             0.043435 *  
## factor(ami_history)1                                 0.007474 ** 
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk              0.954925    
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'             0.632953    
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''            0.620433    
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''           0.504136    
## rcs(hba1c)hba1c                                      0.008925 ** 
## rcs(hba1c)hba1c'                                     0.017365 *  
## rcs(hba1c)hba1c''                                    0.023718 *  
## rcs(hba1c)hba1c'''                                   0.035484 *  
## factor(rokare)1                                      0.050049 .  
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk            0.865091    
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'           0.939114    
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''          0.935891    
## rcs(DispInkKEHB04)DispInkKEHB04                      0.119695    
## rcs(DispInkKEHB04)DispInkKEHB04'                     0.478340    
## rcs(DispInkKEHB04)DispInkKEHB04''                    0.471820    
## rcs(DispInkKEHB04)DispInkKEHB04'''                   0.527917    
## factor(FodelseLand_EU27_2020)1                       0.042127 *  
## factor(antithrombotic_agents)1                       0.031217 *  
## factor(lipid_modifying_agents)1                      0.039393 *  
## rcs(alder)alder:rcs(GFR)GFR                          0.927853    
## rcs(alder)alder':rcs(GFR)GFR                         0.864339    
## rcs(alder)alder'':rcs(GFR)GFR                        0.640560    
## rcs(alder)alder''':rcs(GFR)GFR                       0.498721    
## rcs(alder)alder:rcs(GFR)GFR'                         0.518559    
## rcs(alder)alder':rcs(GFR)GFR'                        0.611805    
## rcs(alder)alder'':rcs(GFR)GFR'                       0.606206    
## rcs(alder)alder''':rcs(GFR)GFR'                      0.644648    
## rcs(alder)alder:rcs(GFR)GFR''                        0.386328    
## rcs(alder)alder':rcs(GFR)GFR''                       0.326811    
## rcs(alder)alder'':rcs(GFR)GFR''                      0.265653    
## rcs(alder)alder''':rcs(GFR)GFR''                     0.269103    
## rcs(alder)alder:rcs(GFR)GFR'''                       0.309382    
## rcs(alder)alder':rcs(GFR)GFR'''                      0.195222    
## rcs(alder)alder'':rcs(GFR)GFR'''                     0.140686    
## rcs(alder)alder''':rcs(GFR)GFR'''                    0.142649    
## factor(cpap_treated)1:rcs(GFR)GFR                    0.000350 ***
## factor(cpap_treated)1:rcs(GFR)GFR'                   0.003905 ** 
## factor(cpap_treated)1:rcs(GFR)GFR''                  0.013996 *  
## factor(cpap_treated)1:rcs(GFR)GFR'''                 0.032415 *  
## factor(cpap_treated)1:factor(antihypertensive_comb)1 0.052391 .  
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
##                                                       exp(coef) exp(-coef)
## factor(cpap_treated)1                                 5.776e+00  1.731e-01
## rcs(alder)alder                                       7.942e-01  1.259e+00
## rcs(alder)alder'                                      2.436e+00  4.105e-01
## rcs(alder)alder''                                     5.689e-01  1.758e+00
## rcs(alder)alder'''                                    7.469e-02  1.339e+01
## rcs(GFR)GFR                                           2.865e-01  3.490e+00
## rcs(GFR)GFR'                                          6.246e+02  1.601e-03
## rcs(GFR)GFR''                                         1.544e-24  6.476e+23
## rcs(GFR)GFR'''                                        7.591e+47  1.317e-48
## rcs(systoliskt)systoliskt                             5.460e-01  1.831e+00
## rcs(systoliskt)systoliskt'                            4.164e+00  2.402e-01
## rcs(systoliskt)systoliskt''                           1.613e-02  6.199e+01
## rcs(systoliskt)systoliskt'''                          1.514e+02  6.606e-03
## rcs(IV_AverageSaturation)IV_AverageSaturation         8.815e-01  1.134e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation'        6.786e-01  1.474e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation''       2.874e+01  3.480e-02
## rcs(IV_AverageSaturation)IV_AverageSaturation'''      7.323e-03  1.366e+02
## factor(sex)1                                          5.394e-01  1.854e+00
## factor(HushallsTyp_RTB)2                              6.514e-01  1.535e+00
## factor(HushallsTyp_RTB)3                              7.827e-01  1.278e+00
## rcs(bmi)bmi                                           4.426e-01  2.259e+00
## rcs(bmi)bmi'                                          2.945e+02  3.396e-03
## rcs(bmi)bmi''                                         5.070e-08  1.972e+07
## rcs(bmi)bmi'''                                        5.780e+05  1.730e-06
## factor(stroke_history)1                               1.707e+00  5.859e-01
## factor(antihypertensive_comb)1                        1.592e+00  6.283e-01
## factor(Sun2000niva_old)2                              9.662e-01  1.035e+00
## factor(Sun2000niva_old)3                              9.388e-01  1.065e+00
## factor(Sun2000niva_old)4                              8.040e-01  1.244e+00
## factor(Sun2000niva_old)5                              7.011e-01  1.426e+00
## factor(Sun2000niva_old)6                              8.244e-01  1.213e+00
## factor(Sun2000niva_old)7                              2.358e-01  4.241e+00
## factor(ami_history)1                                  1.387e+00  7.209e-01
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk               1.122e+00  8.911e-01
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'                    Inf  0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''             0.000e+00        Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''            3.430e+73  2.916e-74
## rcs(hba1c)hba1c                                       4.489e-01  2.228e+00
## rcs(hba1c)hba1c'                                      5.924e+04  1.688e-05
## rcs(hba1c)hba1c''                                     3.399e-14  2.942e+13
## rcs(hba1c)hba1c'''                                    1.709e+11  5.852e-12
## factor(rokare)1                                       1.236e+00  8.094e-01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk             1.204e+00  8.308e-01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'            1.544e+07  6.477e-08
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''           1.433e-08  6.978e+07
## rcs(DispInkKEHB04)DispInkKEHB04                       6.431e-01  1.555e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                      2.969e-02  3.368e+01
## rcs(DispInkKEHB04)DispInkKEHB04''                     4.413e+05  2.266e-06
## rcs(DispInkKEHB04)DispInkKEHB04'''                    1.347e-06  7.423e+05
## factor(FodelseLand_EU27_2020)1                        1.227e+00  8.152e-01
## factor(antithrombotic_agents)1                        1.202e+00  8.319e-01
## factor(lipid_modifying_agents)1                       8.468e-01  1.181e+00
## rcs(alder)alder:rcs(GFR)GFR                           9.358e-01  1.069e+00
## rcs(alder)alder':rcs(GFR)GFR                          6.712e-01  1.490e+00
## rcs(alder)alder'':rcs(GFR)GFR                         1.067e+03  9.373e-04
## rcs(alder)alder''':rcs(GFR)GFR                        7.492e-08  1.335e+07
## rcs(alder)alder:rcs(GFR)GFR'                          4.263e+01  2.346e-02
## rcs(alder)alder':rcs(GFR)GFR'                         8.448e-05  1.184e+04
## rcs(alder)alder'':rcs(GFR)GFR'                        2.924e+26  3.420e-27
## rcs(alder)alder''':rcs(GFR)GFR'                       4.162e-39  2.402e+38
## rcs(alder)alder:rcs(GFR)GFR''                         7.686e-16  1.301e+15
## rcs(alder)alder':rcs(GFR)GFR''                        5.622e+54  1.779e-55
## rcs(alder)alder'':rcs(GFR)GFR''                       0.000e+00        Inf
## rcs(alder)alder''':rcs(GFR)GFR''                            Inf  0.000e+00
## rcs(alder)alder:rcs(GFR)GFR'''                        4.263e+29  2.346e-30
## rcs(alder)alder':rcs(GFR)GFR'''                      3.893e-122 2.569e+121
## rcs(alder)alder'':rcs(GFR)GFR'''                            Inf  0.000e+00
## rcs(alder)alder''':rcs(GFR)GFR'''                     0.000e+00        Inf
## factor(cpap_treated)1:rcs(GFR)GFR                     1.917e+00  5.218e-01
## factor(cpap_treated)1:rcs(GFR)GFR'                    1.534e-02  6.520e+01
## factor(cpap_treated)1:rcs(GFR)GFR''                   1.744e+11  5.734e-12
## factor(cpap_treated)1:rcs(GFR)GFR'''                  8.599e-18  1.163e+17
## factor(cpap_treated)1:factor(antihypertensive_comb)1  7.138e-01  1.401e+00
##                                                       lower .95  upper .95
## factor(cpap_treated)1                                 2.968e+00  1.124e+01
## rcs(alder)alder                                       6.233e-02  1.012e+01
## rcs(alder)alder'                                      7.927e-04  7.487e+03
## rcs(alder)alder''                                     4.108e-23  7.878e+21
## rcs(alder)alder'''                                    1.531e-37  3.644e+34
## rcs(GFR)GFR                                           4.207e-02  1.951e+00
## rcs(GFR)GFR'                                          1.616e-04  2.414e+09
## rcs(GFR)GFR''                                         4.483e-70  5.319e+21
## rcs(GFR)GFR'''                                        7.191e-29 8.012e+123
## rcs(systoliskt)systoliskt                             4.373e-01  6.818e-01
## rcs(systoliskt)systoliskt'                            7.336e-01  2.363e+01
## rcs(systoliskt)systoliskt''                           1.083e-06  2.402e+02
## rcs(systoliskt)systoliskt'''                          2.143e-07  1.069e+11
## rcs(IV_AverageSaturation)IV_AverageSaturation         7.880e-01  9.862e-01
## rcs(IV_AverageSaturation)IV_AverageSaturation'        3.945e-01  1.168e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation''       7.754e-02  1.065e+04
## rcs(IV_AverageSaturation)IV_AverageSaturation'''      3.575e-13  1.500e+08
## factor(sex)1                                          4.551e-01  6.394e-01
## factor(HushallsTyp_RTB)2                              5.530e-01  7.674e-01
## factor(HushallsTyp_RTB)3                              5.965e-01  1.027e+00
## rcs(bmi)bmi                                           3.086e-01  6.348e-01
## rcs(bmi)bmi'                                          1.075e+01  8.067e+03
## rcs(bmi)bmi''                                         7.298e-14  3.523e-02
## rcs(bmi)bmi'''                                        3.269e-02  1.022e+13
## factor(stroke_history)1                               1.277e+00  2.282e+00
## factor(antihypertensive_comb)1                        1.237e+00  2.048e+00
## factor(Sun2000niva_old)2                              7.400e-01  1.262e+00
## factor(Sun2000niva_old)3                              7.667e-01  1.150e+00
## factor(Sun2000niva_old)4                              6.237e-01  1.037e+00
## factor(Sun2000niva_old)5                              5.227e-01  9.403e-01
## factor(Sun2000niva_old)6                              6.222e-01  1.092e+00
## factor(Sun2000niva_old)7                              5.802e-02  9.583e-01
## factor(ami_history)1                                  1.091e+00  1.763e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk               2.063e-02  6.105e+01
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'              0.000e+00        Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''             0.000e+00        Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''           5.968e-143 1.971e+289
## rcs(hba1c)hba1c                                       2.463e-01  8.182e-01
## rcs(hba1c)hba1c'                                      6.926e+00  5.067e+08
## rcs(hba1c)hba1c''                                     7.233e-26  1.597e-02
## rcs(hba1c)hba1c'''                                    5.794e+00  5.040e+21
## factor(rokare)1                                       1.000e+00  1.527e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk             1.418e-01  1.022e+01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'           5.375e-178 4.436e+191
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''          1.065e-199 1.929e+183
## rcs(DispInkKEHB04)DispInkKEHB04                       3.688e-01  1.121e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                      1.779e-06  4.955e+02
## rcs(DispInkKEHB04)DispInkKEHB04''                     1.856e-10  1.049e+21
## rcs(DispInkKEHB04)DispInkKEHB04'''                    7.944e-25  2.284e+12
## factor(FodelseLand_EU27_2020)1                        1.007e+00  1.494e+00
## factor(antithrombotic_agents)1                        1.017e+00  1.421e+00
## factor(lipid_modifying_agents)1                       7.228e-01  9.920e-01
## rcs(alder)alder:rcs(GFR)GFR                           2.226e-01  3.934e+00
## rcs(alder)alder':rcs(GFR)GFR                          6.923e-03  6.507e+01
## rcs(alder)alder'':rcs(GFR)GFR                         2.075e-10  5.485e+15
## rcs(alder)alder''':rcs(GFR)GFR                        1.701e-28  3.299e+13
## rcs(alder)alder:rcs(GFR)GFR'                          4.807e-04  3.781e+06
## rcs(alder)alder':rcs(GFR)GFR'                         1.570e-20  4.547e+11
## rcs(alder)alder'':rcs(GFR)GFR'                        6.919e-75 1.235e+127
## rcs(alder)alder''':rcs(GFR)GFR'                      3.285e-202 5.274e+124
## rcs(alder)alder:rcs(GFR)GFR''                         4.899e-50  1.206e+19
## rcs(alder)alder':rcs(GFR)GFR''                        2.062e-55 1.533e+164
## rcs(alder)alder'':rcs(GFR)GFR''                       0.000e+00 9.070e+305
## rcs(alder)alder''':rcs(GFR)GFR''                      0.000e+00        Inf
## rcs(alder)alder:rcs(GFR)GFR'''                        3.164e-28  5.743e+86
## rcs(alder)alder':rcs(GFR)GFR'''                      7.562e-306  2.004e+62
## rcs(alder)alder'':rcs(GFR)GFR'''                     4.742e-299        Inf
## rcs(alder)alder''':rcs(GFR)GFR'''                     0.000e+00        Inf
## factor(cpap_treated)1:rcs(GFR)GFR                     1.342e+00  2.738e+00
## factor(cpap_treated)1:rcs(GFR)GFR'                    8.985e-04  2.618e-01
## factor(cpap_treated)1:rcs(GFR)GFR''                   1.886e+02  1.613e+20
## factor(cpap_treated)1:rcs(GFR)GFR'''                  1.991e-33  3.713e-02
## factor(cpap_treated)1:factor(antihypertensive_comb)1  5.077e-01  1.003e+00
## 
## Concordance= 0.813  (se = 0.009 )
## Likelihood ratio test= 1137  on 73 df,   p=<2e-16
## Wald test            = 1171  on 73 df,   p=<2e-16
## Score (logrank) test = 1613  on 73 df,   p=<2e-16

## Warning in termplot(cph): 'model' appears to involve interactions: see the help
## page

## [1] "--- CONCORDANCE RESULTS ---"
## C-index train: 0.8129236 
## C-index test: 0.8206258

AMI

Time-dependent

Group 1

Group 2

run_models(c(list_forms_sleep[["form_tdep_spl"]], list_forms_sleep[["form_tdep_cat"]]), df_ami_sub_tv_train, df_ami_sub_tv_test, "stop", "event", cont_var, "prof_ami_dep_g2.html", bigd=F)

## [1] "### FORMULA 1 ###"
## Start:  AIC=10600.63
## Surv(start, stop, event) ~ factor(cpap_treated)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df   AIC
## + factor(antithrombotic_agents)   1 10481
## + rcs(alder)                      4 10505
## + factor(ami_history)             1 10531
## + rcs(GFR)                        4 10552
## + factor(lipid_modifying_agents)  1 10563
## + factor(sex)                     1 10565
## + factor(antihypertensive_comb)   1 10566
## + rcs(hba1c)                      4 10568
## + rcs(systoliskt)                 4 10574
## + factor(Sun2000niva_old)         6 10585
## + rcs(IV_ODI)                     4 10594
## + rcs(IV_AHI)                     4 10595
## + rcs(bmi)                        4 10595
## + factor(stroke_history)          1 10598
## + factor(rokare)                  1 10599
## + rcs(kolesterol)                 4 10599
## + rcs(Raks_AndelSjukInk)          4 10600
## <none>                              10601
## + factor(HushallsTyp_RTB)         2 10601
## + factor(FodelseLand_EU27_2020)   1 10601
## + factor(Civil)                   1 10602
## + rcs(DispInkKEHB04)              4 10603
## + rcs(Raks_AndelEkBisInk)         3 10604
## + rcs(Raks_AndelArblosInk)        4 10605
## + rcs(IV_AverageSaturation)       4 10606
## 
## Step:  AIC=10481.41
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                                      Df   AIC
## + factor(ami_history)                                 1 10359
## + rcs(alder)                                          4 10437
## + rcs(systoliskt)                                     4 10453
## + rcs(hba1c)                                          4 10455
## + rcs(GFR)                                            4 10456
## + factor(sex)                                         1 10456
## + factor(antihypertensive_comb)                       1 10470
## + factor(Sun2000niva_old)                             6 10476
## + factor(lipid_modifying_agents)                      1 10476
## + factor(rokare)                                      1 10478
## + rcs(bmi)                                            4 10479
## + rcs(IV_ODI)                                         4 10480
## + rcs(IV_AHI)                                         4 10480
## + factor(cpap_treated):factor(antithrombotic_agents)  1 10481
## <none>                                                  10481
## + rcs(Raks_AndelSjukInk)                              4 10482
## + rcs(kolesterol)                                     4 10482
## + factor(FodelseLand_EU27_2020)                       1 10483
## + factor(Civil)                                       1 10483
## + factor(HushallsTyp_RTB)                             2 10483
## + factor(stroke_history)                              1 10483
## + rcs(IV_AverageSaturation)                           4 10484
## + rcs(DispInkKEHB04)                                  4 10485
## + rcs(Raks_AndelEkBisInk)                             3 10486
## + rcs(Raks_AndelArblosInk)                            4 10486
## - factor(antithrombotic_agents)                       1 10601

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## 
## Step:  AIC=10359.13
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history)

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.
## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

##                                                      Df   AIC
## + rcs(alder)                                          4 10315
## + factor(sex)                                         1 10329
## + rcs(GFR)                                            4 10333
## + rcs(hba1c)                                          4 10334
## + rcs(systoliskt)                                     4 10334
## + factor(antihypertensive_comb)                       1 10346
## + factor(lipid_modifying_agents)                      1 10346
## + factor(Sun2000niva_old)                             6 10354
## + factor(rokare)                                      1 10356
## + rcs(bmi)                                            4 10356
## + factor(cpap_treated):factor(antithrombotic_agents)  1 10357
## + rcs(IV_ODI)                                         4 10358
## + rcs(IV_AHI)                                         4 10358
## + rcs(kolesterol)                                     4 10358
## <none>                                                  10359
## + rcs(Raks_AndelSjukInk)                              4 10360
## + factor(stroke_history)                              1 10361
## + factor(FodelseLand_EU27_2020)                       1 10361
## + factor(HushallsTyp_RTB)                             2 10361
## + factor(Civil)                                       1 10361
## + rcs(IV_AverageSaturation)                           4 10361
## + rcs(DispInkKEHB04)                                  4 10362
## + rcs(Raks_AndelArblosInk)                            4 10363
## + rcs(Raks_AndelEkBisInk)                             3 10364
## - factor(ami_history)                                 1 10481
## - factor(antithrombotic_agents)                       1 10531

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## 
## Step:  AIC=10315.41
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder)

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

##                                                      Df   AIC
## + factor(sex)                                         1 10282
## + rcs(hba1c)                                          4 10287
## + rcs(systoliskt)                                     4 10296
## + rcs(GFR)                                            4 10300
## + factor(rokare)                                      1 10307
## + factor(lipid_modifying_agents)                      1 10308
## + factor(antihypertensive_comb)                       1 10310
## + factor(cpap_treated):factor(antithrombotic_agents)  1 10314
## + rcs(IV_AverageSaturation)                           4 10314
## + rcs(DispInkKEHB04)                                  4 10315
## + rcs(kolesterol)                                     4 10315
## <none>                                                  10315
## + factor(Sun2000niva_old)                             6 10316
## + factor(Civil)                                       1 10316
## + rcs(Raks_AndelSjukInk)                              4 10317
## + factor(stroke_history)                              1 10317
## + factor(FodelseLand_EU27_2020)                       1 10317
## + rcs(IV_ODI)                                         4 10318
## + factor(HushallsTyp_RTB)                             2 10318
## + rcs(Raks_AndelEkBisInk)                             3 10318
## + rcs(IV_AHI)                                         4 10318
## + rcs(bmi)                                            4 10319
## + rcs(Raks_AndelArblosInk)                            4 10320
## - rcs(alder)                                          4 10359
## - factor(antithrombotic_agents)                       1 10423
## - factor(ami_history)                                 1 10437

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## 
## Step:  AIC=10281.98
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex)

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

##                                                      Df   AIC
## + rcs(hba1c)                                          4 10255
## + rcs(systoliskt)                                     4 10263
## + rcs(GFR)                                            4 10263
## + factor(rokare)                                      1 10272
## + rcs(DispInkKEHB04)                                  4 10276
## + factor(lipid_modifying_agents)                      1 10276
## + factor(antihypertensive_comb)                       1 10278
## + rcs(kolesterol)                                     4 10280
## + factor(cpap_treated):factor(antithrombotic_agents)  1 10280
## + rcs(IV_AverageSaturation)                           4 10281
## + factor(Sun2000niva_old)                             6 10281
## <none>                                                  10282
## + rcs(Raks_AndelSjukInk)                              4 10283
## + factor(FodelseLand_EU27_2020)                       1 10284
## + factor(stroke_history)                              1 10284
## + rcs(Raks_AndelEkBisInk)                             3 10284
## + factor(Civil)                                       1 10284
## + factor(HushallsTyp_RTB)                             2 10286
## + rcs(IV_ODI)                                         4 10286
## + rcs(Raks_AndelArblosInk)                            4 10286
## + rcs(IV_AHI)                                         4 10286
## + rcs(bmi)                                            4 10288
## - factor(sex)                                         1 10315
## - rcs(alder)                                          4 10329
## - factor(antithrombotic_agents)                       1 10378
## - factor(ami_history)                                 1 10409

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## 
## Step:  AIC=10255
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

##                                                      Df   AIC
## + rcs(systoliskt)                                     4 10239
## + rcs(GFR)                                            4 10239
## + factor(rokare)                                      1 10247
## + factor(lipid_modifying_agents)                      1 10250
## + factor(antihypertensive_comb)                       1 10252
## + rcs(kolesterol)                                     4 10253
## + rcs(DispInkKEHB04)                                  4 10253
## + factor(cpap_treated):factor(antithrombotic_agents)  1 10253
## + rcs(IV_AverageSaturation)                           4 10253
## <none>                                                  10255
## + rcs(Raks_AndelSjukInk)                              4 10256
## + factor(FodelseLand_EU27_2020)                       1 10256
## + factor(stroke_history)                              1 10257
## + factor(Civil)                                       1 10257
## + factor(Sun2000niva_old)                             6 10257
## + rcs(Raks_AndelEkBisInk)                             3 10258
## + factor(HushallsTyp_RTB)                             2 10258
## + rcs(Raks_AndelArblosInk)                            4 10259
## + rcs(IV_ODI)                                         4 10260
## + rcs(IV_AHI)                                         4 10260
## + rcs(bmi)                                            4 10261
## - rcs(hba1c)                                          4 10282
## - factor(sex)                                         1 10287
## - rcs(alder)                                          4 10305
## - factor(antithrombotic_agents)                       1 10344
## - factor(ami_history)                                 1 10380

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## 
## Step:  AIC=10238.63
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c) + 
##     rcs(systoliskt)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

##                                                      Df   AIC
## + rcs(GFR)                                            4 10224
## + factor(rokare)                                      1 10230
## + factor(lipid_modifying_agents)                      1 10233
## + rcs(DispInkKEHB04)                                  4 10237
## + rcs(IV_AverageSaturation)                           4 10237
## + factor(cpap_treated):factor(antithrombotic_agents)  1 10237
## + rcs(kolesterol)                                     4 10237
## + factor(antihypertensive_comb)                       1 10237
## <none>                                                  10239
## + rcs(Raks_AndelSjukInk)                              4 10240
## + factor(FodelseLand_EU27_2020)                       1 10240
## + factor(Sun2000niva_old)                             6 10240
## + factor(stroke_history)                              1 10240
## + factor(Civil)                                       1 10241
## + rcs(Raks_AndelEkBisInk)                             3 10241
## + factor(HushallsTyp_RTB)                             2 10242
## + rcs(Raks_AndelArblosInk)                            4 10243
## + rcs(IV_ODI)                                         4 10244
## + rcs(bmi)                                            4 10244
## + rcs(IV_AHI)                                         4 10244
## - rcs(systoliskt)                                     4 10255
## - rcs(hba1c)                                          4 10263
## - factor(sex)                                         1 10270
## - rcs(alder)                                          4 10284
## - factor(antithrombotic_agents)                       1 10330
## - factor(ami_history)                                 1 10361

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## 
## Step:  AIC=10223.67
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c) + 
##     rcs(systoliskt) + rcs(GFR)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

##                                                      Df   AIC
## + factor(rokare)                                      1 10215
## + factor(lipid_modifying_agents)                      1 10218
## + rcs(IV_AverageSaturation)                           4 10221
## + factor(cpap_treated):factor(antithrombotic_agents)  1 10222
## + rcs(DispInkKEHB04)                                  4 10222
## + rcs(kolesterol)                                     4 10223
## + factor(antihypertensive_comb)                       1 10223
## <none>                                                  10224
## + rcs(Raks_AndelSjukInk)                              4 10225
## + factor(FodelseLand_EU27_2020)                       1 10225
## + factor(Sun2000niva_old)                             6 10225
## + factor(stroke_history)                              1 10226
## + factor(cpap_treated):rcs(GFR)                       4 10226
## + factor(Civil)                                       1 10226
## + rcs(Raks_AndelEkBisInk)                             3 10226
## + factor(HushallsTyp_RTB)                             2 10227
## + rcs(Raks_AndelArblosInk)                            4 10228
## + rcs(IV_ODI)                                         4 10229
## + rcs(bmi)                                            4 10229
## + rcs(IV_AHI)                                         4 10230
## - rcs(GFR)                                            4 10239
## - rcs(systoliskt)                                     4 10239
## + rcs(alder):rcs(GFR)                                16 10241
## - rcs(hba1c)                                          4 10246
## - rcs(alder)                                          4 10255
## - factor(sex)                                         1 10258
## - factor(antithrombotic_agents)                       1 10309
## - factor(ami_history)                                 1 10347

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## 
## Step:  AIC=10215.23
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c) + 
##     rcs(systoliskt) + rcs(GFR) + factor(rokare)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

##                                                      Df   AIC
## + factor(lipid_modifying_agents)                      1 10210
## + rcs(IV_AverageSaturation)                           4 10212
## + factor(cpap_treated):factor(antithrombotic_agents)  1 10214
## + factor(antihypertensive_comb)                       1 10214
## + rcs(kolesterol)                                     4 10215
## + rcs(DispInkKEHB04)                                  4 10215
## <none>                                                  10215
## + rcs(Raks_AndelSjukInk)                              4 10217
## + factor(FodelseLand_EU27_2020)                       1 10217
## + factor(stroke_history)                              1 10217
## + factor(cpap_treated):rcs(GFR)                       4 10217
## + factor(Civil)                                       1 10217
## + factor(Sun2000niva_old)                             6 10218
## + factor(HushallsTyp_RTB)                             2 10218
## + rcs(Raks_AndelEkBisInk)                             3 10218
## + rcs(Raks_AndelArblosInk)                            4 10220
## + rcs(IV_ODI)                                         4 10220
## + rcs(bmi)                                            4 10221
## + rcs(IV_AHI)                                         4 10221
## - factor(rokare)                                      1 10224
## - rcs(GFR)                                            4 10230
## - rcs(systoliskt)                                     4 10231
## + rcs(alder):rcs(GFR)                                16 10232
## - rcs(hba1c)                                          4 10236
## - rcs(alder)                                          4 10250
## - factor(sex)                                         1 10251
## - factor(antithrombotic_agents)                       1 10298
## - factor(ami_history)                                 1 10339

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## 
## Step:  AIC=10210.16
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c) + 
##     rcs(systoliskt) + rcs(GFR) + factor(rokare) + factor(lipid_modifying_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

##                                                       Df   AIC
## + rcs(IV_AverageSaturation)                            4 10206
## + factor(cpap_treated):factor(antithrombotic_agents)   1 10208
## + rcs(kolesterol)                                      4 10209
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 10210
## <none>                                                   10210
## + rcs(DispInkKEHB04)                                   4 10210
## + factor(antihypertensive_comb)                        1 10210
## + rcs(Raks_AndelSjukInk)                               4 10211
## + factor(stroke_history)                               1 10212
## + factor(FodelseLand_EU27_2020)                        1 10212
## + factor(cpap_treated):rcs(GFR)                        4 10212
## + factor(Civil)                                        1 10212
## + factor(Sun2000niva_old)                              6 10213
## + factor(HushallsTyp_RTB)                              2 10213
## + rcs(Raks_AndelEkBisInk)                              3 10214
## + rcs(Raks_AndelArblosInk)                             4 10215
## - factor(lipid_modifying_agents)                       1 10215
## + rcs(IV_ODI)                                          4 10215
## + rcs(bmi)                                             4 10216
## + rcs(IV_AHI)                                          4 10216
## - factor(rokare)                                       1 10218
## - rcs(GFR)                                             4 10224
## - rcs(systoliskt)                                      4 10226
## + rcs(alder):rcs(GFR)                                 16 10227
## - rcs(hba1c)                                           4 10231
## - rcs(alder)                                           4 10242
## - factor(sex)                                          1 10244
## - factor(antithrombotic_agents)                        1 10277
## - factor(ami_history)                                  1 10338

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## 
## Step:  AIC=10205.69
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c) + 
##     rcs(systoliskt) + rcs(GFR) + factor(rokare) + factor(lipid_modifying_agents) + 
##     rcs(IV_AverageSaturation)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

##                                                       Df   AIC
## + factor(cpap_treated):factor(antithrombotic_agents)   1 10204
## + rcs(kolesterol)                                      4 10205
## + factor(antihypertensive_comb)                        1 10205
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 10205
## + rcs(DispInkKEHB04)                                   4 10206
## <none>                                                   10206
## + rcs(Raks_AndelSjukInk)                               4 10207
## + factor(cpap_treated):rcs(GFR)                        4 10207
## + factor(stroke_history)                               1 10207
## + factor(FodelseLand_EU27_2020)                        1 10208
## + factor(Civil)                                        1 10208
## + rcs(IV_ODI)                                          4 10208
## + factor(Sun2000niva_old)                              6 10208
## + factor(HushallsTyp_RTB)                              2 10209
## + rcs(IV_AHI)                                          4 10209
## + rcs(Raks_AndelEkBisInk)                              3 10210
## - rcs(IV_AverageSaturation)                            4 10210
## + rcs(Raks_AndelArblosInk)                             4 10210
## + rcs(bmi)                                             4 10211
## - factor(lipid_modifying_agents)                       1 10212
## - factor(rokare)                                       1 10215
## - rcs(GFR)                                             4 10220
## - rcs(systoliskt)                                      4 10222
## + rcs(alder):rcs(GFR)                                 16 10222
## - rcs(hba1c)                                           4 10227
## - factor(sex)                                          1 10240
## - rcs(alder)                                           4 10240
## - factor(antithrombotic_agents)                        1 10274
## - factor(ami_history)                                  1 10335

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## 
## Step:  AIC=10204.01
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c) + 
##     rcs(systoliskt) + rcs(GFR) + factor(rokare) + factor(lipid_modifying_agents) + 
##     rcs(IV_AverageSaturation) + factor(cpap_treated):factor(antithrombotic_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

##                                                       Df   AIC
## + rcs(kolesterol)                                      4 10203
## + factor(antihypertensive_comb)                        1 10204
## <none>                                                   10204
## + rcs(DispInkKEHB04)                                   4 10204
## + rcs(Raks_AndelSjukInk)                               4 10205
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 10205
## + factor(stroke_history)                               1 10206
## + factor(cpap_treated):rcs(GFR)                        4 10206
## - factor(cpap_treated):factor(antithrombotic_agents)   1 10206
## + factor(FodelseLand_EU27_2020)                        1 10206
## + factor(Civil)                                        1 10206
## + rcs(IV_ODI)                                          4 10206
## + factor(Sun2000niva_old)                              6 10207
## + rcs(IV_AHI)                                          4 10207
## + factor(HushallsTyp_RTB)                              2 10207
## + rcs(Raks_AndelEkBisInk)                              3 10208
## - rcs(IV_AverageSaturation)                            4 10208
## + rcs(Raks_AndelArblosInk)                             4 10209
## + rcs(bmi)                                             4 10209
## - factor(lipid_modifying_agents)                       1 10210
## - factor(rokare)                                       1 10213
## - rcs(GFR)                                             4 10219
## - rcs(systoliskt)                                      4 10220
## + rcs(alder):rcs(GFR)                                 16 10221
## - rcs(hba1c)                                           4 10226
## - rcs(alder)                                           4 10238
## - factor(sex)                                          1 10238
## - factor(ami_history)                                  1 10335

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## 
## Step:  AIC=10202.98
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c) + 
##     rcs(systoliskt) + rcs(GFR) + factor(rokare) + factor(lipid_modifying_agents) + 
##     rcs(IV_AverageSaturation) + rcs(kolesterol) + factor(cpap_treated):factor(antithrombotic_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

##                                                       Df   AIC
## + factor(antihypertensive_comb)                        1 10202
## + rcs(DispInkKEHB04)                                   4 10203
## <none>                                                   10203
## + rcs(Raks_AndelSjukInk)                               4 10204
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 10204
## - rcs(kolesterol)                                      4 10204
## + factor(stroke_history)                               1 10204
## + factor(cpap_treated):rcs(GFR)                        4 10205
## - factor(cpap_treated):factor(antithrombotic_agents)   1 10205
## + factor(FodelseLand_EU27_2020)                        1 10205
## + factor(Civil)                                        1 10205
## + rcs(IV_ODI)                                          4 10205
## + factor(Sun2000niva_old)                              6 10205
## + rcs(IV_AHI)                                          4 10206
## + factor(HushallsTyp_RTB)                              2 10206
## + rcs(Raks_AndelEkBisInk)                              3 10207
## - rcs(IV_AverageSaturation)                            4 10207
## + rcs(Raks_AndelArblosInk)                             4 10208
## + rcs(bmi)                                             4 10208
## - factor(lipid_modifying_agents)                       1 10210
## - factor(rokare)                                       1 10212
## - rcs(GFR)                                             4 10217
## - rcs(systoliskt)                                      4 10218
## + rcs(alder):rcs(GFR)                                 16 10220
## - rcs(hba1c)                                           4 10225
## - rcs(alder)                                           4 10238
## - factor(sex)                                          1 10238
## - factor(ami_history)                                  1 10333

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## 
## Step:  AIC=10202.28
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c) + 
##     rcs(systoliskt) + rcs(GFR) + factor(rokare) + factor(lipid_modifying_agents) + 
##     rcs(IV_AverageSaturation) + rcs(kolesterol) + factor(antihypertensive_comb) + 
##     factor(cpap_treated):factor(antithrombotic_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

##                                                       Df   AIC
## + rcs(DispInkKEHB04)                                   4 10202
## + factor(cpap_treated):factor(antihypertensive_comb)   1 10202
## <none>                                                   10202
## - factor(antihypertensive_comb)                        1 10203
## + rcs(Raks_AndelSjukInk)                               4 10203
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 10203
## - rcs(kolesterol)                                      4 10204
## + factor(cpap_treated):rcs(GFR)                        4 10204
## + factor(stroke_history)                               1 10204
## - factor(cpap_treated):factor(antithrombotic_agents)   1 10204
## + factor(FodelseLand_EU27_2020)                        1 10204
## + factor(Civil)                                        1 10204
## + rcs(IV_ODI)                                          4 10205
## + factor(Sun2000niva_old)                              6 10205
## + factor(HushallsTyp_RTB)                              2 10206
## + rcs(IV_AHI)                                          4 10206
## + rcs(Raks_AndelEkBisInk)                              3 10206
## + rcs(Raks_AndelArblosInk)                             4 10207
## - rcs(IV_AverageSaturation)                            4 10208
## - factor(lipid_modifying_agents)                       1 10208
## + rcs(bmi)                                             4 10208
## - factor(rokare)                                       1 10212
## - rcs(systoliskt)                                      4 10215
## - rcs(GFR)                                             4 10216
## + rcs(alder):rcs(GFR)                                 16 10219
## - rcs(hba1c)                                           4 10225
## - rcs(alder)                                           4 10235
## - factor(sex)                                          1 10237
## - factor(ami_history)                                  1 10333

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## 
## Step:  AIC=10201.76
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c) + 
##     rcs(systoliskt) + rcs(GFR) + factor(rokare) + factor(lipid_modifying_agents) + 
##     rcs(IV_AverageSaturation) + rcs(kolesterol) + factor(antihypertensive_comb) + 
##     rcs(DispInkKEHB04) + factor(cpap_treated):factor(antithrombotic_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

##                                                       Df   AIC
## + factor(cpap_treated):factor(antihypertensive_comb)   1 10202
## <none>                                                   10202
## + rcs(Raks_AndelSjukInk)                               4 10202
## - rcs(DispInkKEHB04)                                   4 10202
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 10203
## - factor(antihypertensive_comb)                        1 10203
## - rcs(kolesterol)                                      4 10203
## + factor(stroke_history)                               1 10203
## - factor(cpap_treated):factor(antithrombotic_agents)   1 10203
## + factor(cpap_treated):rcs(GFR)                        4 10203
## + factor(Civil)                                        1 10204
## + factor(FodelseLand_EU27_2020)                        1 10204
## + rcs(IV_ODI)                                          4 10204
## + factor(HushallsTyp_RTB)                              2 10204
## + rcs(IV_AHI)                                          4 10205
## + rcs(Raks_AndelArblosInk)                             4 10207
## - factor(lipid_modifying_agents)                       1 10207
## + rcs(Raks_AndelEkBisInk)                              3 10207
## + factor(Sun2000niva_old)                              6 10207
## - rcs(IV_AverageSaturation)                            4 10207
## + rcs(bmi)                                             4 10207
## - factor(rokare)                                       1 10210
## - rcs(systoliskt)                                      4 10214
## - rcs(GFR)                                             4 10214
## + rcs(alder):rcs(GFR)                                 16 10219
## - rcs(hba1c)                                           4 10221
## - rcs(alder)                                           4 10236
## - factor(sex)                                          1 10240
## - factor(ami_history)                                  1 10333

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## 
## Step:  AIC=10201.47
## Surv(start, stop, event) ~ factor(cpap_treated) + factor(antithrombotic_agents) + 
##     factor(ami_history) + rcs(alder) + factor(sex) + rcs(hba1c) + 
##     rcs(systoliskt) + rcs(GFR) + factor(rokare) + factor(lipid_modifying_agents) + 
##     rcs(IV_AverageSaturation) + rcs(kolesterol) + factor(antihypertensive_comb) + 
##     rcs(DispInkKEHB04) + factor(cpap_treated):factor(antithrombotic_agents) + 
##     factor(cpap_treated):factor(antihypertensive_comb)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 3 ; beta may be infinite.

##                                                       Df   AIC
## <none>                                                   10202
## + rcs(Raks_AndelSjukInk)                               4 10202
## - factor(cpap_treated):factor(antihypertensive_comb)   1 10202
## - factor(cpap_treated):factor(antithrombotic_agents)   1 10202
## - rcs(DispInkKEHB04)                                   4 10202
## + factor(cpap_treated):rcs(GFR)                        4 10203
## - rcs(kolesterol)                                      4 10203
## + factor(cpap_treated):factor(lipid_modifying_agents)  1 10203
## + factor(stroke_history)                               1 10203
## + factor(FodelseLand_EU27_2020)                        1 10203
## + factor(Civil)                                        1 10203
## + rcs(IV_ODI)                                          4 10204
## + factor(HushallsTyp_RTB)                              2 10204
## + rcs(IV_AHI)                                          4 10205
## + rcs(Raks_AndelArblosInk)                             4 10206
## - factor(lipid_modifying_agents)                       1 10206
## + rcs(Raks_AndelEkBisInk)                              3 10206
## + factor(Sun2000niva_old)                              6 10207
## - rcs(IV_AverageSaturation)                            4 10207
## + rcs(bmi)                                             4 10207
## - factor(rokare)                                       1 10210
## - rcs(GFR)                                             4 10214
## - rcs(systoliskt)                                      4 10214
## + rcs(alder):rcs(GFR)                                 16 10218
## - rcs(hba1c)                                           4 10220
## - rcs(alder)                                           4 10236
## - factor(sex)                                          1 10240
## - factor(ami_history)                                  1 10333
## [1] "--- SURVIVAL RESULTS ---"
## Call:
## coxph(formula = Surv(start, stop, event) ~ factor(cpap_treated) + 
##     factor(antithrombotic_agents) + factor(ami_history) + rcs(alder) + 
##     factor(sex) + rcs(hba1c) + rcs(systoliskt) + rcs(GFR) + factor(rokare) + 
##     factor(lipid_modifying_agents) + rcs(IV_AverageSaturation) + 
##     rcs(kolesterol) + factor(antihypertensive_comb) + rcs(DispInkKEHB04) + 
##     factor(cpap_treated):factor(antithrombotic_agents) + factor(cpap_treated):factor(antihypertensive_comb), 
##     data = df_train)
## 
##   n= 149203, number of events= 608 
## 
##                                                            coef  exp(coef)
## factor(cpap_treated)1                                -8.580e-01  4.240e-01
## factor(antithrombotic_agents)1                        6.684e-01  1.951e+00
## factor(ami_history)1                                 -1.800e+01  1.527e-08
## rcs(alder)alder                                       8.898e-01  2.435e+00
## rcs(alder)alder'                                     -1.461e+00  2.320e-01
## rcs(alder)alder''                                     6.245e+00  5.152e+02
## rcs(alder)alder'''                                   -1.015e+01  3.919e-05
## factor(sex)1                                         -6.079e-01  5.445e-01
## rcs(hba1c)hba1c                                       9.687e-01  2.634e+00
## rcs(hba1c)hba1c'                                     -6.722e+00  1.204e-03
## rcs(hba1c)hba1c''                                     1.625e+01  1.138e+07
## rcs(hba1c)hba1c'''                                   -1.136e+01  1.164e-05
## rcs(systoliskt)systoliskt                            -1.613e-01  8.510e-01
## rcs(systoliskt)systoliskt'                            6.285e-01  1.875e+00
## rcs(systoliskt)systoliskt''                           1.070e+00  2.915e+00
## rcs(systoliskt)systoliskt'''                         -9.046e+00  1.179e-04
## rcs(GFR)GFR                                          -3.496e-01  7.050e-01
## rcs(GFR)GFR'                                          1.463e+00  4.320e+00
## rcs(GFR)GFR''                                        -1.169e+01  8.377e-06
## rcs(GFR)GFR'''                                        2.283e+01  8.220e+09
## factor(rokare)1                                       3.600e-01  1.433e+00
## factor(lipid_modifying_agents)1                       2.345e-01  1.264e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation        -1.961e-01  8.219e-01
## rcs(IV_AverageSaturation)IV_AverageSaturation'        7.393e-01  2.094e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation''      -4.249e+00  1.427e-02
## rcs(IV_AverageSaturation)IV_AverageSaturation'''      1.070e+01  4.427e+04
## rcs(kolesterol)kolesterol                            -1.346e-01  8.741e-01
## rcs(kolesterol)kolesterol'                           -6.052e-01  5.460e-01
## rcs(kolesterol)kolesterol''                           5.759e+00  3.170e+02
## rcs(kolesterol)kolesterol'''                         -1.213e+01  5.410e-06
## factor(antihypertensive_comb)1                        1.088e-01  1.115e+00
## rcs(DispInkKEHB04)DispInkKEHB04                      -2.456e-02  9.757e-01
## rcs(DispInkKEHB04)DispInkKEHB04'                     -2.872e+00  5.656e-02
## rcs(DispInkKEHB04)DispInkKEHB04''                     4.823e+00  1.243e+02
## rcs(DispInkKEHB04)DispInkKEHB04'''                    1.518e+00  4.564e+00
## factor(cpap_treated)1:factor(antithrombotic_agents)1  3.386e-01  1.403e+00
## factor(cpap_treated)1:factor(antihypertensive_comb)1  3.922e-01  1.480e+00
##                                                        se(coef)      z Pr(>|z|)
## factor(cpap_treated)1                                 2.512e-01 -3.416 0.000635
## factor(antithrombotic_agents)1                        9.959e-02  6.712 1.93e-11
## factor(ami_history)1                                  9.291e+02 -0.019 0.984546
## rcs(alder)alder                                       3.119e-01  2.853 0.004330
## rcs(alder)alder'                                      1.035e+00 -1.411 0.158145
## rcs(alder)alder''                                     5.261e+00  1.187 0.235276
## rcs(alder)alder'''                                    9.036e+00 -1.123 0.261479
## factor(sex)1                                          9.983e-02 -6.089 1.14e-09
## rcs(hba1c)hba1c                                       4.462e-01  2.171 0.029922
## rcs(hba1c)hba1c'                                      6.125e+00 -1.098 0.272378
## rcs(hba1c)hba1c''                                     1.797e+01  0.904 0.365800
## rcs(hba1c)hba1c'''                                    1.638e+01 -0.694 0.487978
## rcs(systoliskt)systoliskt                             1.980e-01 -0.815 0.415106
## rcs(systoliskt)systoliskt'                            1.212e+00  0.519 0.603965
## rcs(systoliskt)systoliskt''                           6.056e+00  0.177 0.859782
## rcs(systoliskt)systoliskt'''                          1.187e+01 -0.762 0.445892
## rcs(GFR)GFR                                           1.470e-01 -2.378 0.017390
## rcs(GFR)GFR'                                          8.938e-01  1.637 0.101592
## rcs(GFR)GFR''                                         5.853e+00 -1.997 0.045783
## rcs(GFR)GFR'''                                        9.783e+00  2.334 0.019614
## factor(rokare)1                                       1.094e-01  3.290 0.001003
## factor(lipid_modifying_agents)1                       9.005e-02  2.604 0.009226
## rcs(IV_AverageSaturation)IV_AverageSaturation         7.574e-02 -2.589 0.009625
## rcs(IV_AverageSaturation)IV_AverageSaturation'        3.412e-01  2.167 0.030262
## rcs(IV_AverageSaturation)IV_AverageSaturation''       3.431e+00 -1.238 0.215542
## rcs(IV_AverageSaturation)IV_AverageSaturation'''      1.289e+01  0.830 0.406579
## rcs(kolesterol)kolesterol                             2.291e-01 -0.587 0.557042
## rcs(kolesterol)kolesterol'                            1.718e+00 -0.352 0.724626
## rcs(kolesterol)kolesterol''                           6.682e+00  0.862 0.388769
## rcs(kolesterol)kolesterol'''                          9.580e+00 -1.266 0.205556
## factor(antihypertensive_comb)1                        1.075e-01  1.012 0.311572
## rcs(DispInkKEHB04)DispInkKEHB04                       4.707e-01 -0.052 0.958386
## rcs(DispInkKEHB04)DispInkKEHB04'                      6.345e+00 -0.453 0.650747
## rcs(DispInkKEHB04)DispInkKEHB04''                     2.135e+01  0.226 0.821277
## rcs(DispInkKEHB04)DispInkKEHB04'''                    2.414e+01  0.063 0.949848
## factor(cpap_treated)1:factor(antithrombotic_agents)1  2.146e-01  1.578 0.114539
## factor(cpap_treated)1:factor(antihypertensive_comb)1  2.661e-01  1.474 0.140489
##                                                         
## factor(cpap_treated)1                                ***
## factor(antithrombotic_agents)1                       ***
## factor(ami_history)1                                    
## rcs(alder)alder                                      ** 
## rcs(alder)alder'                                        
## rcs(alder)alder''                                       
## rcs(alder)alder'''                                      
## factor(sex)1                                         ***
## rcs(hba1c)hba1c                                      *  
## rcs(hba1c)hba1c'                                        
## rcs(hba1c)hba1c''                                       
## rcs(hba1c)hba1c'''                                      
## rcs(systoliskt)systoliskt                               
## rcs(systoliskt)systoliskt'                              
## rcs(systoliskt)systoliskt''                             
## rcs(systoliskt)systoliskt'''                            
## rcs(GFR)GFR                                          *  
## rcs(GFR)GFR'                                            
## rcs(GFR)GFR''                                        *  
## rcs(GFR)GFR'''                                       *  
## factor(rokare)1                                      ** 
## factor(lipid_modifying_agents)1                      ** 
## rcs(IV_AverageSaturation)IV_AverageSaturation        ** 
## rcs(IV_AverageSaturation)IV_AverageSaturation'       *  
## rcs(IV_AverageSaturation)IV_AverageSaturation''         
## rcs(IV_AverageSaturation)IV_AverageSaturation'''        
## rcs(kolesterol)kolesterol                               
## rcs(kolesterol)kolesterol'                              
## rcs(kolesterol)kolesterol''                             
## rcs(kolesterol)kolesterol'''                            
## factor(antihypertensive_comb)1                          
## rcs(DispInkKEHB04)DispInkKEHB04                         
## rcs(DispInkKEHB04)DispInkKEHB04'                        
## rcs(DispInkKEHB04)DispInkKEHB04''                       
## rcs(DispInkKEHB04)DispInkKEHB04'''                      
## factor(cpap_treated)1:factor(antithrombotic_agents)1    
## factor(cpap_treated)1:factor(antihypertensive_comb)1    
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
##                                                      exp(coef) exp(-coef)
## factor(cpap_treated)1                                4.240e-01  2.359e+00
## factor(antithrombotic_agents)1                       1.951e+00  5.125e-01
## factor(ami_history)1                                 1.527e-08  6.547e+07
## rcs(alder)alder                                      2.435e+00  4.107e-01
## rcs(alder)alder'                                     2.320e-01  4.311e+00
## rcs(alder)alder''                                    5.152e+02  1.941e-03
## rcs(alder)alder'''                                   3.919e-05  2.552e+04
## factor(sex)1                                         5.445e-01  1.837e+00
## rcs(hba1c)hba1c                                      2.634e+00  3.796e-01
## rcs(hba1c)hba1c'                                     1.204e-03  8.307e+02
## rcs(hba1c)hba1c''                                    1.138e+07  8.784e-08
## rcs(hba1c)hba1c'''                                   1.164e-05  8.588e+04
## rcs(systoliskt)systoliskt                            8.510e-01  1.175e+00
## rcs(systoliskt)systoliskt'                           1.875e+00  5.334e-01
## rcs(systoliskt)systoliskt''                          2.915e+00  3.431e-01
## rcs(systoliskt)systoliskt'''                         1.179e-04  8.483e+03
## rcs(GFR)GFR                                          7.050e-01  1.418e+00
## rcs(GFR)GFR'                                         4.320e+00  2.315e-01
## rcs(GFR)GFR''                                        8.377e-06  1.194e+05
## rcs(GFR)GFR'''                                       8.220e+09  1.217e-10
## factor(rokare)1                                      1.433e+00  6.977e-01
## factor(lipid_modifying_agents)1                      1.264e+00  7.910e-01
## rcs(IV_AverageSaturation)IV_AverageSaturation        8.219e-01  1.217e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation'       2.094e+00  4.774e-01
## rcs(IV_AverageSaturation)IV_AverageSaturation''      1.427e-02  7.006e+01
## rcs(IV_AverageSaturation)IV_AverageSaturation'''     4.427e+04  2.259e-05
## rcs(kolesterol)kolesterol                            8.741e-01  1.144e+00
## rcs(kolesterol)kolesterol'                           5.460e-01  1.832e+00
## rcs(kolesterol)kolesterol''                          3.170e+02  3.154e-03
## rcs(kolesterol)kolesterol'''                         5.410e-06  1.849e+05
## factor(antihypertensive_comb)1                       1.115e+00  8.969e-01
## rcs(DispInkKEHB04)DispInkKEHB04                      9.757e-01  1.025e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                     5.656e-02  1.768e+01
## rcs(DispInkKEHB04)DispInkKEHB04''                    1.243e+02  8.044e-03
## rcs(DispInkKEHB04)DispInkKEHB04'''                   4.564e+00  2.191e-01
## factor(cpap_treated)1:factor(antithrombotic_agents)1 1.403e+00  7.128e-01
## factor(cpap_treated)1:factor(antihypertensive_comb)1 1.480e+00  6.756e-01
##                                                      lower .95 upper .95
## factor(cpap_treated)1                                2.592e-01 6.937e-01
## factor(antithrombotic_agents)1                       1.605e+00 2.372e+00
## factor(ami_history)1                                 0.000e+00       Inf
## rcs(alder)alder                                      1.321e+00 4.486e+00
## rcs(alder)alder'                                     3.050e-02 1.765e+00
## rcs(alder)alder''                                    1.712e-02 1.551e+07
## rcs(alder)alder'''                                   7.968e-13 1.928e+03
## factor(sex)1                                         4.477e-01 6.622e-01
## rcs(hba1c)hba1c                                      1.099e+00 6.316e+00
## rcs(hba1c)hba1c'                                     7.368e-09 1.967e+02
## rcs(hba1c)hba1c''                                    5.804e-09 2.233e+22
## rcs(hba1c)hba1c'''                                   1.326e-19 1.022e+09
## rcs(systoliskt)systoliskt                            5.774e-01 1.254e+00
## rcs(systoliskt)systoliskt'                           1.744e-01 2.015e+01
## rcs(systoliskt)systoliskt''                          2.041e-05 4.161e+05
## rcs(systoliskt)systoliskt'''                         9.340e-15 1.488e+06
## rcs(GFR)GFR                                          5.285e-01 9.404e-01
## rcs(GFR)GFR'                                         7.494e-01 2.491e+01
## rcs(GFR)GFR''                                        8.736e-11 8.033e-01
## rcs(GFR)GFR'''                                       3.870e+01 1.746e+18
## factor(rokare)1                                      1.157e+00 1.776e+00
## factor(lipid_modifying_agents)1                      1.060e+00 1.508e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation        7.085e-01 9.535e-01
## rcs(IV_AverageSaturation)IV_AverageSaturation'       1.073e+00 4.088e+00
## rcs(IV_AverageSaturation)IV_AverageSaturation''      1.714e-05 1.189e+01
## rcs(IV_AverageSaturation)IV_AverageSaturation'''     4.718e-07 4.154e+15
## rcs(kolesterol)kolesterol                            5.578e-01 1.370e+00
## rcs(kolesterol)kolesterol'                           1.884e-02 1.583e+01
## rcs(kolesterol)kolesterol''                          6.505e-04 1.545e+08
## rcs(kolesterol)kolesterol'''                         3.789e-14 7.724e+02
## factor(antihypertensive_comb)1                       9.031e-01 1.376e+00
## rcs(DispInkKEHB04)DispInkKEHB04                      3.878e-01 2.455e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                     2.248e-07 1.423e+04
## rcs(DispInkKEHB04)DispInkKEHB04''                    8.361e-17 1.848e+20
## rcs(DispInkKEHB04)DispInkKEHB04'''                   1.302e-20 1.600e+21
## factor(cpap_treated)1:factor(antithrombotic_agents)1 9.213e-01 2.136e+00
## factor(cpap_treated)1:factor(antihypertensive_comb)1 8.787e-01 2.494e+00
## 
## Concordance= 0.745  (se = 0.01 )
## Likelihood ratio test= 489.4  on 37 df,   p=<2e-16
## Wald test            = 376.5  on 37 df,   p=<2e-16
## Score (logrank) test = 465.7  on 37 df,   p=<2e-16

## Warning in termplot(cph): 'model' appears to involve interactions: see the help
## page

## [1] "--- CONCORDANCE RESULTS ---"
## C-index train: 0.7453331 
## C-index test: 0.7453331

Stroke

Time-dependent

Group 1

run_models(c(list_forms[["form_tdep_spl"]], list_forms[["form_tdep_cat"]]), df_stroke_tv_train, df_stroke_tv_test, "stop", "event", cont_var, "prof_stroke_dep_g1.html")

## [1] "### FORMULA 1 ###"

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 13 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(x = X[idx, ], y = Y[idx, ], strata = strata[idx], offset =
## offset[idx], : Loglik converged before variable 13 ; beta may be infinite.

## [1] "--- SURVIVAL RESULTS ---"
## Call:
## coxph(formula = form, data = df_train, x = T)
## 
##   n= 7086751, number of events= 36051 
## 
##                                                              coef   exp(coef)
## factor(cpap_treated)1                                   6.724e-02   1.070e+00
## rcs(alder)alder                                         1.151e+00   3.162e+00
## rcs(alder)alder'                                       -1.701e+00   1.825e-01
## rcs(alder)alder''                                       1.057e+01   3.893e+04
## rcs(alder)alder'''                                     -2.084e+01   8.866e-10
## factor(sex)1                                           -2.809e-01   7.551e-01
## rcs(bmi)bmi                                             1.075e-01   1.113e+00
## rcs(bmi)bmi'                                           -3.822e+00   2.189e-02
## rcs(bmi)bmi''                                           1.620e+01   1.084e+07
## rcs(bmi)bmi'''                                         -1.771e+01   2.033e-08
## factor(rokare)1                                         3.180e-01   1.374e+00
## factor(ami_history)1                                    2.997e-03   1.003e+00
## factor(stroke_history)1                                -1.675e+01   5.312e-08
## factor(Civil)1                                         -3.443e-02   9.662e-01
## factor(HushallsTyp_RTB)2                               -1.073e-01   8.982e-01
## factor(HushallsTyp_RTB)3                               -1.920e-02   9.810e-01
## factor(Sun2000niva_old)2                                4.780e-02   1.049e+00
## factor(Sun2000niva_old)3                                1.536e-02   1.015e+00
## factor(Sun2000niva_old)4                                1.491e-02   1.015e+00
## factor(Sun2000niva_old)5                                2.736e-02   1.028e+00
## factor(Sun2000niva_old)6                               -1.280e-02   9.873e-01
## factor(Sun2000niva_old)7                                4.471e-02   1.046e+00
## rcs(DispInkKEHB04)DispInkKEHB04                         8.096e-02   1.084e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                       -7.254e+00   7.070e-04
## rcs(DispInkKEHB04)DispInkKEHB04''                       1.332e+01   6.115e+05
## rcs(DispInkKEHB04)DispInkKEHB04'''                     -2.152e+00   1.163e-01
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk             1.042e+00   2.833e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'           -3.985e+02  9.018e-174
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''           4.288e+02  1.628e+186
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''         -3.223e+01   1.004e-14
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                 2.803e+00   1.650e+01
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'               -3.498e+03   0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''               4.028e+03         Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''             -5.379e+02  2.590e-234
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk               1.084e+00   2.957e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'             -1.855e+02   2.861e-81
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''             1.941e+02   2.033e+84
## factor(FodelseLand_EU27_2020)1                          5.298e-02   1.054e+00
## factor(antithrombotic_agents)1                          5.071e-01   1.661e+00
## factor(antihypertensive_comb)1                          4.178e-02   1.043e+00
## factor(lipid_modifying_agents)1                        -4.068e-03   9.959e-01
## rcs(hba1c)hba1c                                         4.347e-03   1.004e+00
## rcs(hba1c)hba1c'                                        2.181e+00   8.858e+00
## rcs(hba1c)hba1c''                                      -5.008e+00   6.686e-03
## rcs(hba1c)hba1c'''                                      2.160e+00   8.672e+00
## rcs(GFR)GFR                                            -3.599e-01   6.977e-01
## rcs(GFR)GFR'                                           -1.146e+00   3.180e-01
## rcs(GFR)GFR''                                           1.286e+01   3.830e+05
## rcs(GFR)GFR'''                                         -2.463e+01   2.013e-11
## rcs(kolesterol)kolesterol                              -9.338e-02   9.109e-01
## rcs(kolesterol)kolesterol'                              1.068e+00   2.910e+00
## rcs(kolesterol)kolesterol''                            -4.281e+00   1.384e-02
## rcs(kolesterol)kolesterol'''                            4.813e+00   1.231e+02
## rcs(systoliskt)systoliskt                              -1.558e-01   8.557e-01
## rcs(systoliskt)systoliskt'                              5.906e-01   1.805e+00
## rcs(systoliskt)systoliskt''                            -8.857e-01   4.124e-01
## rcs(systoliskt)systoliskt'''                           -6.675e-01   5.130e-01
## factor(cpap_treated)1:factor(antithrombotic_agents)1   -1.335e-01   8.751e-01
## factor(cpap_treated)1:factor(antihypertensive_comb)1   -2.426e-02   9.760e-01
## factor(cpap_treated)1:factor(lipid_modifying_agents)1  -1.286e-01   8.793e-01
## rcs(alder)alder:rcs(bmi)bmi                             2.464e-01   1.279e+00
## rcs(alder)alder':rcs(bmi)bmi                           -8.995e-01   4.068e-01
## rcs(alder)alder'':rcs(bmi)bmi                           5.449e+00   2.324e+02
## rcs(alder)alder''':rcs(bmi)bmi                         -1.066e+01   2.342e-05
## rcs(alder)alder:rcs(bmi)bmi'                           -3.217e+00   4.006e-02
## rcs(alder)alder':rcs(bmi)bmi'                           1.463e+01   2.269e+06
## rcs(alder)alder'':rcs(bmi)bmi'                         -8.473e+01   1.601e-37
## rcs(alder)alder''':rcs(bmi)bmi'                         1.553e+02   2.907e+67
## rcs(alder)alder:rcs(bmi)bmi''                           1.252e+01   2.741e+05
## rcs(alder)alder':rcs(bmi)bmi''                         -6.239e+01   7.995e-28
## rcs(alder)alder'':rcs(bmi)bmi''                         3.609e+02  5.503e+156
## rcs(alder)alder''':rcs(bmi)bmi''                       -6.580e+02  1.717e-286
## rcs(alder)alder:rcs(bmi)bmi'''                         -1.285e+01   2.629e-06
## rcs(alder)alder':rcs(bmi)bmi'''                         7.020e+01   3.069e+30
## rcs(alder)alder'':rcs(bmi)bmi'''                       -4.061e+02  4.115e-177
## rcs(alder)alder''':rcs(bmi)bmi'''                       7.384e+02         Inf
## rcs(alder)alder:rcs(GFR)GFR                             1.816e-01   1.199e+00
## rcs(alder)alder':rcs(GFR)GFR                           -2.897e-01   7.485e-01
## rcs(alder)alder'':rcs(GFR)GFR                           2.139e+00   8.495e+00
## rcs(alder)alder''':rcs(GFR)GFR                         -4.522e+00   1.087e-02
## rcs(alder)alder:rcs(GFR)GFR'                           -1.128e+00   3.238e-01
## rcs(alder)alder':rcs(GFR)GFR'                           4.096e+00   6.011e+01
## rcs(alder)alder'':rcs(GFR)GFR'                         -1.756e+01   2.364e-08
## rcs(alder)alder''':rcs(GFR)GFR'                         2.020e+01   5.917e+08
## rcs(alder)alder:rcs(GFR)GFR''                           9.713e+00   1.653e+04
## rcs(alder)alder':rcs(GFR)GFR''                         -3.102e+01   3.382e-14
## rcs(alder)alder'':rcs(GFR)GFR''                         1.204e+02   1.960e+52
## rcs(alder)alder''':rcs(GFR)GFR''                       -1.268e+02   8.777e-56
## rcs(alder)alder:rcs(GFR)GFR'''                         -1.900e+01   5.582e-09
## rcs(alder)alder':rcs(GFR)GFR'''                         5.410e+01   3.132e+23
## rcs(alder)alder'':rcs(GFR)GFR'''                       -1.954e+02   1.433e-85
## rcs(alder)alder''':rcs(GFR)GFR'''                       1.899e+02   2.896e+82
## factor(cpap_treated)1:rcs(GFR)GFR                       6.030e-02   1.062e+00
## factor(cpap_treated)1:rcs(GFR)GFR'                      1.697e+00   5.455e+00
## factor(cpap_treated)1:rcs(GFR)GFR''                    -1.760e+01   2.279e-08
## factor(cpap_treated)1:rcs(GFR)GFR'''                    3.763e+01   2.206e+16
##                                                          se(coef)       z
## factor(cpap_treated)1                                   4.713e-01   0.143
## rcs(alder)alder                                         5.212e-01   2.209
## rcs(alder)alder'                                        1.561e+00  -1.090
## rcs(alder)alder''                                       7.548e+00   1.400
## rcs(alder)alder'''                                      1.256e+01  -1.660
## factor(sex)1                                            1.191e-02 -23.582
## rcs(bmi)bmi                                             4.706e-01   0.228
## rcs(bmi)bmi'                                            3.722e+00  -1.027
## rcs(bmi)bmi''                                           1.571e+01   1.031
## rcs(bmi)bmi'''                                          1.904e+01  -0.930
## factor(rokare)1                                         1.527e-02  20.826
## factor(ami_history)1                                    1.922e-02   0.156
## factor(stroke_history)1                                 8.574e+01  -0.195
## factor(Civil)1                                          1.709e-02  -2.015
## factor(HushallsTyp_RTB)2                                1.377e-02  -7.793
## factor(HushallsTyp_RTB)3                                2.111e-02  -0.909
## factor(Sun2000niva_old)2                                1.983e-02   2.410
## factor(Sun2000niva_old)3                                1.385e-02   1.109
## factor(Sun2000niva_old)4                                1.921e-02   0.776
## factor(Sun2000niva_old)5                                2.164e-02   1.264
## factor(Sun2000niva_old)6                                2.177e-02  -0.588
## factor(Sun2000niva_old)7                                6.916e-02   0.646
## rcs(DispInkKEHB04)DispInkKEHB04                         1.458e-01   0.555
## rcs(DispInkKEHB04)DispInkKEHB04'                        2.757e+00  -2.631
## rcs(DispInkKEHB04)DispInkKEHB04''                       8.391e+00   1.588
## rcs(DispInkKEHB04)DispInkKEHB04'''                      7.966e+00  -0.270
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk             2.204e-01   4.726
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'            9.576e+01  -4.161
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''           1.036e+02   4.137
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''          8.913e+00  -3.616
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                 3.793e-01   7.391
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'                5.499e+02  -6.361
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''               6.351e+02   6.341
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''              8.715e+01  -6.172
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk               1.560e-01   6.951
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'              2.791e+01  -6.644
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''             2.924e+01   6.639
## factor(FodelseLand_EU27_2020)1                          1.503e-02   3.524
## factor(antithrombotic_agents)1                          1.197e-02  42.362
## factor(antihypertensive_comb)1                          1.231e-02   3.393
## factor(lipid_modifying_agents)1                         1.176e-02  -0.346
## rcs(hba1c)hba1c                                         4.730e-02   0.092
## rcs(hba1c)hba1c'                                        5.965e-01   3.657
## rcs(hba1c)hba1c''                                       2.015e+00  -2.485
## rcs(hba1c)hba1c'''                                      2.018e+00   1.071
## rcs(GFR)GFR                                             2.760e-01  -1.304
## rcs(GFR)GFR'                                            1.744e+00  -0.657
## rcs(GFR)GFR''                                           9.562e+00   1.344
## rcs(GFR)GFR'''                                          1.472e+01  -1.673
## rcs(kolesterol)kolesterol                               3.012e-02  -3.100
## rcs(kolesterol)kolesterol'                              1.954e-01   5.467
## rcs(kolesterol)kolesterol''                             9.492e-01  -4.509
## rcs(kolesterol)kolesterol'''                            1.357e+00   3.548
## rcs(systoliskt)systoliskt                               2.566e-02  -6.074
## rcs(systoliskt)systoliskt'                              1.700e-01   3.475
## rcs(systoliskt)systoliskt''                             8.418e-01  -1.052
## rcs(systoliskt)systoliskt'''                            1.616e+00  -0.413
## factor(cpap_treated)1:factor(antithrombotic_agents)1    1.675e-01  -0.797
## factor(cpap_treated)1:factor(antihypertensive_comb)1    1.802e-01  -0.135
## factor(cpap_treated)1:factor(lipid_modifying_agents)1   1.663e-01  -0.773
## rcs(alder)alder:rcs(bmi)bmi                             3.779e-01   0.652
## rcs(alder)alder':rcs(bmi)bmi                            1.178e+00  -0.764
## rcs(alder)alder'':rcs(bmi)bmi                           5.805e+00   0.939
## rcs(alder)alder''':rcs(bmi)bmi                          9.737e+00  -1.095
## rcs(alder)alder:rcs(bmi)bmi'                            3.012e+00  -1.068
## rcs(alder)alder':rcs(bmi)bmi'                           9.350e+00   1.565
## rcs(alder)alder'':rcs(bmi)bmi'                          4.628e+01  -1.831
## rcs(alder)alder''':rcs(bmi)bmi'                         7.867e+01   1.975
## rcs(alder)alder:rcs(bmi)bmi''                           1.271e+01   0.985
## rcs(alder)alder':rcs(bmi)bmi''                          3.959e+01  -1.576
## rcs(alder)alder'':rcs(bmi)bmi''                         1.971e+02   1.831
## rcs(alder)alder''':rcs(bmi)bmi''                        3.381e+02  -1.946
## rcs(alder)alder:rcs(bmi)bmi'''                          1.538e+01  -0.835
## rcs(alder)alder':rcs(bmi)bmi'''                         4.816e+01   1.458
## rcs(alder)alder'':rcs(bmi)bmi'''                        2.413e+02  -1.683
## rcs(alder)alder''':rcs(bmi)bmi'''                       4.180e+02   1.767
## rcs(alder)alder:rcs(GFR)GFR                             2.243e-01   0.810
## rcs(alder)alder':rcs(GFR)GFR                            6.911e-01  -0.419
## rcs(alder)alder'':rcs(GFR)GFR                           3.396e+00   0.630
## rcs(alder)alder''':rcs(GFR)GFR                          5.729e+00  -0.789
## rcs(alder)alder:rcs(GFR)GFR'                            1.463e+00  -0.771
## rcs(alder)alder':rcs(GFR)GFR'                           4.337e+00   0.944
## rcs(alder)alder'':rcs(GFR)GFR'                          2.097e+01  -0.837
## rcs(alder)alder''':rcs(GFR)GFR'                         3.520e+01   0.574
## rcs(alder)alder:rcs(GFR)GFR''                           7.936e+00   1.224
## rcs(alder)alder':rcs(GFR)GFR''                          2.399e+01  -1.293
## rcs(alder)alder'':rcs(GFR)GFR''                         1.185e+02   1.016
## rcs(alder)alder''':rcs(GFR)GFR''                        2.047e+02  -0.619
## rcs(alder)alder:rcs(GFR)GFR'''                          1.201e+01  -1.583
## rcs(alder)alder':rcs(GFR)GFR'''                         3.740e+01   1.446
## rcs(alder)alder'':rcs(GFR)GFR'''                        1.903e+02  -1.027
## rcs(alder)alder''':rcs(GFR)GFR'''                       3.402e+02   0.558
## factor(cpap_treated)1:rcs(GFR)GFR                       3.166e-01   0.190
## factor(cpap_treated)1:rcs(GFR)GFR'                      1.890e+00   0.898
## factor(cpap_treated)1:rcs(GFR)GFR''                     1.095e+01  -1.607
## factor(cpap_treated)1:rcs(GFR)GFR'''                    1.806e+01   2.084
##                                                       Pr(>|z|)    
## factor(cpap_treated)1                                 0.886547    
## rcs(alder)alder                                       0.027191 *  
## rcs(alder)alder'                                      0.275854    
## rcs(alder)alder''                                     0.161418    
## rcs(alder)alder'''                                    0.096931 .  
## factor(sex)1                                           < 2e-16 ***
## rcs(bmi)bmi                                           0.819342    
## rcs(bmi)bmi'                                          0.304544    
## rcs(bmi)bmi''                                         0.302588    
## rcs(bmi)bmi'''                                        0.352254    
## factor(rokare)1                                        < 2e-16 ***
## factor(ami_history)1                                  0.876121    
## factor(stroke_history)1                               0.845108    
## factor(Civil)1                                        0.043866 *  
## factor(HushallsTyp_RTB)2                              6.52e-15 ***
## factor(HushallsTyp_RTB)3                              0.363113    
## factor(Sun2000niva_old)2                              0.015936 *  
## factor(Sun2000niva_old)3                              0.267607    
## factor(Sun2000niva_old)4                              0.437853    
## factor(Sun2000niva_old)5                              0.206191    
## factor(Sun2000niva_old)6                              0.556476    
## factor(Sun2000niva_old)7                              0.518005    
## rcs(DispInkKEHB04)DispInkKEHB04                       0.578562    
## rcs(DispInkKEHB04)DispInkKEHB04'                      0.008514 ** 
## rcs(DispInkKEHB04)DispInkKEHB04''                     0.112317    
## rcs(DispInkKEHB04)DispInkKEHB04'''                    0.787100    
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk           2.29e-06 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'          3.17e-05 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''         3.52e-05 ***
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''        0.000299 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk               1.46e-13 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'              2.00e-10 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''             2.28e-10 ***
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''            6.75e-10 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk             3.64e-12 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'            3.06e-11 ***
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''           3.17e-11 ***
## factor(FodelseLand_EU27_2020)1                        0.000425 ***
## factor(antithrombotic_agents)1                         < 2e-16 ***
## factor(antihypertensive_comb)1                        0.000691 ***
## factor(lipid_modifying_agents)1                       0.729352    
## rcs(hba1c)hba1c                                       0.926772    
## rcs(hba1c)hba1c'                                      0.000256 ***
## rcs(hba1c)hba1c''                                     0.012949 *  
## rcs(hba1c)hba1c'''                                    0.284338    
## rcs(GFR)GFR                                           0.192277    
## rcs(GFR)GFR'                                          0.511167    
## rcs(GFR)GFR''                                         0.178818    
## rcs(GFR)GFR'''                                        0.094388 .  
## rcs(kolesterol)kolesterol                             0.001935 ** 
## rcs(kolesterol)kolesterol'                            4.57e-08 ***
## rcs(kolesterol)kolesterol''                           6.50e-06 ***
## rcs(kolesterol)kolesterol'''                          0.000389 ***
## rcs(systoliskt)systoliskt                             1.25e-09 ***
## rcs(systoliskt)systoliskt'                            0.000511 ***
## rcs(systoliskt)systoliskt''                           0.292761    
## rcs(systoliskt)systoliskt'''                          0.679580    
## factor(cpap_treated)1:factor(antithrombotic_agents)1  0.425640    
## factor(cpap_treated)1:factor(antihypertensive_comb)1  0.892873    
## factor(cpap_treated)1:factor(lipid_modifying_agents)1 0.439377    
## rcs(alder)alder:rcs(bmi)bmi                           0.514437    
## rcs(alder)alder':rcs(bmi)bmi                          0.445117    
## rcs(alder)alder'':rcs(bmi)bmi                         0.347949    
## rcs(alder)alder''':rcs(bmi)bmi                        0.273531    
## rcs(alder)alder:rcs(bmi)bmi'                          0.285401    
## rcs(alder)alder':rcs(bmi)bmi'                         0.117524    
## rcs(alder)alder'':rcs(bmi)bmi'                        0.067121 .  
## rcs(alder)alder''':rcs(bmi)bmi'                       0.048311 *  
## rcs(alder)alder:rcs(bmi)bmi''                         0.324537    
## rcs(alder)alder':rcs(bmi)bmi''                        0.115049    
## rcs(alder)alder'':rcs(bmi)bmi''                       0.067027 .  
## rcs(alder)alder''':rcs(bmi)bmi''                      0.051634 .  
## rcs(alder)alder:rcs(bmi)bmi'''                        0.403522    
## rcs(alder)alder':rcs(bmi)bmi'''                       0.144944    
## rcs(alder)alder'':rcs(bmi)bmi'''                      0.092353 .  
## rcs(alder)alder''':rcs(bmi)bmi'''                     0.077310 .  
## rcs(alder)alder:rcs(GFR)GFR                           0.418125    
## rcs(alder)alder':rcs(GFR)GFR                          0.675024    
## rcs(alder)alder'':rcs(GFR)GFR                         0.528690    
## rcs(alder)alder''':rcs(GFR)GFR                        0.429904    
## rcs(alder)alder:rcs(GFR)GFR'                          0.440718    
## rcs(alder)alder':rcs(GFR)GFR'                         0.344934    
## rcs(alder)alder'':rcs(GFR)GFR'                        0.402376    
## rcs(alder)alder''':rcs(GFR)GFR'                       0.566092    
## rcs(alder)alder:rcs(GFR)GFR''                         0.220959    
## rcs(alder)alder':rcs(GFR)GFR''                        0.196010    
## rcs(alder)alder'':rcs(GFR)GFR''                       0.309575    
## rcs(alder)alder''':rcs(GFR)GFR''                      0.535626    
## rcs(alder)alder:rcs(GFR)GFR'''                        0.113493    
## rcs(alder)alder':rcs(GFR)GFR'''                       0.148042    
## rcs(alder)alder'':rcs(GFR)GFR'''                      0.304521    
## rcs(alder)alder''':rcs(GFR)GFR'''                     0.576758    
## factor(cpap_treated)1:rcs(GFR)GFR                     0.848954    
## factor(cpap_treated)1:rcs(GFR)GFR'                    0.369319    
## factor(cpap_treated)1:rcs(GFR)GFR''                   0.108019    
## factor(cpap_treated)1:rcs(GFR)GFR'''                  0.037162 *  
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
##                                                        exp(coef) exp(-coef)
## factor(cpap_treated)1                                  1.070e+00  9.350e-01
## rcs(alder)alder                                        3.162e+00  3.162e-01
## rcs(alder)alder'                                       1.825e-01  5.479e+00
## rcs(alder)alder''                                      3.893e+04  2.569e-05
## rcs(alder)alder'''                                     8.866e-10  1.128e+09
## factor(sex)1                                           7.551e-01  1.324e+00
## rcs(bmi)bmi                                            1.113e+00  8.981e-01
## rcs(bmi)bmi'                                           2.189e-02  4.568e+01
## rcs(bmi)bmi''                                          1.084e+07  9.225e-08
## rcs(bmi)bmi'''                                         2.033e-08  4.918e+07
## factor(rokare)1                                        1.374e+00  7.276e-01
## factor(ami_history)1                                   1.003e+00  9.970e-01
## factor(stroke_history)1                                5.312e-08  1.883e+07
## factor(Civil)1                                         9.662e-01  1.035e+00
## factor(HushallsTyp_RTB)2                               8.982e-01  1.113e+00
## factor(HushallsTyp_RTB)3                               9.810e-01  1.019e+00
## factor(Sun2000niva_old)2                               1.049e+00  9.533e-01
## factor(Sun2000niva_old)3                               1.015e+00  9.848e-01
## factor(Sun2000niva_old)4                               1.015e+00  9.852e-01
## factor(Sun2000niva_old)5                               1.028e+00  9.730e-01
## factor(Sun2000niva_old)6                               9.873e-01  1.013e+00
## factor(Sun2000niva_old)7                               1.046e+00  9.563e-01
## rcs(DispInkKEHB04)DispInkKEHB04                        1.084e+00  9.222e-01
## rcs(DispInkKEHB04)DispInkKEHB04'                       7.070e-04  1.414e+03
## rcs(DispInkKEHB04)DispInkKEHB04''                      6.115e+05  1.635e-06
## rcs(DispInkKEHB04)DispInkKEHB04'''                     1.163e-01  8.598e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk            2.833e+00  3.529e-01
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'          9.018e-174 1.109e+173
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''         1.628e+186 6.142e-187
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''         1.004e-14  9.956e+13
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                1.650e+01  6.061e-02
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'               0.000e+00        Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''                    Inf  0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''            2.590e-234 3.862e+233
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk              2.957e+00  3.382e-01
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'             2.861e-81  3.496e+80
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''            2.033e+84  4.920e-85
## factor(FodelseLand_EU27_2020)1                         1.054e+00  9.484e-01
## factor(antithrombotic_agents)1                         1.661e+00  6.022e-01
## factor(antihypertensive_comb)1                         1.043e+00  9.591e-01
## factor(lipid_modifying_agents)1                        9.959e-01  1.004e+00
## rcs(hba1c)hba1c                                        1.004e+00  9.957e-01
## rcs(hba1c)hba1c'                                       8.858e+00  1.129e-01
## rcs(hba1c)hba1c''                                      6.686e-03  1.496e+02
## rcs(hba1c)hba1c'''                                     8.672e+00  1.153e-01
## rcs(GFR)GFR                                            6.977e-01  1.433e+00
## rcs(GFR)GFR'                                           3.180e-01  3.144e+00
## rcs(GFR)GFR''                                          3.830e+05  2.611e-06
## rcs(GFR)GFR'''                                         2.013e-11  4.967e+10
## rcs(kolesterol)kolesterol                              9.109e-01  1.098e+00
## rcs(kolesterol)kolesterol'                             2.910e+00  3.436e-01
## rcs(kolesterol)kolesterol''                            1.384e-02  7.228e+01
## rcs(kolesterol)kolesterol'''                           1.231e+02  8.120e-03
## rcs(systoliskt)systoliskt                              8.557e-01  1.169e+00
## rcs(systoliskt)systoliskt'                             1.805e+00  5.540e-01
## rcs(systoliskt)systoliskt''                            4.124e-01  2.425e+00
## rcs(systoliskt)systoliskt'''                           5.130e-01  1.949e+00
## factor(cpap_treated)1:factor(antithrombotic_agents)1   8.751e-01  1.143e+00
## factor(cpap_treated)1:factor(antihypertensive_comb)1   9.760e-01  1.025e+00
## factor(cpap_treated)1:factor(lipid_modifying_agents)1  8.793e-01  1.137e+00
## rcs(alder)alder:rcs(bmi)bmi                            1.279e+00  7.816e-01
## rcs(alder)alder':rcs(bmi)bmi                           4.068e-01  2.458e+00
## rcs(alder)alder'':rcs(bmi)bmi                          2.324e+02  4.303e-03
## rcs(alder)alder''':rcs(bmi)bmi                         2.342e-05  4.270e+04
## rcs(alder)alder:rcs(bmi)bmi'                           4.006e-02  2.496e+01
## rcs(alder)alder':rcs(bmi)bmi'                          2.269e+06  4.407e-07
## rcs(alder)alder'':rcs(bmi)bmi'                         1.601e-37  6.248e+36
## rcs(alder)alder''':rcs(bmi)bmi'                        2.907e+67  3.440e-68
## rcs(alder)alder:rcs(bmi)bmi''                          2.741e+05  3.649e-06
## rcs(alder)alder':rcs(bmi)bmi''                         7.995e-28  1.251e+27
## rcs(alder)alder'':rcs(bmi)bmi''                       5.503e+156 1.817e-157
## rcs(alder)alder''':rcs(bmi)bmi''                      1.717e-286 5.824e+285
## rcs(alder)alder:rcs(bmi)bmi'''                         2.629e-06  3.804e+05
## rcs(alder)alder':rcs(bmi)bmi'''                        3.069e+30  3.258e-31
## rcs(alder)alder'':rcs(bmi)bmi'''                      4.115e-177 2.430e+176
## rcs(alder)alder''':rcs(bmi)bmi'''                            Inf 2.055e-321
## rcs(alder)alder:rcs(GFR)GFR                            1.199e+00  8.339e-01
## rcs(alder)alder':rcs(GFR)GFR                           7.485e-01  1.336e+00
## rcs(alder)alder'':rcs(GFR)GFR                          8.495e+00  1.177e-01
## rcs(alder)alder''':rcs(GFR)GFR                         1.087e-02  9.203e+01
## rcs(alder)alder:rcs(GFR)GFR'                           3.238e-01  3.089e+00
## rcs(alder)alder':rcs(GFR)GFR'                          6.011e+01  1.664e-02
## rcs(alder)alder'':rcs(GFR)GFR'                         2.364e-08  4.229e+07
## rcs(alder)alder''':rcs(GFR)GFR'                        5.917e+08  1.690e-09
## rcs(alder)alder:rcs(GFR)GFR''                          1.653e+04  6.049e-05
## rcs(alder)alder':rcs(GFR)GFR''                         3.382e-14  2.956e+13
## rcs(alder)alder'':rcs(GFR)GFR''                        1.960e+52  5.101e-53
## rcs(alder)alder''':rcs(GFR)GFR''                       8.777e-56  1.139e+55
## rcs(alder)alder:rcs(GFR)GFR'''                         5.582e-09  1.791e+08
## rcs(alder)alder':rcs(GFR)GFR'''                        3.132e+23  3.193e-24
## rcs(alder)alder'':rcs(GFR)GFR'''                       1.433e-85  6.980e+84
## rcs(alder)alder''':rcs(GFR)GFR'''                      2.896e+82  3.453e-83
## factor(cpap_treated)1:rcs(GFR)GFR                      1.062e+00  9.415e-01
## factor(cpap_treated)1:rcs(GFR)GFR'                     5.455e+00  1.833e-01
## factor(cpap_treated)1:rcs(GFR)GFR''                    2.279e-08  4.388e+07
## factor(cpap_treated)1:rcs(GFR)GFR'''                   2.206e+16  4.534e-17
##                                                        lower .95  upper .95
## factor(cpap_treated)1                                  4.247e-01  2.694e+00
## rcs(alder)alder                                        1.138e+00  8.784e+00
## rcs(alder)alder'                                       8.561e-03  3.890e+00
## rcs(alder)alder''                                      1.464e-02  1.035e+11
## rcs(alder)alder'''                                     1.816e-20  4.328e+01
## factor(sex)1                                           7.377e-01  7.730e-01
## rcs(bmi)bmi                                            4.427e-01  2.801e+00
## rcs(bmi)bmi'                                           1.485e-05  3.226e+01
## rcs(bmi)bmi''                                          4.570e-07  2.571e+20
## rcs(bmi)bmi'''                                         1.264e-24  3.270e+08
## factor(rokare)1                                        1.334e+00  1.416e+00
## factor(ami_history)1                                   9.659e-01  1.042e+00
## factor(stroke_history)1                                5.525e-81  5.107e+65
## factor(Civil)1                                         9.343e-01  9.991e-01
## factor(HushallsTyp_RTB)2                               8.743e-01  9.228e-01
## factor(HushallsTyp_RTB)3                               9.412e-01  1.022e+00
## factor(Sun2000niva_old)2                               1.009e+00  1.091e+00
## factor(Sun2000niva_old)3                               9.883e-01  1.043e+00
## factor(Sun2000niva_old)4                               9.775e-01  1.054e+00
## factor(Sun2000niva_old)5                               9.851e-01  1.072e+00
## factor(Sun2000niva_old)6                               9.460e-01  1.030e+00
## factor(Sun2000niva_old)7                               9.132e-01  1.198e+00
## rcs(DispInkKEHB04)DispInkKEHB04                        8.149e-01  1.443e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                       3.180e-06  1.572e-01
## rcs(DispInkKEHB04)DispInkKEHB04''                      4.406e-02  8.487e+12
## rcs(DispInkKEHB04)DispInkKEHB04'''                     1.926e-08  7.023e+05
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk            1.840e+00  4.364e+00
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'          2.805e-255  2.899e-92
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk''          9.813e+97 2.701e+274
## rcs(Raks_AndelArblosInk)Raks_AndelArblosInk'''         2.601e-22  3.879e-07
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk                7.845e+00  3.470e+01
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'               0.000e+00  0.000e+00
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk''                    Inf        Inf
## rcs(Raks_AndelSjukInk)Raks_AndelSjukInk'''            1.718e-308 3.904e-160
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk              2.178e+00  4.014e+00
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk'            4.962e-105  1.649e-57
## rcs(Raks_AndelEkBisInk)Raks_AndelEkBisInk''            2.613e+59 1.581e+109
## factor(FodelseLand_EU27_2020)1                         1.024e+00  1.086e+00
## factor(antithrombotic_agents)1                         1.622e+00  1.700e+00
## factor(antihypertensive_comb)1                         1.018e+00  1.068e+00
## factor(lipid_modifying_agents)1                        9.733e-01  1.019e+00
## rcs(hba1c)hba1c                                        9.154e-01  1.102e+00
## rcs(hba1c)hba1c'                                       2.751e+00  2.852e+01
## rcs(hba1c)hba1c''                                      1.288e-04  3.470e-01
## rcs(hba1c)hba1c'''                                     1.662e-01  4.523e+02
## rcs(GFR)GFR                                            4.062e-01  1.199e+00
## rcs(GFR)GFR'                                           1.043e-02  9.696e+00
## rcs(GFR)GFR''                                          2.777e-03  5.281e+13
## rcs(GFR)GFR'''                                         5.899e-24  6.870e+01
## rcs(kolesterol)kolesterol                              8.586e-01  9.662e-01
## rcs(kolesterol)kolesterol'                             1.984e+00  4.268e+00
## rcs(kolesterol)kolesterol''                            2.153e-03  8.892e-02
## rcs(kolesterol)kolesterol'''                           8.620e+00  1.759e+03
## rcs(systoliskt)systoliskt                              8.137e-01  8.998e-01
## rcs(systoliskt)systoliskt'                             1.294e+00  2.519e+00
## rcs(systoliskt)systoliskt''                            7.921e-02  2.147e+00
## rcs(systoliskt)systoliskt'''                           2.161e-02  1.218e+01
## factor(cpap_treated)1:factor(antithrombotic_agents)1   6.301e-01  1.215e+00
## factor(cpap_treated)1:factor(antihypertensive_comb)1   6.857e-01  1.389e+00
## factor(cpap_treated)1:factor(lipid_modifying_agents)1  6.347e-01  1.218e+00
## rcs(alder)alder:rcs(bmi)bmi                            6.100e-01  2.683e+00
## rcs(alder)alder':rcs(bmi)bmi                           4.042e-02  4.094e+00
## rcs(alder)alder'':rcs(bmi)bmi                          2.660e-03  2.030e+07
## rcs(alder)alder''':rcs(bmi)bmi                         1.205e-13  4.549e+03
## rcs(alder)alder:rcs(bmi)bmi'                           1.094e-04  1.467e+01
## rcs(alder)alder':rcs(bmi)bmi'                          2.496e-02  2.063e+14
## rcs(alder)alder'':rcs(bmi)bmi'                         6.515e-77  3.932e+02
## rcs(alder)alder''':rcs(bmi)bmi'                        3.169e+00 2.666e+134
## rcs(alder)alder:rcs(bmi)bmi''                          4.164e-06  1.804e+16
## rcs(alder)alder':rcs(bmi)bmi''                         1.592e-61  4.016e+06
## rcs(alder)alder'':rcs(bmi)bmi''                        1.013e-11        Inf
## rcs(alder)alder''':rcs(bmi)bmi''                       0.000e+00  1.061e+02
## rcs(alder)alder:rcs(bmi)bmi'''                         2.122e-19  3.256e+07
## rcs(alder)alder':rcs(bmi)bmi'''                        3.114e-11  3.025e+71
## rcs(alder)alder'':rcs(bmi)bmi'''                       0.000e+00  1.030e+29
## rcs(alder)alder''':rcs(bmi)bmi'''                      7.615e-36        Inf
## rcs(alder)alder:rcs(GFR)GFR                            7.726e-01  1.861e+00
## rcs(alder)alder':rcs(GFR)GFR                           1.932e-01  2.900e+00
## rcs(alder)alder'':rcs(GFR)GFR                          1.093e-02  6.603e+03
## rcs(alder)alder''':rcs(GFR)GFR                         1.444e-07  8.174e+02
## rcs(alder)alder:rcs(GFR)GFR'                           1.841e-02  5.693e+00
## rcs(alder)alder':rcs(GFR)GFR'                          1.222e-02  2.956e+05
## rcs(alder)alder'':rcs(GFR)GFR'                         3.341e-26  1.673e+10
## rcs(alder)alder''':rcs(GFR)GFR'                        6.449e-22  5.429e+38
## rcs(alder)alder:rcs(GFR)GFR''                          2.907e-03  9.400e+10
## rcs(alder)alder':rcs(GFR)GFR''                         1.288e-34  8.882e+06
## rcs(alder)alder'':rcs(GFR)GFR''                        2.671e-49 1.439e+153
## rcs(alder)alder''':rcs(GFR)GFR''                      5.485e-230 1.405e+119
## rcs(alder)alder:rcs(GFR)GFR'''                         3.359e-19  9.277e+01
## rcs(alder)alder':rcs(GFR)GFR'''                        4.563e-09  2.149e+55
## rcs(alder)alder'':rcs(GFR)GFR'''                      1.598e-247  1.285e+77
## rcs(alder)alder''':rcs(GFR)GFR'''                     7.613e-208        Inf
## factor(cpap_treated)1:rcs(GFR)GFR                      5.711e-01  1.975e+00
## factor(cpap_treated)1:rcs(GFR)GFR'                     1.343e-01  2.215e+02
## factor(cpap_treated)1:rcs(GFR)GFR''                    1.091e-17  4.760e+01
## factor(cpap_treated)1:rcs(GFR)GFR'''                   9.388e+00  5.182e+31
## 
## Concordance= 0.758  (se = 0.001 )
## Likelihood ratio test= 29806  on 96 df,   p=<2e-16
## Wald test            = 23506  on 96 df,   p=<2e-16
## Score (logrank) test = 30597  on 96 df,   p=<2e-16

## Warning in termplot(cph): 'model' appears to involve interactions: see the help
## page

## [1] "--- CONCORDANCE RESULTS ---"
## C-index train: 0.7582911 
## C-index test: 0.7581617

Group 2

run_models(c(list_forms_sleep[["form_tdep_spl"]], list_forms_sleep[["form_tdep_cat"]]), df_stroke_sub_tv_train, df_stroke_sub_tv_test, "stop", "event", cont_var, "prof_stroke_dep_g2.html", bigd=F)

## [1] "### FORMULA 1 ###"
## Start:  AIC=7501.25
## Surv(start, stop, event) ~ factor(cpap_treated)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df    AIC
## + rcs(alder)                      4 7401.1
## + factor(antithrombotic_agents)   1 7453.9
## + factor(stroke_history)          1 7479.0
## + rcs(systoliskt)                 4 7481.0
## + rcs(GFR)                        4 7481.0
## + rcs(DispInkKEHB04)              4 7484.2
## + rcs(hba1c)                      4 7491.2
## + rcs(IV_AHI)                     4 7492.2
## + rcs(IV_ODI)                     4 7492.7
## + factor(antihypertensive_comb)   1 7494.8
## + factor(lipid_modifying_agents)  1 7494.9
## + factor(ami_history)             1 7499.6
## + factor(Civil)                   1 7501.2
## <none>                              7501.2
## + factor(sex)                     1 7501.3
## + factor(FodelseLand_EU27_2020)   1 7501.6
## + rcs(Raks_AndelArblosInk)        4 7501.8
## + factor(HushallsTyp_RTB)         2 7502.6
## + rcs(bmi)                        4 7502.6
## + factor(Sun2000niva_old)         6 7502.9
## + factor(rokare)                  1 7503.1
## + rcs(Raks_AndelEkBisInk)         3 7505.6
## + rcs(Raks_AndelSjukInk)          4 7505.8
## + rcs(IV_AverageSaturation)       4 7505.8
## + rcs(kolesterol)                 4 7506.7

## number of knots in rcs defaulting to 5

## 
## Step:  AIC=7401.05
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

##                                  Df    AIC
## + factor(stroke_history)          1 7371.9
## + rcs(DispInkKEHB04)              4 7380.0
## + rcs(hba1c)                      4 7384.9
## + factor(antithrombotic_agents)   1 7386.5
## + rcs(systoliskt)                 4 7387.0
## + rcs(IV_ODI)                     4 7397.2
## + factor(rokare)                  1 7399.2
## + rcs(IV_AHI)                     4 7400.0
## + factor(sex)                     1 7400.3
## + rcs(Raks_AndelEkBisInk)         3 7400.9
## <none>                              7401.1
## + factor(lipid_modifying_agents)  1 7401.9
## + factor(ami_history)             1 7402.1
## + rcs(Raks_AndelArblosInk)        4 7402.3
## + factor(antihypertensive_comb)   1 7402.5
## + factor(Civil)                   1 7402.6
## + factor(FodelseLand_EU27_2020)   1 7402.9
## + rcs(GFR)                        4 7403.8
## + factor(HushallsTyp_RTB)         2 7404.6
## + rcs(kolesterol)                 4 7405.8
## + rcs(IV_AverageSaturation)       4 7406.9
## + rcs(Raks_AndelSjukInk)          4 7407.5
## + factor(Sun2000niva_old)         6 7408.7
## + rcs(bmi)                        4 7408.9
## - rcs(alder)                      4 7501.2

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## 
## Step:  AIC=7371.86
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history)

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

##                                  Df    AIC
## + factor(antithrombotic_agents)   1 7350.8
## + rcs(DispInkKEHB04)              4 7351.1
## + rcs(hba1c)                      4 7355.2
## + rcs(systoliskt)                 4 7358.0
## + rcs(IV_ODI)                     4 7367.7
## + factor(rokare)                  1 7369.7
## + rcs(IV_AHI)                     4 7370.1
## + factor(sex)                     1 7370.8
## + rcs(Raks_AndelEkBisInk)         3 7371.7
## + factor(lipid_modifying_agents)  1 7371.7
## <none>                              7371.9
## + factor(ami_history)             1 7372.8
## + factor(antihypertensive_comb)   1 7373.2
## + rcs(Raks_AndelArblosInk)        4 7373.2
## + factor(Civil)                   1 7373.4
## + factor(FodelseLand_EU27_2020)   1 7373.8
## + rcs(GFR)                        4 7374.2
## + factor(HushallsTyp_RTB)         2 7375.4
## + rcs(kolesterol)                 4 7376.7
## + rcs(IV_AverageSaturation)       4 7377.7
## + rcs(Raks_AndelSjukInk)          4 7378.0
## + factor(Sun2000niva_old)         6 7379.3
## + rcs(bmi)                        4 7379.7
## - factor(stroke_history)          1 7401.1
## - rcs(alder)                      4 7479.0

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## 
## Step:  AIC=7350.85
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents)

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

##                                                      Df    AIC
## + rcs(DispInkKEHB04)                                  4 7331.3
## + rcs(systoliskt)                                     4 7335.5
## + rcs(hba1c)                                          4 7336.4
## + rcs(IV_ODI)                                         4 7347.4
## + factor(rokare)                                      1 7349.2
## + rcs(IV_AHI)                                         4 7349.4
## + factor(cpap_treated):factor(antithrombotic_agents)  1 7349.5
## + rcs(Raks_AndelEkBisInk)                             3 7350.8
## <none>                                                  7350.8
## + factor(sex)                                         1 7351.4
## + rcs(Raks_AndelArblosInk)                            4 7352.3
## + factor(Civil)                                       1 7352.5
## + factor(ami_history)                                 1 7352.7
## + factor(FodelseLand_EU27_2020)                       1 7352.8
## + factor(lipid_modifying_agents)                      1 7352.8
## + factor(antihypertensive_comb)                       1 7352.8
## + factor(HushallsTyp_RTB)                             2 7354.2
## + rcs(GFR)                                            4 7354.3
## + rcs(kolesterol)                                     4 7355.0
## + rcs(IV_AverageSaturation)                           4 7356.8
## + rcs(Raks_AndelSjukInk)                              4 7357.3
## + rcs(bmi)                                            4 7358.7
## + factor(Sun2000niva_old)                             6 7359.0
## - factor(antithrombotic_agents)                       1 7371.9
## - factor(stroke_history)                              1 7386.5
## - rcs(alder)                                          4 7420.3

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## 
## Step:  AIC=7331.29
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04)

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

##                                                      Df    AIC
## + rcs(systoliskt)                                     4 7315.9
## + rcs(hba1c)                                          4 7319.7
## + rcs(IV_ODI)                                         4 7328.2
## + factor(cpap_treated):factor(antithrombotic_agents)  1 7329.7
## + rcs(IV_AHI)                                         4 7329.8
## + factor(rokare)                                      1 7330.3
## + factor(sex)                                         1 7330.3
## <none>                                                  7331.3
## + factor(Civil)                                       1 7332.7
## + factor(FodelseLand_EU27_2020)                       1 7332.8
## + factor(ami_history)                                 1 7333.2
## + rcs(Raks_AndelArblosInk)                            4 7333.3
## + factor(antihypertensive_comb)                       1 7333.3
## + factor(lipid_modifying_agents)                      1 7333.3
## + rcs(Raks_AndelEkBisInk)                             3 7333.5
## + factor(HushallsTyp_RTB)                             2 7334.6
## + rcs(kolesterol)                                     4 7335.3
## + rcs(GFR)                                            4 7335.4
## + rcs(IV_AverageSaturation)                           4 7337.6
## + rcs(Raks_AndelSjukInk)                              4 7337.9
## + rcs(bmi)                                            4 7338.9
## + factor(Sun2000niva_old)                             6 7341.4
## - rcs(DispInkKEHB04)                                  4 7350.8
## - factor(antithrombotic_agents)                       1 7351.1
## - factor(stroke_history)                              1 7366.4
## - rcs(alder)                                          4 7403.9

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## 
## Step:  AIC=7315.9
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + rcs(systoliskt)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

##                                                      Df    AIC
## + rcs(hba1c)                                          4 7305.8
## + rcs(IV_ODI)                                         4 7313.4
## + factor(cpap_treated):factor(antithrombotic_agents)  1 7314.2
## + factor(rokare)                                      1 7314.8
## + factor(sex)                                         1 7315.0
## + rcs(IV_AHI)                                         4 7315.1
## <none>                                                  7315.9
## + factor(Civil)                                       1 7317.1
## + factor(FodelseLand_EU27_2020)                       1 7317.5
## + factor(antihypertensive_comb)                       1 7317.7
## + factor(ami_history)                                 1 7317.8
## + factor(lipid_modifying_agents)                      1 7317.9
## + rcs(Raks_AndelArblosInk)                            4 7318.0
## + rcs(Raks_AndelEkBisInk)                             3 7318.1
## + factor(HushallsTyp_RTB)                             2 7319.2
## + rcs(GFR)                                            4 7320.1
## + rcs(kolesterol)                                     4 7320.5
## + rcs(IV_AverageSaturation)                           4 7322.3
## + rcs(Raks_AndelSjukInk)                              4 7322.4
## + rcs(bmi)                                            4 7323.4
## + factor(Sun2000niva_old)                             6 7326.0
## - rcs(systoliskt)                                     4 7331.3
## - rcs(DispInkKEHB04)                                  4 7335.5
## - factor(antithrombotic_agents)                       1 7337.1
## - factor(stroke_history)                              1 7351.2
## - rcs(alder)                                          4 7381.7

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## 
## Step:  AIC=7305.75
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + rcs(systoliskt) + rcs(hba1c)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

##                                                      Df    AIC
## + factor(cpap_treated):factor(antithrombotic_agents)  1 7304.3
## + factor(rokare)                                      1 7304.7
## + factor(sex)                                         1 7305.3
## + rcs(IV_ODI)                                         4 7305.7
## <none>                                                  7305.8
## + factor(Civil)                                       1 7306.9
## + rcs(IV_AHI)                                         4 7306.9
## + factor(FodelseLand_EU27_2020)                       1 7307.5
## + factor(antihypertensive_comb)                       1 7307.5
## + factor(ami_history)                                 1 7307.7
## + factor(lipid_modifying_agents)                      1 7307.7
## + rcs(Raks_AndelArblosInk)                            4 7307.8
## + rcs(Raks_AndelEkBisInk)                             3 7308.0
## + factor(HushallsTyp_RTB)                             2 7309.0
## + rcs(GFR)                                            4 7310.6
## + rcs(kolesterol)                                     4 7310.7
## + rcs(Raks_AndelSjukInk)                              4 7312.0
## + rcs(IV_AverageSaturation)                           4 7312.4
## + rcs(bmi)                                            4 7312.7
## - rcs(hba1c)                                          4 7315.9
## + factor(Sun2000niva_old)                             6 7315.9
## - rcs(systoliskt)                                     4 7319.7
## - rcs(DispInkKEHB04)                                  4 7322.6
## - factor(antithrombotic_agents)                       1 7325.2
## - factor(stroke_history)                              1 7341.2
## - rcs(alder)                                          4 7377.6

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## 
## Step:  AIC=7304.3
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + rcs(systoliskt) + rcs(hba1c) + factor(cpap_treated):factor(antithrombotic_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

##                                                      Df    AIC
## + factor(rokare)                                      1 7303.1
## + factor(sex)                                         1 7303.8
## <none>                                                  7304.3
## + rcs(IV_ODI)                                         4 7304.5
## + factor(Civil)                                       1 7305.4
## + rcs(IV_AHI)                                         4 7305.6
## - factor(cpap_treated):factor(antithrombotic_agents)  1 7305.8
## + factor(antihypertensive_comb)                       1 7306.0
## + factor(FodelseLand_EU27_2020)                       1 7306.1
## + rcs(Raks_AndelArblosInk)                            4 7306.3
## + factor(ami_history)                                 1 7306.3
## + factor(lipid_modifying_agents)                      1 7306.3
## + rcs(Raks_AndelEkBisInk)                             3 7306.5
## + factor(HushallsTyp_RTB)                             2 7307.6
## + rcs(GFR)                                            4 7309.1
## + rcs(kolesterol)                                     4 7309.2
## + rcs(Raks_AndelSjukInk)                              4 7310.6
## + rcs(IV_AverageSaturation)                           4 7311.0
## + rcs(bmi)                                            4 7311.1
## - rcs(hba1c)                                          4 7314.2
## + factor(Sun2000niva_old)                             6 7314.5
## - rcs(systoliskt)                                     4 7318.3
## - rcs(DispInkKEHB04)                                  4 7321.4
## - factor(stroke_history)                              1 7339.6
## - rcs(alder)                                          4 7376.5

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## 
## Step:  AIC=7303.07
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + rcs(systoliskt) + rcs(hba1c) + factor(rokare) + 
##     factor(cpap_treated):factor(antithrombotic_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

##                                                      Df    AIC
## + factor(sex)                                         1 7302.6
## <none>                                                  7303.1
## + rcs(IV_ODI)                                         4 7303.2
## + factor(Civil)                                       1 7304.2
## - factor(rokare)                                      1 7304.3
## + rcs(IV_AHI)                                         4 7304.4
## - factor(cpap_treated):factor(antithrombotic_agents)  1 7304.7
## + factor(FodelseLand_EU27_2020)                       1 7304.8
## + factor(antihypertensive_comb)                       1 7304.8
## + rcs(Raks_AndelArblosInk)                            4 7305.0
## + factor(ami_history)                                 1 7305.1
## + factor(lipid_modifying_agents)                      1 7305.1
## + rcs(Raks_AndelEkBisInk)                             3 7305.6
## + factor(HushallsTyp_RTB)                             2 7306.2
## + rcs(GFR)                                            4 7307.9
## + rcs(kolesterol)                                     4 7308.1
## + rcs(Raks_AndelSjukInk)                              4 7309.3
## + rcs(IV_AverageSaturation)                           4 7309.9
## + rcs(bmi)                                            4 7310.1
## - rcs(hba1c)                                          4 7313.0
## + factor(Sun2000niva_old)                             6 7313.3
## - rcs(systoliskt)                                     4 7317.3
## - rcs(DispInkKEHB04)                                  4 7319.6
## - factor(stroke_history)                              1 7338.6
## - rcs(alder)                                          4 7378.4

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## 
## Step:  AIC=7302.6
## Surv(start, stop, event) ~ factor(cpap_treated) + rcs(alder) + 
##     factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + rcs(systoliskt) + rcs(hba1c) + factor(rokare) + 
##     factor(sex) + factor(cpap_treated):factor(antithrombotic_agents)

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5
## number of knots in rcs defaulting to 5

## Warning in agreg.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 6 ; beta may be infinite.

##                                                      Df    AIC
## <none>                                                  7302.6
## - factor(sex)                                         1 7303.1
## + rcs(IV_ODI)                                         4 7303.4
## - factor(rokare)                                      1 7303.8
## + factor(Civil)                                       1 7304.2
## - factor(cpap_treated):factor(antithrombotic_agents)  1 7304.2
## + factor(FodelseLand_EU27_2020)                       1 7304.3
## + factor(antihypertensive_comb)                       1 7304.3
## + rcs(Raks_AndelArblosInk)                            4 7304.5
## + factor(ami_history)                                 1 7304.6
## + factor(lipid_modifying_agents)                      1 7304.6
## + rcs(IV_AHI)                                         4 7304.7
## + rcs(Raks_AndelEkBisInk)                             3 7305.2
## + factor(HushallsTyp_RTB)                             2 7305.8
## + rcs(kolesterol)                                     4 7307.1
## + rcs(GFR)                                            4 7307.2
## + rcs(Raks_AndelSjukInk)                              4 7308.7
## + rcs(IV_AverageSaturation)                           4 7309.3
## + rcs(bmi)                                            4 7309.9
## - rcs(hba1c)                                          4 7312.0
## + factor(Sun2000niva_old)                             6 7313.0
## - rcs(systoliskt)                                     4 7316.9
## - rcs(DispInkKEHB04)                                  4 7320.2
## - factor(stroke_history)                              1 7338.0
## - rcs(alder)                                          4 7379.5
## [1] "--- SURVIVAL RESULTS ---"
## Call:
## coxph(formula = Surv(start, stop, event) ~ factor(cpap_treated) + 
##     rcs(alder) + factor(stroke_history) + factor(antithrombotic_agents) + 
##     rcs(DispInkKEHB04) + rcs(systoliskt) + rcs(hba1c) + factor(rokare) + 
##     factor(sex) + factor(cpap_treated):factor(antithrombotic_agents), 
##     data = df_train)
## 
##   n= 151245, number of events= 433 
## 
##                                                            coef  exp(coef)
## factor(cpap_treated)1                                 1.538e-01  1.166e+00
## rcs(alder)alder                                       4.764e-01  1.610e+00
## rcs(alder)alder'                                      1.847e-01  1.203e+00
## rcs(alder)alder''                                     3.223e-01  1.380e+00
## rcs(alder)alder'''                                   -4.026e+00  1.785e-02
## factor(stroke_history)1                              -1.672e+01  5.460e-08
## factor(antithrombotic_agents)1                        5.572e-01  1.746e+00
## rcs(DispInkKEHB04)DispInkKEHB04                      -1.304e-01  8.777e-01
## rcs(DispInkKEHB04)DispInkKEHB04'                      3.884e+00  4.863e+01
## rcs(DispInkKEHB04)DispInkKEHB04''                    -2.677e+01  2.359e-12
## rcs(DispInkKEHB04)DispInkKEHB04'''                    4.615e+01  1.103e+20
## rcs(systoliskt)systoliskt                            -2.891e-01  7.490e-01
## rcs(systoliskt)systoliskt'                            1.273e+00  3.571e+00
## rcs(systoliskt)systoliskt''                          -1.276e+00  2.791e-01
## rcs(systoliskt)systoliskt'''                         -6.155e+00  2.122e-03
## rcs(hba1c)hba1c                                      -4.468e-01  6.397e-01
## rcs(hba1c)hba1c'                                      1.116e+01  7.004e+04
## rcs(hba1c)hba1c''                                    -3.319e+01  3.864e-15
## rcs(hba1c)hba1c'''                                    2.950e+01  6.478e+12
## factor(rokare)1                                       2.510e-01  1.285e+00
## factor(sex)1                                         -1.658e-01  8.472e-01
## factor(cpap_treated)1:factor(antithrombotic_agents)1 -4.143e-01  6.608e-01
##                                                        se(coef)      z Pr(>|z|)
## factor(cpap_treated)1                                 1.471e-01  1.046   0.2957
## rcs(alder)alder                                       3.311e-01  1.439   0.1502
## rcs(alder)alder'                                      1.182e+00  0.156   0.8759
## rcs(alder)alder''                                     6.159e+00  0.052   0.9583
## rcs(alder)alder'''                                    1.061e+01 -0.379   0.7045
## factor(stroke_history)1                               9.692e+02 -0.017   0.9862
## factor(antithrombotic_agents)1                        1.168e-01  4.769 1.86e-06
## rcs(DispInkKEHB04)DispInkKEHB04                       4.496e-01 -0.290   0.7718
## rcs(DispInkKEHB04)DispInkKEHB04'                      6.523e+00  0.596   0.5515
## rcs(DispInkKEHB04)DispInkKEHB04''                     2.298e+01 -1.165   0.2439
## rcs(DispInkKEHB04)DispInkKEHB04'''                    2.675e+01  1.725   0.0845
## rcs(systoliskt)systoliskt                             2.239e-01 -1.291   0.1966
## rcs(systoliskt)systoliskt'                            1.367e+00  0.931   0.3520
## rcs(systoliskt)systoliskt''                           6.931e+00 -0.184   0.8539
## rcs(systoliskt)systoliskt'''                          1.378e+01 -0.447   0.6551
## rcs(hba1c)hba1c                                       4.447e-01 -1.005   0.3151
## rcs(hba1c)hba1c'                                      6.601e+00  1.690   0.0910
## rcs(hba1c)hba1c''                                     1.979e+01 -1.677   0.0935
## rcs(hba1c)hba1c'''                                    1.844e+01  1.600   0.1096
## factor(rokare)1                                       1.362e-01  1.842   0.0655
## factor(sex)1                                          1.065e-01 -1.558   0.1193
## factor(cpap_treated)1:factor(antithrombotic_agents)1  2.201e-01 -1.882   0.0598
##                                                         
## factor(cpap_treated)1                                   
## rcs(alder)alder                                         
## rcs(alder)alder'                                        
## rcs(alder)alder''                                       
## rcs(alder)alder'''                                      
## factor(stroke_history)1                                 
## factor(antithrombotic_agents)1                       ***
## rcs(DispInkKEHB04)DispInkKEHB04                         
## rcs(DispInkKEHB04)DispInkKEHB04'                        
## rcs(DispInkKEHB04)DispInkKEHB04''                       
## rcs(DispInkKEHB04)DispInkKEHB04'''                   .  
## rcs(systoliskt)systoliskt                               
## rcs(systoliskt)systoliskt'                              
## rcs(systoliskt)systoliskt''                             
## rcs(systoliskt)systoliskt'''                            
## rcs(hba1c)hba1c                                         
## rcs(hba1c)hba1c'                                     .  
## rcs(hba1c)hba1c''                                    .  
## rcs(hba1c)hba1c'''                                      
## factor(rokare)1                                      .  
## factor(sex)1                                            
## factor(cpap_treated)1:factor(antithrombotic_agents)1 .  
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
##                                                      exp(coef) exp(-coef)
## factor(cpap_treated)1                                1.166e+00  8.574e-01
## rcs(alder)alder                                      1.610e+00  6.210e-01
## rcs(alder)alder'                                     1.203e+00  8.314e-01
## rcs(alder)alder''                                    1.380e+00  7.245e-01
## rcs(alder)alder'''                                   1.785e-02  5.602e+01
## factor(stroke_history)1                              5.460e-08  1.832e+07
## factor(antithrombotic_agents)1                       1.746e+00  5.728e-01
## rcs(DispInkKEHB04)DispInkKEHB04                      8.777e-01  1.139e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                     4.863e+01  2.056e-02
## rcs(DispInkKEHB04)DispInkKEHB04''                    2.359e-12  4.239e+11
## rcs(DispInkKEHB04)DispInkKEHB04'''                   1.103e+20  9.069e-21
## rcs(systoliskt)systoliskt                            7.490e-01  1.335e+00
## rcs(systoliskt)systoliskt'                           3.571e+00  2.800e-01
## rcs(systoliskt)systoliskt''                          2.791e-01  3.583e+00
## rcs(systoliskt)systoliskt'''                         2.122e-03  4.713e+02
## rcs(hba1c)hba1c                                      6.397e-01  1.563e+00
## rcs(hba1c)hba1c'                                     7.004e+04  1.428e-05
## rcs(hba1c)hba1c''                                    3.864e-15  2.588e+14
## rcs(hba1c)hba1c'''                                   6.478e+12  1.544e-13
## factor(rokare)1                                      1.285e+00  7.780e-01
## factor(sex)1                                         8.472e-01  1.180e+00
## factor(cpap_treated)1:factor(antithrombotic_agents)1 6.608e-01  1.513e+00
##                                                      lower .95 upper .95
## factor(cpap_treated)1                                8.742e-01 1.556e+00
## rcs(alder)alder                                      8.416e-01 3.081e+00
## rcs(alder)alder'                                     1.185e-01 1.221e+01
## rcs(alder)alder''                                    7.889e-06 2.415e+05
## rcs(alder)alder'''                                   1.646e-11 1.936e+07
## factor(stroke_history)1                              0.000e+00       Inf
## factor(antithrombotic_agents)1                       1.388e+00 2.195e+00
## rcs(DispInkKEHB04)DispInkKEHB04                      3.637e-01 2.119e+00
## rcs(DispInkKEHB04)DispInkKEHB04'                     1.364e-04 1.734e+07
## rcs(DispInkKEHB04)DispInkKEHB04''                    6.548e-32 8.500e+07
## rcs(DispInkKEHB04)DispInkKEHB04'''                   1.875e-03 6.485e+42
## rcs(systoliskt)systoliskt                            4.830e-01 1.161e+00
## rcs(systoliskt)systoliskt'                           2.448e-01 5.209e+01
## rcs(systoliskt)systoliskt''                          3.520e-07 2.213e+05
## rcs(systoliskt)systoliskt'''                         3.947e-15 1.141e+09
## rcs(hba1c)hba1c                                      2.676e-01 1.529e+00
## rcs(hba1c)hba1c'                                     1.684e-01 2.914e+10
## rcs(hba1c)hba1c''                                    5.550e-32 2.689e+02
## rcs(hba1c)hba1c'''                                   1.306e-03 3.214e+28
## factor(rokare)1                                      9.841e-01 1.679e+00
## factor(sex)1                                         6.877e-01 1.044e+00
## factor(cpap_treated)1:factor(antithrombotic_agents)1 4.292e-01 1.017e+00
## 
## Concordance= 0.721  (se = 0.012 )
## Likelihood ratio test= 240.9  on 22 df,   p=<2e-16
## Wald test            = 210.5  on 22 df,   p=<2e-16
## Score (logrank) test = 248.3  on 22 df,   p=<2e-16

## Warning in termplot(cph): 'model' appears to involve interactions: see the help
## page

## [1] "--- CONCORDANCE RESULTS ---"
## C-index train: 0.7213385 
## C-index test: 0.7300355